{"id":"https://openalex.org/W2671017731","doi":"https://doi.org/10.1371/journal.pcbi.1005594","title":"Transmembrane helical interactions in the CFTR channel pore","display_name":"Transmembrane helical interactions in the CFTR channel pore","publication_year":2017,"publication_date":"2017-06-22","ids":{"openalex":"https://openalex.org/W2671017731","doi":"https://doi.org/10.1371/journal.pcbi.1005594","mag":"2671017731","pmid":"https://pubmed.ncbi.nlm.nih.gov/28640808"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005594","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005594","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005594&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005594&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036631162","display_name":"Jhuma Das","orcid":"https://orcid.org/0000-0003-3548-3105"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jhuma Das","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3548-3105","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023676292","display_name":"Andrei A. Aleksandrov","orcid":"https://orcid.org/0000-0002-8671-2732"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrei A. Aleksandrov","raw_affiliation_strings":["Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071209172","display_name":"Liying Cui","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liying Cui","raw_affiliation_strings":["Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101520150","display_name":"Lihua He","orcid":"https://orcid.org/0000-0002-2965-5225"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua He","raw_affiliation_strings":["Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108426897","display_name":"John R. Riordan","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John R. Riordan","raw_affiliation_strings":["Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033490428","display_name":"Nikolay V. Dokholyan","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nikolay V. Dokholyan","raw_affiliation_strings":["Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8225-4025","affiliations":[{"raw_affiliation_string":"Cystic Fibrosis Treatment and Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5033490428","https://openalex.org/A5108426897"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6409,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.84372177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"6","first_page":"e1005594","last_page":"e1005594"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"Cystic fibrosis transmembrane conductance regulator","score":0.7981603145599365},{"id":"https://openalex.org/keywords/chloride-channel","display_name":"Chloride channel","score":0.6021926999092102},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.5907072424888611},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.588824450969696},{"id":"https://openalex.org/keywords/atp-binding-cassette-transporter","display_name":"ATP-binding cassette transporter","score":0.5677882432937622},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5541167855262756},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.5132455825805664},{"id":"https://openalex.org/keywords/gating","display_name":"Gating","score":0.511756181716919},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.46705615520477295},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.46544134616851807},{"id":"https://openalex.org/keywords/biogenesis","display_name":"Biogenesis","score":0.42282718420028687},{"id":"https://openalex.org/keywords/threading","display_name":"Threading (protein sequence)","score":0.4207901954650879},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.31692808866500854},{"id":"https://openalex.org/keywords/transporter","display_name":"Transporter","score":0.2875555753707886},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26018989086151123},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12464052438735962},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.08837607502937317}],"concepts":[{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.7981603145599365},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.6021926999092102},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.5907072424888611},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.588824450969696},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.5677882432937622},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5541167855262756},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.5132455825805664},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.511756181716919},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.46705615520477295},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.46544134616851807},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.42282718420028687},{"id":"https://openalex.org/C200307862","wikidata":"https://www.wikidata.org/wiki/Q7797175","display_name":"Threading (protein sequence)","level":3,"score":0.4207901954650879},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31692808866500854},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.2875555753707886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26018989086151123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12464052438735962},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.08837607502937317},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002713","descriptor_name":"Chlorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002713","descriptor_name":"Chlorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002713","descriptor_name":"Chlorine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005594","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005594","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005594&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28640808","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28640808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:3b54a3936e7746278f49da7bf9c1ce85","is_oa":false,"landing_page_url":"https://doaj.org/article/3b54a3936e7746278f49da7bf9c1ce85","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 6, p e1005594 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5136460","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Transmembrane_helical_interactions_in_the_CFTR_channel_pore/5136460","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5501672","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5501672","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005594","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005594","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005594&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.5199999809265137,"display_name":"Clean water and sanitation"}],"awards":[{"id":"https://openalex.org/G6667032261","display_name":null,"funder_award_id":"DK051870","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8484069412","display_name":null,"funder_award_id":"DK051870 and HL11087","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2671017731.pdf","grobid_xml":"https://content.openalex.org/works/W2671017731.