{"id":"https://openalex.org/W2759472391","doi":"https://doi.org/10.1371/journal.pcbi.1005707","title":"Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease","display_name":"Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease","publication_year":2017,"publication_date":"2017-09-22","ids":{"openalex":"https://openalex.org/W2759472391","doi":"https://doi.org/10.1371/journal.pcbi.1005707","mag":"2759472391","pmid":"https://pubmed.ncbi.nlm.nih.gov/28938009"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005707","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005707","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005707&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005707&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043644825","display_name":"Willem de Haan","orcid":"https://orcid.org/0000-0003-3876-1764"},"institutions":[{"id":"https://openalex.org/I4210108594","display_name":"Amsterdam Neuroscience","ror":"https://ror.org/01x2d9f70","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210108594"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Willem de Haan","raw_affiliation_strings":["Alzheimer Center and Department of Neurology, VUmc, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands","Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3876-1764","affiliations":[{"raw_affiliation_string":"Alzheimer Center and Department of Neurology, VUmc, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108594"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045364545","display_name":"Elisabeth C.W. van Straaten","orcid":"https://orcid.org/0009-0002-0385-6608"},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elisabeth C. W. van Straaten","raw_affiliation_strings":["Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066482735","display_name":"Alida A. Gouw","orcid":"https://orcid.org/0000-0003-1481-3881"},"institutions":[{"id":"https://openalex.org/I4210108594","display_name":"Amsterdam Neuroscience","ror":"https://ror.org/01x2d9f70","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210108594"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alida A. Gouw","raw_affiliation_strings":["Alzheimer Center and Department of Neurology, VUmc, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands","Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer Center and Department of Neurology, VUmc, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108594"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015546124","display_name":"Cornelis J. Stam","orcid":"https://orcid.org/0000-0001-9163-7274"},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cornelis J. Stam","raw_affiliation_strings":["Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology and MEG, VUmc, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043644825"],"corresponding_institution_ids":["https://openalex.org/I4210108594","https://openalex.org/I911458345"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.0681,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92265106,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"13","issue":"9","first_page":"e1005707","last_page":"e1005707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.85581374168396},{"id":"https://openalex.org/keywords/premovement-neuronal-activity","display_name":"Premovement neuronal activity","score":0.5576079487800598},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.5074962973594666},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.5069130063056946},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.4511963725090027},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.4435046315193176},{"id":"https://openalex.org/keywords/network-dynamics","display_name":"Network dynamics","score":0.4288562834262848},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3815309703350067},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3404642343521118},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3289187550544739}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.85581374168396},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.5576079487800598},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5074962973594666},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5069130063056946},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4511963725090027},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4435046315193176},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.4288562834262848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3815309703350067},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3404642343521118},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3289187550544739},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005707","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005707","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005707&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28938009","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28938009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/d781e7e2-b259-4190-ab21-7bb5a1888d24","is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/d781e7e2-b259-4190-ab21-7bb5a1888d24","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"de Haan, W, van Straaten, E C W, Gouw, A A & Stam, C J 2017, 'Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease', PLoS Computational Biology, vol. 13, no. 9, e1005707. https://doi.org/10.1371/journal.pcbi.1005707","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/72c9618c-4b31-4f44-9a49-4e9fc9393efd","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/72c9618c-4b31-4f44-9a49-4e9fc9393efd","pdf_url":"https://pure.amsterdamumc.nl/ws/files/172061536/Altering-neuronal-excitability-to-preserve-network-connectivity-in-a-computational-model-of-alzheimers-disease.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Haan, W, van Straaten, E C W, Gouw, A A & Stam, C J 2017, 'Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease', PLoS computational biology, vol. 13, no. 9, e1005707. https://doi.org/10.1371/journal.pcbi.1005707","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:4566452","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5627940","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1ebdde2d00124e7a8bc6f3b15dcd45a8","is_oa":true,"landing_page_url":"https://doaj.org/article/1ebdde2d00124e7a8bc6f3b15dcd45a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 9, p e1005707 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5433517","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Altering_neuronal_excitability_to_preserve_network_connectivity_in_a_computational_model_of_Alzheimer_s_disease/5433517","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005707","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005707","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005707&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.41999998688697815,"display_name":"Partnerships for the goals"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2759472391.pdf","grobid_xml":"https://content.openalex.org/works/W2759472391.