{"id":"https://openalex.org/W2622490204","doi":"https://doi.org/10.1371/journal.pcbi.1005571","title":"Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation","display_name":"Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation","publication_year":2017,"publication_date":"2017-06-05","ids":{"openalex":"https://openalex.org/W2622490204","doi":"https://doi.org/10.1371/journal.pcbi.1005571","mag":"2622490204","pmid":"https://pubmed.ncbi.nlm.nih.gov/28582397"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005571","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005571&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005571&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067034493","display_name":"Jae Kyoung Kim","orcid":"https://orcid.org/0000-0001-7842-2172"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Kyoung Kim","raw_affiliation_strings":["Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7842-2172","affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068753451","display_name":"Eduardo D. Sontag","orcid":"https://orcid.org/0000-0001-8020-5783"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eduardo D. Sontag","raw_affiliation_strings":["Department of Mathematics and Center for Quantitative Biology, Rutgers University, New Brunswick, New Jersey, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8020-5783","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Center for Quantitative Biology, Rutgers University, New Brunswick, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067034493","https://openalex.org/A5068753451"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I157485424"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2168,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.78211219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"13","issue":"6","first_page":"e1005571","last_page":"e1005571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9714000225067139,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feed-forward","display_name":"Feed forward","score":0.6033700704574585},{"id":"https://openalex.org/keywords/moment","display_name":"Moment (physics)","score":0.5449087619781494},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5344998240470886},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.5298901200294495},{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.5005216598510742},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.49130335450172424},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4864163398742676},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.46527549624443054},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.45275211334228516},{"id":"https://openalex.org/keywords/stationary-state","display_name":"Stationary state","score":0.4520374536514282},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.45177218317985535},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2883463501930237},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.27576640248298645},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.239926278591156},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2161160409450531},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15126588940620422},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14986330270767212},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11604005098342896},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.10302555561065674},{"id":"https://openalex.org/keywords/classical-mechanics","display_name":"Classical mechanics","score":0.09183663129806519},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.08167839050292969}],"concepts":[{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.6033700704574585},{"id":"https://openalex.org/C179254644","wikidata":"https://www.wikidata.org/wiki/Q13222844","display_name":"Moment (physics)","level":2,"score":0.5449087619781494},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5344998240470886},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.5298901200294495},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.5005216598510742},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.49130335450172424},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4864163398742676},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.46527549624443054},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.45275211334228516},{"id":"https://openalex.org/C47458137","wikidata":"https://www.wikidata.org/wiki/Q911951","display_name":"Stationary