{"id":"https://openalex.org/W2600179491","doi":"https://doi.org/10.1371/journal.pcbi.1005395","title":"Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome","display_name":"Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome","publication_year":2017,"publication_date":"2017-03-30","ids":{"openalex":"https://openalex.org/W2600179491","doi":"https://doi.org/10.1371/journal.pcbi.1005395","mag":"2600179491","pmid":"https://pubmed.ncbi.nlm.nih.gov/28358814"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005395","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005395","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005395&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005395&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060335674","display_name":"Daniele Caligiore","orcid":"https://orcid.org/0000-0002-3040-9961"},"institutions":[{"id":"https://openalex.org/I4210113153","display_name":"Neuroscience Institute","ror":"https://ror.org/0240rwx68","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210113153","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210166865","display_name":"Institute of Cognitive Sciences and Technologies","ror":"https://ror.org/05w9g2j85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210166865"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Daniele Caligiore","raw_affiliation_strings":["Laboratory of Computational Embodied Neuroscience, Institute of Cognitive Sciences and Technologies, National Research Council (CNR-ISTC-LOCEN), Roma, Italy","Istituto di Scienze e Tecnologie della Cognizione"],"raw_orcid":"https://orcid.org/0000-0002-3040-9961","affiliations":[{"raw_affiliation_string":"Laboratory of Computational Embodied Neuroscience, Institute of Cognitive Sciences and Technologies, National Research Council (CNR-ISTC-LOCEN), Roma, Italy","institution_ids":["https://openalex.org/I4210166865","https://openalex.org/I4210113153","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Istituto di Scienze e Tecnologie della Cognizione","institution_ids":["https://openalex.org/I4210166865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083397379","display_name":"Francesco Mannella","orcid":"https://orcid.org/0000-0002-7308-0844"},"institutions":[{"id":"https://openalex.org/I4210113153","display_name":"Neuroscience Institute","ror":"https://ror.org/0240rwx68","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210113153","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210166865","display_name":"Institute of Cognitive Sciences and Technologies","ror":"https://ror.org/05w9g2j85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210166865"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Mannella","raw_affiliation_strings":["Laboratory of Computational Embodied Neuroscience, Institute of Cognitive Sciences and Technologies, National Research Council (CNR-ISTC-LOCEN), Roma, Italy","Istituto di Scienze e Tecnologie della Cognizione"],"raw_orcid":"https://orcid.org/0000-0002-7308-0844","affiliations":[{"raw_affiliation_string":"Laboratory of Computational Embodied Neuroscience, Institute of Cognitive Sciences and Technologies, National Research Council (CNR-ISTC-LOCEN), Roma, Italy","institution_ids":["https://openalex.org/I4210166865","https://openalex.org/I4210113153","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Istituto di Scienze e Tecnologie della Cognizione","institution_ids":["https://openalex.org/I4210166865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039686801","display_name":"Michael A. Arbib","orcid":"https://orcid.org/0000-0002-6902-3580"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Arbib","raw_affiliation_strings":["Neuroscience Program, USC Brain Project, Computer Science Department, University of Southern California, Los Angeles, California, United States of America","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, USC Brain Project, Computer Science Department, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076711458","display_name":"Gianluca Baldassarre","orcid":"https://orcid.org/0000-0002-1277-4447"},"institutions":[{"id":"https://openalex.org/I4210113153","display_name":"Neuroscience Institute","ror":"https://ror.org/0240rwx68","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210113153","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210166865","display_name":"Institute of Cognitive Sciences and Technologies","ror":"https://ror.org/05w9g2j85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210166865"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Baldassarre","raw_affiliation_strings":["Laboratory of Computational Embodied Neuroscience, Institute of Cognitive Sciences and Technologies, National Research Council (CNR-ISTC-LOCEN), Roma, Italy","Istituto di Scienze e Tecnologie della Cognizione"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Embodied Neuroscience, Institute of Cognitive Sciences and Technologies, National Research Council (CNR-ISTC-LOCEN), Roma, Italy","institution_ids":["https://openalex.org/I4210166865","https://openalex.org/I4210113153","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Istituto