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1479710013","https://openalex.org/W1559483365","https://openalex.org/W1590184168","https://openalex.org/W1963790115","https://openalex.org/W1971761143","https://openalex.org/W1972554093","https://openalex.org/W1990193846","https://openalex.org/W1992504499","https://openalex.org/W1992571797","https://openalex.org/W1993932273","https://openalex.org/W1994600134","https://openalex.org/W2005789874","https://openalex.org/W2007762759","https://openalex.org/W2011861676","https://openalex.org/W2013889053","https://openalex.org/W2014729467","https://openalex.org/W2015655328","https://openalex.org/W2020558888","https://openalex.org/W2021688909","https://openalex.org/W2022242801","https://openalex.org/W2024412356","https://openalex.org/W2025546802","https://openalex.org/W2028778570","https://openalex.org/W2037312364","https://openalex.org/W2039882599","https://openalex.org/W2043064789","https://openalex.org/W2043673791","https://openalex.org/W2050573110","https://openalex.org/W2058530636","https://openalex.org/W2065039955","https://openalex.org/W2066266956","https://openalex.org/W2067260609","https://openalex.org/W2074636518","https://openalex.org/W2078234381","https://openalex.org/W2079748100","https://openalex.org/W2090926282","https://openalex.org/W2092523568","https://openalex.org/W2093327413","https://openalex.org/W2095182463","https://openalex.org/W2098354135","https://openalex.org/W2100774313","https://openalex.org/W2105505871","https://openalex.org/W2107696550","https://openalex.org/W2111026952","https://openalex.org/W2111935912","https://openalex.org/W2118780761","https://openalex.org/W2127402429","https://openalex.org/W2132957145","https://openalex.org/W2152289994","https://openalex.org/W2155201844","https://openalex.org/W2156406348","https://openalex.org/W2157393167","https://openalex.org/W2161983628","https://openalex.org/W2171584248","https://openalex.org/W2200475468","https://openalex.org/W2382781498","https://openalex.org/W2414149553","https://openalex.org/W2559666645","https://openalex.org/W6654198743"],"related_works":["https://openalex.org/W2113074631","https://openalex.org/W2041984778","https://openalex.org/W2015531712","https://openalex.org/W2164659357","https://openalex.org/W2035177679","https://openalex.org/W1977188111","https://openalex.org/W2366353213","https://openalex.org/W1968164965","https://openalex.org/W2117143712","https://openalex.org/W2367070451"],"abstract_inverted_index":{"Mutations":[0],"in":[1,22,28,35,111,193,233,275],"the":[2,29,49,60,163,179,194,198,207,245,253,258,268],"Cystic":[3],"Fibrosis":[4],"Transmembrane":[5],"Conductance":[6],"Regulator":[7],"(CFTR)":[8],"gene":[9],"affect":[10],"CFTR":[11,80,99,144],"protein":[12],"biogenesis":[13],"or":[14],"its":[15,69],"function":[16],"as":[17,90],"a":[18,137,143,169,183],"chloride":[19],"channel,":[20,64],"resulting":[21],"dysregulation":[23],"of":[24,40,48,68,74,142,156,162,175,178,189,213,227,231,247,255,257,280],"epithelial":[25],"fluid":[26],"transport":[27],"lung,":[30],"pancreas":[31],"and":[32,72,100,115,154,166,210,236,238,240],"other":[33],"organs":[34],"cystic":[36,75],"fibrosis":[37,76],"(CF).":[38],"Development":[39],"pharmaceutical":[41],"strategies":[42],"to":[43,98,151,167,186,262],"treat":[44,267],"CF":[45],"requires":[46],"understanding":[47],"mechanisms":[50],"underlying":[51],"channel":[52,219,259],"function.":[53],"However,":[54],"incomplete":[55],"3D":[56],"structural":[57,203],"information":[58],"on":[59,249],"unique":[61],"ABC":[62,88],"ion":[63,103,283],"CFTR,":[65],"hinders":[66],"elucidation":[67],"functional":[70],"mechanism":[71],"correction":[73],"causing":[77],"mutants.":[78],"Several":[79],"homology":[81],"models":[82],"have":[83,94],"been":[84],"developed":[85],"using":[86],"bacterial":[87],"transporters":[89],"templates":[91],"but":[92,196],"these":[93],"low":[95],"sequence":[96],"similarity":[97],"are":[101,252],"not":[102,197],"channels.":[104],"Here,":[105],"we":[106,221,265],"refine":[107],"an":[108,112,117,123],"earlier":[109],"model":[110,121],"outward":[113],"(OWF)":[114],"develop":[116],"inward":[118],"(IWF)":[119],"facing":[120],"employing":[122],"integrated":[124],"experimental-molecular":[125],"dynamics":[126],"simulation":[127],"(200":[128],"ns)":[129],"approach.":[130],"Our":[131],"IWF":[132,145,199],"structure":[133,141],"agrees":[134],"well":[135],"with":[136,272],"recently":[138],"solved":[139],"cryo-EM":[140],"state.":[146],"We":[147],"utilize":[148],"cysteine":[149],"cross-linking":[150,223,248],"verify":[152],"positions":[153],"orientations":[155],"residues":[157],"within":[158,215],"trans-membrane":[159],"helices":[160],"(TMHs)":[161],"OWF":[164,195],"conformation":[165],"reconstruct":[168],"physiologically":[170],"relevant":[171],"pore":[172,176,287],"structure.":[173],"Comparison":[174],"profiles":[177],"two":[180,208],"conformations":[181,209],"reveal":[182],"radius":[184],"sufficient":[185],"permit":[187],"passage":[188],"hydrated":[190],"Cl-":[191],"ions":[192],"model.":[200],"To":[201,242],"identify":[202],"determinants":[204],"that":[205,286],"distinguish":[206],"possible":[211],"rearrangements":[212],"TMHs":[214],"them":[216],"responsible":[217],"for":[218],"gating,":[220],"perform":[222],"by":[224],"bifunctional":[225],"reagents":[226,274,281],"multiple":[228],"predicted":[229],"pairs":[230,271],"cysteines":[232],"TMH":[234],"6":[235,239],"12":[237],"9.":[241],"determine":[243],"whether":[244],"effects":[246],"gating":[250],"observed":[251],"result":[254],"switching":[256],"from":[260],"open":[261],"close":[263],"state,":[264],"also":[266],"same":[269],"residue":[270],"monofunctional":[273],"separate":[276],"experiments.":[277],"Both":[278],"types":[279],"prevent":[282],"currents":[284],"indicating":[285],"blockage":[288],"is":[289],"primarily":[290],"responsible.":[291]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}