{"id":"https://openalex.org/W2745757065","doi":"https://doi.org/10.1371/journal.pcbi.1005939","title":"Interactions between species introduce spurious associations in microbiome studies","display_name":"Interactions between species introduce spurious associations in microbiome studies","publication_year":2018,"publication_date":"2018-01-16","ids":{"openalex":"https://openalex.org/W2745757065","doi":"https://doi.org/10.1371/journal.pcbi.1005939","mag":"2745757065","pmid":"https://pubmed.ncbi.nlm.nih.gov/29338008"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005939","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005939","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005939&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005939&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026960940","display_name":"Rajita Menon","orcid":"https://orcid.org/0000-0002-4767-0971"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajita Menon","raw_affiliation_strings":["Department of Physics, Boston University, Boston, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4767-0971","affiliations":[{"raw_affiliation_string":"Department of Physics, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055428336","display_name":"Vivek Ramanan","orcid":"https://orcid.org/0000-0002-6406-3938"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I118020396","display_name":"Swarthmore College","ror":"https://ror.org/012dg8a96","country_code":"US","type":"education","lineage":["https://openalex.org/I118020396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Ramanan","raw_affiliation_strings":["BRITE Bioinformatics REU Program, Boston University, Boston, Massachusetts, United States of America","Department of Biology and Computer Science, Swarthmore College, Swarthmore, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BRITE Bioinformatics REU Program, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Biology and Computer Science, Swarthmore College, Swarthmore, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I118020396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005848494","display_name":"Kirill S. Korolev","orcid":"https://orcid.org/0000-0003-1988-0645"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kirill S. Korolev","raw_affiliation_strings":["Department of Physics, Boston University, Boston, Massachusetts, United States of America","Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1988-0645","affiliations":[{"raw_affiliation_string":"Department of Physics, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005848494"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3199,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.89001857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"e1005939","last_page":"e1005939"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.724343478679657},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.7050735950469971},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6709570288658142},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"Inflammatory bowel disease","score":0.5572293996810913},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5508626699447632},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4848855435848236},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"Clinical phenotype","score":0.47204291820526123},{"id":"https://openalex.org/keywords/gut-flora","display_name":"Gut flora","score":0.43717411160469055},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40004029870033264},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39758068323135376},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33511069416999817},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.32545357942581177},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.22539547085762024},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1729656159877777},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.13176429271697998},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09402608871459961},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09234952926635742},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08792537450790405}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.724343478679657},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.7050735950469971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6709570288658142},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5572293996810913},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5508626699447632},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4848855435848236},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.47204291820526123},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.43717411160469055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40004029870033264},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39758068323135376},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33511069416999817},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32545357942581177},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22539547085762024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1729656159877777},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13176429271697998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09402608871459961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09234952926635742},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08792537450790405}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005939","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005939","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005939&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29338008","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29338008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1708.04577","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1708.04577","pdf_url":"https://arxiv.org/pdf/1708.04577","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1005939","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005939","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ce8bb338b47143a593fa562b0f9ad2ba","is_oa":true,"landing_page_url":"https://doaj.org/article/ce8bb338b47143a593fa562b0f9ad2ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 1, p e1005939 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4713317","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5786326","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/5789856","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Interactions_between_species_introduce_spurious_associations_in_microbiome_studies/5789856","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005939","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005939","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005939&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G4835949301","display_name":"REU Site: Bioinformatics Research and Interdisciplinary Training Experience in Analysis and Interpretation of Information-Rich Biological Data Sets (REU-BRITE)","funder_award_id":"1559829","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5447713250","display_name":null,"funder_award_id":"409704","funder_id":"https://openalex.org/F4320306164","funder_display_name":"Simons Foundation"},{"id":"https://openalex.org/G579990027","display_name":null,"funder_award_id":"DBI-1559829","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320309565","display_name":"Boston University","ror":"https://ror.org/05qwgg493"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2745757065.pdf","grobid_xml":"https://content.openalex.org/works/W2745757065.