{"id":"https://openalex.org/W2771468115","doi":"https://doi.org/10.1371/journal.pcbi.1005839","title":"Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy","display_name":"Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2771468115","doi":"https://doi.org/10.1371/journal.pcbi.1005839","mag":"2771468115","pmid":"https://pubmed.ncbi.nlm.nih.gov/29194434"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005839","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005839&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005839&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005198021","display_name":"Rico Rueedi","orcid":"https://orcid.org/0000-0002-6713-2214"},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rico Rueedi","raw_affiliation_strings":["Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002110259","display_name":"Roger Mallol","orcid":"https://orcid.org/0000-0001-5374-1580"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roger Mallol","raw_affiliation_strings":["Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031572559","display_name":"Johannes Raffler","orcid":"https://orcid.org/0000-0003-2495-4020"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210100097","display_name":"Institute of Bioinformatics and Systems Biology","ror":"https://ror.org/0127fwn18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Raffler","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany","institution_ids":["https://openalex.org/I4210100097","https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069489297","display_name":"David Lamparter","orcid":"https://orcid.org/0000-0002-9216-8825"},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David Lamparter","raw_affiliation_strings":["Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039414277","display_name":"Nele Friedrich","orcid":"https://orcid.org/0000-0002-1017-7622"},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nele Friedrich","raw_affiliation_strings":["German Centre for Cardiovascular Research (DZHK), Partner site, Greifswald, Germany","Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany"],"affiliations":[{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site, Greifswald, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108167377","display_name":"P\u00e9ter Vollenweider","orcid":"https://orcid.org/0000-0002-0765-896X"},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Vollenweider","raw_affiliation_strings":["Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047797878","display_name":"G\u00e9rard Waeber","orcid":"https://orcid.org/0000-0003-4193-788X"},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G\u00e9rard Waeber","raw_affiliation_strings":["Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072509338","display_name":"Gabi Kastenm\u00fcller","orcid":"https://orcid.org/0000-0002-2368-7322"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I4210160326","display_name":"German Center for Diabetes Research","ror":"https://ror.org/04qq88z54","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210160326","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210152419","display_name":"Deutsches Diabetes-Zentrum e.V.","ror":"https://ror.org/04ews3245","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210152419","https://openalex.org/I44260953"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210100097","display_name":"Institute of Bioinformatics and Systems Biology","ror":"https://ror.org/0127fwn18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabi Kastenm\u00fcller","raw_affiliation_strings":["German Center for Diabetes Research, Neuherberg, Germany","Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"German Center for Diabetes Research, Neuherberg, Germany","institution_ids":["https://openalex.org/I4210160326","https://openalex.org/I44260953","https://openalex.org/I4210152419"]},{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany","institution_ids":["https://openalex.org/I4210100097","https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075453835","display_name":"Zolt\u00e1n Kutalik","orcid":"https://orcid.org/0000-0001-8285-7523"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I4210135124","display_name":"Institute of Social and Preventive Medicine","ror":"https://ror.org/038esz880","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210135124","https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n Kutalik","raw_affiliation_strings":["Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210135124"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062662732","display_name":"Sven Bergmann","orcid":"https://orcid.org/0000-0002-6785-9034"},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH","ZA"],"is_corresponding":true,"raw_author_name":"Sven Bergmann","raw_affiliation_strings":["Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5062662732"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I157614274","https://openalex.org/I97565354"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0818,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.77167176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"12","first_page":"e1005839","last_page":"e1005839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9703999757766724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolome","display_name":"Metabolome","score":0.990673840045929},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.8834817409515381},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.752315878868103},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6499388813972473},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6294134259223938},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5576164126396179},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5077918171882629},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.47382983565330505},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4015459418296814},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.28215891122817993},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1525959074497223},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.15181389451026917},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.14008298516273499},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1229080855846405}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.990673840045929},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8834817409515381},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.752315878868103},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6499388813972473},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6294134259223938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5576164126396179},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5077918171882629},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47382983565330505},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4015459418296814},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28215891122817993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1525959074497223},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.15181389451026917},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.14008298516273499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1229080855846405},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1005839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005839","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005839&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29194434","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29194434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:serval.unil.ch:BIB_C001C1DFA970","is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_C001C1DFA970","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology, vol. 