{"id":"https://openalex.org/W2754684752","doi":"https://doi.org/10.1371/journal.pcbi.1005745","title":"Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies","display_name":"Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies","publication_year":2017,"publication_date":"2017-09-15","ids":{"openalex":"https://openalex.org/W2754684752","doi":"https://doi.org/10.1371/journal.pcbi.1005745","mag":"2754684752","pmid":"https://pubmed.ncbi.nlm.nih.gov/28915236"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005745","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005745","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005745&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005745&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077336507","display_name":"Burcu Tepekule","orcid":"https://orcid.org/0000-0001-6936-9138"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Burcu Tepekule","raw_affiliation_strings":["Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6936-9138","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037864316","display_name":"Hildegard Uecker","orcid":"https://orcid.org/0000-0001-9435-2813"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hildegard Uecker","raw_affiliation_strings":["Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003820807","display_name":"Isabel Derungs","orcid":null},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Isabel Derungs","raw_affiliation_strings":["Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074810950","display_name":"Antoine Fr\u00e9noy","orcid":"https://orcid.org/0000-0002-3539-8915"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Antoine Frenoy","raw_affiliation_strings":["Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3539-8915","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054236642","display_name":"Sebastian Bonhoeffer","orcid":"https://orcid.org/0000-0001-8052-3925"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sebastian Bonhoeffer","raw_affiliation_strings":["Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8052-3925","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077336507"],"corresponding_institution_ids":["https://openalex.org/I35440088"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2143,"currency":"EUR","value_usd":2311},"fwci":4.9618,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.95599632,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"9","first_page":"e1005745","last_page":"e1005745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combination-therapy","display_name":"Combination therapy","score":0.606957197189331},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5954102873802185},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5109416842460632},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"Antibiotic resistance","score":0.5051122307777405},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.5017244815826416},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4828370213508606},{"id":"https://openalex.org/keywords/pharmacotherapy","display_name":"Pharmacotherapy","score":0.44453346729278564},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"Antibiotic therapy","score":0.41349127888679504},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.3921186029911041},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23801550269126892},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17535528540611267},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.13763272762298584}],"concepts":[{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.606957197189331},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5954102873802185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5109416842460632},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5051122307777405},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5017244815826416},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4828370213508606},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.44453346729278564},{"id":"https://openalex.org/C2993328841","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotic therapy","level":3,"score":0.41349127888679504},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3921186029911041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23801550269126892},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17535528540611267},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13763272762298584},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006761","descriptor_name":"Hospitals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006761","descriptor_name":"Hospitals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006761","descriptor_name":"Hospitals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1005745","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005745","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005745&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28915236","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28915236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1005745","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005745","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c2135b1deec84fefa7a5d7c2a49a643c","is_oa":true,"landing_page_url":"https://doaj.org/article/c2135b1deec84fefa7a5d7c2a49a643c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 9, p e1005745 (2017)","raw_type":"article"},{"id":"pmh:oai:escidoc.org:escidoc:2527679","is_oa":true,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0000-39C8-F","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/5411671","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Modeling_antibiotic_treatment_in_hospitals_A_systematic_approach_shows_benefits_of_combination_therapy_over_cycling_mixing_and_mono-drug_therapies/5411671","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5600366","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5600366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/197708","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/197708","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 