{"id":"https://openalex.org/W2949148219","doi":"https://doi.org/10.1371/journal.pcbi.1005973","title":"GSimp: A Gibbs sampler based left-censored missing value imputation approach for metabolomics studies","display_name":"GSimp: A Gibbs sampler based left-censored missing value imputation approach for metabolomics studies","publication_year":2018,"publication_date":"2018-01-31","ids":{"openalex":"https://openalex.org/W2949148219","doi":"https://doi.org/10.1371/journal.pcbi.1005973","mag":"2949148219","pmid":"https://pubmed.ncbi.nlm.nih.gov/29385130"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005973","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005973","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005973&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005973&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018164370","display_name":"Runmin Wei","orcid":"https://orcid.org/0000-0001-7707-0160"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210093646","display_name":"Cancer Center of Hawaii","ror":"https://ror.org/0065jhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093646"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runmin Wei","raw_affiliation_strings":["Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7707-0160","affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America","institution_ids":["https://openalex.org/I117965899"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America","institution_ids":["https://openalex.org/I4210093646","https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057578539","display_name":"Jingye Wang","orcid":"https://orcid.org/0000-0003-4626-0003"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210093646","display_name":"Cancer Center of Hawaii","ror":"https://ror.org/0065jhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093646"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jingye Wang","raw_affiliation_strings":["Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4626-0003","affiliations":[{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America","institution_ids":["https://openalex.org/I4210093646","https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107892123","display_name":"Erik Jia","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik Jia","raw_affiliation_strings":["High School, Punahou School, Honolulu, Hawaii, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High School, Punahou School, Honolulu, Hawaii, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987223","display_name":"Tianlu Chen","orcid":"https://orcid.org/0000-0003-1798-5435"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianlu Chen","raw_affiliation_strings":["Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210144482","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055572946","display_name":"Yan Ni","orcid":"https://orcid.org/0000-0003-1779-7266"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210093646","display_name":"Cancer Center of Hawaii","ror":"https://ror.org/0065jhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093646"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Ni","raw_affiliation_strings":["Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1779-7266","affiliations":[{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America","institution_ids":["https://openalex.org/I4210093646","https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Jia","orcid":"https://orcid.org/0000-0002-3739-8994"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210093646","display_name":"Cancer Center of Hawaii","ror":"https://ror.org/0065jhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093646"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Jia","raw_affiliation_strings":["Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3739-8994","affiliations":[{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America","institution_ids":["https://openalex.org/I4210093646","https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5057578539"],"corresponding_institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210093646","https://openalex.org/I4390039246"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.2872,"has_fulltext":true,"cited_by_count":175,"citation_normalized_percentile":{"value":0.96695584,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"e1005973","last_page":"e1005973"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9753999710083008,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.9018555283546448},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.816942572593689},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.7177077531814575},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6222484111785889},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5056495666503906},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.46886661648750305},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.43543893098831177},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.41619056463241577},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20378488302230835},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.19646838307380676}],"concepts":[{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.9018555283546448},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.816942572593689},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.7177077531814575},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6222484111785889},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5056495666503906},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.46886661648750305},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.43543893098831177},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.41619056463241577},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20378488302230835},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.19646838307380676},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1005973","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005973","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005973&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29385130","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29385130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1005973","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005973","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ced149225b9d4c729794aef1e59465c0","is_oa":true,"landing_page_url":"https://doaj.org/article/ced149225b9d4c729794aef1e59465c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 