di Scienze e Tecnologie della Cognizione","institution_ids":["https://openalex.org/I4210166865"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060335674"],"corresponding_institution_ids":["https://openalex.org/I4210113153","https://openalex.org/I4210155236","https://openalex.org/I4210166865"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":15.0282,"has_fulltext":true,"cited_by_count":110,"citation_normalized_percentile":{"value":0.99079824,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"13","issue":"3","first_page":"e1005395","last_page":"e1005395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9847999811172485,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":0.9474999904632568,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"Basal ganglia","score":0.9011416435241699},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7813847064971924},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.7516853213310242},{"id":"https://openalex.org/keywords/tics","display_name":"Tics","score":0.7372989654541016},{"id":"https://openalex.org/keywords/cerebellum","display_name":"Cerebellum","score":0.6009087562561035},{"id":"https://openalex.org/keywords/indirect-pathway-of-movement","display_name":"Indirect pathway of movement","score":0.5966426730155945},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5494533777236938},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"Motor cortex","score":0.48938053846359253},{"id":"https://openalex.org/keywords/cerebellar-cortex","display_name":"Cerebellar cortex","score":0.4513305127620697},{"id":"https://openalex.org/keywords/cortex","display_name":"Cortex (anatomy)","score":0.4391217529773712},{"id":"https://openalex.org/keywords/movement-disorders","display_name":"Movement disorders","score":0.43534231185913086},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.4277244210243225},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.3873988091945648},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.2515083849430084},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11393952369689941},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.07351425290107727}],"concepts":[{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.9011416435241699},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7813847064971924},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.7516853213310242},{"id":"https://openalex.org/C2777200579","wikidata":"https://www.wikidata.org/wiki/Q738538","display_name":"Tics","level":2,"score":0.7372989654541016},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.6009087562561035},{"id":"https://openalex.org/C162536842","wikidata":"https://www.wikidata.org/wiki/Q6025117","display_name":"Indirect pathway of movement","level":4,"score":0.5966426730155945},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5494533777236938},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.48938053846359253},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.4513305127620697},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4391217529773712},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.43534231185913086},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4277244210243225},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3873988091945648},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2515083849430084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11393952369689941},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07351425290107727},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020323","descriptor_name":"Tics","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020323","descriptor_name":"Tics","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020323","descriptor_name":"Tics","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005395","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005395","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005395&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28358814","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28358814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-01739534v1","is_oa":true,"landing_page_url":"https://hal.science/hal-01739534","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2017, 13 (3), pp.e1005395. ⟨10.1371/journal.pcbi.1005395⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:29fe1082d6ff419ab6adab6a2cb30040","is_oa":true,"landing_page_url":"https://doaj.org/article/29fe1082d6ff419ab6adab6a2cb30040","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 3, p e1005395 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4802425","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Dysfunctions_of_the_basal_ganglia-cerebellar-thalamo-cortical_system_produce_motor_tics_in_Tourette_syndrome/4802425","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5373520","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5373520","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pumaoai.isti.cnr.it:cnr.istc/cnr.istc/2017-A0-007","is_oa":true,"landing_page_url":"http://puma.isti.cnr.it/dfdownloadnew.php?ident=cnr.istc/cnr.istc/2017-A0-007","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: PLoS Computational Biology, vol. 13 (3) article n. e1005395. Public Library of Science, 2017.