{"id":"https://openalex.org/W2606201370","doi":"https://doi.org/10.1371/journal.pcbi.1005428","title":"Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples","display_name":"Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples","publication_year":2017,"publication_date":"2017-04-20","ids":{"openalex":"https://openalex.org/W2606201370","doi":"https://doi.org/10.1371/journal.pcbi.1005428","mag":"2606201370","pmid":"https://pubmed.ncbi.nlm.nih.gov/28426665"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005428","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005428","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005428&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005428&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035694428","display_name":"Thomas Peterson","orcid":"https://orcid.org/0000-0002-9933-7556"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Peterson","raw_affiliation_strings":["Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America","University of California, San Francisco, Institute for Computational Health Science, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I79272384"]},{"raw_affiliation_string":"University of California, San Francisco, Institute for Computational Health Science, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090127959","display_name":"Iris Ivy Gauran","orcid":"https://orcid.org/0000-0002-7067-7012"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iris Ivy M. Gauran","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7067-7012","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695872","display_name":"Junyong Park","orcid":"https://orcid.org/0000-0002-5618-8220"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junyong Park","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052506231","display_name":"DoHwan Park","orcid":"https://orcid.org/0000-0002-9132-5040"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DoHwan Park","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9132-5040","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013292761","display_name":"Maricel G. Kann","orcid":"https://orcid.org/0000-0003-0116-3883"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maricel G. Kann","raw_affiliation_strings":["Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0116-3883","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I79272384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5013292761"],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6408,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.81851341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"4","first_page":"e1005428","last_page":"e1005428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.8409171104431152},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7432692050933838},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6591240763664246},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6165401935577393},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5911591053009033},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5815693140029907},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.4881742596626282},{"id":"https://openalex.org/keywords/germline-mutation","display_name":"Germline mutation","score":0.45877206325531006},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4430548846721649},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44271060824394226}],"concepts":[{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.8409171104431152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7432692050933838},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6591240763664246},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6165401935577393},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5911591053009033},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5815693140029907},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4881742596626282},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.45877206325531006},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4430548846721649},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44271060824394226}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005428","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005428","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005428&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28426665","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28426665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:99f357ce4fc643a5925013301e5e3804","is_oa":true,"landing_page_url":"https://doaj.org/article/99f357ce4fc643a5925013301e5e3804","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 4, p e1005428 