{"id":"https://openalex.org/W2786627077","doi":"https://doi.org/10.1371/journal.pcbi.1006010","title":"Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield","display_name":"Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield","publication_year":2018,"publication_date":"2018-02-16","ids":{"openalex":"https://openalex.org/W2786627077","doi":"https://doi.org/10.1371/journal.pcbi.1006010","mag":"2786627077","pmid":"https://pubmed.ncbi.nlm.nih.gov/29451895"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006010","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006010","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006010&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006010&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061645901","display_name":"Meike T. Wortel","orcid":"https://orcid.org/0000-0002-3191-2710"},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL","NO"],"is_corresponding":false,"raw_author_name":"Meike T. Wortel","raw_affiliation_strings":["Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Oslo, Norway","Systems Bioinformatics Section, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit, Amsterdam, The Netherlands","VU - Vrije Universiteit Amsterdam [Amsterdam] (De Boelelaan 1105 1081 HV Amsterdam - Netherlands)","Department of Biosciences [Oslo] (PO box 1066 Blindern\r\n0316 Oslo - Norway)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Systems Bioinformatics Section, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"VU - Vrije Universiteit Amsterdam [Amsterdam] (De Boelelaan 1105 1081 HV Amsterdam - Netherlands)","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Department of Biosciences [Oslo] (PO box 1066 Blindern\r\n0316 Oslo - Norway)","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021074279","display_name":"\u0395lad Noor","orcid":"https://orcid.org/0000-0001-8776-4799"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elad Noor","raw_affiliation_strings":["Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule, Z\u00fcrich, Switzerland","Institute of Molecular Systems Biology (Z\u00fcrich - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute of Molecular Systems Biology (Z\u00fcrich - Switzerland)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088455558","display_name":"Michael C. Ferris","orcid":"https://orcid.org/0000-0002-7652-6776"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2802999273","display_name":"Wisconsin Institutes for Discovery","ror":"https://ror.org/05gbven85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802999273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Ferris","raw_affiliation_strings":["Computer Sciences Department and Wisconsin Institute for Discovery, University of Wisconsin, Madison, Wisconsin, United States of America","University of Wisconsin-Madison (Madison, WI 53706 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Sciences Department and Wisconsin Institute for Discovery, University of Wisconsin, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I2802999273"]},{"raw_affiliation_string":"University of Wisconsin-Madison (Madison, WI 53706 - United States)","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047855050","display_name":"Frank J. Bruggeman","orcid":"https://orcid.org/0000-0002-0255-4766"},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank J. Bruggeman","raw_affiliation_strings":["Systems Bioinformatics Section, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit, Amsterdam, The Netherlands","VU - Vrije Universiteit Amsterdam [Amsterdam] (De Boelelaan 1105 1081 HV Amsterdam - Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Bioinformatics Section, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"VU - Vrije Universiteit Amsterdam [Amsterdam] (De Boelelaan 1105 1081 HV Amsterdam - Netherlands)","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046914403","display_name":"Wolfram Liebermeister","orcid":"https://orcid.org/0000-0002-2568-2381"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210159481","display_name":"Math\u00e9matiques et Informatique Appliqu\u00e9es du G\u00e9nome \u00e0 l'Environnement","ror":"https://ror.org/05qdnns64","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210159481"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR"],"is_corresponding":true,"raw_author_name":"Wolfram Liebermeister","raw_affiliation_strings":["INRA, UR1404, MaIAGE, Universit\u00e9 Paris-Saclay, Jouy-en-Josas, France","Institute of Biochemistry, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","MaIAGE - Math\u00e9matiques et