{"id":"https://openalex.org/W2598739641","doi":"https://doi.org/10.1371/journal.pcbi.1005449","title":"Network perturbation by recurrent regulatory variants in cancer","display_name":"Network perturbation by recurrent regulatory variants in cancer","publication_year":2017,"publication_date":"2017-03-23","ids":{"openalex":"https://openalex.org/W2598739641","doi":"https://doi.org/10.1371/journal.pcbi.1005449","mag":"2598739641","pmid":"https://pubmed.ncbi.nlm.nih.gov/28333928"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005449","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005449","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005449&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005449&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078112973","display_name":"Kiwon Jang","orcid":"https://orcid.org/0000-0002-3789-5667"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kiwon Jang","raw_affiliation_strings":["Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027316497","display_name":"Kwoneel Kim","orcid":"https://orcid.org/0000-0002-4221-3421"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwoneel Kim","raw_affiliation_strings":["Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101544289","display_name":"A\u2010Ra Cho","orcid":"https://orcid.org/0000-0002-3645-2282"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ara Cho","raw_affiliation_strings":["Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035867403","display_name":"Insuk Lee","orcid":"https://orcid.org/0000-0003-3146-6180"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Insuk Lee","raw_affiliation_strings":["Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001892334","display_name":"Jung Kyoon Choi","orcid":"https://orcid.org/0000-0003-2077-8947"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung Kyoon Choi","raw_affiliation_strings":["Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001892334"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.4674,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.89598037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"3","first_page":"e1005449","last_page":"e1005449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.7655727863311768},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7378687858581543},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6829527616500854},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5808722376823425},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5547807216644287},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5543227195739746},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5227839350700378},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5184075832366943},{"id":"https://openalex.org/keywords/regulatory-sequence","display_name":"Regulatory sequence","score":0.46582576632499695},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"Transcriptional regulation","score":0.45932716131210327},{"id":"https://openalex.org/keywords/coding-region","display_name":"Coding region","score":0.41550761461257935},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.177372008562088}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.7655727863311768},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7378687858581543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6829527616500854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5808722376823425},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5547807216644287},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5543227195739746},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5227839350700378},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5184075832366943},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.46582576632499695},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.45932716131210327},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.41550761461257935},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.177372008562088}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005449","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005449","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005449&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28333928","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28333928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:6668f1f982d84e208337284e20f8fcab","is_oa":true,"landing_page_url":"https://doaj.org/article/6668f1f982d84e208337284e20f8fcab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 3, p e1005449 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4781347","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Network_perturbation_by_recurrent_regulatory_variants_in_cancer/4781347","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5383347","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5383347","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005449","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005449","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005449&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1170316335","display_name":null,"funder_award_id":"K-16-L03-C02-S02","funder_id":"https://openalex.org/F4320322105","funder_display_name":"Korea Institute of Science and Technology Information"}],"funders":[{"id":"https://openalex.org/F4320322105","display_name":"Korea Institute of Science and Technology Information","ror":"https://ror.org/01k4yrm29"},{"id":"https://openalex.org/F4320324161","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63"},{"id":"https://openalex.org/F4320337027","display_name":"Great Southern Development Commission, Government of Western Australia","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2598739641.pdf","grobid_xml":"https://content.openalex.org/works/W2598739641.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1806685502","https://openalex.org/W1977955083","https://openalex.org/W1985621639","https://openalex.org/W1987371782","https://openalex.org/W1989795110","https://openalex.org/W1995837988","https://openalex.org/W2009019945","https://openalex.org/W2011463791","https://openalex.org/W2015845481","https://openalex.org/W2030209169","https://openalex.org/W2033169664","https://openalex.org/W2039877945","https://openalex.org/W2044433401","https://openalex.org/W2056198580","https://openalex.org/W2056782561","https://openalex.org/W2065006553","https://openalex.org/W2078059415","https://openalex.org/W2081375228","https://openalex.org/W2086239585","https://openalex.org/W2088544963","https://openalex.org/W2088891952","https://openalex.org/W2096465161","https://openalex.org/W2102140136","https://openalex.org/W2103857869","https://openalex.org/W2104500293","https://openalex.org/W2111384508","https://openalex.org/W2117792884","https://openalex.org/W2122785666","https://openalex.org/W2125118217","https://openalex.org/W2125805216","https://openalex.org/W2128528820","https://openalex.org/W2137506169","https://openalex.org/W2140883620","https://openalex.org/W2140952049","https://openalex.org/W2141811925","https://openalex.org/W2152061559","https://openalex.org/W2156714600","https://openalex.org/W2161409973","https://openalex.org/W2163296115","https://openalex.org/W2166898290","https://openalex.org/W2167404368","https://openalex.org/W2168191908","https://openalex.org/W2337819340","https://openalex.org/W2339240569","https://openalex.org/W2341025815","https://openalex.org/W2442835468","https://openalex.org/W2508622936","https://openalex.org/W2949122194","https://openalex.org/W2952378442","https://openalex.org/W3099289621"],"related_works":["https://openalex.org/W1986060922","https://openalex.org/W3130139893","https://openalex.org/W2277277196","https://openalex.org/W1973260612","https://openalex.org/W2947121614","https://openalex.org/W2620422757","https://openalex.org/W2043274041","https://openalex.org/W1973423104","https://openalex.org/W2066717868","https://openalex.org/W285728958"],"abstract_inverted_index":{"Cancer":[0],"driving":[1],"genes":[2,45,56,96],"have":[3],"been":[4],"identified":[5,41,55,85],"as":[6,90,93],"recurrently":[7],"affected":[8],"by":[9,147],"variants":[10,20,113],"that":[11],"alter":[12],"protein-coding":[13],"sequences.":[14],"However,":[15],"a":[16,33,101],"majority":[17],"of":[18,27,142],"cancer":[19,62,134],"arise":[21],"in":[22,51,60],"noncoding":[23],"regions,":[24],"and":[25,70,111,121,126,146],"some":[26],"them":[28],"are":[29],"thought":[30],"to":[31,99],"play":[32],"critical":[34],"role":[35,77],"through":[36,138,152],"transcriptional":[37,43,86,122],"perturbation.":[38],"Here":[39],"we":[40],"putative":[42],"driver":[44,95,156],"based":[46],"on":[47,105],"combinatorial":[48],"variant":[49],"recurrence":[50],"cis-regulatory":[52],"regions.":[53],"The":[54,109],"showed":[57,124],"high":[58,68],"connectivity":[59],"the":[61,81,84,106,119,143],"type-specific":[63],"transcription":[64],"regulatory":[65,112,144],"network,":[66],"with":[67,154],"outdegree":[69],"many":[71],"downstream":[72],"genes,":[73],"highlighting":[74],"their":[75],"causative":[76],"during":[78],"tumorigenesis.":[79],"In":[80],"protein":[82,149],"interactome,":[83],"drivers":[87,123,135],"were":[88],"not":[89],"highly":[91],"connected":[92],"coding":[94,107,110,120,155],"but":[97],"appeared":[98],"form":[100],"network":[102,145,150],"module":[103],"centered":[104],"drivers.":[108],"associated":[114],"via":[115],"these":[116],"interactions":[117,153],"between":[118],"exclusive":[125],"complementary":[127],"occurrence":[128],"patterns":[129],"across":[130],"tumor":[131],"samples.":[132],"Transcriptional":[133],"may":[136],"act":[137],"an":[139],"extensive":[140],"perturbation":[141],"altering":[148],"modules":[151],"genes.":[157]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
