{"id":"https://openalex.org/W2606353404","doi":"https://doi.org/10.1371/journal.pcbi.1005485","title":"Modeling disordered protein interactions from biophysical principles","display_name":"Modeling disordered protein interactions from biophysical principles","publication_year":2017,"publication_date":"2017-04-10","ids":{"openalex":"https://openalex.org/W2606353404","doi":"https://doi.org/10.1371/journal.pcbi.1005485","mag":"2606353404","pmid":"https://pubmed.ncbi.nlm.nih.gov/28394890"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005485","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005485","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005485&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005485&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066071428","display_name":"Lenna X. Peterson","orcid":"https://orcid.org/0000-0001-7734-1784"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lenna X. Peterson","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7734-1784","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066696283","display_name":"Amitava Roy","orcid":"https://orcid.org/0000-0002-9100-4108"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amitava Roy","raw_affiliation_strings":["Bioinformatics and Computational Biosciences Branch, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana, United States of America","Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America","Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9100-4108","affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biosciences Branch, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana, United States of America","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078844851","display_name":"Charles Christoffer","orcid":"https://orcid.org/0000-0002-6163-6323"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Christoffer","raw_affiliation_strings":["Department of Computer Science, Purdue University, West Lafayette, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067994741","display_name":"Genki Terashi","orcid":"https://orcid.org/0000-0002-5339-909X"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Genki Terashi","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America","School of Pharmacy, Kitasato University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"School of Pharmacy, Kitasato University, Tokyo, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062293219","display_name":"Daisuke Kihara","orcid":"https://orcid.org/0000-0003-4091-6614"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daisuke Kihara","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America","Department of Computer Science, Purdue University, West Lafayette, Indiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4091-6614","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Computer Science, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5062293219"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.0275,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92067525,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"13","issue":"4","first_page":"e1005485","last_page":"e1005485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.8700814247131348},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5934937596321106},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5813465118408203},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.5396762490272522},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5393519401550293},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.46200984716415405},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.422563761472702},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40924015641212463},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.400839626789093},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3318359851837158},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2325730323791504},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.12223812937736511},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10955169796943665}],"concepts":[{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.8700814247131348},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5934937596321106},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5813465118408203},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5396762490272522},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5393519401550293},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.46200984716415405},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.422563761472702},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40924015641212463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.400839626789093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3318359851837158},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2325730323791504},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.12223812937736511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10955169796943665},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005485","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005485","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005485&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28394890","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28394890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:3cf5f1d94cc04c2db175e95c3f04636f","is_oa":true,"landing_page_url":"https://doaj.org/article/3cf5f1d94cc04c2db175e95c3f04636f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 4, p e1005485 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4834712","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Modeling_disordered_protein_interactions_from_biophysical_principles/4834712","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5402988","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5402988","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005485","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005485","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005485&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1085316489","display_name":null,"funder_award_id":"IOS1127027","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2879580723","display_name":null,"funder_award_id":"IIS1319551","funder_id":"https://openalex.org/F4320337389","funder_display_name":"Division of Information and Intelligent Systems"},{"id":"https://openalex.org/G3576065052","display_name":null,"funder_award_id":"IIS1319551, DBI1262189, IOS1127027","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3670115429","display_name":null,"funder_award_id":"R01GM097528","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6310544451","display_name":null,"funder_award_id":"DMS1614777","funder_id":"https://openalex.org/F4320337380","funder_display_name":"Division