Informatique Appliqu\u00e9es du G\u00e9nome \u00e0 l'Environnement [Jouy-En-Josas] (B\u00e2t. 233, Domaine de Vilvert - 78352 Jouy-en-Josas Cedex - France)","Charit\u00e9 - Universit\u00e4tsMedizin = Charit\u00e9 - University Hospital [Berlin] (Charit\u00e9platz 1,\r\n10117 Berlin - Germany)"],"raw_orcid":"https://orcid.org/0000-0002-2568-2381","affiliations":[{"raw_affiliation_string":"INRA, UR1404, MaIAGE, Universit\u00e9 Paris-Saclay, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I277688954"]},{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"MaIAGE - Math\u00e9matiques et Informatique Appliqu\u00e9es du G\u00e9nome \u00e0 l'Environnement [Jouy-En-Josas] (B\u00e2t. 233, Domaine de Vilvert - 78352 Jouy-en-Josas Cedex - France)","institution_ids":["https://openalex.org/I4210159481"]},{"raw_affiliation_string":"Charit\u00e9 - Universit\u00e4tsMedizin = Charit\u00e9 - University Hospital [Berlin] (Charit\u00e9platz 1,\r\n10117 Berlin - Germany)","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046914403"],"corresponding_institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210159481","https://openalex.org/I7877124"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.8974,"has_fulltext":true,"cited_by_count":114,"citation_normalized_percentile":{"value":0.94586528,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"14","issue":"2","first_page":"e1006010","last_page":"e1006010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yield","display_name":"Yield (engineering)","score":0.7641052007675171},{"id":"https://openalex.org/keywords/growth-rate","display_name":"Growth rate","score":0.667401909828186},{"id":"https://openalex.org/keywords/biomass","display_name":"Biomass (ecology)","score":0.533191442489624},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.510915219783783},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4904315173625946},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.39084112644195557},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3485264778137207},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3387048542499542},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29810452461242676},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.28679656982421875},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.22957754135131836},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22249695658683777},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.15511247515678406},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07765427231788635}],"concepts":[{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.7641052007675171},{"id":"https://openalex.org/C2778312390","wikidata":"https://www.wikidata.org/wiki/Q4139973","display_name":"Growth rate","level":2,"score":0.667401909828186},{"id":"https://openalex.org/C115540264","wikidata":"https://www.wikidata.org/wiki/Q2945560","display_name":"Biomass (ecology)","level":2,"score":0.533191442489624},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.510915219783783},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4904315173625946},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.39084112644195557},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3485264778137207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3387048542499542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29810452461242676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28679656982421875},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.22957754135131836},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22249695658683777},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.15511247515678406},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07765427231788635},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":13,"locations":[{"id":"doi:10.1371/journal.pcbi.1006010","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006010","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006010&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29451895","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29451895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:research.vu.nl:openaire/d7f4853f-0fd8-4204-b96c-68041ee32dde","is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/d7f4853f-0fd8-4204-b96c-68041ee32dde","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wortel, M T, Noor, E, Ferris, M, Bruggeman, F J & Liebermeister, W 2018, 'Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield', PLoS Computational Biology, vol. 14, no. 