state","level":2,"score":0.4520374536514282},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.45177218317985535},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2883463501930237},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27576640248298645},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.239926278591156},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2161160409450531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15126588940620422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14986330270767212},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11604005098342896},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.10302555561065674},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.09183663129806519},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08167839050292969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005571","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005571&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28582397","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28582397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1005571","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005571","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1b2fec620afb4725861774569fe35882","is_oa":true,"landing_page_url":"https://doaj.org/article/1b2fec620afb4725861774569fe35882","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 6, p e1005571 (2017)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5481150","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5481150","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005571","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005571&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G1523888516","display_name":null,"funder_award_id":"FA9550-","funder_id":"https://openalex.org/F4320338279","funder_display_name":"Air Force Office of Scientific Research"},{"id":"https://openalex.org/G277562485","display_name":null,"funder_award_id":"FA9550-14-1-0060","funder_id":"https://openalex.org/F4320338279","funder_display_name":"Air Force Office of Scientific Research"},{"id":"https://openalex.org/G3877071125","display_name":null,"funder_award_id":"FA9550-14-1-0060","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G555511638","display_name":null,"funder_award_id":"ONR N00014-13-1-0074","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G5850790384","display_name":null,"funder_award_id":"N01160447","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6098521345","display_name":null,"funder_award_id":"FA9550","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G7090116110","display_name":null,"funder_award_id":"FA9550","funder_id":"https://openalex.org/F4320332467","funder_display_name":"U.S. Air Force"},{"id":"https://openalex.org/G8060054297","display_name":null,"funder_award_id":"N00014-13-1-0074","funder_id":"https://openalex.org/F4320338279","funder_display_name":"Air Force Office of Scientific Research"},{"id":"https://openalex.org/G8876996369","display_name":null,"funder_award_id":"N00014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G910434835","display_name":null,"funder_award_id":"N000141310074","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4320315859","display_name":"POSCO TJ Park Foundation","ror":"https://ror.org/0375ste74"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320332467","display_name":"U.S. Air Force","ror":"https://ror.org/006gmme17"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2622490204.pdf","grobid_xml":"https://content.openalex.org/works/W2622490204.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W110971078","https://openalex.org/W177374653","https://openalex.org/W1519546898","https://openalex.org/W1557148833","https://openalex.org/W1572902284","https://openalex.org/W1770716405","https://openalex.org/W1932512987","https://openalex.org/W1963906834","https://openalex.org/W1965435094","https://openalex.org/W1973890190","https://openalex.org/W1976443948","https://openalex.org/W1978750558","https://openalex.org/W1979682650","https://openalex.org/W1982705472","https://openalex.org/W1985448950","https://openalex.org/W1986826390","https://openalex.org/W1992179397","https://openalex.org/W1994021794","https://openalex.org/W1995174791","https://openalex.org/W2002563535","https://openalex.org/W2004604822","https://openalex.org/W2008867005","https://openalex.org/W2009710122","https://openalex.org/W2013947447","https://openalex.org/W2014681825","https://openalex.org/W2018435536","https://openalex.org/W2018598287","https://openalex.org/W2018670096","https://openalex.org/W2019768978","https://openalex.org/W2021290840","https://openalex.org/W2022891974","https://openalex.org/W2023757387","https://openalex.org/W2030102144","https://openalex.org/W2031001038","https://openalex.org/W2033144194","https://openalex.org/W2040258681","https://openalex.org/W2046451925","https://openalex.org/W2047206031","https://openalex.org/W2049926459","https://openalex.org/W2052154287","https://openalex.org/W2052558901","https://openalex.org/W2053156756","https://openalex.org/W2053491613","https://openalex.org/W2061354140","https://openalex.org/W2062856462","https://openalex.org/W2065661100","https://openalex.org/W2067184822","https://openalex.org/W2067630518