{"id":"https://openalex.org/W2603561009","doi":"https://doi.org/10.1371/journal.pcbi.1005459","title":"Beware batch culture: Seasonality and niche construction predicted to favor bacterial adaptive diversification","display_name":"Beware batch culture: Seasonality and niche construction predicted to favor bacterial adaptive diversification","publication_year":2017,"publication_date":"2017-03-30","ids":{"openalex":"https://openalex.org/W2603561009","doi":"https://doi.org/10.1371/journal.pcbi.1005459","mag":"2603561009","pmid":"https://pubmed.ncbi.nlm.nih.gov/28358919"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005459","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005459","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005459&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005459&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090314050","display_name":"Charles Rocabert","orcid":"https://orcid.org/0000-0002-9224-5819"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210155607","display_name":"Laboratoire d'Informatique en Images et Syst\u00e8mes d'Information","ror":"https://ror.org/04dv4he91","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I1294671590","https://openalex.org/I188626449","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210155607","https://openalex.org/I48430043"]},{"id":"https://openalex.org/I48430043","display_name":"Institut National des Sciences Appliqu\u00e9es de Lyon","ror":"https://ror.org/050jn9y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charles Rocabert","raw_affiliation_strings":["Univ. de Lyon, CNRS, INRIA, INSA-Lyon, UCB Lyon 1, LIRIS UMR5205, Lyon, France"],"raw_orcid":"https://orcid.org/0000-0002-9224-5819","affiliations":[{"raw_affiliation_string":"Univ. de Lyon, CNRS, INRIA, INSA-Lyon, UCB Lyon 1, LIRIS UMR5205, Lyon, France","institution_ids":["https://openalex.org/I48430043","https://openalex.org/I4210155607","https://openalex.org/I1326498283","https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071097293","display_name":"Carole Knibbe","orcid":"https://orcid.org/0000-0002-2026-2580"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210155607","display_name":"Laboratoire d'Informatique en Images et Syst\u00e8mes d'Information","ror":"https://ror.org/04dv4he91","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I1294671590","https://openalex.org/I188626449","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210155607","https://openalex.org/I48430043"]},{"id":"https://openalex.org/I48430043","display_name":"Institut National des Sciences Appliqu\u00e9es de Lyon","ror":"https://ror.org/050jn9y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carole Knibbe","raw_affiliation_strings":["Univ. de Lyon, CNRS, INRIA, INSA-Lyon, UCB Lyon 1, LIRIS UMR5205, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. de Lyon, CNRS, INRIA, INSA-Lyon, UCB Lyon 1, LIRIS UMR5205, Lyon, France","institution_ids":["https://openalex.org/I48430043","https://openalex.org/I4210155607","https://openalex.org/I1326498283","https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079716822","display_name":"Jessika Consuegra","orcid":"https://orcid.org/0000-0002-3185-803X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210136308","display_name":"Translational Innovation in Medicine and Complexity","ror":"https://ror.org/03985kf35","country_code":"FR","type":"facility","lineage":["https://openalex.org/I106785703","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210104684","https://openalex.org/I4210136308","https://openalex.org/I4210159245","https://openalex.org/I899635006","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jessika Consuegra","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), TIMC-IMAG, Grenoble, France","Univ. Grenoble Alpes, Laboratoire Techniques de l'Ing\u00e9nierie M\u00e9dicale et de la Complexit\u00e9 - Informatique, Math\u00e9matiques et Applications, Grenoble (TIMC-IMAG), Grenoble, France"],"raw_orcid":"https://orcid.org/0000-0002-3185-803X","affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), TIMC-IMAG, Grenoble, France","institution_ids":["https://openalex.org/I4210136308","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Univ. Grenoble Alpes, Laboratoire Techniques de l'Ing\u00e9nierie M\u00e9dicale et de la Complexit\u00e9 - Informatique, Math\u00e9matiques et Applications, Grenoble (TIMC-IMAG), Grenoble, France","institution_ids":["https://openalex.org/I4210136308","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103196351","display_name":"Dominique Schneider","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210136308","display_name":"Translational Innovation in Medicine and