{"id":"https://openalex.org/W2787499540","doi":"https://doi.org/10.1371/journal.pcbi.1005930","title":"Biophysical network modeling of the dLGN circuit: Effects of cortical feedback on spatial response properties of relay cells","display_name":"Biophysical network modeling of the dLGN circuit: Effects of cortical feedback on spatial response properties of relay cells","publication_year":2018,"publication_date":"2018-01-29","ids":{"openalex":"https://openalex.org/W2787499540","doi":"https://doi.org/10.1371/journal.pcbi.1005930","mag":"2787499540","pmid":"https://pubmed.ncbi.nlm.nih.gov/29377888"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005930","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005930","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005930&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005930&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062616443","display_name":"Pablo Mart\u00ednez\u2010Ca\u00f1ada","orcid":"https://orcid.org/0000-0003-2634-5229"},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]},{"id":"https://openalex.org/I4210112307","display_name":"Fundaci\u00f3n Centro Tecnol\u00f3gico de la Informaci\u00f3n y la Comunicaci\u00f3n","ror":"https://ror.org/01whh8488","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210112307"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Pablo Mart\u00ednez-Ca\u00f1ada","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Tecnolog\u00edas de la Informaci\u00f3n y de las Comunicaciones (CITIC), University of Granada, Granada, Spain","Department of Computer Architecture and Technology, University of Granada, Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Tecnolog\u00edas de la Informaci\u00f3n y de las Comunicaciones (CITIC), University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I4210112307","https://openalex.org/I173304897"]},{"raw_affiliation_string":"Department of Computer Architecture and Technology, University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010457069","display_name":"Milad Hobbi Mobarhan","orcid":"https://orcid.org/0000-0003-1144-8794"},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Milad Hobbi Mobarhan","raw_affiliation_strings":["Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","Department of Biosciences, University of Oslo, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0003-1144-8794","affiliations":[{"raw_affiliation_string":"Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Department of Biosciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083668294","display_name":"Geir Halnes","orcid":"https://orcid.org/0000-0002-4721-1599"},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Geir Halnes","raw_affiliation_strings":["Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","Faculty of Science and Technology, Norwegian University of Life Sciences, \u00c5s, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Faculty of Science and Technology, Norwegian University of Life Sciences, \u00c5s, Norway","institution_ids":["https://openalex.org/I54108979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011330036","display_name":"Marianne Fyhn","orcid":"https://orcid.org/0000-0003-0808-4555"},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Marianne Fyhn","raw_affiliation_strings":["Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","Department of Biosciences, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Department of Biosciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066880888","display_name":"Christian Morillas","orcid":"https://orcid.org/0000-0002-4084-6241"},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]},{"id":"https://openalex.org/I4210112307","display_name":"Fundaci\u00f3n Centro Tecnol\u00f3gico de la Informaci\u00f3n y la Comunicaci\u00f3n","ror":"https://ror.org/01whh8488","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210112307"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Christian Morillas","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Tecnolog\u00edas de la Informaci\u00f3n y de las Comunicaciones (CITIC), University of Granada, Granada, Spain","Department of Computer Architecture and Technology, University of Granada, Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4084-6241","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Tecnolog\u00edas de la Informaci\u00f3n y de las Comunicaciones (CITIC), University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I4210112307","https://openalex.org/I173304897"]},{"raw_affiliation_string":"Department of Computer Architecture and Technology, University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051354391","display_name":"Francisco Pelayo","orcid":"https://orcid.org/0000-0001-7402-9648"},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]},{"id":"https://openalex.org/I4210112307","display_name":"Fundaci\u00f3n Centro Tecnol\u00f3gico de la Informaci\u00f3n y la Comunicaci\u00f3n","ror":"https://ror.org/01whh8488","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210112307"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francisco