{"id":"https://openalex.org/W2767177507","doi":"https://doi.org/10.1371/journal.pcbi.1006113","title":"How stimulation frequency and intensity impact on the long-lasting effects of coordinated reset stimulation","display_name":"How stimulation frequency and intensity impact on the long-lasting effects of coordinated reset stimulation","publication_year":2018,"publication_date":"2018-05-10","ids":{"openalex":"https://openalex.org/W2767177507","doi":"https://doi.org/10.1371/journal.pcbi.1006113","mag":"2767177507","pmid":"https://pubmed.ncbi.nlm.nih.gov/29746458"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006113","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006113","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006113&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006113&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007153850","display_name":"Thanos Manos","orcid":"https://orcid.org/0000-0002-4850-2216"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thanos Manos","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-7), Research Centre J\u00fclich, J\u00fclich, Germany","Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-7), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049181803","display_name":"Magteld Zeitler","orcid":"https://orcid.org/0000-0001-6241-9921"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Magteld Zeitler","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-7), Research Centre J\u00fclich, J\u00fclich, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-7), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078406508","display_name":"Peter A. Tass","orcid":"https://orcid.org/0000-0002-5736-7415"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter A. Tass","raw_affiliation_strings":["Department of Neurosurgery, Stanford University, Stanford, CA, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007153850","https://openalex.org/A5049181803","https://openalex.org/A5078406508"],"corresponding_institution_ids":["https://openalex.org/I44260953","https://openalex.org/I97018004"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1943,"currency":"EUR","value_usd":2095},"fwci":2.0361,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85703195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"14","issue":"5","first_page":"e1006113","last_page":"e1006113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.9164851903915405},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6838619112968445},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.4728313386440277},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3518226444721222},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2953924536705017},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.24740487337112427}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.9164851903915405},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6838619112968445},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4728313386440277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3518226444721222},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2953924536705017},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.24740487337112427}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1006113","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006113","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006113&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29746458","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29746458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03813833v1","is_oa":true,"landing_page_url":"https://hal.science/hal-03813833","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2018, 14, ⟨10.1371/journal.pcbi.1006113⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:b7bb79ddd0ac4c4592956798d00f4a0e","is_oa":true,"landing_page_url":"https://doaj.org/article/b7bb79ddd0ac4c4592956798d00f4a0e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 5, p e1006113 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4935657","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5963814","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/6253445","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/How_stimulation_frequency_and_intensity_impact_on_the_long-lasting_effects_of_coordinated_reset_stimulation/6253445","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:juser.fz-juelich.de:845953","is_oa":true,"landing_page_url":"http://juser.fz-juelich.de/search?p=id:%22FZJ-2018-03131%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401090","display_name":"JuSER (Forschungszentrum J\u00fclich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I171892758","host_organization_name":"Forschungszentrum J\u00fclich","host_organization_lineage":["https://openalex.org/I171892758"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology 14(5), e1006113 - (2018). doi:10.1371/journal.pcbi.1006113","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006113","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006113","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006113&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2767177507.pdf","grobid_xml":"https://content.openalex.org/works/W2767177507.