1, p e1005973 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5841912","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/GSimp_A_Gibbs_sampler_based_left-censored_missing_value_imputation_approach_for_metabolomics_studies/5841912","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5809088","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5809088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005973","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005973","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005973&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G3169533012","display_name":null,"funder_award_id":"P30 CA071789","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3868434305","display_name":null,"funder_award_id":"CA071789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4047408478","display_name":null,"funder_award_id":"CA071789","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4193928615","display_name":null,"funder_award_id":"1U01CA188387-01A1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4595617625","display_name":null,"funder_award_id":"31501079","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4749267370","display_name":null,"funder_award_id":"1U01CA188387-01A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7390220446","display_name":null,"funder_award_id":"P30 CA071789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949148219.pdf","grobid_xml":"https://content.openalex.org/works/W2949148219.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W263545290","https://openalex.org/W1537066827","https://openalex.org/W1591074079","https://openalex.org/W1594031697","https://openalex.org/W1933039715","https://openalex.org/W1963910454","https://openalex.org/W1976327004","https://openalex.org/W1981457167","https://openalex.org/W1982185581","https://openalex.org/W2031813546","https://openalex.org/W2041552396","https://openalex.org/W2044758663","https://openalex.org/W2047028564","https://openalex.org/W2064186732","https://openalex.org/W2096863518","https://openalex.org/W2099598705","https://openalex.org/W2114754207","https://openalex.org/W2122825543","https://openalex.org/W2135046866","https://openalex.org/W2135607659","https://openalex.org/W2137890713","https://openalex.org/W2148036820","https://openalex.org/W2155128881","https://openalex.org/W2167942713","https://openalex.org/W2171118759","https://openalex.org/W2278988761","https://openalex.org/W2313407065","https://openalex.org/W2331951098","https://openalex.org/W2341820027","https://openalex.org/W2480680997","https://openalex.org/W2563394241","https://openalex.org/W2590976943","https://openalex.org/W2614032291","https://openalex.org/W2911964244","https://openalex.org/W2951837249","https://openalex.org/W4234333941","https://openalex.org/W4234698323","https://openalex.org/W6843735874","https://openalex.org/W7062067314"],"related_works":["https://openalex.org/W2181530120","https://openalex.org/W4211215373","https://openalex.org/W1828158523","https://openalex.org/W2049578243","https://openalex.org/W2000145235","https://openalex.org/W2024529227","https://openalex.org/W2055961818","https://openalex.org/W2122079181","https://openalex.org/W2903115227","https://openalex.org/W1574575415"],"abstract_inverted_index":{"Left-censored":[0],"missing":[1,14,24,57,72],"values":[2,25],"commonly":[3],"exist":[4],"in":[5,48,109],"targeted":[6,88,149],"metabolomics":[7,89,136,150],"datasets":[8,90,151],"and":[9,41,91,117,120,147],"can":[10],"be":[11],"considered":[12],"as":[13],"not":[15],"at":[16],"random":[17],"(MNAR).":[18],"Improper":[19],"data":[20],"processing":[21],"procedures":[22],"for":[23,131,141],"will":[26],"cause":[27],"adverse":[28],"impacts":[29],"on":[30,85],"subsequent":[31],"statistical":[32,121],"analyses.":[33],"However,":[34],"few":[35],"imputation":[36,59,74,83,97,107,112],"methods":[37,84,108],"have":[38],"been":[39],"developed":[40,65,130],"applied":[42],"to":[43],"the":[44,49],"situation":[45],"of":[46,51,111,127],"MNAR":[47],"field":[50],"metabolomics.":[52],"Thus,":[53],"a":[54,124],"practical":[55],"left-censored":[56,71],"value":[58,73],"method":[60],"is":[61],"urgently":[62],"needed.":[63],"We":[64,77],"an":[66],"iterative":[67],"Gibbs":[68],"sampler":[69],"based":[70],"approach":[75],"(GSimp).":[76],"compared":[78],"GSimp":[79,104,128],"with":[80,133],"other":[81,106],"three":[82],"two":[86],"real-world":[87,146],"one":[92],"simulation":[93],"dataset":[94],"using":[95],"our":[96],"evaluation":[98,143],"pipeline.":[99],"The":[100,138],"results":[101],"show":[102],"that":[103],"outperforms":[105],"terms":[110],"accuracy,":[113],"observation":[114],"distribution,":[115],"univariate":[116],"multivariate":[118],"analyses,":[119],"sensitivity.":[122],"Additionally,":[123],"parallel":[125],"version":[126],"was":[129],"dealing":[132],"large":[134],"scale":[135],"datasets.":[137],"R":[139],"code":[140],"GSimp,":[142],"pipeline,":[144],"tutorial,":[145],"simulated":[148],"are":[152],"available":[153],"at:":[154],"https://github.com/WandeRum/GSimp.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":4}],"updated_date":"2026-05-27T09:02:27.158192","created_date":"2025-10-10T00:00:00"}