Complexity","ror":"https://ror.org/03985kf35","country_code":"FR","type":"facility","lineage":["https://openalex.org/I106785703","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210104684","https://openalex.org/I4210136308","https://openalex.org/I4210159245","https://openalex.org/I899635006","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Schneider","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), TIMC-IMAG, Grenoble, France","Univ. Grenoble Alpes, Laboratoire Techniques de l'Ing\u00e9nierie M\u00e9dicale et de la Complexit\u00e9 - Informatique, Math\u00e9matiques et Applications, Grenoble (TIMC-IMAG), Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), TIMC-IMAG, Grenoble, France","institution_ids":["https://openalex.org/I4210136308","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Univ. Grenoble Alpes, Laboratoire Techniques de l'Ing\u00e9nierie M\u00e9dicale et de la Complexit\u00e9 - Informatique, Math\u00e9matiques et Applications, Grenoble (TIMC-IMAG), Grenoble, France","institution_ids":["https://openalex.org/I4210136308","https://openalex.org/I899635006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041639459","display_name":"Guillaume Beslon","orcid":"https://orcid.org/0000-0001-8562-0732"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210155607","display_name":"Laboratoire d'Informatique en Images et Syst\u00e8mes d'Information","ror":"https://ror.org/04dv4he91","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I1294671590","https://openalex.org/I188626449","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210155607","https://openalex.org/I48430043"]},{"id":"https://openalex.org/I48430043","display_name":"Institut National des Sciences Appliqu\u00e9es de Lyon","ror":"https://ror.org/050jn9y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Guillaume Beslon","raw_affiliation_strings":["Univ. de Lyon, CNRS, INRIA, INSA-Lyon, UCB Lyon 1, LIRIS UMR5205, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. de Lyon, CNRS, INRIA, INSA-Lyon, UCB Lyon 1, LIRIS UMR5205, Lyon, France","institution_ids":["https://openalex.org/I48430043","https://openalex.org/I4210155607","https://openalex.org/I1326498283","https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041639459"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I4210155607","https://openalex.org/I48430043"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2070,"currency":"EUR","value_usd":2232},"fwci":3.3075,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.91981692,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"3","first_page":"e1005459","last_page":"e1005459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7520437240600586},{"id":"https://openalex.org/keywords/niche","display_name":"Niche","score":0.6453261971473694},{"id":"https://openalex.org/keywords/ecological-niche","display_name":"Ecological niche","score":0.6222988367080688},{"id":"https://openalex.org/keywords/chemostat","display_name":"Chemostat","score":0.6074487566947937},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5230351686477661},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.4975726902484894},{"id":"https://openalex.org/keywords/niche-differentiation","display_name":"Niche differentiation","score":0.4815923869609833},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"Experimental evolution","score":0.47899600863456726},{"id":"https://openalex.org/keywords/character-displacement","display_name":"Character displacement","score":0.46064335107803345},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4464796483516693},{"id":"https://openalex.org/keywords/sympatric-speciation","display_name":"Sympatric speciation","score":0.3848387897014618},{"id":"https://openalex.org/keywords/sympatry","display_name":"Sympatry","score":0.3130152225494385},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22668570280075073},{"id":"https://openalex.org/keywords/habitat","display_name":"Habitat","score":0.178253173828125},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16824322938919067},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.09311357140541077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7520437240600586},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.6453261971473694},{"id":"https://openalex.org/C102715595","wikidata":"https://www.wikidata.org/wiki/Q172861","display_name":"Ecological niche","level":3,"score":0.6222988367080688},{"id":"https://openalex.org/C125111812","wikidata":"https://www.wikidata.org/wiki/Q902311","display_name":"Chemostat","level":3,"score":0.6074487566947937},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5230351686477661},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.4975726902484894},{"id":"https://openalex.org/C78991832","wikidata":"https://www.wikidata.org/wiki/Q3027700","display_name":"Niche