{"id":"https://openalex.org/W2627089767","doi":"https://doi.org/10.1371/journal.pcbi.1005593","title":"Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria","display_name":"Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria","publication_year":2017,"publication_date":"2017-06-13","ids":{"openalex":"https://openalex.org/W2627089767","doi":"https://doi.org/10.1371/journal.pcbi.1005593","mag":"2627089767","pmid":"https://pubmed.ncbi.nlm.nih.gov/28609477"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005593","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005593","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005593&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005593&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036632412","display_name":"David J. Whittaker","orcid":"https://orcid.org/0000-0002-2757-5491"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dominic G. Whittaker","raw_affiliation_strings":["Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2757-5491","affiliations":[{"raw_affiliation_string":"Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002106325","display_name":"Haibo Ni","orcid":"https://orcid.org/0000-0003-0083-4286"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haibo Ni","raw_affiliation_strings":["Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-0083-4286","affiliations":[{"raw_affiliation_string":"Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076411219","display_name":"Aziza El Harchi","orcid":"https://orcid.org/0000-0003-3329-6234"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aziza El Harchi","raw_affiliation_strings":["Department of Physiology, Pharmacology and Neuroscience, and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Pharmacology and Neuroscience, and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037737415","display_name":"Jules C. Hancox","orcid":"https://orcid.org/0000-0002-2055-6482"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jules C. Hancox","raw_affiliation_strings":["Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","Department of Physiology, Pharmacology and Neuroscience, and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Department of Physiology, Pharmacology and Neuroscience, and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043271142","display_name":"Henggui Zhang","orcid":"https://orcid.org/0000-0002-0863-5807"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"Henggui Zhang","raw_affiliation_strings":["Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","Space Institute of Southern China, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-0863-5807","affiliations":[{"raw_affiliation_string":"Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Space Institute of Southern China, Shenzhen, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037737415","https://openalex.org/A5043271142"],"corresponding_institution_ids":["https://openalex.org/I204983213","https://openalex.org/I28407311","https://openalex.org/I36234482"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2414,"currency":"EUR","value_usd":2603},"fwci":3.5925,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.94268031,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"6","first_page":"e1005593","last_page":"e1005593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proarrhythmia","display_name":"Proarrhythmia","score":0.7569140195846558},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.642379641532898},{"id":"https://openalex.org/keywords/effective-refractory-period","display_name":"Effective refractory period","score":0.5775432586669922},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"Long QT syndrome","score":0.5033792853355408},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.502150297164917},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.49332395195961},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4294314980506897},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.4173874258995056},{"id":"https://openalex.org/keywords/short-qt-syndrome","display_name":"Short QT syndrome","score":0.41318532824516296},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.37906768918037415},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3689157962799072},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3446241319179535},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26414036750793457},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26232457160949707},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1618846356868744}],"concepts":[{"id":"https://openalex.org/C2777008848","wikidata":"https://www.wikidata.org/wiki/Q7246836","display_name":"Proarrhythmia","level":3,"score":0.7569140195846558},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.642379641532898},{"id":"https://openalex.org/C189327125","wikidata":"https://www.wikidata.org/wiki/Q5347276","display_name":"Effective refractory period","level":3,"score":0.5775432586669922},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.5033792853355408},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.502150297164917},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.49332395195961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4294314980506897},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.4173874258995056},{"id":"https://openalex.org/C2779578097","wikidata":"https://www.wikidata.org/wiki/Q1484058","display_name":"Short QT