{"id":"https://openalex.org/W2735619894","doi":"https://doi.org/10.1371/journal.pcbi.1005663","title":"Atomistic fingerprint of hyaluronan\u2013CD44 binding","display_name":"Atomistic fingerprint of hyaluronan\u2013CD44 binding","publication_year":2017,"publication_date":"2017-07-17","ids":{"openalex":"https://openalex.org/W2735619894","doi":"https://doi.org/10.1371/journal.pcbi.1005663","mag":"2735619894","pmid":"https://pubmed.ncbi.nlm.nih.gov/28715483"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005663","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005663","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005663&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005663&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048399469","display_name":"Joni Vuorio","orcid":"https://orcid.org/0000-0003-2404-4545"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Joni Vuorio","raw_affiliation_strings":["Department of Physics, Tampere University of Technology, Tampere, Finland","Department of Physics, University of Helsinki, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0003-2404-4545","affiliations":[{"raw_affiliation_string":"Department of Physics, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133110"]},{"raw_affiliation_string":"Department of Physics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082983574","display_name":"Ilpo Vattulainen","orcid":"https://orcid.org/0000-0001-7408-3214"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["DK","FI"],"is_corresponding":false,"raw_author_name":"Ilpo Vattulainen","raw_affiliation_strings":["Department of Physics, Tampere University of Technology, Tampere, Finland","Department of Physics, University of Helsinki, Helsinki, Finland","MEMPHYS - Centre for Biomembrane Physics, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133110"]},{"raw_affiliation_string":"Department of Physics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"MEMPHYS - Centre for Biomembrane Physics, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075124865","display_name":"Hector Martinez\u2010Seara","orcid":"https://orcid.org/0000-0001-9716-1713"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ","FI"],"is_corresponding":true,"raw_author_name":"Hector Martinez-Seara","raw_affiliation_strings":["Department of Physics, Tampere University of Technology, Tampere, Finland","Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0001-9716-1713","affiliations":[{"raw_affiliation_string":"Department of Physics, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133110"]},{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210145889"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5075124865"],"corresponding_institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133110","https://openalex.org/I4210145889"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3959,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.79108491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"7","first_page":"e1005663","last_page":"e1005663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6847265958786011},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.6307628750801086},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.5632449388504028},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.4541941285133362},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.44900473952293396},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.4401310682296753},{"id":"https://openalex.org/keywords/macromolecule","display_name":"Macromolecule","score":0.43085977435112},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.42676177620887756},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3272295594215393},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2996886968612671},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2574616074562073},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.1265769898891449}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6847265958786011},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6307628750801086},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5632449388504028},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4541941285133362},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44900473952293396},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4401310682296753},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.43085977435112},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42676177620887756},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3272295594215393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2996886968612671},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2574616074562073},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.1265769898891449}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1005663","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005663","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005663&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28715483","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28715483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:sdu.dk:openaire/245375ce-f7fd-4f75-b911-e3ade3993089","is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/245375ce-f7fd-4f75-b911-e3ade3993089","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vuorio, J, Vattulainen, I & Martinez-Seara, H 2017, 'Atomistic fingerprint of hyaluronan-CD44 binding', PLOS Computational Biology, vol. 13, no. 7, pp. e1005663. https://doi.org/10.1371/journal.pcbi.1005663","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:asep.lib.cas.cz:CavUnEpca/0478304","is_oa":false,"landing_page_url":"http://hdl.handle.net/11104/0274415","pdf_url":null,"source":{"id":"https://openalex.org/S7407055266","display_name":"ASEP","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3e9b4da8318e4de18da1906f413b08d7","is_oa":true,"landing_page_url":"https://doaj.org/article/3e9b4da8318e4de18da1906f413b08d7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 