differentiation","level":3,"score":0.4815923869609833},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.47899600863456726},{"id":"https://openalex.org/C160704849","wikidata":"https://www.wikidata.org/wiki/Q4116407","display_name":"Character displacement","level":4,"score":0.46064335107803345},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4464796483516693},{"id":"https://openalex.org/C53889494","wikidata":"https://www.wikidata.org/wiki/Q1240247","display_name":"Sympatric speciation","level":2,"score":0.3848387897014618},{"id":"https://openalex.org/C92274894","wikidata":"https://www.wikidata.org/wiki/Q1246431","display_name":"Sympatry","level":3,"score":0.3130152225494385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22668570280075073},{"id":"https://openalex.org/C185933670","wikidata":"https://www.wikidata.org/wiki/Q52105","display_name":"Habitat","level":2,"score":0.178253173828125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16824322938919067},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.09311357140541077},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060146","descriptor_name":"Ecotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060146","descriptor_name":"Ecotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060146","descriptor_name":"Ecotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061249","descriptor_name":"Batch Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D061249","descriptor_name":"Batch Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D061249","descriptor_name":"Batch Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D061350","descriptor_name":"Sympatry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061350","descriptor_name":"Sympatry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061350","descriptor_name":"Sympatry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005459","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005459","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005459&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28358919","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28358919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:ee0737152e2944e39e86828f6dcbdf48","is_oa":true,"landing_page_url":"https://doaj.org/article/ee0737152e2944e39e86828f6dcbdf48","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 3, p e1005459 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4802518","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Beware_batch_culture_Seasonality_and_niche_construction_predicted_to_favor_bacterial_adaptive_diversification/4802518","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5391122","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5391122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005459","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005459","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005459&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G2157462966","display_name":null,"funder_award_id":"610427","funder_id":"https://openalex.org/F4320338370","funder_display_name":"FP7 Information and Communication Technologies"},{"id":"https://openalex.org/G5483342299","display_name":null,"funder_award_id":"FP7-ICT","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6020706601","display_name":null,"funder_award_id":"610427","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G7396511206","display_name":"Evolution of Evolution","funder_award_id":"610427","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320310016","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322890","display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche","ror":"https://ror.org/03sjk9a61"},{"id":"https://openalex.org/F4320332431","display_name":"College of Engineering, Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338370","display_name":"FP7 Information and Communication Technologies","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2603561009.pdf","grobid_xml":"https://content.openalex.org/works/W2603561009.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1498617765","https://openalex.org/W1583030352","https://openalex.org/W1700488175","https://openalex.org/W1710414392","https://openalex.org/W1963630768","https://openalex.org/W1967190757","https://openalex.org/W1973081915","https://openalex.org/W1975691160","https://openalex.org/W1990585969","https://openalex.org/W1998846911","https://openalex.org/W2001403617","https://openalex.org/W2009837386","https://openalex.org/W2010534192","https://openalex.org/W2012047014","https://openalex.org/W2018745056","https://openalex.org/W2020021522","https://openalex.org/W2035525755","https://openalex.org/W2041651453","https://openalex.org/W2044321897","https://openalex.org/W2046050098","https://openalex.org/W2052856054","https://openalex.org/W2060860079","https://openalex.org/W2067731680","https://openalex.org/W2076687415","https://openalex.org/W2093345038","https://openalex.org/W2105333758","https://openalex.org/W2112945902","https://openalex.org/W2125327011","https://openalex.org/W2125846972","https://openalex.org/W2147123807","https://openalex.org/W2147276070","https://openalex.org/W2153473918","https://openalex.org/W2160137338","https://openalex.org/W2160530185","https://openalex.org/W2164296191","https://openalex.org/W2169597409","https://openalex.org/W2174328995","https://openalex.org/W2344342664","https://openalex.org/W2509782679","https://openalex.org/W2565315144","https://openalex.org/W2574587147","https://openalex.org/W2952487927","https://openalex.org/W4230135690"],"related_works":["https://openalex.org/W2300505278","https://openalex.org/W2090543149","https://openalex.org/W2149241375","https://openalex.org/W1959928836","https://openalex.org/W2177311604","https://openalex.org/W2063306401","https://openalex.org/W2141891410","https://openalex.org/W2587620327","https://openalex.org/W3185741870","https://openalex.org/W2079801464"],"abstract_inverted_index":{"Metabolic":[0],"cross-feeding":[1,38,144,244,304,330],"interactions":[2,39,145,245],"between":[3,296],"microbial":[4],"strains":[5],"are":[6,248],"common":[7],"in":[8,15,19,63,73,117,157,311,323,328],"nature,":[9],"and":[10,44,169,199,327],"emerge":[11],"during":[12],"evolution":[13,61,141,268],"experiments":[14,62],"the":[16,30,34,64,79,120,140,166,170,177,185,188,211,227,252,259,266,270,279,282,288,300,303,307,317],"laboratory,":[17,65],"even":[18,242],"homogeneous":[20],"environments":[21,118],"providing":[22,131],"a":[23,69,132,217,335],"single":[24,133],"carbon":[25],"source.":[26],"In":[27,150,239],"sympatry,":[28],"when":[29,306],"environment":[31],"is":[32,182,207,220,230,309],"well-mixed,":[33],"reasons":[35],"why":[36],"emerging":[37],"may":[40],"sometimes":[41],"become":[42],"stable":[43,143,197,250,272,333],"lead":[45],"to":[46,60,275,337],"monophyletic":[47],"genotypic":[48],"clusters":[49],"occupying":[50],"specific":[51],"niches,":[52],"named":[53],"ecotypes,":[54,161,334],"remain":[55],"unclear.":[56],"As":[57],"an":[58,101,106],"alternative":[59],"we":[66],"developed":[67],"Evo2Sim,":[68],"multi-scale":[70],"model":[71],"of":[72,83,113,115,122,142,179,187,269,281,287,293,302],"silico":[74],"experimental":[75,84],"evolution,":[76],"equipped":[77],"with":[78,100,162],"whole":[80,260],"tool":[81],"case":[82],"setups,":[85],"competition":[86],"assays,":[87],"phylogenetic":[88],"analysis,":[89],"and,":[90],"most":[91],"importantly,":[92],"allowing":[93],"for":[94,111,184,193],"evolvable":[95,102,107],"ecological":[96],"interactions.":[97],"Digital":[98],"organisms":[99],"genome":[103,289,294],"structure":[104,295],"encoding":[105],"metabolic":[108,283],"network":[109,284],"evolved":[110],"tens":[112],"thousands":[114],"generations":[116],"mimicking":[119],"dynamics":[121],"real":[123],"controlled":[124],"environments,":[125],"including":[126],"chemostat":[127,240,312],"or":[128],"batch":[129,148],"culture":[130],"limiting":[134],"resource.":[135],"We":[136,174,262],"show":[137,175,264],"here":[138],"that":[139,176,265],"requires":[146],"seasonal":[147],"conditions.":[149,313],"this":[151],"case,":[152],"adaptive":[153],"diversification":[154],"events":[155],"result":[156],"two":[158,196,201,271],"stably":[159],"co-existing":[160],"one":[163,219],"feeding":[164],"on":[165,172,251],"primary":[167],"resource":[168],"other":[171],"by-products.":[173],"regularity":[178],"serial":[180],"transfers":[181],"essential":[183],"maintenance":[186],"polymorphism,":[189],"as":[190,226],"it":[191],"allows":[192],"at":[194,278],"least":[195],"seasons":[198],"thus":[200],"temporal":[202,324],"niches.":[203],"A":[204],"first":[205],"season":[206],"externally":[208],"generated":[209,222],"by":[210,223,232,321],"transfer":[212],"into":[213,332],"fresh":[214],"medium,":[215],"while":[216],"second":[218],"internally":[221],"niche":[224,325],"construction":[225],"provided":[228],"nutrient":[229],"replaced":[231],"secreted":[233],"by-products":[234],"derived":[235],"from":[236],"bacterial":[237],"growth.":[238],"conditions,":[241],"if":[243],"emerge,":[246],"they":[247],"not":[249],"long-term":[253,267],"because":[254],"fitter":[255],"mutants":[256],"eventually":[257],"invade":[258],"population.":[261],"also":[263,286],"ecotypes":[273,298],"leads":[274],"character":[276],"displacement,":[277],"level":[280],"but":[285],"structure.":[290],"This":[291,314],"difference":[292],"both":[297],"impacts":[299],"stability":[301],"interaction,":[305],"population":[308],"propagated":[310],"study":[315],"shows":[316],"crucial":[318],"role":[319],"played":[320],"seasonality":[322],"partitioning":[326],"promoting":[329],"subgroups":[331],"premise":[336],"sympatric":[338],"speciation.":[339]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}