{"id":"https://openalex.org/W2791727059","doi":"https://doi.org/10.1371/journal.pcbi.1006051","title":"Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state","display_name":"Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state","publication_year":2018,"publication_date":"2018-03-12","ids":{"openalex":"https://openalex.org/W2791727059","doi":"https://doi.org/10.1371/journal.pcbi.1006051","mag":"2791727059","pmid":"https://pubmed.ncbi.nlm.nih.gov/29529037"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006051","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006051","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006051&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006051&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101567547","display_name":"Hao Ge","orcid":"https://orcid.org/0000-0003-0404-5268"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Ge","raw_affiliation_strings":["Beijing International Center for Mathematical Research (BICMR), Peking University, Beijing, P.R.China","Biodynamic Optical Imaging Center (BIOPIC), Peking University, Beijing, P.R.China"],"raw_orcid":"https://orcid.org/0000-0003-0404-5268","affiliations":[{"raw_affiliation_string":"Beijing International Center for Mathematical Research (BICMR), Peking University, Beijing, P.R.China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Biodynamic Optical Imaging Center (BIOPIC), Peking University, Beijing, P.R.China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109470587","display_name":"Pingping Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingping Wu","raw_affiliation_strings":["School of Mathematical Sciences and Centre for Computational Systems Biology, Fudan University, Shanghai, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences and Centre for Computational Systems Biology, Fudan University, Shanghai, P.R.China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027668881","display_name":"Hong Qian","orcid":"https://orcid.org/0000-0002-5466-8650"},"institutions":[{"id":"https://openalex.org/I4210138199","display_name":"University of Washington Applied Physics Laboratory","ror":"https://ror.org/03d17d270","country_code":"US","type":"facility","lineage":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Qian","raw_affiliation_strings":["Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5466-8650","affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210138199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102919090","display_name":"X. Sunney Xie","orcid":"https://orcid.org/0000-0001-7714-9776"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xiaoliang Sunney Xie","raw_affiliation_strings":["Biodynamic Optical Imaging Center (BIOPIC), Peking University, Beijing, P.R.China","Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodynamic Optical Imaging Center (BIOPIC), Peking University, Beijing, P.R.China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101567547","https://openalex.org/A5102919090"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I20231570"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8352,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.71796139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"e1006051","last_page":"e1006051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.8823477625846863},{"id":"https://openalex.org/keywords/operon","display_name":"Operon","score":0.8122770190238953},{"id":"https://openalex.org/keywords/phenotypic-switching","display_name":"Phenotypic switching","score":0.6506991982460022},{"id":"https://openalex.org/keywords/bimodality","display_name":"Bimodality","score":0.6081323623657227},{"id":"https://openalex.org/keywords/positive-feedback","display_name":"Positive feedback","score":0.48341286182403564},{"id":"https://openalex.org/keywords/stationary-state","display_name":"Stationary state","score":0.4825296103954315},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.4511623978614807},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.42910832166671753},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41570568084716797},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.34539610147476196},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.33389148116111755},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.32490652799606323},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2977903187274933},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1789972186088562},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.14809396862983704},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.12325900793075562},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.09148529171943665}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.8823477625846863},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.8122770190238953},{"id":"https://openalex.org/C2781011225","wikidata":"https://www.wikidata.org/wiki/Q7181400","display_name":"Phenotypic switching","level":4,"score":0.6506991982460022},{"id":"https://openalex.org/C2779287300","wikidata":"https://www.wikidata.org/wiki/Q4913752","display_name":"Bimodality","level":3,"score":0.6081323623657227},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.48341286182403564},{"id":"https://openalex.org/C47458137","wikidata":"https://www.wikidata.org/wiki/Q911951","display_name":"Stationary state","level":2,"score":0.4825296103954315},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.4511623978614807},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.42910832166671753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41570568084716797},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.34539610147476196},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33389148116111755},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.32490652799606323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2977903187274933},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1789972186088562},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.14809396862983704},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12325900793075562},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.09148529171943665},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C98444146","wikidata":"https://www.wikidata.org/wiki/Q318","display_name":"Galaxy","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1006051","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006051","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006051&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29529037","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29529037","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/35982713","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:35982713","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1006051","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006051","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:dac9ecbbb50241f0860d0d5244890173","is_oa":false,"landing_page_url":"https://doaj.org/article/dac9ecbbb50241f0860d0d5244890173","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 3, p e1006051 