{"id":"https://openalex.org/W2796419182","doi":"https://doi.org/10.1371/journal.pcbi.1006072","title":"Effect of Ca2+ on the promiscuous target-protein binding of calmodulin","display_name":"Effect of Ca2+ on the promiscuous target-protein binding of calmodulin","publication_year":2018,"publication_date":"2018-04-03","ids":{"openalex":"https://openalex.org/W2796419182","doi":"https://doi.org/10.1371/journal.pcbi.1006072","mag":"2796419182","pmid":"https://pubmed.ncbi.nlm.nih.gov/29614072"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006072","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006072&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006072&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027895655","display_name":"Annie M. Westerlund","orcid":"https://orcid.org/0000-0003-2288-5711"},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Annie M. Westerlund","raw_affiliation_strings":["Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016","https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027666305","display_name":"Lucie Delemotte","orcid":"https://orcid.org/0000-0002-0828-3899"},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Lucie Delemotte","raw_affiliation_strings":["Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0828-3899","affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016","https://openalex.org/I2800139495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027666305"],"corresponding_institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1860,"currency":"EUR","value_usd":2006},"fwci":3.061,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.92409252,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"14","issue":"4","first_page":"e1006072","last_page":"e1006072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"Calmodulin","score":0.813282310962677},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.630757749080658},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6304538249969482},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6179717779159546},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.5716755390167236},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5124319195747375},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.45118600130081177},{"id":"https://openalex.org/keywords/ef-hand","display_name":"EF hand","score":0.44359785318374634},{"id":"https://openalex.org/keywords/calcium-binding-protein","display_name":"Calcium-binding protein","score":0.43651461601257324},{"id":"https://openalex.org/keywords/umbrella-sampling","display_name":"Umbrella sampling","score":0.4229377508163452},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.377932071685791},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.34845805168151855},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.2361639142036438},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19708910584449768},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.10505363345146179}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.813282310962677},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.630757749080658},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6304538249969482},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6179717779159546},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5716755390167236},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5124319195747375},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.45118600130081177},{"id":"https://openalex.org/C42086223","wikidata":"https://www.wikidata.org/wiki/Q24723907","display_name":"EF hand","level":4,"score":0.44359785318374634},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.43651461601257324},{"id":"https://openalex.org/C128747166","wikidata":"https://www.wikidata.org/wiki/Q7881414","display_name":"Umbrella sampling","level":3,"score":0.4229377508163452},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.377932071685791},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34845805168151855},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2361639142036438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19708910584449768},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.10505363345146179},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001059","descriptor_name":"Apoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001059","descriptor_name":"Apoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001059","descriptor_name":"Apoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001059","descriptor_name":"Apoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001059","descriptor_name":"Apoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001059","descriptor_name":"Apoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1006072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006072","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006072&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29614072","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29614072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1006072","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006072","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5bfac498198d47578ed72e7644358e1f","is_oa":false,"landing_page_url":"https://doaj.org/article/5bfac498198d47578ed72e7644358e1f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 4, p e1006072 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4835205","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5898786","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/6081437","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Effect_of_Ca_sup_2_sup_on_the_promiscuous_target-protein_binding_of_calmodulin/6081437","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5898786","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5898786","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006072","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006072&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2796419182.pdf","grobid_xml":"https://content.openalex.org/works/W2796419182.