{"id":"https://openalex.org/W2786092929","doi":"https://doi.org/10.1371/journal.pcbi.1006008","title":"Same but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains","display_name":"Same but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains","publication_year":2018,"publication_date":"2018-02-12","ids":{"openalex":"https://openalex.org/W2786092929","doi":"https://doi.org/10.1371/journal.pcbi.1006008","mag":"2786092929","pmid":"https://pubmed.ncbi.nlm.nih.gov/29432415"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006008","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006008","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006008&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006008&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025504735","display_name":"Sneha Vishwanath","orcid":"https://orcid.org/0000-0001-9960-547X"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sneha Vishwanath","raw_affiliation_strings":["Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024376929","display_name":"Alexandre G. de Brevern","orcid":"https://orcid.org/0000-0001-7112-5626"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre G. de Brevern","raw_affiliation_strings":["INSERM, U 1134, DSIMB, Paris, France","Institut National de la Transfusion Sanguine (INTS), Paris, France","Laboratoire d' Excellence GR-Ex, Paris, France","Univ. Paris Diderot, Sorbonne Paris Cit\u00e9, Univ de la R\u00e9union, Univ des Antilles, UMR_S 1134, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-7112-5626","affiliations":[{"raw_affiliation_string":"INSERM, U 1134, DSIMB, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut National de la Transfusion Sanguine (INTS), Paris, France","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d' Excellence GR-Ex, Paris, France","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Univ. Paris Diderot, Sorbonne Paris Cit\u00e9, Univ de la R\u00e9union, Univ des Antilles, UMR_S 1134, Paris, France","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I4210091437","https://openalex.org/I204730241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076920718","display_name":"Narayanaswamy Srinivasan","orcid":"https://orcid.org/0000-0002-6566-6239"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narayanaswamy Srinivasan","raw_affiliation_strings":["Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India"],"raw_orcid":"https://orcid.org/0000-0002-6566-6239","affiliations":[{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076920718"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.1343,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.87810636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"14","issue":"2","first_page":"e1006008","last_page":"e1006008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9652000069618225,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.7055772542953491},{"id":"https://openalex.org/keywords/hamp-domain","display_name":"HAMP domain","score":0.6592804789543152},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.6045820116996765},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.5694486498832703},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.5394144654273987},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.5316615104675293},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.459611177444458},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.44886457920074463},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4431014657020569},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4304075539112091},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41325998306274414},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3302714228630066},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3119506239891052},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23596715927124023},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2302989363670349},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19555523991584778},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11084762215614319}],"concepts":[{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.7055772542953491},{"id":"https://openalex.org/C10522644","wikidata":"https://www.wikidata.org/wiki/Q24775216","display_name":"HAMP domain","level":4,"score":0.6592804789543152},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.6045820116996765},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.5694486498832703},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5394144654273987},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5316615104675293},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.459611177444458},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.44886457920074463},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4431014657020569},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4304075539112091},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41325998306274414},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3302714228630066},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3119506239891052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23596715927124023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2302989363670349},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19555523991584778},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11084762215614319},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006593","descriptor_name":"Hexokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006593","descriptor_name":"Hexokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006593","descriptor_name":"Hexokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019951","descriptor_name":"DNA Polymerase beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019951","descriptor_name":"DNA Polymerase beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019951","descriptor_name":"DNA Polymerase beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021983","descriptor_name":"Cyclophilins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021983","descriptor_name":"Cyclophilins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021983","descriptor_name":"Cyclophilins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1006008","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006008","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006008&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29432415","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29432415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.iisc.ac.in:59534","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:1808.03642","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1808.03642","pdf_url":"https://arxiv.org/pdf/1808.03642","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:HAL:inserm-02147944v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-02147944","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2018, 14 (2), pp.e1006008. &#x27E8;10.1371/journal.pcbi.1006008&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1006008","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006008","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2de3dcc463654bbba1ec54b737773d0b","is_oa":true,"landing_page_url":"https://doaj.org/article/2de3dcc463654bbba1ec54b737773d0b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 2, p e1006008 