{"id":"https://openalex.org/W2735262164","doi":"https://doi.org/10.1371/journal.pcbi.1005658","title":"Spatial organization of the budding yeast genome in the cell nucleus and identification of specific chromatin interactions from multi-chromosome constrained chromatin model","display_name":"Spatial organization of the budding yeast genome in the cell nucleus and identification of specific chromatin interactions from multi-chromosome constrained chromatin model","publication_year":2017,"publication_date":"2017-07-13","ids":{"openalex":"https://openalex.org/W2735262164","doi":"https://doi.org/10.1371/journal.pcbi.1005658","mag":"2735262164","pmid":"https://pubmed.ncbi.nlm.nih.gov/28704374"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005658","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005658","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005658&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005658&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040793469","display_name":"Gamze G\u00fcrsoy","orcid":"https://orcid.org/0000-0002-1352-8686"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gamze G\u00fcrsoy","raw_affiliation_strings":["The Richard and Loan Hill Department of Bioengineering, Program in Bioinformatics, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Richard and Loan Hill Department of Bioengineering, Program in Bioinformatics, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067366815","display_name":"Yun Xu","orcid":"https://orcid.org/0000-0003-3228-5111"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Xu","raw_affiliation_strings":["The Richard and Loan Hill Department of Bioengineering, Program in Bioinformatics, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Richard and Loan Hill Department of Bioengineering, Program in Bioinformatics, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091558783","display_name":"Jie Liang","orcid":"https://orcid.org/0000-0002-2773-6427"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Liang","raw_affiliation_strings":["The Richard and Loan Hill Department of Bioengineering, Program in Bioinformatics, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2773-6427","affiliations":[{"raw_affiliation_string":"The Richard and Loan Hill Department of Bioengineering, Program in Bioinformatics, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091558783"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2163,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.78360417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"7","first_page":"e1005658","last_page":"e1005658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.7872622013092041},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7476819753646851},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.7207513451576233},{"id":"https://openalex.org/keywords/centromere","display_name":"Centromere","score":0.6867607831954956},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6320743560791016},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5170110464096069},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.5077358484268188},{"id":"https://openalex.org/keywords/chromosome-conformation-capture","display_name":"Chromosome conformation capture","score":0.5052242875099182},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44655269384384155},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.445220947265625},{"id":"https://openalex.org/keywords/gene-density","display_name":"Gene density","score":0.44050711393356323},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43813759088516235},{"id":"https://openalex.org/keywords/genomic-organization","display_name":"Genomic organization","score":0.42662110924720764},{"id":"https://openalex.org/keywords/genome-evolution","display_name":"Genome evolution","score":0.4102059006690979},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.07582077383995056}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7872622013092041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7476819753646851},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7207513451576233},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.6867607831954956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6320743560791016},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5170110464096069},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5077358484268188},{"id":"https://openalex.org/C93946551","wikidata":"https://www.wikidata.org/wiki/Q5113914","display_name":"Chromosome conformation capture","level":5,"score":0.5052242875099182},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44655269384384155},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.445220947265625},{"id":"https://openalex.org/C163096569","wikidata":"https://www.wikidata.org/wiki/Q16966366","display_name":"Gene density","level":5,"score":0.44050711393356323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43813759088516235},{"id":"https://openalex.org/C22322919","wikidata":"https://www.wikidata.org/wiki/Q5533501","display_name":"Genomic organization","level":4,"score":0.42662110924720764},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.4102059006690979},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07582077383995056},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1005658","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005658","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005658&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28704374","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28704374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:91871c503cf14506b7dd9a3484a9a4f2","is_oa":true,"landing_page_url":"https://doaj.org/article/91871c503cf14506b7dd9a3484a9a4f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 7, p e1005658 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4387758","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5531658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005658","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005658","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005658&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.47999998927116394}],"awards":[{"id":"https://openalex.org/G2351127914","display_name":null,"funder_award_id":"R21 