7, p e1005663 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4458835","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5549728","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/5213449","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Atomistic_fingerprint_of_hyaluronan_CD44_binding/5213449","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:helda.helsinki.fi:10138/217912","is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/217912","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:sdu.dk:Publications/245375ce-f7fd-4f75-b911-e3ade3993089","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:trepo.tuni.fi:10024/213959","is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/213959","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005663","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005663","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005663&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735619894.pdf","grobid_xml":"https://content.openalex.org/works/W2735619894.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W335748649","https://openalex.org/W569868126","https://openalex.org/W1570558241","https://openalex.org/W1973573706","https://openalex.org/W1975361755","https://openalex.org/W1981971440","https://openalex.org/W1989462635","https://openalex.org/W1995104908","https://openalex.org/W1996760509","https://openalex.org/W2008752573","https://openalex.org/W2012008110","https://openalex.org/W2014967479","https://openalex.org/W2036476969","https://openalex.org/W2036484340","https://openalex.org/W2037632318","https://openalex.org/W2041768758","https://openalex.org/W2043411450","https://openalex.org/W2047836750","https://openalex.org/W2050644354","https://openalex.org/W2052478045","https://openalex.org/W2052965509","https://openalex.org/W2055072451","https://openalex.org/W2057477511","https://openalex.org/W2062842950","https://openalex.org/W2064414576","https://openalex.org/W2067174909","https://openalex.org/W2081693079","https://openalex.org/W2088128469","https://openalex.org/W2089753996","https://openalex.org/W2098943363","https://openalex.org/W2099067304","https://openalex.org/W2105246691","https://openalex.org/W2110434905","https://openalex.org/W2111271799","https://openalex.org/W2111861824","https://openalex.org/W2119139128","https://openalex.org/W2127053176","https://openalex.org/W2128572087","https://openalex.org/W2129081579","https://openalex.org/W2133620840","https://openalex.org/W2139082708","https://openalex.org/W2152252241","https://openalex.org/W2153315863","https://openalex.org/W2157131142","https://openalex.org/W2160544821","https://openalex.org/W2161605421","https://openalex.org/W2163592912","https://openalex.org/W2166246682","https://openalex.org/W2290737450","https://openalex.org/W2334439863"],"related_works":["https://openalex.org/W1570348606","https://openalex.org/W2073626691","https://openalex.org/W1973479917","https://openalex.org/W2097544532","https://openalex.org/W2337329154","https://openalex.org/W2951275810","https://openalex.org/W2462655579","https://openalex.org/W2328917962","https://openalex.org/W2733723768","https://openalex.org/W2528170488"],"abstract_inverted_index":{"Hyaluronan":[0],"is":[1,118,186],"a":[2,55,65,100,203],"polyanionic,":[3],"megadalton-scale":[4],"polysaccharide,":[5],"which":[6],"initiates":[7],"cell":[8,23],"signaling":[9],"by":[10,163],"interacting":[11],"with":[12,60,85,177],"several":[13],"receptor":[14],"proteins":[15,185],"including":[16],"CD44":[17,29,52,84,196],"involved":[18],"in":[19,92,137,153,206],"cell-cell":[20],"interactions":[21,61],"and":[22,144],"adhesion.":[24],"Previous":[25],"studies":[26],"of":[27,51,67,121,141,182,193],"the":[28,47,104,107,114,119,122,138,142,148,164,178,183,190],"hyaluronan":[30,81],"binding":[31,57,89,124,166],"domain":[32],"have":[33],"identified":[34],"multiple":[35],"widespread":[36],"residues":[37],"to":[38,188,201],"be":[39,202],"responsible":[40],"for":[41,103],"its":[42],"recognition":[43],"capacity.":[44],"In":[45,70],"contrast,":[46],"X-ray":[48],"structural":[49],"characterization":[50],"has":[53,198],"revealed":[54],"single":[56],"mode":[58,117],"associated":[59],"that":[62,80,91,113,133],"involve":[63],"just":[64],"fraction":[66],"these":[68],"residues.":[69],"this":[71],"study,":[72],"we":[73],"show":[74],"through":[75],"atomistic":[76],"molecular":[77],"dynamics":[78],"simulations":[79],"can":[82],"bind":[83],"three":[86,123],"topographically":[87],"different":[88],"modes":[90,129,152],"unison":[93],"define":[94],"an":[95],"interaction":[96],"fingerprint,":[97],"thus":[98],"providing":[99],"plausible":[101],"explanation":[102],"disagreement":[105],"between":[106],"earlier":[108],"studies.":[109],"Our":[110],"results":[111],"confirm":[112],"known":[115],"crystallographic":[116],"strongest":[120],"modes.":[125],"The":[126],"other":[127],"two":[128],"represent":[130],"metastable":[131],"configurations":[132],"are":[134,146],"readily":[135],"available":[136],"initial":[139],"stages":[140],"binding,":[143],"they":[145],"also":[147],"most":[149],"frequently":[150],"observed":[151],"our":[154],"unbiased":[155],"simulations.":[156],"We":[157],"further":[158],"discuss":[159],"how":[160],"CD44,":[161],"fostered":[162],"weaker":[165],"modes,":[167],"diffuses":[168],"along":[169],"HA":[170],"when":[171],"attached.":[172],"This":[173],"1D":[174],"diffusion":[175],"combined":[176],"constrained":[179],"relative":[180],"orientation":[181],"diffusing":[184],"likely":[187],"influence":[189],"aggregation":[191,197],"kinetics":[192],"CD44.":[194],"Importantly,":[195],"been":[199],"suggested":[200],"possible":[204],"mechanism":[205],"CD44-mediated":[207],"signaling.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3}],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2025-10-10T00:00:00"}