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4893359","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Oncodomains_A_protein_domain-centric_framework_for_analyzing_rare_variants_in_tumor_samples/4893359","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5398485","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5398485","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005428","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005428","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005428&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1016573829","display_name":null,"funder_award_id":"1446406","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G200805936","display_name":null,"funder_award_id":"1K22CA143148","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G620793561","display_name":null,"funder_award_id":"R01LM009722 (Subcontract)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7174641041","display_name":null,"funder_award_id":"R01LM009722","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606201370.pdf","grobid_xml":"https://content.openalex.org/works/W2606201370.grobid-xml"},"referenced_works_count":151,"referenced_works":["https://openalex.org/W118065332","https://openalex.org/W132955270","https://openalex.org/W194044816","https://openalex.org/W196052217","https://openalex.org/W318041929","https://openalex.org/W1490161904","https://openalex.org/W1490655572","https://openalex.org/W1498534194","https://openalex.org/W1533992092","https://openalex.org/W1574807134","https://openalex.org/W1587423226","https://openalex.org/W1823227001","https://openalex.org/W1903402416","https://openalex.org/W1916128385","https://openalex.org/W1922783847","https://openalex.org/W1957275269","https://openalex.org/W1967653499","https://openalex.org/W1967700176","https://openalex.org/W1969361257","https://openalex.org/W1969735624","https://openalex.org/W1971871586","https://openalex.org/W1973728613","https://openalex.org/W1979522770","https://openalex.org/W1980740976","https://openalex.org/W1983589381","https://openalex.org/W1983728054","https://openalex.org/W1985199765","https://openalex.org/W1986430836","https://openalex.org/W1989773675","https://openalex.org/W1989848777","https://openalex.org/W1991944021","https://openalex.org/W1994517178","https://openalex.org/W1995972219","https://openalex.org/W1998991259","https://openalex.org/W2000969246","https://openalex.org/W2005168105","https://openalex.org/W2005984639","https://openalex.org/W2008791994","https://openalex.org/W2009720434","https://openalex.org/W2011941471","https://openalex.org/W2013469333","https://openalex.org/W2015049472","https://openalex.org/W2015631955","https://openalex.org/W2018336040","https://openalex.org/W2019423829","https://openalex.org/W2023568503","https://openalex.org/W2023790301","https://openalex.org/W2027569448","https://openalex.org/W2028897202","https://openalex.org/W2029995169","https://openalex.org/W2033715459","https://openalex.org/W2036096786","https://openalex.org/W2038744035","https://openalex.org/W2041919461","https://openalex.org/W2042160423","https://openalex.org/W2043350310","https://openalex.org/W2043816461","https://openalex.org/W2044433401","https://openalex.org/W2045914655","https://openalex.org/W2047067490","https://openalex.org/W2049775573","https://openalex.org/W2052593722","https://openalex.org/W2053324328","https://openalex.org/W2058043554","https://openalex.org/W2058539819","https://openalex.org/W2059145105","https://openalex.org/W2059300459","https://openalex.org/W2060411619","https://openalex.org/W2060791849","https://openalex.org/W2062312459","https://openalex.org/W2063858714","https://openalex.org/W2064843753","https://openalex.org/W2065262208","https://openalex.org/W2065808150","https://openalex.org/W2068974935","https://openalex.org/W2069081118","https://openalex.org/W2072572998","https://openalex.org/W2072881647","https://openalex.org/W2075585084","https://openalex.org/W2075661710","https://openalex.org/W2076894763","https://openalex.org/W2078484286","https://openalex.org/W2081933021","https://openalex.org/W2085277871","https://openalex.org/W2088891952","https://openalex.org/W2094122486","https://openalex.org/W2096606586","https://openalex.org/W2097744984","https://openalex.org/W2100638553","https://openalex.org/W2100714130","https://openalex.org/W2102140136","https://openalex.org/W2103883318","https://openalex.org/W2104233512","https://openalex.org/W2104570606","https://openalex.org/W2104840503","https://openalex.org/W2105928180","https://openalex.org/W2108215899","https://openalex.org/W2108649941","https://openalex.org/W2109860416","https://openalex.org/W2111253773","https://openalex.org/W2111326065","https://openalex.org/W2112005039","https://openalex.org/W2113532366","https://openalex.org/W2114843025","https://openalex.org/W2117243134","https://openalex.org/W2120609522","https://openalex.org/W2120627772","https://openalex.org/W2124045232","https://openalex.org/W2131554707","https://openalex.org/W2132566055","https://openalex.org/W2133428001","https://openalex.org/W2134266932","https://openalex.org/W2134499258","https://openalex.org/W2135640980","https://openalex.org/W2138675773","https://openalex.org/W2140349867","https://openalex.org/W2141885858","https://openalex.org/W2143191174","https://openalex.org/W2144302847","https://openalex.org/W2145247101","https://openalex.org/W2146980885","https://openalex.org/W2148158431","https://openalex.org/W2148853951","https://openalex.org/W2149441684","https://openalex.org/W2150066952","https://openalex.org/W2150473997","https://openalex.org/W2151684398","https://openalex.org/W2152037201","https://openalex.org/W2152776641","https://openalex.org/W2155173231","https://openalex.org/W2165083157","https://openalex.org/W2165757245","https://openalex.org/W2168303063","https://openalex.org/W2168470080","https://openalex.org/W2177605184","https://openalex.org/W2253928581","https://openalex.org/W2338992976","https://openalex.org/W2360761080","https://openalex.org/W2396351046","https://openalex.org/W2411701108","https://openalex.org/W2510333966","https://openalex.org/W2739999456","https://openalex.org/W2756787081","https://openalex.org/W3147254695","https://openalex.org/W4210623056","https://openalex.org/W4238448376","https://openalex.org/W4240237951","https://openalex.org/W4253557583","https://openalex.org/W4299296321","https://openalex.org/W6605435136","https://openalex.org/W6682156016"],"related_works":["https://openalex.org/W4296060409","https://openalex.org/W2016712296","https://openalex.org/W2623784472","https://openalex.org/W2041452721","https://openalex.org/W1972248466","https://openalex.org/W3111064715","https://openalex.org/W3159783651","https://openalex.org/W2054270613","https://openalex.org/W824391999","https://openalex.org/W2065180810"],"abstract_inverted_index":{"The":[0],"fight":[1],"against":[2],"cancer":[3,82,205],"is":[4],"hindered":[5],"by":[6,157,176],"its":[7],"highly":[8],"heterogeneous":[9],"nature.":[10],"Genome-wide":[11],"sequencing":[12],"studies":[13],"have":[14,70],"shown":[15],"that":[16,22,80,86,108,144,190],"individual":[17],"malignancies":[18],"contain":[19],"many":[20],"mutations":[21,52,60,132],"range":[23],"from":[24],"those":[25],"commonly":[26],"found":[27,61],"in":[28,37,53,62,85,104,114,166],"tumor":[29,240],"genomes":[30],"to":[31,57,100,178,201,217,222,230],"rare":[32,44,173,224],"somatic":[33,45,59,78,90,131,164,174,188],"variants":[34,46,79,91,165,175,189],"present":[35,120],"only":[36,89],"a":[38,93,111,123,148,184],"small":[39],"fraction":[40],"of":[41,50,130,163,171,187,195,238],"lesions.":[42],"Such":[43],"dominate":[47],"the":[48,105,161,169,193,236],"landscape":[49,186],"genomic":[51],"cancer,":[54,167],"yet":[55],"efforts":[56],"correlate":[58],"one":[63],"or":[64],"few":[65],"individuals":[66],"with":[67,204],"functional":[68,154],"roles":[69],"been":[71],"largely":[72],"unsuccessful.":[73],"Traditional":[74],"methods":[75],"for":[76,127,150,235],"identifying":[77,128],"drive":[81],"are":[83],"'gene-centric'":[84],"they":[87],"consider":[88],"within":[92],"particular":[94],"gene":[95,135,211],"and":[96,153,213],"make":[97],"no":[98],"comparison":[99,177],"other":[101],"similar":[102,112,179],"genes":[103],"same":[106],"family":[107],"may":[109],"play":[110],"role":[113],"cancer.":[115],"In":[116],"this":[117],"work,":[118],"we":[119,226],"oncodomain":[121,218],"hotspots,":[122],"new":[124],"'domain-centric'":[125],"method":[126,229],"clusters":[129],"across":[133],"entire":[134],"families":[136,197],"using":[137],"protein":[138,158,208],"domain":[139,196],"models.":[140],"Our":[141,181],"analysis":[142,162,237],"confirms":[143],"our":[145,228],"approach":[146],"creates":[147],"framework":[149],"leveraging":[151],"structural":[152],"information":[155],"encapsulated":[156],"domains":[159],"into":[160],"enabling":[168],"assessment":[170],"even":[172],"genes.":[180],"results":[182],"reveal":[183],"vast":[185],"act":[191],"at":[192],"level":[194],"altering":[198],"pathways":[199],"known":[200],"be":[202],"involved":[203],"such":[206],"as":[207],"phosphorylation,":[209],"signaling,":[210],"regulation,":[212],"cell":[214],"metabolism.":[215],"Due":[216],"hotspots'":[219],"unique":[220],"ability":[221],"assess":[223],"variants,":[225],"expect":[227],"become":[231],"an":[232],"important":[233],"tool":[234],"sequenced":[239],"genomes,":[241],"complementing":[242],"existing":[243],"methods.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