","https://openalex.org/W2075678158","https://openalex.org/W2078027626","https://openalex.org/W2084927133","https://openalex.org/W2087760732","https://openalex.org/W2091991333","https://openalex.org/W2094781369","https://openalex.org/W2095324538","https://openalex.org/W2096065176","https://openalex.org/W2107342968","https://openalex.org/W2109110326","https://openalex.org/W2109117831","https://openalex.org/W2115354930","https://openalex.org/W2119127509","https://openalex.org/W2121633536","https://openalex.org/W2124015059","https://openalex.org/W2125085714","https://openalex.org/W2142484802","https://openalex.org/W2146125875","https://openalex.org/W2146547352","https://openalex.org/W2147078972","https://openalex.org/W2148192047","https://openalex.org/W2149886218","https://openalex.org/W2155418451","https://openalex.org/W2157886837","https://openalex.org/W2164665803","https://openalex.org/W2165688051","https://openalex.org/W2166132142","https://openalex.org/W2167154952","https://openalex.org/W2169578394","https://openalex.org/W2169696276","https://openalex.org/W2174187976","https://openalex.org/W2177377120","https://openalex.org/W2240819236","https://openalex.org/W2463467382","https://openalex.org/W2467011953","https://openalex.org/W2501802262","https://openalex.org/W2554221761","https://openalex.org/W2609780203","https://openalex.org/W2963802777","https://openalex.org/W2963867670","https://openalex.org/W3097995899","https://openalex.org/W3098243436","https://openalex.org/W3103966169","https://openalex.org/W3104744823","https://openalex.org/W3125980488","https://openalex.org/W4298401620","https://openalex.org/W6655242574","https://openalex.org/W6674432084","https://openalex.org/W7005582718"],"related_works":["https://openalex.org/W2286391053","https://openalex.org/W2982600058","https://openalex.org/W1963486701","https://openalex.org/W2312483540","https://openalex.org/W4249477090","https://openalex.org/W191745111","https://openalex.org/W1522083559","https://openalex.org/W2007570603","https://openalex.org/W259785927","https://openalex.org/W2410697658"],"abstract_inverted_index":{"Biochemical":[0],"reaction":[1],"networks":[2,214],"(BRNs)":[3],"in":[4,121,193,249],"a":[5,67,105,169,173,194],"cell":[6,195],"frequently":[7,191],"consist":[8],"of":[9,17,32,98,124,148,202,205,219,258],"reactions":[10,50],"with":[11,263],"disparate":[12],"timescales.":[13],"The":[14,233],"stochastic":[15],"simulations":[16,31],"such":[18,101,223],"multiscale":[19,149],"BRNs":[20,150,189],"are":[21,60,92,111,190],"prohibitively":[22],"slow":[23,58,68,87,99,255],"due":[24],"to":[25,37,53,62,104,117,140],"high":[26],"computational":[27,246,266],"cost":[28],"for":[29,85,131],"the":[30,42,90,96,119,122,132,177,182,197,245,254,259],"fast":[33,45,49,70,109,165,220],"reactions.":[34,126],"One":[35],"way":[36],"resolve":[38],"this":[39,250],"problem":[40],"uses":[41],"fact":[43],"that":[44],"species":[46,59,71,110,166],"regulated":[47],"by":[48,75,95,155,244],"quickly":[51],"equilibrate":[52],"their":[54,76,80],"stationary":[55,81],"distribution":[56],"while":[57],"unlikely":[61],"be":[63,73,153,186,242],"changed.":[64],"Thus,":[65],"on":[66,181,237],"timescale,":[69],"can":[72,152,185,241],"replaced":[74],"quasi-steady":[77],"state":[78,97],"(QSS):":[79],"conditional":[82],"expectation":[83],"values":[84],"given":[86],"species.":[88],"As":[89],"QSS":[91,120,133,159,184],"determined":[93],"solely":[94],"species,":[100],"replacement":[102],"leads":[103],"reduced":[106,154,178,234],"model,":[107],"where":[108],"eliminated.":[112],"However,":[113],"it":[114],"is":[115,200],"challenging":[116],"derive":[118],"presence":[123],"nonlinear":[125],"While":[127],"various":[128,217],"approximation":[129],"schemes":[130],"have":[134],"been":[135],"developed,":[136],"they":[137],"often":[138],"lead":[139],"considerable":[141],"errors.":[142],"Here,":[143],"we":[144],"propose":[145],"two":[146],"classes":[147],"which":[151,240],"deriving":[156],"an":[157],"exact":[158,183,238],"rather":[160],"than":[161],"approximations.":[162],"Specifically,":[163],"if":[164],"constitute":[167],"either":[168],"feedforward":[170,198],"network":[171,199],"or":[172,207],"complex":[174,212],"balanced":[175,213],"network,":[176],"model":[179,262],"based":[180,236],"derived.":[187],"Such":[188],"observed":[192],"as":[196,224],"one":[201],"fundamental":[203],"motifs":[204],"gene":[206,230],"protein":[208],"regulatory":[209,231],"networks.":[210],"Furthermore,":[211],"also":[215],"include":[216],"types":[218],"reversible":[221],"bindings":[222,225],"between":[226],"transcriptional":[227],"factors":[228],"and":[229],"sites.":[232],"models":[235],"QSS,":[239],"calculated":[243],"packages":[247],"provided":[248],"work,":[251],"accurately":[252],"approximate":[253],"scale":[256],"dynamics":[257],"original":[260],"full":[261],"much":[264],"lower":[265],"cost.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
