{"id":"https://openalex.org/W2619319449","doi":"https://doi.org/10.1371/journal.pcbi.1005835","title":"Characterizing steady states of genome-scale metabolic networks in continuous cell cultures","display_name":"Characterizing steady states of genome-scale metabolic networks in continuous cell cultures","publication_year":2017,"publication_date":"2017-11-13","ids":{"openalex":"https://openalex.org/W2619319449","doi":"https://doi.org/10.1371/journal.pcbi.1005835","mag":"2619319449","pmid":"https://pubmed.ncbi.nlm.nih.gov/29131817"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005835","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005835","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005835&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005835&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002616738","display_name":"Jorge Fern\u00e1ndez-de-Cossio-D\u00edaz","orcid":"https://orcid.org/0000-0002-4476-805X"},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]},{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":true,"raw_author_name":"Jorge Fernandez-de-Cossio-Diaz","raw_affiliation_strings":["Group of Complex Systems and Statistical Physics. Department of Theoretical Physics, Physics Faculty, University of Havana, Cuba","Systems Biology Department, Center of Molecular Immunlogy, Havana, Cuba"],"raw_orcid":"https://orcid.org/0000-0002-4476-805X","affiliations":[{"raw_affiliation_string":"Group of Complex Systems and Statistical Physics. Department of Theoretical Physics, Physics Faculty, University of Havana, Cuba","institution_ids":["https://openalex.org/I2656126"]},{"raw_affiliation_string":"Systems Biology Department, Center of Molecular Immunlogy, Havana, Cuba","institution_ids":["https://openalex.org/I2355400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063118355","display_name":"Kalet Le\u00f3n","orcid":"https://orcid.org/0000-0002-3709-7091"},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Kalet Leon","raw_affiliation_strings":["Systems Biology Department, Center of Molecular Immunlogy, Havana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Department, Center of Molecular Immunlogy, Havana, Cuba","institution_ids":["https://openalex.org/I2355400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047259721","display_name":"Roberto Mulet","orcid":"https://orcid.org/0000-0001-5168-5116"},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Roberto Mulet","raw_affiliation_strings":["Group of Complex Systems and Statistical Physics. Department of Theoretical Physics, Physics Faculty, University of Havana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Complex Systems and Statistical Physics. Department of Theoretical Physics, Physics Faculty, University of Havana, Cuba","institution_ids":["https://openalex.org/I2656126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002616738"],"corresponding_institution_ids":["https://openalex.org/I2355400","https://openalex.org/I2656126"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2334,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.78787731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"13","issue":"11","first_page":"e1005835","last_page":"e1005835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemostat","display_name":"Chemostat","score":0.8435971140861511},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.689717173576355},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.6500493288040161},{"id":"https://openalex.org/keywords/chinese-hamster-ovary-cell","display_name":"Chinese hamster ovary cell","score":0.594895601272583},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.525773286819458},{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.4630373418331146},{"id":"https://openalex.org/keywords/dilution","display_name":"Dilution","score":0.4360825717449188},{"id":"https://openalex.org/keywords/cell-metabolism","display_name":"Cell metabolism","score":0.4333333969116211},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.43094608187675476},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37241584062576294},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.3591766953468323},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3447408974170685},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3090575337409973},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.297951877117157},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2518273591995239},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.19452586770057678},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.18143194913864136},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1461990773677826}],"concepts":[{"id":"https://openalex.org/C125111812","wikidata":"https://www.wikidata.org/wiki/Q902311","display_name":"Chemostat","level":3,"score":0.8435971140861511},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.689717173576355},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.6500493288040161},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.594895601272583},