{"id":"https://openalex.org/W2738871673","doi":"https://doi.org/10.1371/journal.pcbi.1005671","title":"Reconstructing the regulatory circuit of cell fate determination in yeast mating response","display_name":"Reconstructing the regulatory circuit of cell fate determination in yeast mating response","publication_year":2017,"publication_date":"2017-07-24","ids":{"openalex":"https://openalex.org/W2738871673","doi":"https://doi.org/10.1371/journal.pcbi.1005671","mag":"2738871673","pmid":"https://pubmed.ncbi.nlm.nih.gov/28742153"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005671","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005671","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005671&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005671&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017693930","display_name":"Bin Shao","orcid":"https://orcid.org/0000-0001-8697-2174"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Shao","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101001879","display_name":"Haiyu Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyu Yuan","raw_affiliation_strings":["The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039186384","display_name":"Rongfei Zhang","orcid":"https://orcid.org/0000-0003-0297-5146"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongfei Zhang","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328968","display_name":"Xuan Wang","orcid":"https://orcid.org/0000-0001-6925-6264"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuan Wang","raw_affiliation_strings":["School of Informatics and Computing, Indiana University, Bloomington, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics and Computing, Indiana University, Bloomington, Indiana, United States of America","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100777357","display_name":"Shuwen Zhang","orcid":"https://orcid.org/0009-0002-7825-8741"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuwen Zhang","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056459691","display_name":"Qi Ouyang","orcid":"https://orcid.org/0000-0003-1585-7368"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Ouyang","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China","The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I20231570"]},{"raw_affiliation_string":"The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047936092","display_name":"Nan Hao","orcid":"https://orcid.org/0000-0003-2857-4789"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nan Hao","raw_affiliation_strings":["Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2857-4789","affiliations":[{"raw_affiliation_string":"Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009594443","display_name":"Chunxiong Luo","orcid":"https://orcid.org/0000-0001-8974-7693"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunxiong Luo","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-8974-7693","affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5009594443","https://openalex.org/A5047936092"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I36258959"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4486,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63550296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"13","issue":"7","first_page":"e1005671","last_page":"e1005671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8086313009262085},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6835750341415405},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.6619505882263184},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5348483324050903},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5131350159645081},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.5076810121536255},{"id":"https://openalex.org/keywords/mating-of-yeast","display_name":"Mating of yeast","score":0.4717458188533783},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.4429393410682678},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4294050931930542},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42892590165138245},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.42323732376098633},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.4126799404621124},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4073246717453003},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.31430745124816895},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.1837107241153717}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8086313009262085},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6835750341415405},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6619505882263184},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5348483324050903},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5131350159645081},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5076810121536255},{"id":"https://openalex.org/C46909000","wikidata":"https://www.wikidata.org/wiki/Q3604177","display_name":"Mating of yeast","level":4,"score":0.4717458188533783},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4429393410682678},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4294050931930542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42892590165138245},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42323732376098633},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4126799404621124},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4073246717453003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31430745124816895},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1837107241153717},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010675","descriptor_name":"Pheromones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010675","descriptor_name":"Pheromones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010675","descriptor_name":"Pheromones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005671","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005671","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005671&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28742153","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28742153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:ark:/13030/qt9vc8k7h4","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:cb1d27e45f544884bce72f5e6d9ed319","is_oa":false,"landing_page_url":"https://doaj.org/article/cb1d27e45f544884bce72f5e6d9ed319","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 7, p e1005671 (2017)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9vc8k7h4","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9vc8k7h4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 