13 (9)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.3929/ethz-b-000197708","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000197708","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005745","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005745","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005745&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.6499999761581421,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G1279391289","display_name":"Evolution and spread of drug resistance: A combined computational and experimental approach","funder_award_id":"155866","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G1374227521","display_name":null,"funder_award_id":"268540","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2754684752.pdf","grobid_xml":"https://content.openalex.org/works/W2754684752.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W656230083","https://openalex.org/W659475733","https://openalex.org/W851687779","https://openalex.org/W1496200171","https://openalex.org/W1988629557","https://openalex.org/W1991811123","https://openalex.org/W2007331931","https://openalex.org/W2011274088","https://openalex.org/W2014847700","https://openalex.org/W2018554274","https://openalex.org/W2023134185","https://openalex.org/W2026248979","https://openalex.org/W2029353484","https://openalex.org/W2038014125","https://openalex.org/W2046616491","https://openalex.org/W2053872241","https://openalex.org/W2063563543","https://openalex.org/W2081749411","https://openalex.org/W2090936186","https://openalex.org/W2097408958","https://openalex.org/W2099264750","https://openalex.org/W2103863773","https://openalex.org/W2108505069","https://openalex.org/W2117438320","https://openalex.org/W2123370987","https://openalex.org/W2126077014","https://openalex.org/W2127485648","https://openalex.org/W2129061602","https://openalex.org/W2134516082","https://openalex.org/W2136994256","https://openalex.org/W2140353364","https://openalex.org/W2143972668","https://openalex.org/W2145952139","https://openalex.org/W2149923935","https://openalex.org/W2150772812","https://openalex.org/W2152195021","https://openalex.org/W2156416784","https://openalex.org/W2156920884","https://openalex.org/W2159680005","https://openalex.org/W2161084401","https://openalex.org/W2163756523","https://openalex.org/W2164697816","https://openalex.org/W2171284117","https://openalex.org/W2171609823","https://openalex.org/W2224600235","https://openalex.org/W2301797697","https://openalex.org/W2345430760","https://openalex.org/W2442246762","https://openalex.org/W2573928791","https://openalex.org/W2607012049","https://openalex.org/W2751060233","https://openalex.org/W2799061466","https://openalex.org/W2799148064","https://openalex.org/W3023757607","https://openalex.org/W4230289800","https://openalex.org/W4230556569","https://openalex.org/W6991957103","https://openalex.org/W7014191107","https://openalex.org/W7074198121"],"related_works":["https://openalex.org/W36216555","https://openalex.org/W2122882834","https://openalex.org/W3029621145","https://openalex.org/W4294203409","https://openalex.org/W4317555504","https://openalex.org/W2011296644","https://openalex.org/W2005805966","https://openalex.org/W2032491470","https://openalex.org/W3032317009","https://openalex.org/W85574166"],"abstract_inverted_index":{"Multiple":[0],"treatment":[1,43,95,124,173],"strategies":[2,44,125,174],"are":[3,126,175,197],"available":[4],"for":[5,181],"empiric":[6],"antibiotic":[7],"therapy":[8,89,119,184],"in":[9,136],"hospitals,":[10],"but":[11],"neither":[12],"clinical":[13],"studies":[14],"nor":[15],"theoretical":[16],"investigations":[17],"have":[18],"yielded":[19],"a":[20,39,70,214],"clear":[21],"picture":[22],"when":[23],"which":[24,153,182],"strategy":[25],"is":[26,156,223],"optimal":[27],"and":[28,35,57,102,142,217],"why.":[29],"Extending":[30],"earlier":[31],"work":[32],"of":[33,82,117,131,133,203,207,220,229,232],"others":[34],"us,":[36],"we":[37,106],"present":[38],"mathematical":[40],"model":[41],"capturing":[42],"using":[45,98],"two":[46],"drugs,":[47],"i.e":[48],"the":[49,76,93,109,122,127,143,159,165,218,227,230],"multi-drug":[50],"therapies":[51],"referred":[52],"to":[53,74,91,121,187,209,213],"as":[54,60,62,171,195],"cycling,":[55],"mixing,":[56],"combination":[58,88,118,183],"therapy,":[59],"well":[61],"monotherapy":[63],"with":[64,139,147,191],"either":[65],"drug.":[66],"We":[67,85],"randomly":[68],"sample":[69],"large":[71],"parameter":[72,179],"space":[73],"determine":[75],"conditions":[77],"determining":[78,113],"success":[79,114],"or":[80,115],"failure":[81,116],"these":[83],"strategies.":[84,96],"find":[86,107],"that":[87,108],"tends":[90],"outperform":[92],"other":[94,123],"By":[97],"linear":[99],"discriminant":[100],"analysis":[101],"particle":[103],"swarm":[104],"optimization,":[105],"most":[110],"important":[111],"parameters":[112],"relative":[120],"de":[128,204],"novo":[129,205],"rate":[130,151],"emergence":[132,206],"double":[134,148,154,221],"resistance":[135,155,208,222],"patients":[137,162],"infected":[138],"sensitive":[140],"bacteria":[141],"fitness":[144],"costs":[145,231],"associated":[146],"resistance.":[149,234],"The":[150,178],"at":[152],"imported":[157],"into":[158,189],"hospital":[160],"via":[161],"admitted":[163],"from":[164],"outside":[166],"community":[167],"has":[168],"little":[169],"influence,":[170],"all":[172],"affected":[176],"equally.":[177],"sets":[180],"fails":[185],"tend":[186],"fall":[188],"areas":[190],"low":[192],"biological":[193],"plausibility":[194],"they":[196],"characterised":[198],"by":[199],"very":[200],"high":[201],"rates":[202],"both":[210],"drugs":[211],"compared":[212],"single":[215,233],"drug,":[216],"cost":[219],"considerably":[224],"smaller":[225],"than":[226],"sum":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}