syndrome","level":4,"score":0.41318532824516296},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37906768918037415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3689157962799072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3446241319179535},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26414036750793457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26232457160949707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1618846356868744}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1005593","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005593","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005593&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28609477","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28609477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/f60eba77-b4f3-4163-b953-f679b31df312","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/f60eba77-b4f3-4163-b953-f679b31df312","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Whittaker, D G, Ni, H, Harchi, A E, Hancox, J C & Zhang, H 2017, 'Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome : Insights from virtual human atria', PL o S Computational Biology, vol. 13, no. 6, e1005593. https://doi.org/10.1371/journal.pcbi.1005593","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/bc5d1a64-384e-47fa-bcc4-77e284ead96d","is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/bc5d1a64-384e-47fa-bcc4-77e284ead96d","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Whittaker, D G, Ni, H, Harchi, A E, Hancox, J C & Zhang, H 2017, 'Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome : Insights from virtual human atria', PLOS Computational Biology, vol. 13, no. 6, e1005593. https://doi.org/10.1371/journal.pcbi.1005593","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:126320","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:f2d19fe48f1841bb94810020e5719bb8","is_oa":true,"landing_page_url":"https://doaj.org/article/f2d19fe48f1841bb94810020e5719bb8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 6, p e1005593 (2017)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5cq6m43h","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5cq6m43h","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 13, iss 6","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/5105077","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Atrial_arrhythmogenicity_of_KCNJ2_mutations_in_short_QT_syndrome_Insights_from_virtual_human_atria/5105077","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5487071","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5487071","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005593","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005593","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005593&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1050937521","display_name":null,"funder_award_id":"JSGG20160229125049615","funder_id":"https://openalex.org/F4320329174","funder_display_name":"Shenzhen Municipal Science and Technology Innovation Council"},{"id":"https://openalex.org/G1263606477","display_name":"Identifying atrial arrhythmia substrate(s) in the short QT syndrome","funder_award_id":"FS/14/5/30533","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G1941568226","display_name":null,"funder_award_id":"EP/J00958X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2388942088","display_name":null,"funder_award_id":"RG2640","funder_id":"https://openalex.org/F4320320036","funder_display_name":"Heart Research UK"},{"id":"https://openalex.org/G3518305660","display_name":"Multi-scale Approaches to Mechanical Contraction and Electrical Wave Conduction in A 3D Model of Human Atria during Fibrillation","funder_award_id":"EP/J00958X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6999771811","display_name":"BeatBox - HPC Environment for Biophysically and Anatomically Realistic Cardiac Simulations","funder_award_id":"EP/I029826/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G704554160","display_name":null,"funder_award_id":"EP/I029826/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8063836340","display_name":null,"funder_award_id":"JCYJ20151029173639477","funder_id":"https://openalex.org/F4320329174","funder_display_name":"Shenzhen Municipal Science and Technology Innovation Council"},{"id":"https://openalex.org/G8548008881","display_name":"\u57fa\u4e8e\u8ba1\u7b97\u5fc3\u810f\u6a21\u578b\u7684\u9057\u4f20\u6027\u77edQT\u7efc\u5408\u5f81\u53d1\u75c5\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"61179009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8626858852","display_name":null,"funder_award_id":"EP/J00958X/1","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8828877192","display_name":"Comparative electrophysiology and pharmacology of mutant potassium channels in different variants of the short QT syndrome","funder_award_id":"PG/06/147","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320036","display_name":"Heart Research UK","ror":"https://ror.org/04j68sw28"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329174","display_name":"Shenzhen Municipal Science and Technology Innovation Council","ror":"https://ror.org/017n8df75"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2627089767.pdf","grobid_xml":"https://content.openalex.org/works/W2627089767.