{"id":"https://openalex.org/W2767942532","doi":"https://doi.org/10.1371/journal.pcbi.1005825","title":"Insight into glucocorticoid receptor signalling through interactome model analysis","display_name":"Insight into glucocorticoid receptor signalling through interactome model analysis","publication_year":2017,"publication_date":"2017-11-06","ids":{"openalex":"https://openalex.org/W2767942532","doi":"https://doi.org/10.1371/journal.pcbi.1005825","mag":"2767942532","pmid":"https://pubmed.ncbi.nlm.nih.gov/29107989"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005825","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005825","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005825&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005825&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080825142","display_name":"Emyr Bakker","orcid":"https://orcid.org/0000-0002-0091-1029"},"institutions":[{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emyr Bakker","raw_affiliation_strings":["Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom","institution_ids":["https://openalex.org/I54459138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101477875","display_name":"Kun Tian","orcid":"https://orcid.org/0000-0001-6170-7382"},"institutions":[{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kun Tian","raw_affiliation_strings":["Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom","institution_ids":["https://openalex.org/I54459138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084519811","display_name":"Luciano Mutti","orcid":"https://orcid.org/0000-0002-1578-2637"},"institutions":[{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Luciano Mutti","raw_affiliation_strings":["Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom","institution_ids":["https://openalex.org/I54459138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046342583","display_name":"Constantinos Demonacos","orcid":"https://orcid.org/0000-0002-4515-755X"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Constantinos Demonacos","raw_affiliation_strings":["Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4515-755X","affiliations":[{"raw_affiliation_string":"Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046134592","display_name":"Jean\u2010Marc Schwartz","orcid":"https://orcid.org/0000-0002-6472-0184"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jean-Marc Schwartz","raw_affiliation_strings":["Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027312995","display_name":"Marija Krstic\u2013Demonacos","orcid":"https://orcid.org/0000-0002-3914-4488"},"institutions":[{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Marija Krstic-Demonacos","raw_affiliation_strings":["Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3914-4488","affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford, United Kingdom","institution_ids":["https://openalex.org/I54459138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5027312995","https://openalex.org/A5046134592"],"corresponding_institution_ids":["https://openalex.org/I28407311","https://openalex.org/I54459138"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8742,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.79196555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"11","first_page":"e1005825","last_page":"e1005825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.8054063320159912},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"Glucocorticoid receptor","score":0.7463268041610718},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6989859938621521},{"id":"https://openalex.org/keywords/glucocorticoid","display_name":"Glucocorticoid","score":0.6683703660964966},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.6603584885597229},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6450124979019165},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5816460847854614},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5111480355262756},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.49964189529418945},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4727550148963928},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.365497350692749},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22041046619415283},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19030794501304626},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.15037065744400024}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.8054063320159912},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.7463268041610718},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6989859938621521},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.6683703660964966},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6603584885597229},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6450124979019165},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5816460847854614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5111480355262756},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.49964189529418945},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4727550148963928},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.365497350692749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22041046619415283},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19030794501304626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15037065744400024}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005825","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005825","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005825&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29107989","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29107989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/aca801f9-b58f-401b-b165-11628497b995","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/aca801f9-b58f-401b-b165-11628497b995","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bakker, E Y, Tian, K, Mutti, L, Demonacos, C, Schwartz, J-M & Krstic-Demonacos, M 2017, 'Insight into glucocorticoid receptor signalling through interactome model analysis : Boolean modelling of the glucocorticoid receptor', PL o S Computational Biology, vol. 13, no. 11, e1005825. https://doi.org/10.1371/journal.pcbi.1005825","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:clok.uclan.ac.uk:21183","is_oa":false,"landing_page_url":"http://orcid.org/0000-0002-0091-1029>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306402361","display_name":"CLOK (University of Central Lancashire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I185852735","host_organization_name":"University of