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W22297218","https://openalex.org/W111157985","https://openalex.org/W1504546061","https://openalex.org/W1516596993","https://openalex.org/W1530732299","https://openalex.org/W1542177822","https://openalex.org/W1552174187","https://openalex.org/W1576838367","https://openalex.org/W1620414136","https://openalex.org/W1631356348","https://openalex.org/W1735445987","https://openalex.org/W1747101780","https://openalex.org/W1872235122","https://openalex.org/W1900901185","https://openalex.org/W1940166213","https://openalex.org/W1964251730","https://openalex.org/W1965191393","https://openalex.org/W1968279701","https://openalex.org/W1968919854","https://openalex.org/W1971405195","https://openalex.org/W1971683300","https://openalex.org/W1976149214","https://openalex.org/W1976576140","https://openalex.org/W1977954917","https://openalex.org/W1982575777","https://openalex.org/W1982733111","https://openalex.org/W1982857422","https://openalex.org/W1984866500","https://openalex.org/W1985940938","https://openalex.org/W1986246844","https://openalex.org/W1988922563","https://openalex.org/W1992034695","https://openalex.org/W1992476998","https://openalex.org/W1992592908","https://openalex.org/W1996079598","https://openalex.org/W1996350651","https://openalex.org/W1996447116","https://openalex.org/W1996710543","https://openalex.org/W1998609624","https://openalex.org/W2006438830","https://openalex.org/W2008291171","https://openalex.org/W2008462638","https://openalex.org/W2009375605","https://openalex.org/W2009782005","https://openalex.org/W2011203670","https://openalex.org/W2015133716","https://openalex.org/W2015173963","https://openalex.org/W2018141527","https://openalex.org/W2018830020","https://openalex.org/W2024525458","https://openalex.org/W2024829925","https://openalex.org/W2025040150","https://openalex.org/W2025878824","https://openalex.org/W2028766113","https://openalex.org/W2029609355","https://openalex.org/W2030308994","https://openalex.org/W2036298952","https://openalex.org/W2039033776","https://openalex.org/W2039543692","https://openalex.org/W2042579628","https://openalex.org/W2045695914","https://openalex.org/W2046424015","https://openalex.org/W2047516612","https://openalex.org/W2047787641","https://openalex.org/W2051078121","https://openalex.org/W2052387549","https://openalex.org/W2053168002","https://openalex.org/W2061293139","https://openalex.org/W2062865989","https://openalex.org/W2062946430","https://openalex.org/W2066598509","https://openalex.org/W2073371255","https://openalex.org/W2074959339","https://openalex.org/W2075100344","https://openalex.org/W2083628144","https://openalex.org/W2084249417","https://openalex.org/W2086794075","https://openalex.org/W2091329515","https://openalex.org/W2093267497","https://openalex.org/W2094523157","https://openalex.org/W2095270577","https://openalex.org/W2096892963","https://openalex.org/W2103105094","https://openalex.org/W2103203738","https://openalex.org/W2104966985","https://openalex.org/W2107199167","https://openalex.org/W2112073018","https://openalex.org/W2113345172","https://openalex.org/W2114715506","https://openalex.org/W2115168491","https://openalex.org/W2115992502","https://openalex.org/W2116532979","https://openalex.org/W2119545880","https://openalex.org/W2120259661","https://openalex.org/W2121840032","https://openalex.org/W2124698022","https://openalex.org/W2126003957","https://openalex.org/W2132613708","https://openalex.org/W2135385163","https://openalex.org/W2135498452","https://openalex.org/W2140001342","https://openalex.org/W2141320069","https://openalex.org/W2146729611","https://openalex.org/W2147101007","https://openalex.org/W2149476088","https://openalex.org/W2150135821","https://openalex.org/W2151189162","https://openalex.org/W2153564253","https://openalex.org/W2157586156","https://openalex.org/W2164610565","https://openalex.org/W2167809052","https://openalex.org/W2168003205","https://openalex