2, e1006010. https://doi.org/10.1371/journal.pcbi.1006010","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:HAL:hal-02020718v1","is_oa":true,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-02020718","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-734X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02625591v1","is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02625591","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2018, 14 (2), 21 p. &#x27E8;10.1371/journal.pcbi.1006010&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:002793e8d9c34c49a16ed6cca180f654","is_oa":true,"landing_page_url":"https://doaj.org/article/002793e8d9c34c49a16ed6cca180f654","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 2, p e1006010 (2018)","raw_type":"article"},{"id":"pmh:oai:prodinra.inra.fr:424446","is_oa":false,"landing_page_url":"http://prodinra.inra.fr/ft/47218CD1-9F2D-4979-A950-63F9F7DAD213","pdf_url":null,"source":{"id":"https://openalex.org/S4306400794","display_name":"Prodinra (INRA Bordeaux-Aquitaine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210088668","host_organization_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","host_organization_lineage":["https://openalex.org/I4210088668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Computational Biology 2 (14), 21 p.. (2018)","raw_type":"ARTICLE"},{"id":"pmh:oai:pubmedcentral.nih.gov:5847312","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5847312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:research.vu.nl:openaire_cris_publications/d7f4853f-0fd8-4204-b96c-68041ee32dde","is_oa":true,"landing_page_url":"https://hdl.handle.net/1871.1/d7f4853f-0fd8-4204-b96c-68041ee32dde","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wortel, M T, Noor, E, Ferris, M, Bruggeman, F J & Liebermeister, W 2018, 'Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield', PLoS Computational Biology, vol. 14, no. 2, e1006010. https://doi.org/10.1371/journal.pcbi.1006010","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:www.duo.uio.no:10852/71439","is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/71439","pdf_url":null,"source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1553-734X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/250012","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/250012","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 14 (2)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/0b04c6df-2139-422e-8010-8c54484a1527","is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/metabolic-enzyme-cost-explains-variable-tradeoffs-between-microbial-growth-rate-and-yield(0b04c6df-2139-422e-8010-8c54484a1527).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 14(2):e1006010. Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000250012","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000250012","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006010","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006010","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006010&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4419103099","display_name":null,"funder_award_id":"TPdF fellowship (2014-230)","funder_id":"https://openalex.org/F4320327577","funder_display_name":"SystemsX.ch"},{"id":"https://openalex.org/G4453396087","display_name":null,"funder_award_id":"2014-230","funder_id":"https://openalex.org/F4320327577","funder_display_name":"SystemsX.ch"},{"id":"https://openalex.org/G6329410964","display_name":null,"funder_award_id":"40-41009-98-10038","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320929","display_name":"Universiteit Leiden","ror":"https://ror.org/027bh9e22"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320327577","display_name":"SystemsX.ch","ror":"https://ror.org/02s09gf16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2786627077.pdf","grobid_xml":"https://content.openalex.org/works/W2786627077.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1570124823","https://openalex.org/W1588504519","https://openalex.org/W1758395617","https://openalex.org/W1873506857","https://openalex.org/W1880468382","https://openalex.org/W1967500610","https://openalex.org/W1977688694","https://openalex.org/W1985161570","https://openalex.org/W1996893186","https://openalex.org/W2008195780","https://openalex.org/W2016528906","https://openalex.org/W2022374283","https://openalex.org/W2032890906","https://openalex.org/W2035040435","https://openalex.org/W2035612098","https://openalex.org/W2035934220","https://openalex.org/W2036289648","https://openalex.org/W2038630337","https://openalex.org/W2039230661","https://openalex.org/W2047195