AI126308","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5223790787","display_name":null,"funder_award_id":"1062328","funder_id":"https://openalex.org/F4320332167","funder_display_name":"Directorate for Biological Sciences"},{"id":"https://openalex.org/G5581586232","display_name":null,"funder_award_id":"0800257","funder_id":"https://openalex.org/F4320332172","funder_display_name":"Directorate for Mathematical and Physical Sciences"},{"id":"https://openalex.org/G7211645137","display_name":null,"funder_award_id":"R01 GM126558","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7301432788","display_name":null,"funder_award_id":"079804","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8009226502","display_name":null,"funder_award_id":"R01 GM079804","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320317058","display_name":"Chicago Biomedical Consortium","ror":null},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332172","display_name":"Directorate for Mathematical and Physical Sciences","ror":"https://ror.org/029b7h395"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735262164.pdf","grobid_xml":"https://content.openalex.org/works/W2735262164.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1831401007","https://openalex.org/W1938551914","https://openalex.org/W1975506890","https://openalex.org/W1979015046","https://openalex.org/W1986096983","https://openalex.org/W1993309852","https://openalex.org/W1993570130","https://openalex.org/W1998538536","https://openalex.org/W2000224444","https://openalex.org/W2015128055","https://openalex.org/W2018617695","https://openalex.org/W2019311548","https://openalex.org/W2019672240","https://openalex.org/W2026865241","https://openalex.org/W2031098287","https://openalex.org/W2037158103","https://openalex.org/W2037969252","https://openalex.org/W2059886783","https://openalex.org/W2066834513","https://openalex.org/W2070021921","https://openalex.org/W2073788949","https://openalex.org/W2084133980","https://openalex.org/W2084861373","https://openalex.org/W2087588724","https://openalex.org/W2088815246","https://openalex.org/W2090037139","https://openalex.org/W2099293621","https://openalex.org/W2099357999","https://openalex.org/W2101546138","https://openalex.org/W2102221598","https://openalex.org/W2112348939","https://openalex.org/W2117275660","https://openalex.org/W2118865529","https://openalex.org/W2125372868","https://openalex.org/W2133809942","https://openalex.org/W2144771668","https://openalex.org/W2145065049","https://openalex.org/W2145619687","https://openalex.org/W2157329106","https://openalex.org/W2159479483","https://openalex.org/W2160084724","https://openalex.org/W2161212572","https://openalex.org/W2165219412","https://openalex.org/W2166368890","https://openalex.org/W2169059347","https://openalex.org/W2169113150","https://openalex.org/W2248505433","https://openalex.org/W2328968276","https://openalex.org/W2470258573","https://openalex.org/W2523898334","https://openalex.org/W2561419441","https://openalex.org/W2950153040","https://openalex.org/W2963321236","https://openalex.org/W3098733127","https://openalex.org/W3172404897","https://openalex.org/W6655110735","https://openalex.org/W6671444742","https://openalex.org/W6681411867","https://openalex.org/W6681629767","https://openalex.org/W6685147470","https://openalex.org/W7073595138"],"related_works":["https://openalex.org/W2101754326","https://openalex.org/W2066603386","https://openalex.org/W2169389191","https://openalex.org/W2791141771","https://openalex.org/W2807723702","https://openalex.org/W2083438904","https://openalex.org/W3198238520","https://openalex.org/W2137896927","https://openalex.org/W2079203202","https://openalex.org/W1974981762"],"abstract_inverted_index":{"Nuclear":[0],"landmarks":[1],"and":[2,49,89,122,140,177,205],"biochemical":[3,53],"factors":[4,54],"play":[5,207],"important":[6,133,203],"roles":[7,45,51],"in":[8,55,100],"the":[9,12,39,50,75,119,128],"organization":[10,58],"of":[11,18,41,46,52,74,84,118],"yeast":[13,20,56,77],"genome.":[14],"The":[15],"interaction":[16,91],"pattern":[17],"budding":[19,76],"as":[21,137],"measured":[22],"from":[23,93],"genome-wide":[24,94,164,185],"3C":[25,95,165,186],"studies":[26,96],"are":[27,97,143,168,189,200],"largely":[28,149],"recapitulated":[29],"by":[30,163,192],"model":[31,69,102],"polymer":[32,193],"genomes":[33],"subject":[34],"to":[35,71,145,151,170],"landmark":[36,196],"constraints.":[37,197],"However,":[38],"origin":[40],"inter-chromosomal":[42,90,129],"interactions,":[43,121],"specific":[44,183],"individual":[47],"landmarks,":[48],"genome":[57,78,85],"remain":[59],"unclear.":[60],"Here":[61],"we":[62,181],"describe":[63],"a":[64,115],"multi-chromosome":[65],"constrained":[66],"self-avoiding":[67],"chromatin":[68],"(mC-SAC)":[70],"gain":[72],"understanding":[73],"organization.":[79],"With":[80],"significantly":[81],"improved":[82],"sampling":[83],"structures,":[86],"both":[87],"intra-":[88],"patterns":[92],"accurately":[98],"captured":[99,162],"our":[101],"at":[103],"higher":[104],"resolution":[105],"than":[106],"previous":[107],"studies.":[108],"We":[109,154],"show":[110],"that":[111,159,188],"nuclear":[112],"confinement":[113],"is":[114,125],"key":[116],"determinant":[117],"intra-chromosomal":[120],"centromere":[123,152],"tethering":[124],"responsible":[126],"for":[127,191],"interactions.":[130],"In":[131],"addition,":[132],"genomic":[134],"elements":[135],"such":[136],"fragile":[138],"sites":[139],"tRNA":[141,174],"genes":[142,204],"found":[144,169],"be":[146,171],"clustered":[147],"spatially,":[148],"due":[150],"tethering.":[153],"uncovered":[155],"previously":[156],"unknown":[157],"interactions":[158,187,199],"were":[160],"not":[161],"studies,":[166],"which":[167],"enriched":[172,201],"with":[173,202],"genes,":[175],"RNAPIII":[176],"TFIIS":[178],"binding.":[179],"Moreover,":[180],"identified":[182],"high-frequency":[184],"unaccounted":[190],"effects":[194],"under":[195],"These":[198],"likely":[206],"biological":[208],"roles.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}