{"id":"https://openalex.org/W2523460653","doi":"https://doi.org/10.1371/journal.pcbi.1005788","title":"A quadratically regularized functional canonical correlation analysis for identifying the global structure of pleiotropy with NGS data","display_name":"A quadratically regularized functional canonical correlation analysis for identifying the global structure of pleiotropy with NGS data","publication_year":2017,"publication_date":"2017-10-17","ids":{"openalex":"https://openalex.org/W2523460653","doi":"https://doi.org/10.1371/journal.pcbi.1005788","mag":"2523460653","pmid":"https://pubmed.ncbi.nlm.nih.gov/29040274"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005788","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005788","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005788&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005788&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101865072","display_name":"Nan Lin","orcid":"https://orcid.org/0000-0003-2052-3653"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Lin","raw_affiliation_strings":["Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2052-3653","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052231565","display_name":"Yun Zhu","orcid":"https://orcid.org/0000-0002-9500-5415"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Zhu","raw_affiliation_strings":["Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of America","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013409053","display_name":"Ruzong Fan","orcid":"https://orcid.org/0000-0002-7603-2135"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruzong Fan","raw_affiliation_strings":["Biostatistics and Bioinformatics Branch (BBB), Division of Intramural Population Health Research (DIPHR), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics Branch (BBB), Division of Intramural Population Health Research (DIPHR), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, United States of America","institution_ids":["https://openalex.org/I4210144228","https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017745566","display_name":"Momiao Xiong","orcid":"https://orcid.org/0000-0003-0635-5796"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Momiao Xiong","raw_affiliation_strings":["Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017745566"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6557,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74350662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"10","first_page":"e1005788","last_page":"e1005788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canonical-correlation","display_name":"Canonical correlation","score":0.7691254615783691},{"id":"https://openalex.org/keywords/quadratic-growth","display_name":"Quadratic growth","score":0.7185851335525513},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"Pleiotropy","score":0.5259958505630493},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49872565269470215},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.48871326446533203},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.4392937123775482},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4367560148239136},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42303410172462463},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.4170783460140228},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.3543959856033325},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3421030044555664},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3106856048107147},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.27355146408081055},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.25099238753318787},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.2338886260986328},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21906474232673645},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.21787071228027344},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1836252212524414},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.13107120990753174}],"concepts":[{"id":"https://openalex.org/C153874254","wikidata":"https://www.wikidata.org/wiki/Q115542","display_name":"Canonical correlation","level":2,"score":0.7691254615783691},{"id":"https://openalex.org/C195956108","wikidata":"https://www.wikidata.org/wiki/Q7268362","display_name":"Quadratic growth","level":2,"score":0.7185851335525513},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.5259958505630493},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49872565269470215},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.48871326446533203},{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.4392937123775482},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4367560148239136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42303410172462463},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4170783460140228},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3543959856033325},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3421030044555664},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3106856048107147},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27355146408081055},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.25099238753318787},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2338886260986328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21906474232673645},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21787071228027344},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1836252212524414},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.13107120990753174},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058685","descriptor_name":"Genetic Pleiotropy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005788","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005788","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005788&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29040274","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29040274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1609.04902","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1609.04902","pdf_url":"https://arxiv.org/pdf/1609.04902","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1005788","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005788","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c42a0122cc194c0c9318174f1449b795","is_oa":true,"landing_page_url":"https://doaj.org/article/c42a0122cc194c0c9318174f1449b795","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 10, p e1005788 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4594040","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5659802","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/5505904","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_quadratically_regularized_functional_canonical_correlation_analysis_for_identifying_the_global_structure_of_pleiotropy_with_NGS_data/5505904","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005788","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005788","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005788&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3063705099","display_name":null,"funder_award_id":"U01 HG005728","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5191411233","display_name":null,"funder_award_id":"R01 HL106034","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G844464028","display_name":null,"funder_award_id":"R01 AR057120","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2523460653.pdf","grobid_xml":"https://content.openalex.org/works/W2523460653.