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5973199","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Relatively_slow_stochastic_gene-state_switching_in_the_presence_of_positive_feedback_significantly_broadens_the_region_of_bimodality_through_stabilizing_the_uninduced_phenotypic_state/5973199","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5864076","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5864076","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006051","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006051","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006051&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2557599781","display_name":null,"funder_award_id":"1DP1OD000277","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3787289004","display_name":null,"funder_award_id":"1DP1OD000277","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4205084726","display_name":null,"funder_award_id":"10901040","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4243412236","display_name":null,"funder_award_id":"863 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5875207080","display_name":null,"funder_award_id":"21373021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7577962310","display_name":null,"funder_award_id":"11622101","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2791727059.pdf","grobid_xml":"https://content.openalex.org/works/W2791727059.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1498806721","https://openalex.org/W1725797689","https://openalex.org/W1965644467","https://openalex.org/W1970172201","https://openalex.org/W1973875954","https://openalex.org/W1974090488","https://openalex.org/W1978182054","https://openalex.org/W1980944685","https://openalex.org/W1981969376","https://openalex.org/W1986717140","https://openalex.org/W1989192823","https://openalex.org/W1998477338","https://openalex.org/W2004801113","https://openalex.org/W2007990378","https://openalex.org/W2008467996","https://openalex.org/W2010173857","https://openalex.org/W2013244831","https://openalex.org/W2014409177","https://openalex.org/W2021611402","https://openalex.org/W2023593061","https://openalex.org/W2027733508","https://openalex.org/W2031822229","https://openalex.org/W2039571025","https://openalex.org/W2040889971","https://openalex.org/W2042321087","https://openalex.org/W2043487490","https://openalex.org/W2049336663","https://openalex.org/W2050482128","https://openalex.org/W2053460598","https://openalex.org/W2054627408","https://openalex.org/W2063854986","https://openalex.org/W2064483836","https://openalex.org/W2066416578","https://openalex.org/W2073033182","https://openalex.org/W2080593071","https://openalex.org/W2086048393","https://openalex.org/W2087234479","https://openalex.org/W2089340422","https://openalex.org/W2091198609","https://openalex.org/W2095921114","https://openalex.org/W2096962759","https://openalex.org/W2104525378","https://openalex.org/W2105357149","https://openalex.org/W2105512180","https://openalex.org/W2118274513","https://openalex.org/W2123634285","https://openalex.org/W2125570771","https://openalex.org/W2129375080","https://openalex.org/W2138710479","https://openalex.org/W2139743733","https://openalex.org/W2141545875","https://openalex.org/W2149242848","https://openalex.org/W2155418451","https://openalex.org/W2155929831","https://openalex.org/W2165430487","https://openalex.org/W2168221215","https://openalex.org/W2168804240","https://openalex.org/W2169316089","https://openalex.org/W2288284086","https://openalex.org/W2293026832","https://openalex.org/W2949339049","https://openalex.org/W3101067495","https://openalex.org/W3103862770","https://openalex.org/W3105895233","https://openalex.org/W4205871929","https://openalex.org/W4210516060","https://openalex.org/W4250181240","https://openalex.org/W7051934559"],"related_works":["https://openalex.org/W2060350357","https://openalex.org/W1996912812","https://openalex.org/W3208766294","https://openalex.org/W2101647844","https://openalex.org/W2032674711","https://openalex.org/W1513979854","https://openalex.org/W2123880844","https://openalex.org/W2152293062","https://openalex.org/W3105418583","https://openalex.org/W2095375866"],"abstract_inverted_index":{"Within":[0],"an":[1,78],"isogenic":[2],"population,":[3],"even":[4],"in":[5,31,40,54,57,80,142,160,213,240,253],"the":[6,25,41,64,74,99,112,125,143,161,168,171,178,185,203,209,214,220,241,271],"same":[7],"extracellular":[8],"environment,":[9],"individual":[10],"cells":[11],"can":[12],"exhibit":[13],"various":[14],"phenotypic":[15,29,278],"states.":[16,279],"The":[17,231],"exact":[18],"role":[19],"of":[20,43,67,84,145,163,194,217,222,244,263,273],"stochastic":[21,135,199],"gene-state":[22],"switching":[23,56,103,149,175,211],"regulating":[24],"transition":[26,238,276],"among":[27,266],"these":[28],"states":[30,59],"a":[32,82,89,190,223,236,260],"single":[33],"cell":[34],"is":[35,60,131,248],"not":[36],"fully":[37],"understood,":[38],"especially":[39],"presence":[42,162],"positive":[44,113,146,164],"feedback.":[45],"Recent":[46],"high-precision":[47],"single-cell":[48],"measurements":[49],"showed":[50],"that,":[51],"at":[52],"least":[53],"bacteria,":[55],"gene":[58,95],"slow":[61,153,173],"relative":[62],"to":[63,119,154,183,197],"typical":[65],"rates":[66,212],"active":[68],"transcription":[69],"and":[70,123,275],"translation.":[71],"Hence":[72],"using":[73],"lac":[75],"operon":[76],"as":[77,120,198],"archetype,":[79],"such":[81],"region":[83,180,193,243],"operon-state":[85,102,136,148,174,210,245],"switching,":[86,246],"we":[87],"present":[88],"fluctuating-rate":[90,229],"model":[91],"for":[92,128,228,270],"this":[93],"classical":[94],"regulation":[96],"module,":[97],"incorporating":[98],"more":[100],"realistic":[101],"mechanism":[104,115],"that":[105,111,124,141],"was":[106],"recently":[107,224],"elucidated.":[108],"We":[109,138,201],"found":[110],"feedback":[114],"induces":[116],"bistability":[117,156,195,274],"(referred":[118,196],"deterministic":[121],"bistability),":[122],"parameter":[126,192],"range":[127],"its":[129],"occurrence":[130],"significantly":[132],"broadened":[133,191],"by":[134,157,250],"switching.":[137],"further":[139],"show":[140],"absence":[144],"feedback,":[147,165],"must":[150],"be":[151],"extremely":[152],"trigger":[155],"itself.":[158],"However,":[159],"which":[166,247],"stabilizes":[167],"induced":[169],"state,":[170,187],"relatively":[172],"kinetics":[176],"within":[177],"physiological":[179],"are":[181],"sufficient":[182],"stabilize":[184],"uninduced":[186],"together":[188],"generating":[189],"bistability).":[200],"illustrate":[202],"opposite":[204],"phenotype-transition":[205],"rate":[206,226,232,239],"dependence":[207],"upon":[208],"two":[215],"types":[216],"bistability,":[218],"with":[219],"aid":[221],"proposed":[225],"formula":[227,233],"models.":[230],"also":[234],"predicts":[235],"maximal":[237],"intermediate":[242],"validated":[249],"numerical":[251],"simulations":[252],"our":[254,257],"model.":[255],"Overall,":[256],"findings":[258],"suggest":[259],"biological":[261],"function":[262],"transcriptional":[264],"\"variations\"":[265],"genetically":[267],"identical":[268],"cells,":[269],"emergence":[272],"between":[277]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