Lancashire","host_organization_lineage":["https://openalex.org/I185852735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:usir.salford.ac.uk:44337","is_oa":true,"landing_page_url":null,"pdf_url":"http://usir.salford.ac.uk/id/eprint/44337/6/Bakker-et-al-PLOS-COMP-Accepted-Version-Without-Markup.pdf","source":{"id":"https://openalex.org/S4306401501","display_name":"University of Salford Institutional Repository (University of Salford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I54459138","host_organization_name":"University of Salford","host_organization_lineage":["https://openalex.org/I54459138"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:95ef1fa008d64816af3b0a1d63d3354e","is_oa":true,"landing_page_url":"https://doaj.org/article/95ef1fa008d64816af3b0a1d63d3354e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 11, p e1005825 (2017)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5690696","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5690696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005825","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005825","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005825&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311740","display_name":"University of Salford Manchester","ror":"https://ror.org/01tmqtf75"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2767942532.pdf","grobid_xml":"https://content.openalex.org/works/W2767942532.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1094448410","https://openalex.org/W1591166893","https://openalex.org/W1807981783","https://openalex.org/W1876389666","https://openalex.org/W1926696424","https://openalex.org/W1970259819","https://openalex.org/W1980534892","https://openalex.org/W1984573021","https://openalex.org/W1992339013","https://openalex.org/W1999429145","https://openalex.org/W2003479342","https://openalex.org/W2013980575","https://openalex.org/W2024764187","https://openalex.org/W2031026757","https://openalex.org/W2034459977","https://openalex.org/W2034836489","https://openalex.org/W2042177858","https://openalex.org/W2056949581","https://openalex.org/W2072872641","https://openalex.org/W2077187292","https://openalex.org/W2096173332","https://openalex.org/W2101213159","https://openalex.org/W2103017472","https://openalex.org/W2104360623","https://openalex.org/W2105924489","https://openalex.org/W2105963515","https://openalex.org/W2110490515","https://openalex.org/W2121958755","https://openalex.org/W2127020923","https://openalex.org/W2134054690","https://openalex.org/W2134870125","https://openalex.org/W2136418557","https://openalex.org/W2159675211","https://openalex.org/W2194521648","https://openalex.org/W2295450294","https://openalex.org/W2386019219","https://openalex.org/W2620661764"],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2063905494","https://openalex.org/W2015700328","https://openalex.org/W2364565895","https://openalex.org/W2767847608","https://openalex.org/W2911678823","https://openalex.org/W2152648570","https://openalex.org/W2037892364","https://openalex.org/W2319154570","https://openalex.org/W3152114242"],"abstract_inverted_index":{"Glucocorticoid":[0],"hormones":[1],"(GCs)":[2],"are":[3],"used":[4],"to":[5,20,81,176,257,265],"treat":[6],"a":[7,76,83,208,233,277],"variety":[8],"of":[9,12,55,86,124,147,179,189,224,250,291],"diseases":[10],"because":[11],"their":[13,18],"potent":[14],"anti-inflammatory":[15],"effect":[16],"and":[17,37,45,58,108,135,140,165,226,270,287],"ability":[19],"induce":[21],"apoptosis":[22],"in":[23,40,153,160,247,298],"lymphoid":[24],"malignancies":[25],"through":[26],"the":[27,53,87,98,109,112,117,131,154,205,227,251,274],"glucocorticoid":[28,35,56,88,252,299],"receptor":[29,89,253,300],"(GR).":[30],"Despite":[31],"ongoing":[32],"research,":[33],"high":[34],"efficacy":[36],"widespread":[38],"usage":[39],"medicine,":[41],"resistance,":[42],"disease":[43],"relapse":[44],"toxicity":[46],"remain":[47],"factors":[48],"that":[49,93,105,114,261],"need":[50],"addressing.":[51],"Understanding":[52],"mechanisms":[54],"signalling":[57],"how":[59],"resistance":[60],"may":[61],"arise":[62],"is":[63],"highly":[64],"important":[65],"towards":[66],"improving":[67],"therapy.":[68],"To":[69],"gain":[70],"insight":[71],"into":[72],"this":[73],"we":[74,244],"undertook":[75],"systems":[77],"biology":[78],"approach,":[79],"aiming":[80],"generate":[82],"Boolean":[84],"model":[85,120,132,136,157,173,190,198,206,228,275],"protein":[90],"interaction":[91,254],"network":[92],"encapsulates":[94],"functional":[95],"relationships":[96,155,267],"between":[97,111,156,268],"GR,":[99,107],"its":[100,271],"target":[101,106],"genes":[102,104,113,128],"or":[103,129,149],"interactions":[110,146],"interact":[115],"with":[116,207],"GR.":[118],"This":[119],"named":[121],"GEB052":[122],"consists":[123],"52":[125],"nodes":[126],"representing":[127],"proteins,":[130],"input":[133],"(GC)":[134],"outputs":[137],"(cell":[138],"death":[139],"inflammation),":[141],"connected":[142],"by":[143,169,187,283],"241":[144],"logical":[145],"activation":[148],"inhibition.":[150],"323":[151],"changes":[152],"constituents":[158],"following":[159],"silico":[161,248],"knockouts":[162],"were":[163],"uncovered,":[164],"steady-state":[166],"analysis":[167,199],"followed":[168],"cell-based":[170],"microarray":[171,194,201,240],"genome-wide":[172],"validation":[174],"led":[175],"an":[177,246],"average":[178],"57%":[180],"correct":[181,220],"predictions,":[182],"which":[183,216],"was":[184],"taken":[185],"further":[186,292],"assessment":[188],"predictions":[191],"against":[192],"patient":[193,239],"data.":[195,241],"Lastly,":[196],"semi-quantitative":[197],"via":[200],"data":[202],"superimposed":[203],"onto":[204],"score":[209],"flow":[210],"algorithm":[211],"has":[212,229],"also":[213],"been":[214,230],"performed,":[215],"demonstrated":[217],"significantly":[218],"higher":[219],"prediction":[221],"ratios":[222],"(average":[223],"80%),":[225],"assessed":[231],"as":[232],"predictive":[234],"clinical":[235],"tool":[236],"using":[237],"published":[238],"In":[242],"summary":[243],"present":[245],"simulation":[249],"network,":[255],"linked":[256],"downstream":[258],"biological":[259],"processes":[260],"can":[262],"be":[263],"analysed":[264],"uncover":[266],"GR":[269],"interactants.":[272],"Ultimately":[273],"provides":[276],"platform":[278],"for":[279,289],"future":[280],"development":[281],"both":[282],"directing":[284],"laboratory":[285],"research":[286],"allowing":[288],"incorporation":[290],"components,":[293],"encapsulating":[294],"more":[295],"interactions/genes":[296],"involved":[297],"signalling.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2017-11-17T00:00:00"}