13, iss 7","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5239342","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Reconstructing_the_regulatory_circuit_of_cell_fate_determination_in_yeast_mating_response/5239342","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5546706","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5546706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005671","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005671","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005671&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G1485360947","display_name":null,"funder_award_id":"11674010, 11434001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3912974382","display_name":null,"funder_award_id":"11674010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4756590386","display_name":null,"funder_award_id":"11434001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5856974118","display_name":null,"funder_award_id":"R01 GM111458","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G913767081","display_name":null,"funder_award_id":"GM111458","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2738871673.pdf","grobid_xml":"https://content.openalex.org/works/W2738871673.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W232139476","https://openalex.org/W1481919380","https://openalex.org/W1572779288","https://openalex.org/W1965428318","https://openalex.org/W1975471112","https://openalex.org/W1978794333","https://openalex.org/W1981598092","https://openalex.org/W1997449620","https://openalex.org/W2000189769","https://openalex.org/W2013947447","https://openalex.org/W2028912942","https://openalex.org/W2040622520","https://openalex.org/W2041730675","https://openalex.org/W2049883153","https://openalex.org/W2050618862","https://openalex.org/W2053460598","https://openalex.org/W2057709162","https://openalex.org/W2058274661","https://openalex.org/W2072770862","https://openalex.org/W2072999024","https://openalex.org/W2073307618","https://openalex.org/W2076372398","https://openalex.org/W2079279399","https://openalex.org/W2093627383","https://openalex.org/W2102158172","https://openalex.org/W2104741960","https://openalex.org/W2109281577","https://openalex.org/W2109384743","https://openalex.org/W2115108153","https://openalex.org/W2117875674","https://openalex.org/W2121150592","https://openalex.org/W2126602684","https://openalex.org/W2128551987","https://openalex.org/W2129903089","https://openalex.org/W2141450355","https://openalex.org/W2141999425","https://openalex.org/W2145871402","https://openalex.org/W2161409973","https://openalex.org/W2161922735","https://openalex.org/W2162752401","https://openalex.org/W2163296727","https://openalex.org/W2165054897","https://openalex.org/W2172251739","https://openalex.org/W2270369744","https://openalex.org/W2406388686","https://openalex.org/W4231452879","https://openalex.org/W4242577767","https://openalex.org/W4253661031","https://openalex.org/W6676811725"],"related_works":["https://openalex.org/W4387096194","https://openalex.org/W4387096200","https://openalex.org/W4387095958","https://openalex.org/W4366722611","https://openalex.org/W2156421048","https://openalex.org/W4390011121","https://openalex.org/W1985607197","https://openalex.org/W4281759407","https://openalex.org/W2135896045","https://openalex.org/W1590000685"],"abstract_inverted_index":{"Massive":[0],"technological":[1],"advances":[2],"enabled":[3],"high-throughput":[4,100],"measurements":[5,109],"of":[6,53,63,110,119,157,165,187,209,235,244,254],"proteomic":[7,48],"changes":[8,126,134],"in":[9,31,127,222],"biological":[10,14,273],"processes.":[11],"However,":[12],"retrieving":[13],"insights":[15,250],"from":[16,152],"large-scale":[17],"protein":[18,114,120,128,158,245],"dynamics":[19,49,246],"data":[20],"remains":[21],"a":[22,36,60,74,99,178,198,218],"challenging":[23],"task.":[24],"Here":[25],"we":[26,97,122,168],"used":[27],"the":[28,47,51,66,88,124,153,162,170,184,202,207,232,236,242,252],"mating":[29,64,192,224],"differentiation":[30,95,220],"yeast":[32,67,223],"Saccharomyces":[33],"cerevisiae":[34],"as":[35],"model":[37],"and":[38,42,72,107,113,139,182,206,238,247,264],"developed":[39],"integrated":[40,262],"experimental":[41,263],"computational":[43],"approaches":[44],"to":[45,59,136,147,271],"analyze":[46],"during":[50,191],"process":[52],"cell":[54,68,111,175,219,255],"fate":[55,256],"determination.":[56,257],"When":[57],"exposed":[58],"high":[61],"dose":[62],"pheromone,":[65],"undergoes":[69],"growth":[70,83,112],"arrest":[71],"forms":[73],"shmoo-like":[75],"morphology;":[76],"however,":[77],"at":[78],"intermediate":[79],"doses,":[80],"chemotropic":[81],"elongated":[82],"is":[84],"initialized.":[85],"To":[86],"understand":[87],"gene":[89,188],"regulatory":[90,150,189],"networks":[91],"that":[92,104,260],"control":[93,243],"this":[94],"switch,":[96],"employed":[98],"microfluidic":[101],"imaging":[102],"system":[103],"allows":[105],"real-time":[106],"simultaneous":[108],"expression.":[115],"Using":[116],"kinetic":[117],"modeling":[118,229,265],"dynamics,":[121],"classified":[123],"stimulus-dependent":[125],"abundance":[129],"into":[130,251],"two":[131],"sources:":[132],"global":[133,155,237],"due":[135],"physiological":[137],"alterations":[138],"gene-specific":[140,149,166,239],"changes.":[141],"A":[142],"quantitative":[143],"framework":[144],"was":[145],"proposed":[146],"decouple":[148],"modes":[151],"growth-dependent":[154],"modulation":[156],"abundance.":[159],"Based":[160],"on":[161,241],"temporal":[163],"patterns":[164],"regulation,":[167],"established":[169],"network":[171,190],"architectures":[172],"underlying":[173],"distinct":[174,233],"fates":[176],"using":[177],"reverse":[179],"engineering":[180],"method":[181],"uncovered":[183],"dose-dependent":[185],"rewiring":[186],"differentiation.":[193],"Furthermore,":[194],"our":[195,228,261],"results":[196],"suggested":[197],"potential":[199],"crosstalk":[200],"between":[201],"pheromone":[203],"response":[204],"pathway":[205],"target":[208],"rapamycin":[210],"(TOR)-regulated":[211],"ribosomal":[212],"biogenesis":[213],"pathway,":[214],"which":[215],"might":[216],"underlie":[217],"switch":[221],"response.":[225],"In":[226],"summary,":[227],"approach":[230],"addresses":[231],"impacts":[234],"regulation":[240],"provides":[248],"new":[249],"mechanisms":[253],"We":[258],"anticipate":[259],"strategies":[266],"could":[267],"be":[268],"widely":[269],"applicable":[270],"other":[272],"systems.":[274]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}