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W35800039","https://openalex.org/W571770348","https://openalex.org/W600173711","https://openalex.org/W656395023","https://openalex.org/W1237960302","https://openalex.org/W1522866404","https://openalex.org/W1572331735","https://openalex.org/W1600342531","https://openalex.org/W1606765359","https://openalex.org/W1631314968","https://openalex.org/W1647973912","https://openalex.org/W1815717996","https://openalex.org/W1860290282","https://openalex.org/W1874689950","https://openalex.org/W1892009398","https://openalex.org/W1930624869","https://openalex.org/W1932197482","https://openalex.org/W1964895626","https://openalex.org/W1966665184","https://openalex.org/W1971061059","https://openalex.org/W1972949070","https://openalex.org/W1975825616","https://openalex.org/W1979217507","https://openalex.org/W1988314881","https://openalex.org/W1988925586","https://openalex.org/W1989947363","https://openalex.org/W1992058928","https://openalex.org/W2004362888","https://openalex.org/W2008545402","https://openalex.org/W2009967612","https://openalex.org/W2016073955","https://openalex.org/W2020500318","https://openalex.org/W2022470241","https://openalex.org/W2024192805","https://openalex.org/W2026006003","https://openalex.org/W2028520715","https://openalex.org/W2032230795","https://openalex.org/W2032356948","https://openalex.org/W2034202223","https://openalex.org/W2034793848","https://openalex.org/W2035378093","https://openalex.org/W2037279825","https://openalex.org/W2037833069","https://openalex.org/W2047059509","https://openalex.org/W2050920580","https://openalex.org/W2060758175","https://openalex.org/W2066578413","https://openalex.org/W2071841602","https://openalex.org/W2072970694","https://openalex.org/W2078112764","https://openalex.org/W2078621117","https://openalex.org/W2078770291","https://openalex.org/W2080528636","https://openalex.org/W2085284704","https://openalex.org/W2089474999","https://openalex.org/W2098163072","https://openalex.org/W2101234009","https://openalex.org/W2102119566","https://openalex.org/W2102247752","https://openalex.org/W2102538757","https://openalex.org/W2105480441","https://openalex.org/W2106399600","https://openalex.org/W2108823152","https://openalex.org/W2110065044","https://openalex.org/W2111358533","https://openalex.org/W2113977541","https://openalex.org/W2114283645","https://openalex.org/W2119821739","https://openalex.org/W2126452774","https://openalex.org/W2127922913","https://openalex.org/W2131058075","https://openalex.org/W2131186249","https://openalex.org/W2135046866","https://openalex.org/W2137529401","https://openalex.org/W2139327060","https://openalex.org/W2141125135","https://openalex.org/W2142278772","https://openalex.org/W2143385936","https://openalex.org/W2143625465","https://openalex.org/W2143777796","https://openalex.org/W2147238273","https://openalex.org/W2147637673","https://openalex.org/W2148251643","https://openalex.org/W2148885646","https://openalex.org/W2158341557","https://openalex.org/W2158418718","https://openalex.org/W2160806376","https://openalex.org/W2161377277","https://openalex.org/W2162088497","https://openalex.org/W2165008361","https://openalex.org/W2166325326","https://openalex.org/W2166691283","https://openalex.org/W2167062509","https://openalex.org/W2168887663","https://openalex.org/W2169733549","https://openalex.org/W2183164080","https://openalex.org/W2237343353","https://openalex.org/W2260815707","https://openalex.org/W2276861294","https://openalex.org/W2282772932","https://openalex.org/W2314088936","https://openalex.org/W2322854838","https://openalex.org/W2327543940","https://openalex.org/W2331659866","https://openalex.org/W2335934832","https://openalex.org/W2385413224","https://openalex.org/W2405912010","https://openalex.org/W2409622550","https://openalex.org/W2468124541","https://openalex.org/W2468863425","https://openalex.org/W2469986620","https://openalex.org/W2490249263","https://openalex.org/W2509121705","https://openalex.org/W2531015655","https://openalex.org/W2533385232","https://openalex.org/W2535282914","https://openalex.org/W2548206156","https://openalex.org/W2550084345","https://openalex.org/W2556693791","https://openalex.org/W2558041282","https://openalex.org/W2559597060","https://openalex.org/W2566680380","https://openalex.org/W2609719955","https://openalex.org/W2903950532","https://openalex.org/W2911964244","https://openalex.org/W4230517153","https://openalex.org/W4231270084","https://openalex.org/W4233303333","https://openalex.org/W4239510810","https://openalex.org/W4246237884","https://openalex.org/W4254238137","https://openalex.org/W4299542564","https://openalex.org/W6634141989","https://openalex.org/W6636358373","https://openalex.org/W6675354045","https://openalex.org/W6692546014","https://openalex.org/W7075634869"],"related_works":["https://openalex.org/W3113091479","https://openalex.org/W2162899405","https://openalex.org/W941090075","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2075065631","https://openalex.org/W2519167559","https://openalex.org/W4311248832","https://openalex.org/W4391471021"],"abstract_inverted_index":{"Microbiota":[0],"contribute":[1],"to":[2,14,44,75,82,114,131],"many":[3],"dimensions":[4],"of":[5,26,58,96,109],"host":[6],"phenotype,":[7,38],"including":[8],"disease.":[9,90,116,146],"To":[10],"link":[11],"specific":[12,15],"microbes":[13],"phenotypes,":[16],"microbiome-wide":[17],"association":[18,100],"studies":[19],"compare":[20],"microbial":[21,45,50],"abundances":[22],"between":[23],"two":[24],"groups":[25],"samples.":[27],"Abundance":[28],"differences,":[29],"however,":[30],"reflect":[31],"not":[32],"only":[33,105],"direct":[34],"associations":[35,60,78,110,118],"with":[36],"the":[37,83,94,115,136,143],"but":[39],"also":[40],"indirect":[41,77],"effects":[42],"due":[43],"interactions.":[46],"We":[47],"found":[48],"that":[49,61,104],"interactions":[51],"could":[52],"easily":[53],"generate":[54],"a":[55,73,106,120],"large":[56],"number":[57],"spurious":[59],"provide":[62],"no":[63],"mechanistic":[64],"insight.":[65],"Using":[66],"techniques":[67],"from":[68,127],"statistical":[69],"physics,":[70],"we":[71],"developed":[72],"method":[74,92],"remove":[76],"and":[79,102,129,135],"applied":[80],"it":[81],"largest":[84],"dataset":[85],"on":[86],"pediatric":[87],"inflammatory":[88,144],"bowel":[89,145],"Our":[91],"corrected":[93],"inflation":[95],"p-values":[97],"in":[98,124,142],"standard":[99],"tests":[101],"showed":[103],"small":[107],"subset":[108],"is":[111],"directly":[112],"linked":[113],"Direct":[117],"had":[119],"much":[121],"higher":[122],"accuracy":[123],"separating":[125],"cases":[126],"controls":[128],"pointed":[130],"immunomodulation,":[132],"butyrate":[133],"production,":[134],"brain-gut":[137],"axis":[138],"as":[139],"important":[140],"factors":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}