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W36150391","https://openalex.org/W1482350832","https://openalex.org/W1754996786","https://openalex.org/W1809798419","https://openalex.org/W1881989874","https://openalex.org/W1965633790","https://openalex.org/W1966526405","https://openalex.org/W1966872591","https://openalex.org/W1967159537","https://openalex.org/W1967494220","https://openalex.org/W1969060286","https://openalex.org/W1971837668","https://openalex.org/W1975491324","https://openalex.org/W1976022862","https://openalex.org/W1976910156","https://openalex.org/W1984984289","https://openalex.org/W1990850630","https://openalex.org/W1992458602","https://openalex.org/W1994322021","https://openalex.org/W1994666309","https://openalex.org/W1995182859","https://openalex.org/W2013487019","https://openalex.org/W2018256150","https://openalex.org/W2027405777","https://openalex.org/W2038020853","https://openalex.org/W2042832519","https://openalex.org/W2044933725","https://openalex.org/W2045548568","https://openalex.org/W2053274299","https://openalex.org/W2054158242","https://openalex.org/W2055038470","https://openalex.org/W2056878931","https://openalex.org/W2057323550","https://openalex.org/W2061451182","https://openalex.org/W2063344460","https://openalex.org/W2068524893","https://openalex.org/W2077203000","https://openalex.org/W2078242986","https://openalex.org/W2081150162","https://openalex.org/W2082847223","https://openalex.org/W2083289946","https://openalex.org/W2084985537","https://openalex.org/W2088024909","https://openalex.org/W2089421439","https://openalex.org/W2090077994","https://openalex.org/W2098878594","https://openalex.org/W2103367007","https://openalex.org/W2104749146","https://openalex.org/W2111546434","https://openalex.org/W2119541189","https://openalex.org/W2121040759","https://openalex.org/W2125567290","https://openalex.org/W2126899523","https://openalex.org/W2127748321","https://openalex.org/W2129656446","https://openalex.org/W2130114624","https://openalex.org/W2136239415","https://openalex.org/W2136343630","https://openalex.org/W2137618884","https://openalex.org/W2139222531","https://openalex.org/W2142830159","https://openalex.org/W2149113504","https://openalex.org/W2154122229","https://openalex.org/W2154806697","https://openalex.org/W2160845018","https://openalex.org/W2160851716","https://openalex.org/W2161424604","https://openalex.org/W2161539268","https://openalex.org/W2169679878","https://openalex.org/W2171074980","https://openalex.org/W2175689245","https://openalex.org/W2289337326","https://openalex.org/W2293648330","https://openalex.org/W2531345437","https://openalex.org/W2533507734","https://openalex.org/W2545967755","https://openalex.org/W2560879934","https://openalex.org/W2788580266","https://openalex.org/W3105710497","https://openalex.org/W4237523220","https://openalex.org/W4253911545"],"related_works":["https://openalex.org/W2914679361","https://openalex.org/W2059132091","https://openalex.org/W2063240695","https://openalex.org/W2074159517","https://openalex.org/W1604250740","https://openalex.org/W4401980903","https://openalex.org/W2940115921","https://openalex.org/W2039784878","https://openalex.org/W3106754853","https://openalex.org/W2643139323"],"abstract_inverted_index":{"Gain-of-function":[0],"mutations":[1,36,96,129,139,234],"in":[2,65,147,156,173,184,216],"KCNJ2-encoded":[3],"Kir2.1":[4,78,128,233],"channels":[5],"underlie":[6],"variant":[7],"3":[8],"(SQT3)":[9],"of":[10,47,52,73,95,119,152,171,178,207,219,242],"the":[11,31,53,74,117,202],"short":[12],"QT":[13],"syndrome,":[14],"which":[15],"is":[16],"associated":[17,187],"with":[18,188,231],"atrial":[19,38,55,229],"fibrillation":[20],"(AF).":[21],"Using":[22],"biophysically-detailed":[23],"human":[24,54],"atria":[25],"computer":[26],"models,":[27],"this":[28,223],"study":[29,224],"investigated":[30],"mechanistic":[32,226],"link":[33],"between":[34],"SQT3":[35,232],"and":[37,40,70,76,82,90,111,126,135,149,158,169,180,209,235],"arrhythmogenesis,":[39],"potential":[41,57],"ion":[42],"channel":[43],"targets":[44],"for":[45,142,201,240],"treatment":[46],"SQT3.":[48,220],"A":[49],"contemporary":[50],"model":[51],"action":[56],"(AP)":[58],"was":[59,162,182],"modified":[60],"to":[61,68,166],"recapitulate":[62],"functional":[63],"changes":[64,165],"IK1":[66,134,179],"due":[67],"heterozygous":[69,189],"homozygous":[71],"forms":[72,218],"D172N":[75,125,190],"E299V":[77,127,203],"mutations.":[79],"Wild-type":[80],"(WT)":[81],"mutant":[83],"formulations":[84],"were":[85,122],"incorporated":[86],"into":[87,228],"multi-scale":[88],"homogeneous":[89],"heterogeneous":[91],"tissue":[92,108,160,167],"models.":[93],"Effects":[94],"on":[97,133],"AP":[98],"duration":[99],"(APD),":[100],"conduction":[101],"velocity":[102],"(CV),":[103],"effective":[104,183],"refractory":[105],"period":[106],"(ERP),":[107],"excitation":[109,154],"threshold":[110],"their":[112],"rate-dependence,":[113],"as":[114,116],"well":[115],"wavelength":[118],"re-entry":[120,143,186],"(WL)":[121],"quantified.":[123],"The":[124],"produced":[130,211],"distinct":[131],"effects":[132],"APD":[136,172],"shortening.":[137],"Both":[138],"decreased":[140],"WL":[141],"through":[144],"a":[145,198,212],"reduction":[146],"ERP":[148],"CV.":[150],"Stability":[151],"re-entrant":[153],"waves":[155],"2D":[157],"3D":[159],"models":[161],"mediated":[163],"by":[164],"excitability":[168],"dispersion":[170],"mutation":[174],"conditions.":[175],"Combined":[176,205],"block":[177,194],"IKr":[181,193,208],"terminating":[185],"conditions,":[191],"whereas":[192],"alone":[195],"may":[196],"be":[197],"safer":[199],"alternative":[200],"mutation.":[204],"inhibition":[206],"IKur":[210],"synergistic":[213],"anti-arrhythmic":[214],"effect":[215],"both":[217],"In":[221],"conclusion,":[222],"provides":[225],"insights":[227],"proarrhythmia":[230],"highlights":[236],"possible":[237],"pharmacological":[238],"strategies":[239],"management":[241],"SQT3-linked":[243],"AF.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