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W200409320","https://openalex.org/W1073194301","https://openalex.org/W1510056001","https://openalex.org/W1587744656","https://openalex.org/W1590230654","https://openalex.org/W1593730077","https://openalex.org/W1962254068","https://openalex.org/W1967931162","https://openalex.org/W1990121924","https://openalex.org/W1990897082","https://openalex.org/W1999653836","https://openalex.org/W1999792780","https://openalex.org/W2001778025","https://openalex.org/W2007741111","https://openalex.org/W2009576287","https://openalex.org/W2010388450","https://openalex.org/W2013393341","https://openalex.org/W2013554184","https://openalex.org/W2014022174","https://openalex.org/W2018523864","https://openalex.org/W2020282265","https://openalex.org/W2022040401","https://openalex.org/W2022381144","https://openalex.org/W2026802237","https://openalex.org/W2035462656","https://openalex.org/W2035902012","https://openalex.org/W2040086679","https://openalex.org/W2040628961","https://openalex.org/W2041325253","https://openalex.org/W2046699283","https://openalex.org/W2046952010","https://openalex.org/W2052530454","https://openalex.org/W2058046532","https://openalex.org/W2063497316","https://openalex.org/W2072292615","https://openalex.org/W2074829442","https://openalex.org/W2087938247","https://openalex.org/W2088905367","https://openalex.org/W2096577216","https://openalex.org/W2098676436","https://openalex.org/W2098999434","https://openalex.org/W2104085672","https://openalex.org/W2105504969","https://openalex.org/W2108453299","https://openalex.org/W2109582949","https://openalex.org/W2111710089","https://openalex.org/W2115135551","https://openalex.org/W2115387754","https://openalex.org/W2116083905","https://openalex.org/W2117995966","https://openalex.org/W2118050239","https://openalex.org/W2119642008","https://openalex.org/W2124443688","https://openalex.org/W2124973413","https://openalex.org/W2129478224","https://openalex.org/W2129483560","https://openalex.org/W2131180711","https://openalex.org/W2135232828","https://openalex.org/W2141178737","https://openalex.org/W2148155494","https://openalex.org/W2151393950","https://openalex.org/W2152502378","https://openalex.org/W2156508673","https://openalex.org/W2161493176","https://openalex.org/W2162686834","https://openalex.org/W2164223014","https://openalex.org/W2166931244","https://openalex.org/W2167822639","https://openalex.org/W2168312889","https://openalex.org/W2180397831","https://openalex.org/W2182367256","https://openalex.org/W2298919828","https://openalex.org/W2307176359","https://openalex.org/W2309442902","https://openalex.org/W2549366107","https://openalex.org/W2556389549","https://openalex.org/W2617018884","https://openalex.org/W2885529587","https://openalex.org/W3182215044","https://openalex.org/W4211189332","https://openalex.org/W4243607498","https://openalex.org/W6653931829","https://openalex.org/W6674916259","https://openalex.org/W6827085219"],"related_works":["https://openalex.org/W2950596497","https://openalex.org/W2436760910","https://openalex.org/W4303432678","https://openalex.org/W2043066229","https://openalex.org/W2142526561","https://openalex.org/W2974163011","https://openalex.org/W3210082636","https://openalex.org/W2113744676","https://openalex.org/W3036947769","https://openalex.org/W2771635220"],"abstract_inverted_index":{"Neuronal":[0],"hyperactivity":[1],"and":[2,8,26,78,143,154,240],"hyperexcitability":[3],"of":[4,28,118,157,183,195,200,219],"the":[5,115,138,158,163,175,188,193],"cerebral":[6],"cortex":[7],"hippocampal":[9],"region":[10],"is":[11],"an":[12],"increasingly":[13],"observed":[14],"phenomenon":[15],"in":[16,43,65,187,246,250],"preclinical":[17],"Alzheimer's":[18],"disease":[19],"(AD).":[20],"In":[21,123],"later":[22],"stages,":[23],"oscillatory":[24],"slowing":[25],"loss":[27],"functional":[29,205],"connectivity":[30,153],"are":[31],"ubiquitous.":[32],"Recent":[33],"evidence":[34],"suggests":[35],"that":[36,70,128,204],"neuronal":[37,55,133,211,220,237],"dynamics":[38,74],"have":[39],"a":[40,48,66,88,100,180],"prominent":[41],"role":[42],"AD":[44],"pathophysiology,":[45],"making":[46],"it":[47,190],"potentially":[49],"interesting":[50],"therapeutic":[51,230],"target.":[52],"However,":[53],"although":[54],"activity":[56,212],"can":[57,75,213],"be":[58,214],"manipulated":[59],"by":[60,216],"various":[61,164],"(non-)pharmacological":[62],"means,":[63],"intervening":[64],"highly":[67],"integrated":[68],"system":[69],"depends":[71],"on":[72],"complex":[73],"produce":[76],"counterintuitive":[77],"adverse":[79],"effects.":[80,170],"Computational":[81],"dynamic":[82],"network":[83,106,121,169,196,206,238],"modeling":[84],"may":[85,226],"serve":[86],"as":[87],"virtual":[89],"test":[90],"ground":[91],"for":[92],"developing":[93],"effective":[94],"interventions.":[95],"To":[96],"explore":[97,229],"this":[98,201],"approach,":[99],"previously":[101],"introduced":[102],"large-scale":[103,168],"neural":[104],"mass":[105],"with":[107],"human":[108],"brain":[109],"topology":[110],"was":[111,179],"used":[112],"to":[113,172,209,228,242],"simulate":[114],"temporal":[116],"evolution":[117],"AD-like,":[119],"activity-dependent":[120],"degeneration.":[122],"addition,":[124],"six":[125],"defense":[126],"strategies":[127],"either":[129],"enhanced":[130],"or":[131,147,235],"diminished":[132],"excitability":[134,221],"were":[135],"tested":[136],"against":[137],"degeneration":[139],"process,":[140],"targeting":[141],"excitatory":[142,185],"inhibitory":[144],"neurons":[145,186],"combined":[146],"separately.":[148],"Outcome":[149],"measures":[150],"described":[151],"oscillatory,":[152],"topological":[155],"features":[156],"damaged":[159],"networks.":[160],"Over":[161],"time,":[162],"interventions":[165],"produced":[166],"diverse":[167],"Contrary":[171],"our":[173],"hypothesis,":[174],"most":[176],"successful":[177],"strategy":[178],"selective":[181],"stimulation":[182],"all":[184],"network;":[189],"substantially":[191],"prolonged":[192],"preservation":[194],"integrity.":[197],"The":[198,223],"results":[199],"study":[202],"imply":[203],"damage":[207],"due":[208],"pathological":[210],"opposed":[215],"targeted":[217],"adjustment":[218],"levels.":[222],"present":[224],"approach":[225],"help":[227],"effects":[231],"aimed":[232],"at":[233],"preserving":[234],"restoring":[236],"integrity":[239],"contribute":[241],"better-informed":[243],"intervention":[244],"choices":[245],"future":[247],"clinical":[248],"trials":[249],"AD.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