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1554380657","https://openalex.org/W1594922720","https://openalex.org/W1963766011","https://openalex.org/W1964605826","https://openalex.org/W1965661118","https://openalex.org/W1976298967","https://openalex.org/W1976499671","https://openalex.org/W1976566429","https://openalex.org/W1977643725","https://openalex.org/W1984481443","https://openalex.org/W1985405860","https://openalex.org/W1988512606","https://openalex.org/W1989680282","https://openalex.org/W1991256554","https://openalex.org/W1992062503","https://openalex.org/W2008708467","https://openalex.org/W2013880394","https://openalex.org/W2017196167","https://openalex.org/W2017839008","https://openalex.org/W2020545583","https://openalex.org/W2020612427","https://openalex.org/W2021520922","https://openalex.org/W2027380922","https://openalex.org/W2027408247","https://openalex.org/W2029667189","https://openalex.org/W2029870632","https://openalex.org/W2032363535","https://openalex.org/W2035266068","https://openalex.org/W2036711046","https://openalex.org/W2038071582","https://openalex.org/W2040809566","https://openalex.org/W2041652966","https://openalex.org/W2044091418","https://openalex.org/W2045302481","https://openalex.org/W2046090039","https://openalex.org/W2056408100","https://openalex.org/W2061095840","https://openalex.org/W2061979806","https://openalex.org/W2066358752","https://openalex.org/W2067174909","https://openalex.org/W2069187446","https://openalex.org/W2079916233","https://openalex.org/W2080640239","https://openalex.org/W2081693079","https://openalex.org/W2089119029","https://openalex.org/W2089441230","https://openalex.org/W2097412382","https://openalex.org/W2098208486","https://openalex.org/W2100277708","https://openalex.org/W2100446510","https://openalex.org/W2100977104","https://openalex.org/W2103534503","https://openalex.org/W2116234307","https://openalex.org/W2120385383","https://openalex.org/W2123529526","https://openalex.org/W2124822779","https://openalex.org/W2124914104","https://openalex.org/W2126551164","https://openalex.org/W2128572087","https://openalex.org/W2139214355","https://openalex.org/W2140497644","https://openalex.org/W2142207967","https://openalex.org/W2142497607","https://openalex.org/W2146411229","https://openalex.org/W2146942655","https://openalex.org/W2147988069","https://openalex.org/W2165874743","https://openalex.org/W2166330292","https://openalex.org/W2168398034","https://openalex.org/W2206954826","https://openalex.org/W2254169297","https://openalex.org/W2284222372","https://openalex.org/W2318062538","https://openalex.org/W2323157802","https://openalex.org/W2337942016","https://openalex.org/W2341171179","https://openalex.org/W2405114694","https://openalex.org/W2478288995","https://openalex.org/W2509636029","https://openalex.org/W2512316227","https://openalex.org/W2512813967","https://openalex.org/W2521004646","https://openalex.org/W2559588208","https://openalex.org/W2565246878","https://openalex.org/W2583216773","https://openalex.org/W2594657331","https://openalex.org/W2606841515","https://openalex.org/W2730826573","https://openalex.org/W2748320705","https://openalex.org/W2770567138","https://openalex.org/W2801736584","https://openalex.org/W3105901899","https://openalex.org/W4243556619","https://openalex.org/W6704298589"],"related_works":["https://openalex.org/W86744674","https://openalex.org/W1557482814","https://openalex.org/W192779242","https://openalex.org/W2021432785","https://openalex.org/W2416083076","https://openalex.org/W2004125882","https://openalex.org/W2011281950","https://openalex.org/W2111813889","https://openalex.org/W83773294","https://openalex.org/W4254005245"],"abstract_inverted_index":{"Calmodulin":[0],"(CaM)":[1],"is":[2,63],"a":[3,12,19,40,54,64,154,219,280],"calcium":[4],"sensing":[5],"protein":[6],"that":[7,201],"regulates":[8],"the":[9,29,45,71,111,161,166,189,212,224,229,233,242,249,264,277],"function":[10],"of":[11,15,47,57,73,87,114,121,128,138,165,192,228,232,236,245,252,263,266,283],"large":[13,55],"number":[14,56],"proteins,":[16,208],"thus":[17],"playing":[18],"crucial":[20],"part":[21],"in":[22,39,130,136,148,248],"many":[23],"cell":[24],"signaling":[25],"pathways.":[26],"CaM":[27,51,74,91,145,175,193,237,253,267,284],"has":[28,95],"ability":[30],"to":[31,98,134,188,206,211,216,271],"bind":[32,53],"more":[33,220],"than":[34],"300":[35],"different":[36,272],"target":[37,79,207,273],"peptides":[38],"Ca2+-dependent":[41],"manner,":[42],"mainly":[43],"through":[44,218],"exposure":[46,113,127],"hydrophobic":[48,163,246],"residues.":[49,116,185],"How":[50],"can":[52,202],"targets":[58],"while":[59,209,241],"retaining":[60],"some":[61],"selectivity":[62,270],"fascinating":[65],"open":[66],"question.":[67],"Here,":[68],"we":[69],"explore":[70],"mechanism":[72,265],"selective":[75,195],"promiscuity":[76],"for":[77,119,171,256],"selected":[78],"proteins.":[80],"Analyzing":[81],"enhanced":[82],"sampling":[83],"molecular":[84],"dynamics":[85],"simulations":[86],"Ca2+-bound":[88],"and":[89,110,169,183,196,269,275],"Ca2+-free":[90],"via":[92],"spectral":[93],"clustering":[94],"allowed":[96],"us":[97],"identify":[99],"distinct":[100],"conformational":[101,122,132,199],"states,":[102],"characterized":[103],"by":[104,124],"interhelical":[105],"angles,":[106],"secondary":[107],"structure":[108],"determinants":[109],"solvent":[112,126],"specific":[115,198],"We":[117,142],"searched":[118],"indicators":[120],"selection":[123],"mapping":[125],"residues":[129,231,247],"these":[131],"states":[133,146,200],"contacts":[135],"structures":[137],"CaM/target":[139],"peptide":[140],"complexes.":[141],"thereby":[143],"identified":[144],"involved":[147],"various":[149],"binding":[150,156,179,187,205,210,268],"classes":[151],"arranged":[152],"along":[153],"depth":[155],"gradient.":[157],"Binding":[158],"Ca2+":[159],"modifies":[160],"accessible":[162],"surface":[164],"two":[167],"lobes":[168],"allows":[170],"deeper":[172],"binding.":[173],"Apo":[174],"indeed":[176],"shows":[177],"shallow":[178],"involving":[180],"predominantly":[181],"polar":[182],"charged":[184,230],"Furthermore,":[186],"C-terminal":[190,250],"lobe":[191,214,235,251],"appears":[194,215],"involves":[197],"facilitate":[203],"deep":[204],"N-terminal":[213,234],"happen":[217],"flexible":[221],"mechanism.":[222],"Thus":[223],"long-ranged":[225],"electrostatic":[226],"interactions":[227,244],"may":[238,254],"initiate":[239],"binding,":[240],"short-ranged":[243],"account":[255],"selectivity.":[257,285],"This":[258],"work":[259],"furthers":[260],"our":[261],"understanding":[262],"proteins":[274],"paves":[276],"way":[278],"towards":[279],"comprehensive":[281],"model":[282]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":2}],"updated_date":"2026-05-22T09:01:20.584952","created_date":"2025-10-10T00:00:00"}