.org/W2168358833","https://openalex.org/W2185212694","https://openalex.org/W2186321983","https://openalex.org/W2191811942","https://openalex.org/W2276520015","https://openalex.org/W2297915641","https://openalex.org/W2309909559","https://openalex.org/W2317176447","https://openalex.org/W2319794630","https://openalex.org/W2320586767","https://openalex.org/W2321920940","https://openalex.org/W2335821439","https://openalex.org/W2388478874","https://openalex.org/W2403035290","https://openalex.org/W2407522758","https://openalex.org/W2410061915","https://openalex.org/W2416125190","https://openalex.org/W2465369861","https://openalex.org/W2466713183","https://openalex.org/W2473101345","https://openalex.org/W2511969663","https://openalex.org/W2518643409","https://openalex.org/W2594706212","https://openalex.org/W2617110132","https://openalex.org/W2622514185","https://openalex.org/W2726518832","https://openalex.org/W2768719463","https://openalex.org/W2827941376","https://openalex.org/W2909581717","https://openalex.org/W2947088850","https://openalex.org/W2951234596","https://openalex.org/W2956408057","https://openalex.org/W2964232791","https://openalex.org/W2973588905","https://openalex.org/W3099365323","https://openalex.org/W4251731575","https://openalex.org/W4252684946","https://openalex.org/W4285719527","https://openalex.org/W6600908497","https://openalex.org/W7048666912"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W2110087045"],"abstract_inverted_index":{"Several":[0],"brain":[1],"diseases":[2],"are":[3,99,218],"characterized":[4],"by":[5,24],"abnormally":[6],"strong":[7],"neuronal":[8,21,56,123,240],"synchrony.":[9,57],"Coordinated":[10],"Reset":[11],"(CR)":[12],"stimulation":[13,64,88,120,131,152,190,201,206,227,233,258],"was":[14,132],"computationally":[15],"designed":[16],"to":[17,36,45,83,169,193,245],"specifically":[18],"counteract":[19],"abnormal":[20,51,55],"synchronization":[22],"processes":[23],"desynchronization.":[25,222],"In":[26],"the":[27,86,91,96,104,109,112,118,178,182,187,200,236,239,272],"presence":[28],"of":[29,39,50,62,73,111,151,174,181,199,238,257,274],"spike-timing-dependent":[30],"plasticity":[31],"(STDP)":[32],"this":[33,128,267],"may":[34,268],"lead":[35,168],"a":[37,148,264],"decrease":[38],"synaptic":[40,52],"excitatory":[41],"weights":[42],"and":[43,54,70,114,154,231,248],"ultimately":[44],"an":[46],"anti-kindling,":[47],"i.e.":[48,90],"unlearning":[49],"connectivity":[53],"The":[58],"long-lasting":[59],"desynchronizing":[60],"impact":[61],"CR":[63,87,97,119,130,185,189,205,226,281],"has":[65],"been":[66],"verified":[67],"in":[68,122,147,235,250,271],"pre-clinical":[69],"clinical":[71,265],"proof":[72],"concept":[74],"studies.":[75],"However,":[76,203],"as":[77,139,141,277,279],"yet":[78],"it":[79],"is":[80,260],"unclear":[81],"how":[82],"optimally":[84],"choose":[85],"frequency,":[89],"repetition":[92],"rate":[93],"at":[94,228],"which":[95],"stimuli":[98],"delivered.":[100],"This":[101],"work":[102],"presents":[103],"first":[105],"computational":[106],"study":[107],"on":[108,117],"dependence":[110],"acute":[113,160],"long-term":[115,170,179,221],"outcome":[116],"frequency":[121],"networks":[124],"with":[125,134,142,232],"STDP.":[126],"For":[127,223],"purpose,":[129],"applied":[133],"Rapidly":[135],"Varying":[136,144],"Sequences":[137,145],"(RVS)":[138],"well":[140,278],"Slowly":[143],"(SVS)":[146],"wide":[149],"range":[150,237],"frequencies":[153,234],"intensities.":[155],"Our":[156],"findings":[157],"demonstrate":[158],"that":[159,217],"desynchronization,":[161],"achieved":[162],"during":[163],"stimulation,":[164],"does":[165],"not":[166],"necessarily":[167],"desynchronization":[171],"after":[172],"cessation":[173],"stimulation.":[175,282],"By":[176],"comparing":[177],"effects":[180],"two":[183],"different":[184],"protocols,":[186],"RVS":[188,225],"turned":[191,243],"out":[192,244],"be":[194,246,269],"more":[195],"robust":[196],"against":[197],"variations":[198],"frequency.":[202],"SVS":[204],"can":[207],"obtain":[208],"stronger":[209],"anti-kindling":[210],"effects.":[211],"We":[212],"revealed":[213],"specific":[214],"parameter":[215],"ranges":[216],"favorable":[219],"for":[220],"instance,":[224],"weak":[229],"intensities":[230],"firing":[241],"rates":[242],"effective":[247],"robust,":[249],"particular,":[251],"if":[252],"no":[253],"closed":[254],"loop":[255],"adaptation":[256],"parameters":[259],"(technically)":[261],"available.":[262],"From":[263],"standpoint,":[266],"relevant":[270],"context":[273],"both":[275],"invasive":[276],"non-invasive":[280]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}