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005395","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005395","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005395&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5199999809265137,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1393648375","display_name":null,"funder_award_id":"ICT-IP-231722","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2637517280","display_name":null,"funder_award_id":"BCS-1343544","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2824907042","display_name":"INSPIRE Track 1:  Action, Vision and Language, and their Brain Mechanisms in Evolutionary Relationship","funder_award_id":"1343544","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3143586477","display_name":"Intrinsically Motivated Cumulative Learning Versatile Robots","funder_award_id":"231722","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4104599821","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2600179491.pdf","grobid_xml":"https://content.openalex.org/works/W2600179491.grobid-xml"},"referenced_works_count":161,"referenced_works":["https://openalex.org/W11974443","https://openalex.org/W61007526","https://openalex.org/W125252782","https://openalex.org/W147009424","https://openalex.org/W620439056","https://openalex.org/W639309485","https://openalex.org/W748016041","https://openalex.org/W1482276837","https://openalex.org/W1484585780","https://openalex.org/W1487044250","https://openalex.org/W1496637959","https://openalex.org/W1512746852","https://openalex.org/W1513126258","https://openalex.org/W1525761558","https://openalex.org/W1541122775","https://openalex.org/W1582051163","https://openalex.org/W1582681335","https://openalex.org/W1597203818","https://openalex.org/W1678948049","https://openalex.org/W1833159061","https://openalex.org/W1911169438","https://openalex.org/W1943433854","https://openalex.org/W1960966591","https://openalex.org/W1969271919","https://openalex.org/W1969391889","https://openalex.org/W1969392675","https://openalex.org/W1970375293","https://openalex.org/W1974188121","https://openalex.org/W1980063494","https://openalex.org/W1981609710","https://openalex.org/W1982522250","https://openalex.org/W1986320574","https://openalex.org/W1990080997","https://openalex.org/W1998247306","https://openalex.org/W1998587902","https://openalex.org/W1999181826","https://openalex.org/W2001700591","https://openalex.org/W2005269174","https://openalex.org/W2006921982","https://openalex.org/W2007228716","https://openalex.org/W2008565771","https://openalex.org/W2011857818","https://openalex.org/W2012592267","https://openalex.org/W2015114805","https://openalex.org/W2017539895","https://openalex.org/W2019432365","https://openalex.org/W2020278240","https://openalex.org/W2020925019","https://openalex.org/W2022787026","https://openalex.org/W2023632588","https://openalex.org/W2025220658","https://openalex.org/W2026183293","https://openalex.org/W2027004239","https://openalex.org/W2027044265","https://openalex.org/W2027243898","https://openalex.org/W2028038997","https://openalex.org/W2029374903","https://openalex.org/W2031087758","https://openalex.org/W2031268318","https://openalex.org/W2032330693","https://openalex.org/W2033092191","https://openalex.org/W2036552420","https://openalex.org/W2036764555","https://openalex.org/W2038674173","https://openalex.org/W2039887309","https://openalex.org/W2043561153","https://openalex.org/W2045695914","https://openalex.org/W2046717433","https://openalex.org/W2048249017","https://openalex.org/W2051178577","https://openalex.org/W2051936053","https://openalex.org/W2057166223","https://openalex.org/W2057200630","https://openalex.org/W2058279623","https://openalex.org/W2058998361","https://openalex.org/W2059194600","https://openalex.org/W2060052647","https://openalex.org/W2060128323","https://openalex.org/W2060469305","https://openalex.org/W2075801228","https://openalex.org/W2079355604","https://openalex.org/W2079506095","https://openalex.org/W2083880571","https://openalex.org/W2084462975","https://openalex.org/W2085376923","https://openalex.org/W2086928965","https://openalex.org/W2088495343","https://openalex.org/W2090232493","https://openalex.org/W2093653777","https://openalex.org/W2098957660","https://openalex.org/W2099652807","https://openalex.org/W2100015356","https://openalex.org/W2100817237","https://openalex.org/W2102307461","https://openalex.org/W2103019454","https://openalex.org/W2103179919","https://openalex.org/W2103670858","https://openalex.org/W2103768739","https://openalex.org/W2105515675","https://openalex.org/W2105848810","https://openalex.org/W2105935234","https://openalex.org/W2106205767","https://openalex.org/W2107325954","https://openalex.org/W2108066399","https://openalex.org/W2109042184","https://openalex.org/W