{"id":"https://openalex.org/W2728628739","doi":"https://doi.org/10.1371/journal.pcbi.1005610","title":"Expanding signaling-molecule wavefront model of cell polarization in the Drosophila wing primordium","display_name":"Expanding signaling-molecule wavefront model of cell polarization in the Drosophila wing primordium","publication_year":2017,"publication_date":"2017-07-03","ids":{"openalex":"https://openalex.org/W2728628739","doi":"https://doi.org/10.1371/journal.pcbi.1005610","mag":"2728628739","pmid":"https://pubmed.ncbi.nlm.nih.gov/28671940"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005610","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005610","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005610&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005610&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109427709","display_name":"Juliana C. Wortman","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliana C. Wortman","raw_affiliation_strings":["Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081250710","display_name":"Marcos Nahmad","orcid":"https://orcid.org/0000-0001-6300-5608"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcos Nahmad","raw_affiliation_strings":["Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067298605","display_name":"Peng Cheng Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Cheng Zhang","raw_affiliation_strings":["Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Department of Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030125759","display_name":"Arthur D. Lander","orcid":"https://orcid.org/0000-0002-4380-5525"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur D. Lander","raw_affiliation_strings":["Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Department of Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America","Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065634088","display_name":"Clare C. Yu","orcid":"https://orcid.org/0000-0002-6565-2988"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clare C. Yu","raw_affiliation_strings":["Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5065634088"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6324,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.65820787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"7","first_page":"e1005610","last_page":"e1005610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-polarity","display_name":"Cell polarity","score":0.6341041922569275},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5367286205291748},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4673486351966858},{"id":"https://openalex.org/keywords/wing","display_name":"Wing","score":0.44828781485557556},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.4421575367450714},{"id":"https://openalex.org/keywords/asymmetric-cell-division","display_name":"Asymmetric cell division","score":0.4295184016227722},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.41913172602653503},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3673190474510193},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.21018457412719727},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12751325964927673}],"concepts":[{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.6341041922569275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5367286205291748},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4673486351966858},{"id":"https://openalex.org/C97257150","wikidata":"https://www.wikidata.org/wiki/Q161358","display_name":"Wing","level":2,"score":0.44828781485557556},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4421575367450714},{"id":"https://openalex.org/C2778977658","wikidata":"https://www.wikidata.org/wiki/Q4812070","display_name":"Asymmetric cell division","level":4,"score":0.4295184016227722},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41913172602653503},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3673190474510193},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.21018457412719727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12751325964927673},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1005610","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005610","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005610&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28671940","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28671940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:ark:/13030/qt3db3g09v","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:f7bc4a28f3644286ba20181087f0cc10","is_oa":true,"landing_page_url":"https://doaj.org/article/f7bc4a28f3644286ba20181087f0cc10","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 7, p e1005610 (2017)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3db3g09v","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3db3g09v","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 13, iss 7","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4386576","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5515495","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/5167861","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Expanding_signaling-molecule_wavefront_model_of_cell_polarization_in_the_i_Drosophila_i_wing_primordium/5167861","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:qt3db3g09v","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/3db3g09v","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wortman, JC; Nahmad, M; Zhang, PC; Lander, AD; &amp; Yu, CC. (2017). Expanding signaling-molecule wavefront model of cell polarization in the Drosophila wing primordium. PLOS COMPUTATIONAL BIOLOGY, 13(7). doi: 10.1371/journal.pcbi.1005610. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3db3g09v","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005610","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005610","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005610&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G4158584186","display_name":null,"funder_award_id":"PHY-1066293","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4357913612","display_name":null,"funder_award_id":"1066293","funder_id":"https://openalex.org/F4320310042","funder_display_name":"Aspen Center for Physics"},{"id":"https://openalex.org/G4699830054","display_name":null,"funder_award_id":"P50-GM-076516","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5000848317","display_name":"Programs on Critical Problems in Physics, Astrophysics and Biophysics at the Aspen Center for Physics","funder_award_id":"1066293","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7039555113","display_name":null,"funder_award_id":"PHY-1066293","funder_id":"https://openalex.org/F4320310042","funder_display_name":"Aspen Center for Physics"},{"id":"https://openalex.org/G955258678","display_name":null,"funder_award_id":"D2015-024","funder_id":"https://openalex.org/F4320306536","funder_display_name":"V Foundation for Cancer Research"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306536","display_name":"V Foundation for Cancer Research","ror":"https://ror.org/00kbbk236"},{"id":"https://openalex.org/F4320310042","display_name":"Aspen Center for Physics","ror":"https://ror.org/05gqcbq50"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332898","display_name":"Stand Up To Cancer","ror":"https://ror.org/01dmpb598"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2728628739.pdf","grobid_xml":"https://content.openalex.org/works/W2728628739.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1965753673","https://openalex.org/W1966875890","https://openalex.org/W1969032952","https://openalex.org/W1978772056","https://openalex.org/W1980472339","https://openalex.org/W1981477992","https://openalex.org/W1991100707","https://openalex.org/W1997132344","https://openalex.org/W1997341464","https://openalex.org/W1998671100","https://openalex.org/W2000618372","https://openalex.org/W2000729232","https://openalex.org/W2008161604","https://openalex.org/W2008680715","https://openalex.org/W2008839303","https://openalex.org/W2010567868","https://openalex.org/W2013058724","https://openalex.org/W2017871741","https://openalex.org/W2019621646","https://openalex.org/W2029553949","https://openalex.org/W2038226019","https://openalex.org/W2039696897","https://openalex.org/W2044851525","https://openalex.org/W2046031332","https://openalex.org/W2046970439","https://openalex.org/W2048112280","https://openalex.org/W2048917073","https://openalex.org/W2060114324","https://openalex.org/W2061220010","https://openalex.org/W2063832919","https://openalex.org/W2069446998","https://openalex.org/W2071199204","https://openalex.org/W2072890919","https://openalex.org/W2076247671","https://openalex.org/W2078688385","https://openalex.org/W2080944549","https://openalex.org/W2082265780","https://openalex.org/W2086456864","https://openalex.org/W2099878990","https://openalex.org/W2101996917","https://openalex.org/W2106578476","https://openalex.org/W2111914012","https://openalex.org/W2113695281","https://openalex.org/W2114653173","https://openalex.org/W2118150971","https://openalex.org/W2118674189","https://openalex.org/W2119549820","https://openalex.org/W2126010492","https://openalex.org/W2130269585","https://openalex.org/W2133254839","https://openalex.org/W2138222765","https://openalex.org/W2138729763","https://openalex.org/W2141334319","https://openalex.org/W2146337514","https://openalex.org/W2148258297","https://openalex.org/W2155154349","https://openalex.org/W2157193997","https://openalex.org/W2158422816","https://openalex.org/W2169331639","https://openalex.org/W2228989826"],"related_works":["https://openalex.org/W2158260558","https://openalex.org/W4284964637","https://openalex.org/W2014827703","https://openalex.org/W2085044320","https://openalex.org/W2036483895","https://openalex.org/W2157872437","https://openalex.org/W1572054242","https://openalex.org/W2418580630","https://openalex.org/W3009711854","https://openalex.org/W2108905954"],"abstract_inverted_index":{"In":[0,171],"developing":[1],"tissues,":[2],"cell":[3,139,159,198,207],"polarization":[4,135],"and":[5,11,55,64,77,141,179,270],"proliferation":[6],"are":[7],"regulated":[8],"by":[9,138,184,239],"morphogens":[10],"signaling":[12],"pathways.":[13],"Cells":[14],"throughout":[15,93,259],"the":[16,25,30,36,39,45,51,65,72,87,96,107,110,113,116,121,134,142,152,158,174,189,192,197,201,218,252,260,263,266,271],"Drosophila":[17],"wing":[18,97],"primordium":[19],"typically":[20],"show":[21],"subcellular":[22],"localization":[23,42,254],"of":[24,33,38,48,75,95,112,148,154,177,191,255,265,280],"unconventional":[26],"myosin":[27],"Dachs":[28,41,256],"on":[29,44,182],"distal":[31,253],"side":[32],"cells":[34,225,230,258],"(nearest":[35],"center":[37,108],"disc).":[40],"depends":[43,181],"spatial":[46,278],"distribution":[47,153,195,235],"bonds":[49,243],"between":[50,61],"protocadherins":[52],"Fat":[53],"(Ft)":[54],"Dachsous":[56],"(Ds),":[57],"which":[58,70,149],"form":[59],"heterodimers":[60,156],"adjacent":[62],"cells;":[63],"Golgi":[66],"kinase":[67],"Four-jointed":[68],"(Fj),":[69],"affects":[71],"binding":[73,175],"affinities":[74],"Ft":[76,178],"Ds.":[78],"The":[79],"Fj":[80,122],"concentration":[81,89],"forms":[82],"a":[83,100,164],"linear":[84],"gradient":[85,123],"while":[86],"Ds":[88,144,180,267],"is":[90,124,131,136,215],"roughly":[91],"uniform":[92],"most":[94],"pouch":[98,114,261],"with":[99,203],"steep":[101],"transition":[102,145,220,268],"region":[103,221,269],"that":[104,188,212,222,251],"propagates":[105],"from":[106],"to":[109,167],"edge":[111],"during":[115],"third":[117],"larval":[118],"instar.":[119],"Although":[120],"an":[125],"important":[126],"cue":[127],"for":[128],"polarization,":[129,202],"it":[130],"unclear":[132],"how":[133],"affected":[137],"division":[140,238],"expanding":[143],"region,":[146],"both":[147],"can":[150],"alter":[151],"Ft-Ds":[155,193,242],"around":[157,196],"periphery.":[160],"We":[161,186],"have":[162],"developed":[163],"computational":[165],"model":[166,210],"address":[168],"these":[169],"questions.":[170],"our":[172],"model,":[173],"affinity":[176],"phosphorylation":[183],"Fj.":[185,281],"assume":[187],"asymmetry":[190,205,214,236],"bond":[194,234],"periphery":[199],"defines":[200],"greater":[204],"promoting":[206],"proliferation.":[208],"Our":[209],"predicts":[211],"this":[213],"greatest":[216],"in":[217,226,257],"radially-expanding":[219],"leaves":[223],"polarized":[224],"its":[227],"wake.":[228],"These":[229],"naturally":[231],"retain":[232],"their":[233],"after":[237],"rapidly":[240],"replenishing":[241],"at":[244],"new":[245],"cell-cell":[246],"interfaces.":[247],"Thus":[248],"we":[249],"predict":[250],"requires":[262],"movement":[264],"simple":[272],"presence,":[273],"rather":[274],"than":[275],"any":[276],"specific":[277],"pattern,":[279]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}
