{"id":"https://openalex.org/W2599994550","doi":"https://doi.org/10.1371/journal.pcbi.1005453","title":"Effects of contact structure on the transient evolution of HIV virulence","display_name":"Effects of contact structure on the transient evolution of HIV virulence","publication_year":2017,"publication_date":"2017-03-31","ids":{"openalex":"https://openalex.org/W2599994550","doi":"https://doi.org/10.1371/journal.pcbi.1005453","mag":"2599994550","pmid":"https://pubmed.ncbi.nlm.nih.gov/28362805"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005453","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005453","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005453&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005453&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100750731","display_name":"Sang Woo Park","orcid":"https://orcid.org/0000-0003-2202-3361"},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sang Woo Park","raw_affiliation_strings":["Department of Mathematics & Statistics, McMaster University, Hamilton, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0003-2202-3361","affiliations":[{"raw_affiliation_string":"Department of Mathematics & Statistics, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021063042","display_name":"Benjamin M. Bolker","orcid":"https://orcid.org/0000-0002-2127-0443"},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Benjamin M. Bolker","raw_affiliation_strings":["Department of Biology, McMaster University, Hamilton, Ontario, Canada","Department of Mathematics & Statistics, McMaster University, Hamilton, Ontario, Canada","Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2127-0443","affiliations":[{"raw_affiliation_string":"Department of Biology, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Department of Mathematics & Statistics, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021063042"],"corresponding_institution_ids":["https://openalex.org/I98251732"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4147,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.56383407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"13","issue":"3","first_page":"e1005453","last_page":"e1005453"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.9641566276550293},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5522376298904419},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4640478491783142},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.45110926032066345},{"id":"https://openalex.org/keywords/epidemic-model","display_name":"Epidemic model","score":0.42395520210266113},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.28370195627212524},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2580631375312805},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.19000893831253052},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.11702582240104675}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.9641566276550293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5522376298904419},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4640478491783142},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.45110926032066345},{"id":"https://openalex.org/C1627819","wikidata":"https://www.wikidata.org/wiki/Q2572354","display_name":"Epidemic model","level":3,"score":0.42395520210266113},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.28370195627212524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2580631375312805},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19000893831253052},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.11702582240104675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012725","descriptor_name":"Sexual Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012725","descriptor_name":"Sexual Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012725","descriptor_name":"Sexual Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058872","descriptor_name":"Epidemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058872","descriptor_name":"Epidemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058872","descriptor_name":"Epidemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005453","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005453","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005453&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28362805","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28362805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:3713f94e9cb04541aae0db13fe493f85","is_oa":true,"landing_page_url":"https://doaj.org/article/3713f94e9cb04541aae0db13fe493f85","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 3, p e1005453 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4807726","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Effects_of_contact_structure_on_the_transient_evolution_of_HIV_virulence/4807726","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5391972","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5391972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005453","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005453","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005453&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2595240601","display_name":null,"funder_award_id":"386590-2010","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G3970800724","display_name":null,"funder_award_id":"Discovery grant 2016-5488","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2599994550.pdf","grobid_xml":"https://content.openalex.org/works/W2599994550.