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.525773286819458},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.4630373418331146},{"id":"https://openalex.org/C96618451","wikidata":"https://www.wikidata.org/wiki/Q3028008","display_name":"Dilution","level":2,"score":0.4360825717449188},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.4333333969116211},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.43094608187675476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37241584062576294},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3591766953468323},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3447408974170685},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3090575337409973},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.297951877117157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2518273591995239},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.19452586770057678},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.18143194913864136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1461990773677826},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005835","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005835","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005835&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29131817","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29131817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1705.09708","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1705.09708","pdf_url":"https://arxiv.org/pdf/1705.09708","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:HAL:hal-04734141v1","is_oa":false,"landing_page_url":"https://hal.science/hal-04734141","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2017, 13 (11), pp.e1005835. &#x27E8;10.1371/journal.pcbi.1005835&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:937357311eff44f8a90722a5cd702897","is_oa":true,"landing_page_url":"https://doaj.org/article/937357311eff44f8a90722a5cd702897","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 11, p e1005835 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4634497","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703580","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/5596087","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Characterizing_steady_states_of_genome-scale_metabolic_networks_in_continuous_cell_cultures/5596087","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005835","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005835","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005835&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4333119612","display_name":"New algorithms for inference and optimization from large-scale biological data","funder_award_id":"734439","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G733089986","display_name":null,"funder_award_id":"734439608INFERNET","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G7842005466","display_name":null,"funder_award_id":"Horizon 2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2619319449.pdf","grobid_xml":"https://content.openalex.org/works/W2619319449.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W33636737","https://openalex.org/W70166776","https://openalex.org/W109036694","https://openalex.org/W241694542","https://openalex.org/W1504427177","https://openalex.org/W1529898704","https://openalex.org/W1576666627","https://openalex.org/W1597762351","https://openalex.org/W1718543168","https://openalex.org/W1866080720","https://openalex.org/W1868738225","https://openalex.org/W1876456565","https://openalex.org/W1966293504","https://openalex.org/W1975751663","https://openalex.org/W1978659446","https://openalex.org/W1982465260","https://openalex.org/W1986130675","https://openalex.org/W1987130080","https://openalex.org/W1988681504","https://openalex.org/W1992306474","https://openalex.org/W1999276310","https://openalex.org/W2000065954","https://openalex.org/W2005274107","https://openalex.org/W2005951812","https://openalex.org/W2016937028","https://openalex.org/W2018511706","https://openalex.org/W2020840252","https://openalex.org/W2021351846","https://openalex.org/W2021690696","https://openalex.org/W2025444976","https://openalex.org/W2025663053","https://openalex.org/W2027630798","https://openalex.org/W2029403511","https://openalex.org/W2035787551","https://openalex.org/W2041183456","https://openalex.org/W2042316625","https://openalex.org/W2044581007","https://openalex.org/W2045747090","https://openalex.org/W2046422273","https://openalex.org/W2048465561","https://openalex.org/W2048596643","https://openalex.org/W2055412058","https://openalex.org/W2056228650","https://openalex.org/W2061226704","https://openalex.org/W2062245653","https://openalex.org/W2071254403","https://openalex.org/W2071297165","https://openalex.org/W2071646337","https://openalex.org/W2072863458","https://openalex.org/W2075510908","https://openalex.org/W2076262841","https://openalex.org/W2076311012","https://openalex.org/W2078355959","https://openalex.org/W2082382448","https://openalex.org/W2088349621","https://openalex.