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1534058232","https://openalex.org/W1542819714","https://openalex.org/W1592111270","https://openalex.org/W1703482192","https://openalex.org/W1795113477","https://openalex.org/W1907868928","https://openalex.org/W1952660301","https://openalex.org/W1968700754","https://openalex.org/W1972909901","https://openalex.org/W1975341011","https://openalex.org/W1980540803","https://openalex.org/W1982636457","https://openalex.org/W1983902924","https://openalex.org/W1988103479","https://openalex.org/W1993239839","https://openalex.org/W1996299724","https://openalex.org/W2001974377","https://openalex.org/W2004362570","https://openalex.org/W2004697957","https://openalex.org/W2013455550","https://openalex.org/W2016122322","https://openalex.org/W2019393572","https://openalex.org/W2022307355","https://openalex.org/W2024412831","https://openalex.org/W2024470335","https://openalex.org/W2028416113","https://openalex.org/W2032142579","https://openalex.org/W2036808380","https://openalex.org/W2037217592","https://openalex.org/W2039692656","https://openalex.org/W2045501977","https://openalex.org/W2047605192","https://openalex.org/W2054323570","https://openalex.org/W2056165766","https://openalex.org/W2063698478","https://openalex.org/W2064350862","https://openalex.org/W2064943828","https://openalex.org/W2065397672","https://openalex.org/W2069552222","https://openalex.org/W2070580459","https://openalex.org/W2071956747","https://openalex.org/W2074693857","https://openalex.org/W2077646289","https://openalex.org/W2077723503","https://openalex.org/W2084716055","https://openalex.org/W2098290597","https://openalex.org/W2099086736","https://openalex.org/W2100697065","https://openalex.org/W2104276565","https://openalex.org/W2108102133","https://openalex.org/W2112939554","https://openalex.org/W2122559554","https://openalex.org/W2129531358","https://openalex.org/W2130701931","https://openalex.org/W2133675997","https://openalex.org/W2134599124","https://openalex.org/W2140195155","https://openalex.org/W2144208534","https://openalex.org/W2145506835","https://openalex.org/W2146519949","https://openalex.org/W2147823015","https://openalex.org/W2150067515","https://openalex.org/W2158739914","https://openalex.org/W2163328685","https://openalex.org/W2164616133","https://openalex.org/W2165428161","https://openalex.org/W2169441372","https://openalex.org/W2195783463","https://openalex.org/W2230292985","https://openalex.org/W2232278875","https://openalex.org/W2254979106","https://openalex.org/W2258943325","https://openalex.org/W2289221856","https://openalex.org/W2290321855","https://openalex.org/W2292058622","https://openalex.org/W2295653446","https://openalex.org/W2302979210","https://openalex.org/W2315415639","https://openalex.org/W2319893983","https://openalex.org/W2346664883","https://openalex.org/W2401811918","https://openalex.org/W2464054386","https://openalex.org/W2468727035","https://openalex.org/W2470870544","https://openalex.org/W2512015163","https://openalex.org/W2559028527","https://openalex.org/W2917805318","https://openalex.org/W4206519735","https://openalex.org/W4230149751","https://openalex.org/W4230727635","https://openalex.org/W4292156489","https://openalex.org/W4299153800","https://openalex.org/W6776399789","https://openalex.org/W7048074144"],"related_works":["https://openalex.org/W3106324371","https://openalex.org/W2898194682","https://openalex.org/W2981563631","https://openalex.org/W2096434975","https://openalex.org/W2153103238","https://openalex.org/W2964535699","https://openalex.org/W3030746740","https://openalex.org/W2949331204","https://openalex.org/W3004590415","https://openalex.org/W3211806688"],"abstract_inverted_index":{"Investigating":[0],"the":[1,19,38,56,108,162,172,178,187,196,202,224,233,237],"pleiotropic":[2,73,119],"effects":[3],"of":[4,18,23,48,63,95,110,171,209],"genetic":[5,21,51,96,118],"variants":[6,52,214,220],"can":[7],"increase":[8],"statistical":[9,112],"power,":[10],"provide":[11],"important":[12],"information":[13,94],"to":[14,76,128,195],"achieve":[15],"deep":[16],"understanding":[17],"complex":[20],"structures":[22],"disease,":[24],"and":[25,50,59,65,82,88,102,114,152,189,215],"offer":[26],"powerful":[27],"tools":[28],"for":[29,70,117,136],"designing":[30],"effective":[31],"treatments":[32],"with":[33,212,218,223],"fewer":[34],"side":[35],"effects.":[36],"However,":[37],"current":[39],"multiple":[40],"phenotype":[41,64,89],"association":[42,137],"analysis":[43,74,138,151,156],"paradigm":[44],"lacks":[45],"breadth":[46],"(number":[47],"phenotypes":[49],"jointly":[53],"analyzed":[54],"at":[55],"same":[57],"time)":[58],"depth":[60],"(hierarchical":[61],"structure":[62],"genotypes).":[66],"A":[67],"key":[68],"issue":[69],"high":[71,85],"dimensional":[72,86],"is":[75],"effectively":[77,98],"extract":[78],"informative":[79],"internal":[80],"representation":[81],"features":[83],"from":[84,201],"genotype":[87],"data.":[90],"To":[91,183],"explore":[92],"correlation":[93,155],"variants,":[97],"reduce":[99],"data":[100,150],"dimensions,":[101],"overcome":[103],"critical":[104],"barriers":[105],"in":[106],"advancing":[107],"development":[109],"novel":[111],"methods":[113],"computational":[115],"algorithms":[116],"analysis,":[120],"we":[121],"proposed":[122],"a":[123,130,165,207],"new":[124],"statistic":[125],"method":[126],"referred":[127],"as":[129],"quadratically":[131,144],"regularized":[132,145],"functional":[133,149],"CCA":[134],"(QRFCCA)":[135],"which":[139],"combines":[140],"three":[141],"approaches:":[142],"(1)":[143],"matrix":[146],"factorization,":[147],"(2)":[148],"(3)":[153],"canonical":[154],"(CCA).":[157],"Large-scale":[158],"simulations":[159],"show":[160,231],"that":[161,170,232],"QRFCCA":[163,188,234],"has":[164],"much":[166],"higher":[167],"power":[168],"than":[169],"ten":[173,190,238],"competing":[174],"statistics":[175,192],"while":[176],"retaining":[177],"appropriate":[179],"type":[180],"1":[181],"errors.":[182],"further":[184],"evaluate":[185],"performance,":[186],"other":[191,239],"are":[193],"applied":[194],"whole":[197],"genome":[198],"sequencing":[199],"dataset":[200],"TwinsUK":[203],"study.":[204],"We":[205],"identify":[206],"total":[208],"79":[210],"genes":[211,217],"rare":[213],"67":[216],"common":[219],"significantly":[221],"associated":[222],"46":[225],"traits":[226],"using":[227],"QRFCCA.":[228],"The":[229],"results":[230],"substantially":[235],"outperforms":[236],"statistics.":[240]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}