of Mathematical Sciences"},{"id":"https://openalex.org/G6383005305","display_name":null,"funder_award_id":"R01GM097528","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6575698428","display_name":null,"funder_award_id":"DMS1614777","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7576543473","display_name":null,"funder_award_id":"DBI1262189","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7966915170","display_name":null,"funder_award_id":"DBI1262189","funder_id":"https://openalex.org/F4320337398","funder_display_name":"Division of Biological Infrastructure"},{"id":"https://openalex.org/G8542557503","display_name":null,"funder_award_id":"IOS1127027","funder_id":"https://openalex.org/F4320337378","funder_display_name":"Office of Integrative Activities"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337378","display_name":"Office of Integrative Activities","ror":"https://ror.org/04k9mqs78"},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"},{"id":"https://openalex.org/F4320337389","display_name":"Division of Information and Intelligent Systems","ror":"https://ror.org/053a2cp42"},{"id":"https://openalex.org/F4320337398","display_name":"Division of Biological Infrastructure","ror":"https://ror.org/04qn9mx93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W161796404","https://openalex.org/W1607931568","https://openalex.org/W1609599771","https://openalex.org/W1768303176","https://openalex.org/W1774947891","https://openalex.org/W1938743025","https://openalex.org/W1970431511","https://openalex.org/W1972043325","https://openalex.org/W1979201508","https://openalex.org/W1989880445","https://openalex.org/W1998624640","https://openalex.org/W2003276245","https://openalex.org/W2008708467","https://openalex.org/W2010535661","https://openalex.org/W2014740048","https://openalex.org/W2016170088","https://openalex.org/W2017793317","https://openalex.org/W2021374144","https://openalex.org/W2023272942","https://openalex.org/W2029476353","https://openalex.org/W2044145005","https://openalex.org/W2048643046","https://openalex.org/W2062217029","https://openalex.org/W2065458269","https://openalex.org/W2067780461","https://openalex.org/W2074105113","https://openalex.org/W2084333983","https://openalex.org/W2089772414","https://openalex.org/W2100365601","https://openalex.org/W2101953406","https://openalex.org/W2101980405","https://openalex.org/W2103743266","https://openalex.org/W2104940206","https://openalex.org/W2107933517","https://openalex.org/W2109444605","https://openalex.org/W2111270835","https://openalex.org/W2113149602","https://openalex.org/W2113353838","https://openalex.org/W2114714512","https://openalex.org/W2115133023","https://openalex.org/W2115410056","https://openalex.org/W2116890528","https://openalex.org/W2117163574","https://openalex.org/W2125677968","https://openalex.org/W2130094949","https://openalex.org/W2130479394","https://openalex.org/W2131474431","https://openalex.org/W2136513242","https://openalex.org/W2140574901","https://openalex.org/W2141853020","https://openalex.org/W2142378715","https://openalex.org/W2144020793","https://openalex.org/W2153153865","https://openalex.org/W2153187042","https://openalex.org/W2155796229","https://openalex.org/W2156876686","https://openalex.org/W2157437977","https://openalex.org/W2158714788","https://openalex.org/W2159247900","https://openalex.org/W2162166182","https://openalex.org/W2168375512","https://openalex.org/W2169962011","https://openalex.org/W2171138378","https://openalex.org/W2206815873","https://openalex.org/W2413334978","https://openalex.org/W2419381003","https://openalex.org/W2520917239","https://openalex.org/W2525357266","https://openalex.org/W2541950838","https://openalex.org/W2558628686","https://openalex.org/W2558841060","https://openalex.org/W2739999456","https://openalex.org/W2969719845","https://openalex.org/W4211196614"],"related_works":["https://openalex.org/W2065534861","https://openalex.org/W3187431608","https://openalex.org/W1974422922","https://openalex.org/W4309353019","https://openalex.org/W2914490533","https://openalex.org/W3117205993","https://openalex.org/W2898049514","https://openalex.org/W2187341605","https://openalex.org/W2607853144","https://openalex.org/W4383473016"],"abstract_inverted_index":{"Disordered":[0],"protein-protein":[1,74],"interactions":[2],"(PPIs),":[3],"those":[4],"involving":[5],"a":[6,30,88,98,111,115,139],"folded":[7],"protein":[8,13,181],"and":[9,23,72,75,124,131,159,184],"an":[10,108],"intrinsically":[11],"disordered":[12,50,70,99,143,193],"(IDP),":[14],"are":[15,79],"prevalent":[16],"in":[17,34,68],"the":[18,46,57,61,95,103,119,122,126,134,173,178,189],"cell,":[19],"including":[20],"important":[21],"signaling":[22],"regulatory":[24],"pathways.":[25],"IDPs":[26,146],"do":[27],"not":[28,80],"adopt":[29],"single":[31],"dominant":[32],"structure":[33,59,182],"isolation":[35],"but":[36],"often":[37],"become":[38],"ordered":[39],"upon":[40],"binding.":[41],"To":[42],"aid":[43],"understanding":[44],"of":[45,49,60,97,107,118,141,180,192],"molecular":[47,190],"mechanisms":[48,191],"PPIs,":[51],"it":[52],"is":[53],"crucial":[54,186],"to":[55,82,110,148],"obtain":[56],"tertiary":[58],"PPIs.":[62,194],"However,":[63],"experimental":[64],"methods":[65,78],"have":[66],"difficulty":[67],"solving":[69],"PPIs":[71,144],"existing":[73],"protein-peptide":[76],"docking":[77],"able":[81],"model":[83],"them.":[84],"Here":[85],"we":[86],"present":[87],"novel":[89],"computational":[90],"method,":[91],"IDP-LZerD,":[92],"which":[93],"models":[94],"conformation":[96],"PPI":[100],"by":[101],"considering":[102],"biophysical":[104,170],"binding":[105,136],"mechanism":[106],"IDP":[109,120,128],"structured":[112],"protein,":[113],"whereby":[114],"local":[116],"segment":[117],"initiates":[121],"interaction":[123],"subsequently":[125],"remaining":[127],"regions":[129],"explore":[130],"coalesce":[132],"around":[133],"initial":[135],"site.":[137],"On":[138],"dataset":[140],"22":[142],"with":[145],"up":[147],"69":[149],"amino":[150],"acids,":[151],"successful":[152,164],"predictions":[153],"were":[154],"made":[155],"for":[156,169],"21":[157],"bound":[158],"18":[160],"unbound":[161],"receptors.":[162],"The":[163],"modeling":[165,183],"provides":[166,185],"additional":[167],"support":[168],"principles.":[171],"Moreover,":[172],"new":[174],"technique":[175],"significantly":[176],"expands":[177],"capability":[179],"insights":[187],"into":[188]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3}],"updated_date":"2026-05-19T21:40:30.786675","created_date":"2025-10-10T00:00:00"}