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4757909","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5825166","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/5878981","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Same_but_not_alike_Structure_flexibility_and_energetics_of_domains_in_multi-domain_proteins_are_influenced_by_the_presence_of_other_domains/5878981","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006008","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006008","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006008&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1241245949","display_name":null,"funder_award_id":"ANR-11-IDEX-0005-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2312321515","display_name":null,"funder_award_id":"ANR-11-LABX-0051","funder_id":"https://openalex.org/F4320323399","funder_display_name":"Universit\u00e9 Paris Diderot"},{"id":"https://openalex.org/G3054294689","display_name":null,"funder_award_id":"11-IDEX-0005-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4507058828","display_name":null,"funder_award_id":"ANR-11-LABX-0051","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4774453313","display_name":null,"funder_award_id":"IDEX-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4866930200","display_name":null,"funder_award_id":"ANR-11-IDEX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8336719376","display_name":null,"funder_award_id":"ANR-11-IDEX-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G978751120","display_name":null,"funder_award_id":"5302-2","funder_id":"https://openalex.org/F4320321027","funder_display_name":"Indo-French Centre for the Promotion of Advanced Research"}],"funders":[{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321027","display_name":"Indo-French Centre for the Promotion of Advanced Research","ror":"https://ror.org/017aem598"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320323399","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46"},{"id":"https://openalex.org/F4320337407","display_name":"Division of Human Resource Development","ror":"https://ror.org/03mamvh39"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2786092929.pdf","grobid_xml":"https://content.openalex.org/works/W2786092929.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W29779864","https://openalex.org/W1491824558","https://openalex.org/W1535422202","https://openalex.org/W1700086138","https://openalex.org/W1849202109","https://openalex.org/W1941291890","https://openalex.org/W1969939692","https://openalex.org/W1970054503","https://openalex.org/W1974196894","https://openalex.org/W1975734895","https://openalex.org/W1979632053","https://openalex.org/W1982874561","https://openalex.org/W1983871031","https://openalex.org/W1988298124","https://openalex.org/W1989509003","https://openalex.org/W1995254028","https://openalex.org/W2007808117","https://openalex.org/W2008052738","https://openalex.org/W2014871570","https://openalex.org/W2023604759","https://openalex.org/W2043580883","https://openalex.org/W2043715877","https://openalex.org/W2046518075","https://openalex.org/W2046535373","https://openalex.org/W2049682677","https://openalex.org/W2053197719","https://openalex.org/W2058376509","https://openalex.org/W2063948029","https://openalex.org/W2065090506","https://openalex.org/W2073306024","https://openalex.org/W2076502650","https://openalex.org/W2083975423","https://openalex.org/W2084929233","https://openalex.org/W2095145098","https://openalex.org/W2102245393","https://openalex.org/W2103722193","https://openalex.org/W2110483430","https://openalex.org/W2112600835","https://openalex.org/W2112792893","https://openalex.org/W2117373256","https://openalex.org/W2123681603","https://openalex.org/W2125837124","https://openalex.org/W2128926770","https://openalex.org/W2130581715","https://openalex.org/W2132022337","https://openalex.org/W2132717858","https://openalex.org/W2138008040","https://openalex.org/W2139074914","https://openalex.org/W2152404535","https://openalex.org/W2154139219","https://openalex.org/W2156125289","https://openalex.org/W2157938277","https://openalex.org/W2160975112","https://openalex.org/W2161072217","https://openalex.org/W2161506293","https://openalex.org/W2171268876","https://openalex.org/W2233692211","https://openalex.org/W2436603651","https://openalex.org/W2579272540","https://openalex.org/W2625442522","https://openalex.org/W2741550721","https://openalex.org/W2750436588","https://openalex.org/W4242742089"],"related_works":["https://openalex.org/W2260493136","https://openalex.org/W2113188411","https://openalex.org/W2976965029","https://openalex.org/W2382178265","https://openalex.org/W2055827177","https://openalex.org/W2072666835","https://openalex.org/W4248706500","https://openalex.org/W1999927713","https://openalex.org/W2081866413","https://openalex.org/W2786092929"],"abstract_inverted_index":{"The":[0],"majority":[1],"of":[2,9,20,47,57,69,88,124,136,142,153,164,179,184,189,195,210,254,263],"the":[3,7,61,67,130,137,143,154,165,170,177,182,185,203,248,252,261],"proteins":[4,22,44,102,128,242,256,274],"encoded":[5],"in":[6,23,66,72,95,126,160,169,228,251,272,287,289],"genomes":[8],"eukaryotes":[10],"contain":[11],"more":[12],"than":[13,111],"one":[14,49,194],"domain.":[15,119,265],"Reasons":[16],"for":[17],"high":[18],"prevalence":[19],"multi-domain":[21,58,75,127,212,241,273],"various":[24],"organisms":[25],"have":[26],"been":[27],"attributed":[28,259],"to":[29,100,107,116,260],"higher":[30],"stability":[31,278],"and":[32,34,74,77,104,133,162,202,220,240],"functional":[33,223],"folding":[35,280],"advantages":[36,281],"over":[37],"single-domain":[38,73,200],"proteins.":[39,59],"Despite":[40],"these":[41,246],"advantages,":[42],"many":[43],"are":[45,55,82],"composed":[46],"only":[48,276],"domain":[50,145,156,206],"while":[51,151],"their":[52,78],"homologous":[53,190,229,255],"domains":[54,71,103,110,125,271],"part":[56,209],"In":[60],"study":[62],"presented":[63],"here,":[64],"differences":[65,159,168,249,288],"properties":[68,135],"protein":[70,90,109,118,139,144,155,191,201,205,230,239],"systems":[76],"influence":[79,178,284],"on":[80,176,181],"functions":[81,253],"discussed.":[83],"We":[84],"studied":[85],"20":[86],"pairs":[87,146,157,188],"identical":[89,219],"domains,":[91,186,192],"which":[92],"were":[93,214,243],"crystallized":[94],"two":[96],"forms":[97],"(a)":[98,112],"tethered":[99,106,115,264,270],"other":[101,204],"(b)":[105],"fewer":[108],"or":[113,279,291],"not":[114,275],"any":[117],"Results":[120],"suggest":[121],"that":[122,218,269],"tethering":[123,180],"influences":[129],"structural,":[131],"dynamic":[132],"energetic":[134],"constituent":[138],"domains.":[140],"50%":[141],"show":[147,158,167,225],"significant":[148],"structural":[149],"deviations":[150],"90%":[152],"dynamics":[161,227,234],"12%":[163],"residues":[166,224],"energetics.":[171],"To":[172],"gain":[173],"further":[174],"insights":[175],"function":[183,290],"4":[187],"where":[193],"them":[196],"is":[197,207],"a":[198,208,211],"full-length":[199],"protein,":[213],"studied.":[215],"Analyses":[216],"showed":[217],"structurally":[221],"equivalent":[222],"differential":[226],"domains;":[231],"though":[232],"comparable":[233],"between":[235],"in-silico":[236],"generated":[237],"chimera":[238],"observed.":[244],"From":[245],"observations,":[247],"observed":[250],"could":[257],"be":[258],"presence":[262],"Overall,":[266],"we":[267],"conclude":[268],"provide":[277],"but":[282],"also":[283],"pathways":[285],"resulting":[286],"regulatory":[292],"properties.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-15T08:27:34.491423","created_date":"2025-10-10T00:00:00"}