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1561556104","https://openalex.org/W1973275696","https://openalex.org/W1974577959","https://openalex.org/W1974632401","https://openalex.org/W1991761171","https://openalex.org/W2002834261","https://openalex.org/W2005364009","https://openalex.org/W2010218635","https://openalex.org/W2018945340","https://openalex.org/W2030596540","https://openalex.org/W2047726505","https://openalex.org/W2067705052","https://openalex.org/W2070649137","https://openalex.org/W2071860972","https://openalex.org/W2074878346","https://openalex.org/W2089488912","https://openalex.org/W2103300602","https://openalex.org/W2104746796","https://openalex.org/W2114228201","https://openalex.org/W2117002055","https://openalex.org/W2118249351","https://openalex.org/W2122443569","https://openalex.org/W2136264966","https://openalex.org/W2136829296","https://openalex.org/W2144177385","https://openalex.org/W2144975624","https://openalex.org/W2147171518","https://openalex.org/W2160226661","https://openalex.org/W2163036286","https://openalex.org/W2166854744","https://openalex.org/W2169456785","https://openalex.org/W2203329702","https://openalex.org/W2427536221","https://openalex.org/W2546997765","https://openalex.org/W2950413081","https://openalex.org/W4239155582"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2114009169","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W1979172052","https://openalex.org/W4205148382"],"abstract_inverted_index":{"Early":[0],"in":[1,16,186,277],"an":[2],"epidemic,":[3,18,46],"high":[4,12],"densities":[5,21],"of":[6,30,37,79,109,117,119,132,149,165,179,201,222,247,255,274,284],"susceptible":[7,20],"hosts":[8],"select":[9,22],"for":[10,23,75,143,176],"relatively":[11],"parasite":[13,38],"virulence;":[14],"later":[15],"the":[17,28,34,45,56,76,83,107,115,157,162,172,183,197,202,218,257,263,272,278,282],"lower":[19,24,212],"virulence.":[25],"Thus":[26],"over":[27],"course":[29],"a":[31,73,130,177,245],"typical":[32],"epidemic":[33,185],"average":[35],"virulence":[36,58,88,127,159,190,203,213],"strains":[39],"increases":[40],"initially,":[41],"peaks":[42],"partway":[43],"through":[44],"then":[47],"declines":[48],"again.":[49],"However,":[50],"precise":[51],"quantitative":[52],"outcomes,":[53],"such":[54,155],"as":[55,156],"peak":[57,158,204,219],"reached":[59],"and":[60,87,95,139,141,199,214,232],"its":[61],"timing,":[62],"may":[63],"depend":[64],"sensitively":[65],"on":[66],"epidemiological":[67],"details.":[68],"Fraser":[69],"et":[70],"al.":[71],"proposed":[72],"model":[74,101,280],"eco-evolutionary":[77],"dynamics":[78,111],"HIV":[80,126,184],"that":[81,112],"incorporates":[82],"tradeoffs":[84,128],"between":[85,98],"transmission":[86],"(mediated":[89],"by":[90],"set-point":[91],"viral":[92],"load,":[93],"SPVL)":[94,225],"their":[96],"heritability":[97],"hosts.":[99],"Their":[100],"used":[102],"implicit":[103,209],"equations":[104],"to":[105,145,161,182,228,233],"capture":[106],"effects":[108,283],"partnership":[110,137,239,285],"are":[113,192],"at":[114,217,241],"core":[116],"epidemics":[118],"sexually":[120],"transmitted":[121],"diseases.":[122],"Our":[123],"models":[124,175,210,231,236],"combine":[125],"with":[129,237,244],"range":[131,178,254],"contact":[133,276],"models,":[134,196,256],"explicitly":[135],"modeling":[136],"formation":[138],"dissolution":[140],"allowing":[142],"individuals":[144],"transmit":[146],"disease":[147],"outside":[148],"partnerships.":[150],"We":[151],"assess":[152],"summary":[153],"statistics":[154],"(corresponding":[160],"maximum":[163,221,246],"value":[164],"population":[166],"mean":[167],"log10":[168,224,250],"SPVL":[169],"achieved":[170],"throughout":[171],"epidemic)":[173],"across":[174,195],"parameters":[180],"applicable":[181],"sub-Saharan":[187],"Africa.":[188],"Although":[189],"trajectories":[191],"broadly":[193],"similar":[194],"timing":[198],"magnitude":[200],"vary":[205],"considerably.":[206],"Previously":[207],"developed":[208],"predicted":[211],"slower":[215],"progression":[216],"(a":[220],"3.5":[223],"compared":[226],"both":[227],"more":[229],"realistic":[230,265,279],"simple":[234],"random-mixing":[235,259],"no":[238],"structure":[240,260],"all":[242],"(both":[243],"\u2248":[248],"4.7":[249],"SPVL).":[251],"In":[252],"this":[253,267],"simplest":[258],"best":[261],"approximates":[262],"most":[264],"model;":[266],"surprising":[268],"outcome":[269],"occurs":[270],"because":[271],"dominance":[273],"extra-pair":[275],"swamps":[281],"structure.":[286]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}