Pelayo","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Tecnolog\u00edas de la Informaci\u00f3n y de las Comunicaciones (CITIC), University of Granada, Granada, Spain","Department of Computer Architecture and Technology, University of Granada, Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7402-9648","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Tecnolog\u00edas de la Informaci\u00f3n y de las Comunicaciones (CITIC), University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I4210112307","https://openalex.org/I173304897"]},{"raw_affiliation_string":"Department of Computer Architecture and Technology, University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032715711","display_name":"Gaute T. Einevoll","orcid":"https://orcid.org/0000-0002-5425-5012"},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Gaute T. Einevoll","raw_affiliation_strings":["Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","Department of Physics, University of Oslo, Oslo, Norway","Faculty of Science and Technology, Norwegian University of Life Sciences, \u00c5s, Norway"],"raw_orcid":"https://orcid.org/0000-0002-5425-5012","affiliations":[{"raw_affiliation_string":"Center for Integrative Neuroplasticity (CINPLA), University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Department of Physics, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Faculty of Science and Technology, Norwegian University of Life Sciences, \u00c5s, Norway","institution_ids":["https://openalex.org/I54108979"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5010457069","https://openalex.org/A5011330036","https://openalex.org/A5032715711","https://openalex.org/A5051354391","https://openalex.org/A5062616443","https://openalex.org/A5066880888","https://openalex.org/A5083668294"],"corresponding_institution_ids":["https://openalex.org/I173304897","https://openalex.org/I184942183","https://openalex.org/I4210112307","https://openalex.org/I54108979"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5134,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.62479203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"e1005930","last_page":"e1005930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptive-field","display_name":"Receptive field","score":0.7736507058143616},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"Visual cortex","score":0.767147421836853},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7300852537155151},{"id":"https://openalex.org/keywords/lateral-geniculate-nucleus","display_name":"Lateral geniculate nucleus","score":0.5818194150924683},{"id":"https://openalex.org/keywords/feed-forward","display_name":"Feed forward","score":0.5258931517601013},{"id":"https://openalex.org/keywords/thalamus","display_name":"Thalamus","score":0.5241796374320984},{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.5174441933631897},{"id":"https://openalex.org/keywords/hebbian-theory","display_name":"Hebbian theory","score":0.486304372549057},{"id":"https://openalex.org/keywords/cortex","display_name":"Cortex (anatomy)","score":0.46142083406448364},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4445033073425293},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4035790264606476},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30368703603744507},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20155957341194153},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.17756006121635437}],"concepts":[{"id":"https://openalex.org/C19071747","wikidata":"https://www.wikidata.org/wiki/Q1755207","display_name":"Receptive field","level":2,"score":0.7736507058143616},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.767147421836853},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7300852537155151},{"id":"https://openalex.org/C2776362945","wikidata":"https://www.wikidata.org/wiki/Q719179","display_name":"Lateral geniculate nucleus","level":3,"score":0.5818194150924683},{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.5258931517601013},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.5241796374320984},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5174441933631897},{"id":"https://openalex.org/C111437709","wikidata":"https://www.wikidata.org/wiki/Q1277874","display_name":"Hebbian theory","level":3,"score":0.486304372549057},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.46142083406448364},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4445033073425293},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4035790264606476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30368703603744507},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20155957341194153},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.17756006121635437},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005829","descriptor_name":"Geniculate Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005829","descriptor_name":"Geniculate Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005829","descriptor_name":"Geniculate Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009949","descriptor_name":"Orientation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009949","descriptor_name":"Orientation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009949","descriptor_name":"Orientation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014795","descriptor_name":"Visual Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014795","descriptor_name":"Visual Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014795","descriptor_name":"Visual Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005930","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005930","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005930&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29377888","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29377888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:digibug.ugr.es:10481/95508","is_oa":true,"landing_page_url":"https://hdl.handle.net/10481/95508","pdf_url":"https://digibug.ugr.es/bitstream/10481/95508/1/journal.pcbi.1005930.pdf","source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:brage.bibsys.no:11250/2567836","is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/2567836","pdf_url":null,"source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"14","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:2c4b3d52a3764902a5d0b7ee1e948a4f","is_oa":true,"landing_page_url":"https://doaj.org/article/2c4b3d52a3764902a5d0b7ee1e948a4f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 1, p e1005930 (2018)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5805346","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5805346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:www.duo.uio.no:10852/65959","is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/65959","pdf_url":null,"source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1553-734X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005930","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005930","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005930&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1429491158","display_name":null,"funder_award_id":"BIOTEK2021","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G2761271363","display_name":null,"funder_award_id":"248828","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320323260","display_name":"Universitetet i Oslo","ror":"https://ror.org/01xtthb56"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2787499540.pdf","grobid_xml":"https://content.openalex.org/works/W2787499540.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W81409850","https://openalex.org/W172225110","https://openalex.org/W648800387","https://openalex.org/W1034309145","https://openalex.org/W1510543252","https://openalex.org/W1514161587","https://openalex.org/W1569611781","https://openalex.org/W1572034159","https://openalex.org/W1576971765","https://openalex.org/W1601419037","https://openalex.org/W1659146383","https://openalex.org/W1843427334","https://openalex.org/W1867287134","https://openalex.org/W1869936268","https://openalex.org/W1929757528","https://openalex.org/W1955585424","https://openalex.org/W1960161395","https://openalex.org/W1969043989","https://openalex.org/W1974261011","https://openalex.org/W1974979654","https://openalex.org/W1975252397","https://openalex.org/W1975867390","https://openalex.org/W1978677882","https://openalex.org/W1982757535","https://openalex.org/W1983965536","https://openalex.org/W1988849438","https://openalex.org/W1993962620","https://openalex.org/W1999260939","https://openalex.org/W1999675973","https://openalex.org/W2001032894","https://openalex.org/W2001635516","https://openalex.org/W2016159363","https://openalex.org/W2017682809","https://openalex.org/W2023539733","https://openalex.org/W2024997165","https://openalex.org/W2027752570","https://openalex.org/W2028595898","https://openalex.org/W2035773029","https://openalex.org/W2041461999","https://openalex.org/W2043630083","https://openalex.org/W2044986415","https://openalex.org/W2045109540","https://openalex.org/W2045933100","https://openalex.org/W2047125044","https://openalex.org/W2047806066","https://openalex.org/W2049040467","https://openalex.org/W2050022878","https://openalex.org/W2050935821","https://openalex.org/W2052547347","https://openalex.org/W2057684768","https://openalex.org/W2059058130","https://openalex.org/W2059390121","https://openalex.org/W2063094367","https://openalex.org/W2068970713","https://openalex.org/W2071020514","https://openalex.org/W2079701726","https://openalex.org/W2079955569","https://openalex.org/W2085740291","https://openalex.org/W2087861759","https://openalex.org/W2091181932","https://openalex.org/W2094286475","https://openalex.org/W2094627441","https://openalex.org/W2103113084","https://openalex.org/W2108692322","https://openalex.org/W2109172810","https://openalex.org/W2110120162","https://openalex.org/W2110285260","https://openalex.org/W2110521397","https://openalex.org/W2111976708","https://openalex.org/W2112014690","https://openalex.org/W2116055168","https://openalex.org/W2116279703","https://openalex.org/W2116