2112653387","https://openalex.org/W2115066732","https://openalex.org/W2123649732","https://openalex.org/W2123742740","https://openalex.org/W2127541876","https://openalex.org/W2127704250","https://openalex.org/W2127918219","https://openalex.org/W2128820615","https://openalex.org/W2129585049","https://openalex.org/W2131349989","https://openalex.org/W2132858536","https://openalex.org/W2133709709","https://openalex.org/W2134762206","https://openalex.org/W2139513028","https://openalex.org/W2139693994","https://openalex.org/W2140270073","https://openalex.org/W2141951582","https://openalex.org/W2143951357","https://openalex.org/W2144132156","https://openalex.org/W2147439698","https://openalex.org/W2148181696","https://openalex.org/W2149661045","https://openalex.org/W2149936635","https://openalex.org/W2150412113","https://openalex.org/W2153456724","https://openalex.org/W2153617058","https://openalex.org/W2155051950","https://openalex.org/W2158900973","https://openalex.org/W2160017783","https://openalex.org/W2163200475","https://openalex.org/W2163647009","https://openalex.org/W2165095254","https://openalex.org/W2165106227","https://openalex.org/W2167987951","https://openalex.org/W2168529864","https://openalex.org/W2169502988","https://openalex.org/W2170172094","https://openalex.org/W2171884247","https://openalex.org/W2190930741","https://openalex.org/W2192277428","https://openalex.org/W2193155057","https://openalex.org/W2229830468","https://openalex.org/W2256962117","https://openalex.org/W2261666310","https://openalex.org/W2321749259","https://openalex.org/W2343296810","https://openalex.org/W2397424515","https://openalex.org/W2404016981","https://openalex.org/W2520120973","https://openalex.org/W2559687221","https://openalex.org/W2616548380","https://openalex.org/W2783182505","https://openalex.org/W4241522672","https://openalex.org/W4248881935","https://openalex.org/W4297067014","https://openalex.org/W6676279030"],"related_works":["https://openalex.org/W4381434097","https://openalex.org/W935000320","https://openalex.org/W2016052345","https://openalex.org/W3014506158","https://openalex.org/W2292207655","https://openalex.org/W2010269029","https://openalex.org/W2519639851","https://openalex.org/W2081073419","https://openalex.org/W2381794320","https://openalex.org/W2344916247"],"abstract_inverted_index":{"Motor":[0],"tics":[1,67,155],"are":[2,10,42,68],"a":[3,27,55,237,250],"cardinal":[4],"feature":[5],"of":[6,16,58,82,88,100,142,154,194,232,249],"Tourette":[7,71,234],"syndrome":[8,235],"and":[9,33,120,129,161,221],"traditionally":[11],"associated":[12],"with":[13,39,218,222],"an":[14,98],"excess":[15],"striatal":[17,158],"dopamine":[18,159],"in":[19,37,45,70,93,108,145,173],"the":[20,59,75,79,86,89,101,111,115,126,131,140,143,152,163,183,186,192,195,223,226,230,247],"basal":[21,40,60,90,134,198,205],"ganglia.":[22],"Recent":[23],"evidence":[24],"increasingly":[25],"supports":[26],"more":[28],"articulated":[29],"view":[30],"where":[31],"cerebellum":[32,144],"cortex,":[34],"working":[35],"closely":[36],"concert":[38],"ganglia,":[41],"also":[43,228],"involved":[44],"tic":[46,94,106,127,146],"production.":[47],"Building":[48],"on":[49,151],"such":[50],"evidence,":[51],"this":[52,109,203],"article":[53],"proposes":[54],"computational":[56,188],"model":[57,112,184,227],"ganglia-cerebellar-thalamo-cortical":[61,91],"system":[62,92],"to":[63,124,190,246],"study":[64,191],"how":[65,214],"motor":[66,105],"generated":[69,156],"syndrome.":[72],"In":[73],"particular,":[74],"model:":[76],"(i)":[77],"reproduces":[78],"main":[80],"results":[81],"recent":[83],"experiments":[84],"about":[85,213],"involvement":[87,141],"generation;":[95],"(ii)":[96],"suggests":[97],"explanation":[99],"system-level":[102,238],"mechanisms":[103],"underlying":[104],"production:":[107],"respect,":[110],"predicts":[113],"that":[114,130],"interplay":[116],"between":[117],"dopaminergic":[118],"signal":[119],"cortical":[121],"activity":[122],"contributes":[123],"triggering":[125],"event":[128],"recently":[132,196],"discovered":[133,197],"ganglia-cerebellar":[135,199,206],"anatomical":[136,200],"pathway":[137],"may":[138],"support":[139],"production;":[147],"(iii)":[148],"furnishes":[149],"predictions":[150,169],"amount":[153],"when":[157,162],"increases":[160],"cortex":[164],"is":[165],"externally":[166],"stimulated.":[167],"These":[168],"could":[170,208],"be":[171],"important":[172],"identifying":[174],"new":[175],"brain":[176,252],"target":[177],"areas":[178,216],"for":[179],"future":[180],"therapies.":[181],"Finally,":[182],"represents":[185],"first":[187],"attempt":[189],"role":[193],"links.":[201],"Studying":[202],"non-cortex-mediated":[204],"interaction":[207],"radically":[209],"change":[210],"our":[211],"perspective":[212,239],"these":[215],"interact":[217],"each":[219],"other":[220],"cortex.":[224],"Overall,":[225],"shows":[229],"utility":[231],"casting":[233],"within":[236],"rather":[240],"than":[241],"viewing":[242],"it":[243],"as":[244],"related":[245],"dysfunction":[248],"single":[251],"area.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}