788","https://openalex.org/W2048243530","https://openalex.org/W2049328674","https://openalex.org/W2054566090","https://openalex.org/W2064225140","https://openalex.org/W2081580266","https://openalex.org/W2090098817","https://openalex.org/W2094399313","https://openalex.org/W2099039198","https://openalex.org/W2099257216","https://openalex.org/W2100799019","https://openalex.org/W2103238085","https://openalex.org/W2105462639","https://openalex.org/W2107275175","https://openalex.org/W2113468128","https://openalex.org/W2116324021","https://openalex.org/W2122860350","https://openalex.org/W2130934749","https://openalex.org/W2132105526","https://openalex.org/W2144068357","https://openalex.org/W2144683622","https://openalex.org/W2145302559","https://openalex.org/W2157457604","https://openalex.org/W2159379185","https://openalex.org/W2160259320","https://openalex.org/W2162712351","https://openalex.org/W2163433435","https://openalex.org/W2165254936","https://openalex.org/W2168360074","https://openalex.org/W2170298003","https://openalex.org/W2171745314","https://openalex.org/W2176208791","https://openalex.org/W2176595367","https://openalex.org/W2187089797","https://openalex.org/W2293953879","https://openalex.org/W2312280072","https://openalex.org/W2345232881","https://openalex.org/W2416065856","https://openalex.org/W2460563608","https://openalex.org/W2465128457","https://openalex.org/W2468889898","https://openalex.org/W2522753993","https://openalex.org/W2591030939","https://openalex.org/W2593549191","https://openalex.org/W2606897259","https://openalex.org/W2612612547","https://openalex.org/W2614283331","https://openalex.org/W2737557435","https://openalex.org/W2760308229","https://openalex.org/W2784273533","https://openalex.org/W2962760960","https://openalex.org/W3142465472","https://openalex.org/W4234174709","https://openalex.org/W7075630165"],"related_works":["https://openalex.org/W2087715585","https://openalex.org/W2393387567","https://openalex.org/W2394833619","https://openalex.org/W3169423050","https://openalex.org/W1990088060","https://openalex.org/W2068260376","https://openalex.org/W4214899539","https://openalex.org/W2064445380","https://openalex.org/W2031825920","https://openalex.org/W2076700267"],"abstract_inverted_index":{"Microbes":[0],"may":[1],"maximize":[2],"the":[3,22,77,83,115,124,127,134,140],"number":[4],"of":[5,13,24,88,96,126,192],"daughter":[6],"cells":[7],"per":[8,11,86],"time":[9],"or":[10,26,197],"amount":[12],"nutrients":[14],"consumed.":[15],"These":[16],"two":[17],"strategies":[18],"correspond,":[19],"respectively,":[20],"to":[21,55,109,179],"use":[23],"enzyme-efficient":[25],"substrate-efficient":[27],"metabolic":[28,149,182],"pathways.":[29,173],"In":[30,91],"reality,":[31],"fast":[32],"growth":[33,47,60,78,116,169,185],"is":[34,143],"often":[35],"associated":[36],"with":[37],"wasteful,":[38],"yield-inefficient":[39,162],"metabolism,":[40],"and":[41,49,73,118,122,151,184,195],"a":[42,65,92,165],"general":[43],"thermodynamic":[44],"trade-off":[45,142,156],"between":[46],"rate":[48,79,87,170],"biomass":[50,89],"yield":[51],"has":[52],"been":[53],"proposed":[54],"explain":[56],"this.":[57],"We":[58],"studied":[59,123],"rate/yield":[61,129,141],"trade-offs":[62],"by":[63,74,114],"using":[64],"novel":[66],"modeling":[67],"framework,":[68],"Enzyme-Flux":[69],"Cost":[70],"Minimization":[71],"(EFCM)":[72],"assuming":[75],"that":[76,139],"depends":[80,147],"directly":[81],"on":[82,148],"enzyme":[84,193],"investment":[85],"production.":[90],"comprehensive":[93],"mathematical":[94],"model":[95,135],"core":[97],"metabolism":[98],"in":[99],"E.":[100],"coli,":[101],"we":[102,137],"screened":[103],"all":[104],"elementary":[105],"flux":[106],"modes":[107],"leading":[108],"cell":[110],"synthesis,":[111],"characterized":[112],"them":[113],"rates":[117,186],"yields":[119],"they":[120],"provide,":[121],"shape":[125],"resulting":[128],"Pareto":[130],"front.":[131],"By":[132],"varying":[133,188],"parameters,":[136,194],"found":[138],"not":[144],"universal,":[145],"but":[146],"kinetics":[150],"environmental":[152],"conditions.":[153],"A":[154],"prominent":[155],"emerges":[157],"under":[158,187],"oxygen-limited":[159],"growth,":[160],"where":[161],"pathways":[163],"support":[164],"2-to-3":[166],"times":[167],"higher":[168],"than":[171],"yield-efficient":[172],"EFCM":[174],"can":[175],"be":[176],"widely":[177],"used":[178],"predict":[180],"optimal":[181],"states":[183],"nutrient":[189],"levels,":[190],"perturbations":[191],"single":[196],"multiple":[198],"gene":[199],"knockouts.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}