360511","https://openalex.org/W2117119577","https://openalex.org/W2118064385","https://openalex.org/W2119610790","https://openalex.org/W2120836623","https://openalex.org/W2121238618","https://openalex.org/W2122476423","https://openalex.org/W2122539011","https://openalex.org/W2126020484","https://openalex.org/W2127660458","https://openalex.org/W2127749879","https://openalex.org/W2128481675","https://openalex.org/W2132225692","https://openalex.org/W2133625110","https://openalex.org/W2135908272","https://openalex.org/W2137413309","https://openalex.org/W2138048651","https://openalex.org/W2141700222","https://openalex.org/W2150232640","https://openalex.org/W2153113253","https://openalex.org/W2153918507","https://openalex.org/W2155706938","https://openalex.org/W2159049013","https://openalex.org/W2160305166","https://openalex.org/W2165586822","https://openalex.org/W2168779967","https://openalex.org/W2170565973","https://openalex.org/W2222721727","https://openalex.org/W2259459243","https://openalex.org/W2293813869","https://openalex.org/W2315788237","https://openalex.org/W2342354792","https://openalex.org/W2365924967","https://openalex.org/W2394883599","https://openalex.org/W2410083981","https://openalex.org/W2499905000","https://openalex.org/W2565971026","https://openalex.org/W2788026236","https://openalex.org/W4206184909","https://openalex.org/W4244237099","https://openalex.org/W4298509031","https://openalex.org/W4307697508","https://openalex.org/W6630888863","https://openalex.org/W6636043696"],"related_works":["https://openalex.org/W2951938151","https://openalex.org/W1917631856","https://openalex.org/W2054235222","https://openalex.org/W2155258764","https://openalex.org/W1969635941","https://openalex.org/W2947672356","https://openalex.org/W2799754716","https://openalex.org/W2153918507","https://openalex.org/W84201194","https://openalex.org/W56938330"],"abstract_inverted_index":{"Despite":[0],"half-a-century":[1],"of":[2,8,14,47,80,95,113,120,139,148,162,168,175,185,212],"research":[3],"since":[4],"the":[5,12,15,23,40,48,54,96,110,118,121,136,143,189,195,199,213,235,278,286],"seminal":[6],"work":[7],"Hubel":[9],"and":[10,58,91,158,165,191,203,265],"Wiesel,":[11],"role":[13],"dorsal":[16],"lateral":[17],"geniculate":[18],"nucleus":[19],"(dLGN)":[20],"in":[21,39,77,194,240,277],"shaping":[22],"visual":[24,37,42,81,196],"signals":[25],"is":[26,51,280,296],"not":[27,61],"properly":[28],"understood.":[29],"Placed":[30],"on":[31,142],"route":[32],"from":[33,66,75,188,261,269],"retina":[34],"to":[35,88,104,123,128,198,233],"primary":[36],"cortex":[38,197],"early":[41],"pathway,":[43],"a":[44,72,149,150,166,222,226],"striking":[45],"feature":[46],"dLGN":[49],"circuit":[50],"that":[52,221,255],"both":[53,242],"relay":[55],"cells":[56,76,177,264],"(RCs)":[57],"interneurons":[59],"(INs)":[60],"only":[62],"receive":[63,258],"feedforward":[64],"input":[65],"retinal":[67],"ganglion":[68],"cells,":[69,173],"but":[70],"also":[71,101],"prominent":[73],"feedback":[74,84,141,187,232,268,295],"layer":[78,170],"6":[79,171],"cortex.":[82],"This":[83,253],"has":[85,100],"been":[86,102],"proposed":[87],"affect":[89,105],"synchronicity":[90],"other":[92],"temporal":[93],"properties":[94,107],"RC":[97,144,288],"firing.":[98],"It":[99],"seen":[103,239],"spatial":[106,137,210,283],"such":[108],"as":[109,206,208],"center-surround":[111,237,275],"antagonism":[112,238,276],"thalamic":[114],"receptive":[115],"fields,":[116],"i.e.,":[117,285],"suppression":[119],"response":[122,145,289],"very":[124],"large":[125],"stimuli":[126,293],"compared":[127],"smaller,":[129],"more":[130,227,248],"optimal":[131],"stimuli.":[132],"Here":[133],"we":[134],"explore":[135],"effects":[138],"cortical":[140,231,263,271],"by":[146,282],"means":[147],"comprehensive":[151],"network":[152],"model":[153,279],"with":[154],"biophysically":[155],"detailed,":[156],"single-compartment":[157],"multicompartment":[159],"neuron":[160],"models":[161],"RCs,":[163],"INs":[164],"population":[167],"orientation-selective":[169],"simple":[172],"consisting":[174],"pyramidal":[176],"(PY).":[178],"We":[179],"have":[180],"considered":[181],"two":[182],"different":[183,209],"arrangements":[184],"synaptic":[186],"ON":[190],"OFF":[192],"zones":[193],"dLGN:":[200],"phase-reversed":[201,223],"('push-pull')":[202],"phase-matched":[204],"('push-push'),":[205],"well":[207],"extents":[211],"corticothalamic":[214],"projection":[215],"pattern.":[216],"Our":[217],"simulation":[218],"results":[219],"support":[220],"arrangement":[224],"provides":[225],"effective":[228],"way":[229],"for":[230,243,250,291],"provide":[234],"increased":[236,274],"experiments":[241],"flashing":[244],"spots":[245],"and,":[246],"even":[247],"prominently,":[249],"patch":[251],"gratings.":[252],"implies":[254],"ON-center":[256],"RCs":[257],"direct":[259],"excitation":[260],"OFF-dominated":[262],"indirect":[266],"inhibitory":[267],"ON-dominated":[270],"cells.":[272],"The":[273],"accompanied":[281],"focusing,":[284],"maximum":[287],"occurs":[290],"smaller":[292],"when":[294],"present.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}