org/W2095649592","https://openalex.org/W2098201181","https://openalex.org/W2104413400","https://openalex.org/W2107597623","https://openalex.org/W2109382720","https://openalex.org/W2109922742","https://openalex.org/W2113674809","https://openalex.org/W2117727600","https://openalex.org/W2118540273","https://openalex.org/W2120575449","https://openalex.org/W2124855891","https://openalex.org/W2128601422","https://openalex.org/W2129833909","https://openalex.org/W2130608566","https://openalex.org/W2131848047","https://openalex.org/W2139132159","https://openalex.org/W2140937954","https://openalex.org/W2142963315","https://openalex.org/W2144046747","https://openalex.org/W2147472054","https://openalex.org/W2149717386","https://openalex.org/W2152363110","https://openalex.org/W2155216573","https://openalex.org/W2157457604","https://openalex.org/W2161809910","https://openalex.org/W2163578961","https://openalex.org/W2169313759","https://openalex.org/W2273015459","https://openalex.org/W2278141187","https://openalex.org/W2312280072","https://openalex.org/W2399597196","https://openalex.org/W2416065856","https://openalex.org/W2505355291","https://openalex.org/W2506127557","https://openalex.org/W2539462439","https://openalex.org/W2555369234","https://openalex.org/W2589558544","https://openalex.org/W2994669432","https://openalex.org/W3101164084","https://openalex.org/W3102197517","https://openalex.org/W3173114588","https://openalex.org/W4230770774","https://openalex.org/W4236463097","https://openalex.org/W4238101851","https://openalex.org/W4238483696","https://openalex.org/W4245974524","https://openalex.org/W4247091348","https://openalex.org/W4250273006","https://openalex.org/W4256259619","https://openalex.org/W4256513792","https://openalex.org/W4297988093","https://openalex.org/W4300059230","https://openalex.org/W6639355426","https://openalex.org/W6670176882","https://openalex.org/W6817966389"],"related_works":["https://openalex.org/W1608758340","https://openalex.org/W2123404724","https://openalex.org/W47420346","https://openalex.org/W1505019344","https://openalex.org/W4237795480","https://openalex.org/W2143478158","https://openalex.org/W2081172030","https://openalex.org/W4400578632","https://openalex.org/W2899598286","https://openalex.org/W3213275467"],"abstract_inverted_index":{"In":[0],"the":[1,37,40,45,49,52,64,96,119,155,208,227,240],"continuous":[2,27,216],"mode":[3],"of":[4,39,48,54,67,76,95,116,124,157,178,243],"cell":[5,28,50,100,130,217],"culture,":[6],"a":[7,24,60,84,91,114,142,166],"constant":[8],"flow":[9],"carrying":[10],"fresh":[11],"media":[12,195],"replaces":[13],"culture":[14,29,201],"fluid,":[15],"cells,":[16],"nutrients":[17],"and":[18,51,88,132,194],"secreted":[19],"metabolites.":[20],"Here":[21],"we":[22,211],"present":[23],"model":[25,86,120,164,233],"for":[26,73,234],"coupling":[30],"intra-cellular":[31],"metabolism":[32],"to":[33,62,140,171,205],"extracellular":[34],"variables":[35],"describing":[36],"state":[38,144],"bioreactor,":[41],"taking":[42],"into":[43],"account":[44],"growth":[46],"capacity":[47],"impact":[53],"toxic":[55,172],"byproduct":[56,173],"accumulation.":[57,174],"We":[58,79,112],"provide":[59],"method":[61],"determine":[63],"steady":[65,143,179],"states":[66,180],"this":[68],"system":[69],"that":[70,104,121,226],"is":[71,135,151,160,225,229,246],"tractable":[72],"metabolic":[74,93,147,187,244],"networks":[75],"arbitrary":[77],"complexity.":[78],"demonstrate":[80],"our":[81,163,183],"approach":[82],"in":[83,90,106,154,162,199],"toy":[85],"first,":[87],"then":[89],"genome-scale":[92],"network":[94],"Chinese":[97],"hamster":[98],"ovary":[99],"line,":[101],"obtaining":[102],"results":[103],"are":[105,122],"qualitative":[107],"agreement":[108],"with":[109,145,219],"experimental":[110,232],"observations.":[111],"derive":[113],"number":[115],"consequences":[117],"from":[118,182],"independent":[123],"parameter":[125,139],"values.":[126],"The":[127],"ratio":[128],"between":[129,215],"density":[131],"dilution":[133],"rate":[134],"an":[136,230],"ideal":[137,231],"control":[138],"fix":[141],"desired":[146],"properties.":[148],"This":[149],"conclusion":[150],"robust":[152],"even":[153],"presence":[156],"multi-stability,":[158],"which":[159,189],"explained":[161],"by":[165],"negative":[167],"feedback":[168],"loop":[169],"due":[170],"A":[175,222],"complex":[176,241],"landscape":[177,242],"emerges":[181],"simulations,":[184],"including":[185],"multiple":[186],"switches,":[188],"also":[190],"explain":[191],"why":[192],"cell-line":[193],"benchmarks":[196],"carried":[197],"out":[198],"batch":[200],"cannot":[202],"be":[203],"extrapolated":[204],"perfusion.":[206],"On":[207],"other":[209],"hand,":[210],"predict":[212],"invariance":[213],"laws":[214],"cultures":[218],"different":[220],"parameters.":[221],"practical":[223],"consequence":[224],"chemostat":[228],"large-scale":[235],"high-density":[236],"perfusion":[237],"cultures,":[238],"where":[239],"transitions":[245],"faithfully":[247],"reproduced.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-19T08:33:51.333923","created_date":"2025-10-10T00:00:00"}