13, no. 12, pp. e1005839","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:iris.unil.ch:iris/198916","is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/198916","pdf_url":"https://iris.unil.ch/bitstreams/2fd3df54-15a1-4901-8144-2ed46fca57d2/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:981553f39e56474c9525b060a0e577b2","is_oa":true,"landing_page_url":"https://doaj.org/article/981553f39e56474c9525b060a0e577b2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 12, p e1005839 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4642845","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5711027","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/5659624","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Metabomatching_Using_genetic_association_to_identify_metabolites_in_proton_NMR_spectroscopy/5659624","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:52451","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52451","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput. Biol. 13, e1005839:e1005839 (2017)","raw_type":""},{"id":"pmh:oai:pubmedcentral.nih.gov:5711027","is_oa":true,"landing_page_url":"http://doi.org/10.1371/journal.pcbi.1005839","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:52451","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=52451","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput. Biol. 13, e1005839:e1005839 (2017)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005839","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005839&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.6100000143051147}],"awards":[{"id":"https://openalex.org/G5988465809","display_name":null,"funder_award_id":"310030-152724","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6785335373","display_name":null,"funder_award_id":"51RTP0-151019","funder_id":"https://openalex.org/F4320327577","funder_display_name":"SystemsX.ch"},{"id":"https://openalex.org/G8635846943","display_name":null,"funder_award_id":"654241","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323828","display_name":"Fondation Leenaards","ror":"https://ror.org/004h88r69"},{"id":"https://openalex.org/F4320327577","display_name":"SystemsX.ch","ror":"https://ror.org/02s09gf16"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2771468115.pdf","grobid_xml":"https://content.openalex.org/works/W2771468115.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1828872283","https://openalex.org/W1985412335","https://openalex.org/W1989568128","https://openalex.org/W1990512452","https://openalex.org/W1990824174","https://openalex.org/W1992910413","https://openalex.org/W1994967480","https://openalex.org/W2006141598","https://openalex.org/W2027878425","https://openalex.org/W2039671079","https://openalex.org/W2053949852","https://openalex.org/W2054822194","https://openalex.org/W2063028213","https://openalex.org/W2080426060","https://openalex.org/W2081712640","https://openalex.org/W2082169625","https://openalex.org/W2084830302","https://openalex.org/W2088944177","https://openalex.org/W2096325702","https://openalex.org/W2098499808","https://openalex.org/W2107869090","https://openalex.org/W2113710565","https://openalex.org/W2122282311","https://openalex.org/W2131014997","https://openalex.org/W2164339823","https://openalex.org/W2166711199","https://openalex.org/W2169718193","https://openalex.org/W2233065681","https://openalex.org/W2321040821","https://openalex.org/W2335596686","https://openalex.org/W4229743141","https://openalex.org/W6666450722","https://openalex.org/W6810858104"],"related_works":["https://openalex.org/W1996644818","https://openalex.org/W1965468642","https://openalex.org/W2093500216","https://openalex.org/W2053588008","https://openalex.org/W2916376502","https://openalex.org/W2260452057","https://openalex.org/W3101161779","https://openalex.org/W423371831","https://openalex.org/W2777729175","https://openalex.org/W4295779760"],"abstract_inverted_index":{"A":[0],"metabolome-wide":[1],"genome-wide":[2],"association":[3,58,137],"study":[4],"(mGWAS)":[5],"aims":[6],"to":[7,90,123,125,143],"discover":[8],"the":[9,63,75,92,111,126,129,133,144,148,160,167,202],"effects":[10],"of":[11,23,26,77,128,132,159,172,176,184,204],"genetic":[12,60,109,120,136],"variants":[13],"on":[14,101,108],"metabolome":[15,53,104,115,162],"phenotypes.":[16],"Most":[17],"mGWASes":[18,100,146],"use":[19],"as":[20],"phenotypes":[21],"concentrations":[22],"limited":[24],"sets":[25],"metabolites":[27,93],"that":[28,70,113],"can":[29,138],"be":[30],"identified":[31,166],"and":[32,45,150,153,174,182],"quantified":[33],"from":[34],"spectral":[35],"information.":[36],"In":[37],"contrast,":[38],"in":[39,98,147,170,198],"an":[40],"untargeted":[41,64,99,145],"mGWAS":[42],"both":[43],"identification":[44],"quantification":[46,214],"are":[47,55],"forgone":[48],"and,":[49],"instead,":[50],"all":[51],"measured":[52],"features":[54,79,116],"tested":[56],"for":[57,140,192],"with":[59,118],"variants.":[61],"While":[62],"approach":[65],"does":[66],"not":[67],"discard":[68],"data":[69],"may":[71],"have":[72],"eluded":[73],"identification,":[74],"interpretation":[76],"associated":[78,117],"remains":[80],"a":[81,119,189],"challenge.":[82],"To":[83],"address":[84],"this":[85],"issue,":[86],"we":[87],"developed":[88],"metabomatching":[89,164],"identify":[91],"underlying":[94,134,168],"significant":[95],"associations":[96],"observed":[97],"proton":[102],"NMR":[103,130,157],"data.":[105],"Metabomatching":[106],"capitalizes":[107],"spiking,":[110],"concept":[112],"because":[114],"variant":[121],"tend":[122],"correspond":[124],"peaks":[127],"spectrum":[131],"metabolite,":[135],"allow":[139],"identification.":[141],"Applied":[142],"SHIP":[149],"CoLaus":[151],"cohorts":[152],"using":[154],"180":[155],"reference":[156],"spectra":[158],"urine":[161],"database,":[163],"successfully":[165],"metabolite":[169],"14":[171],"19,":[173],"8":[175],"9":[177],"associations,":[178],"respectively.":[179],"The":[180],"accuracy":[181],"efficiency":[183],"our":[185,210],"method":[186],"make":[187],"it":[188],"strong":[190],"contender":[191],"facilitating":[193],"or":[194,206],"complementing":[195],"metabolomics":[196],"analyses":[197],"large":[199],"cohorts,":[200],"where":[201],"availability":[203],"genetic,":[205],"other":[207],"data,":[208],"enables":[209],"approach,":[211],"but":[212],"targeted":[213],"is":[215],"limited.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}