{"id":"https://openalex.org/W2801206142","doi":"https://doi.org/10.1371/journal.pcbi.1006128","title":"EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos","display_name":"EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos","publication_year":2018,"publication_date":"2018-04-19","ids":{"openalex":"https://openalex.org/W2801206142","doi":"https://doi.org/10.1371/journal.pcbi.1006128","mag":"2801206142","pmid":"https://pubmed.ncbi.nlm.nih.gov/29672531"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006128","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006128","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006128&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006128&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004036245","display_name":"Benjamin Schott","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Benjamin Schott","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021823914","display_name":"Manuel Traub","orcid":"https://orcid.org/0000-0003-0897-1701"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuel Traub","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050009700","display_name":"Cornelia Schlagenhauf","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelia Schlagenhauf","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106173143","display_name":"Masanari Takamiya","orcid":"https://orcid.org/0000-0002-6524-5813"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Masanari Takamiya","raw_affiliation_strings":["Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003352895","display_name":"Thomas Antritter","orcid":"https://orcid.org/0000-0002-9344-1598"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Antritter","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045144723","display_name":"Andreas Bartschat","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Bartschat","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031674165","display_name":"Katharina L\u00f6ffler","orcid":"https://orcid.org/0000-0001-9769-3517"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina L\u00f6ffler","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012897974","display_name":"Denis Blessing","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denis Blessing","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087873910","display_name":"Jens C. Otte","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens C. Otte","raw_affiliation_strings":["Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003809213","display_name":"Andrei Yu Kobitski","orcid":"https://orcid.org/0000-0002-5569-2310"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrei Y. Kobitski","raw_affiliation_strings":["Institute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5569-2310","affiliations":[{"raw_affiliation_string":"Institute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079879196","display_name":"G. Ulrich Nienhaus","orcid":"https://orcid.org/0000-0002-5027-3192"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"G. Ulrich Nienhaus","raw_affiliation_strings":["Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","Institute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany","Institute of Nanotechnology, Karlsruhe Institute of Technology, Karlsruhe, Germany","Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Institute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]},{"raw_affiliation_string":"Institute of Nanotechnology, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]},{"raw_affiliation_string":"Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110431301","display_name":"Uwe Str\u00e4hle","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Str\u00e4hle","raw_affiliation_strings":["Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001459055","display_name":"Ralf Mikut","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Mikut","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9100-5496","affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062748514","display_name":"Johannes Stegmaier","orcid":"https://orcid.org/0000-0003-4072-3759"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johannes Stegmaier","raw_affiliation_strings":["Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4072-3759","affiliations":[{"raw_affiliation_string":"Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]},{"raw_affiliation_string":"Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5004036245","https://openalex.org/A5062748514"],"corresponding_institution_ids":["https://openalex.org/I102335020","https://openalex.org/I887968799"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2260,"currency":"EUR","value_usd":2437},"fwci":6.4244,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.96627891,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"14","issue":"4","first_page":"e1006128","last_page":"e1006128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10531","display_name":"Advanced Vision and Imaging","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/terabyte","display_name":"Terabyte","score":0.7054292559623718},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7008962035179138},{"id":"https://openalex.org/keywords/trajectory","display_name":"Trajectory","score":0.6014703512191772},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.5969403386116028},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.5626381635665894},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5569745302200317},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5379154682159424},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.46669772267341614},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.4620124399662018},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43884509801864624},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.417500376701355},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2629168629646301},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.08277353644371033},{"id":"https://openalex.org/keywords/cartography","display_name":"Cartography","score":0.08158445358276367}],"concepts":[{"id":"https://openalex.org/C199683683","wikidata":"https://www.wikidata.org/wiki/Q8799","display_name":"Terabyte","level":2,"score":0.7054292559623718},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7008962035179138},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.6014703512191772},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.5969403386116028},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.5626381635665894},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5569745302200317},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5379154682159424},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.46669772267341614},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4620124399662018},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43884509801864624},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.417500376701355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2629168629646301},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.08277353644371033},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.08158445358276367},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005855","descriptor_name":"Germ Layers","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005855","descriptor_name":"Germ Layers","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005855","descriptor_name":"Germ Layers","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D054262","descriptor_name":"Gastrulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054262","descriptor_name":"Gastrulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054262","descriptor_name":"Gastrulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1006128","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006128","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006128&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29672531","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29672531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:EVASTAR-Karlsruhe.de:1000082328","is_oa":true,"landing_page_url":"https://publikationen.bibliothek.kit.edu/1000082328","pdf_url":null,"source":{"id":"https://openalex.org/S4306401992","display_name":"Repository KITopen (Karlsruhe Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I102335020","host_organization_name":"Karlsruhe Institute of Technology","host_organization_lineage":["https://openalex.org/I102335020"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology, 14 (4), e1006128","raw_type":"doc-type:article"},{"id":"pmh:oai:doaj.org/article:7f33f09408ae4be590227c09b01c12b0","is_oa":false,"landing_page_url":"https://doaj.org/article/7f33f09408ae4be590227c09b01c12b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 4, p e1006128 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4865623","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5929571","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/6163280","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/EmbryoMiner_A_new_framework_for_interactive_knowledge_discovery_in_large-scale_cell_tracking_data_of_developing_embryos/6163280","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5929571","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5929571","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"doi:10.5445/ir/1000082328","is_oa":true,"landing_page_url":"https://doi.org/10.5445/ir/1000082328","pdf_url":null,"source":{"id":"https://openalex.org/S7407052948","display_name":"KITopen","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006128","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006128","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006128&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4279291631","display_name":null,"funder_award_id":"MI 1315/4","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8909796238","display_name":null,"funder_award_id":"SPP 1736","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320876","display_name":"Helmholtz-Gemeinschaft","ror":"https://ror.org/0281dp749"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2801206142.pdf","grobid_xml":"https://content.openalex.org/works/W2801206142.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W149540474","https://openalex.org/W1487395029","https://openalex.org/W1498712972","https://openalex.org/W1530061582","https://openalex.org/W1580913419","https://openalex.org/W1596141725","https://openalex.org/W1667206495","https://openalex.org/W1829737140","https://openalex.org/W1890963650","https://openalex.org/W1893967239","https://openalex.org/W1966459214","https://openalex.org/W1969083288","https://openalex.org/W1970480709","https://openalex.org/W1970884399","https://openalex.org/W1971831631","https://openalex.org/W1977786555","https://openalex.org/W1983600460","https://openalex.org/W1994602988","https://openalex.org/W2009908021","https://openalex.org/W2010780698","https://openalex.org/W2015193409","https://openalex.org/W2017951283","https://openalex.org/W2018983987","https://openalex.org/W2023701980","https://openalex.org/W2030233281","https://openalex.org/W2037947871","https://openalex.org/W2046451474","https://openalex.org/W2050032205","https://openalex.org/W2070585173","https://openalex.org/W2073057651","https://openalex.org/W2084140575","https://openalex.org/W2092272443","https://openalex.org/W2095238531","https://openalex.org/W2097443486","https://openalex.org/W2098667096","https://openalex.org/W2099052097","https://openalex.org/W2114245270","https://openalex.org/W2117697057","https://openalex.org/W2125295969","https://openalex.org/W2127312018","https://openalex.org/W2135362419","https://openalex.org/W2137788460","https://openalex.org/W2141273399","https://openalex.org/W2141952782","https://openalex.org/W2142532592","https://openalex.org/W2147292469","https://openalex.org/W2148993822","https://openalex.org/W2151530263","https://openalex.org/W2151637834","https://openalex.org/W2155321073","https://openalex.org/W2157519031","https://openalex.org/W2167874275","https://openalex.org/W2168391253","https://openalex.org/W2195858147","https://openalex.org/W2245458847","https://openalex.org/W2260455672","https://openalex.org/W2266545981","https://openalex.org/W2274131568","https://openalex.org/W2281148031","https://openalex.org/W2337441569","https://openalex.org/W2400515097","https://openalex.org/W2468991623","https://openalex.org/W2473746984","https://openalex.org/W2479893456","https://openalex.org/W2511233357","https://openalex.org/W2529052661","https://openalex.org/W2758694956","https://openalex.org/W2775939089","https://openalex.org/W2787736564","https://openalex.org/W3006610610","https://openalex.org/W3103217191","https://openalex.org/W3174834309","https://openalex.org/W4250902252","https://openalex.org/W6629401987"],"related_works":["https://openalex.org/W2066858118","https://openalex.org/W1976914335","https://openalex.org/W3011699130","https://openalex.org/W2134017072","https://openalex.org/W2915208987","https://openalex.org/W2152256925","https://openalex.org/W1940452713","https://openalex.org/W1994777790","https://openalex.org/W2005567565","https://openalex.org/W2058150833"],"abstract_inverted_index":{"State-of-the-art":[0],"light-sheet":[1,149],"and":[2,12,25,65,100,105],"confocal":[3],"microscopes":[4],"allow":[5],"recording":[6],"of":[7,36,67,74,93,144,152],"entire":[8,68],"embryos":[9,131],"in":[10,28,34,129],"3D":[11],"over":[13],"time":[14],"(3D+t)":[15],"for":[16,62],"many":[17],"hours.":[18],"Fluorescently":[19],"labeled":[20],"structures":[21],"can":[22,84,160],"be":[23,85,161],"segmented":[24],"tracked":[26],"automatically":[27],"these":[29],"terabyte-scale":[30],"3D+t":[31,148],"images,":[32],"resulting":[33],"thousands":[35],"cell":[37],"migration":[38],"trajectories":[39],"that":[40,132,159],"provide":[41],"detailed":[42],"insights":[43],"to":[44,87,98,106,123],"large-scale":[45],"tissue":[46],"reorganization":[47],"at":[48,78],"the":[49,79,82,96,111,115,164],"cellular":[50],"level.":[51],"Here":[52],"we":[53,146],"present":[54],"EmbryoMiner,":[55],"a":[56,91,119,142],"new":[57,116,121,165],"interactive":[58],"open-source":[59],"framework":[60,83,117],"suitable":[61],"in-depth":[63],"analyses":[64],"comparisons":[66],"embryos,":[69,154],"including":[70],"an":[71],"extensive":[72],"set":[73],"trajectory":[75],"features.":[76],"Starting":[77],"whole-embryo":[80],"level,":[81],"used":[86],"iteratively":[88],"focus":[89],"on":[90,137],"region":[92],"interest":[94],"within":[95],"embryo,":[97],"investigate":[99],"test":[101],"specific":[102],"trajectory-based":[103],"hypotheses":[104],"extract":[107],"quantitative":[108],"features":[109],"from":[110],"isolated":[112],"trajectories.":[113],"Thus,":[114],"provides":[118],"valuable":[120],"way":[122],"quantitatively":[124],"compare":[125],"corresponding":[126],"anatomical":[127],"regions":[128],"different":[130],"were":[133],"manually":[134],"selected":[135],"based":[136],"biological":[138],"prior":[139],"knowledge.":[140],"As":[141],"proof":[143],"concept,":[145],"analyzed":[147],"microscopy":[150],"images":[151],"zebrafish":[153],"showcasing":[155],"potential":[156],"user":[157],"applications":[158],"performed":[162],"using":[163],"framework.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}