{"id":"https://openalex.org/W2582554495","doi":"https://doi.org/10.1371/journal.pcbi.1005354","title":"Exploring the inhibitory effect of membrane tension on cell polarization","display_name":"Exploring the inhibitory effect of membrane tension on cell polarization","publication_year":2017,"publication_date":"2017-01-30","ids":{"openalex":"https://openalex.org/W2582554495","doi":"https://doi.org/10.1371/journal.pcbi.1005354","mag":"2582554495","pmid":"https://pubmed.ncbi.nlm.nih.gov/28135277"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005354","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005354","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005354&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005354&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100663686","display_name":"Weikang Wang","orcid":"https://orcid.org/0000-0002-2780-0783"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391767693","display_name":"State Key Laboratory of Nuclear Physics and Technology","ror":"https://ror.org/00tp8bz22","country_code":null,"type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weikang Wang","raw_affiliation_strings":["State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083054305","display_name":"Kuan Tao","orcid":"https://orcid.org/0000-0003-0363-9865"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kuan Tao","raw_affiliation_strings":["Center for Quantitative Biology, Peking University, Beijing, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-0363-9865","affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452381","display_name":"Jing Wang","orcid":"https://orcid.org/0009-0007-9352-2850"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391767693","display_name":"State Key Laboratory of Nuclear Physics and Technology","ror":"https://ror.org/00tp8bz22","country_code":null,"type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113640972","display_name":"Gen Yang","orcid":"https://orcid.org/0000-0002-0695-5583"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391767693","display_name":"State Key Laboratory of Nuclear Physics and Technology","ror":"https://ror.org/00tp8bz22","country_code":null,"type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gen Yang","raw_affiliation_strings":["State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056459691","display_name":"Qi Ouyang","orcid":"https://orcid.org/0000-0003-1585-7368"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Ouyang","raw_affiliation_strings":["Center for Quantitative Biology, Peking University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834746","display_name":"Yugang Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391767693","display_name":"State Key Laboratory of Nuclear Physics and Technology","ror":"https://ror.org/00tp8bz22","country_code":null,"type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yugang Wang","raw_affiliation_strings":["State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433917","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-4880-824X"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Beijing International Center for Mathematical Research, Peking University, Beijing, People's Republic of China","Center for Quantitative Biology, Peking University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing International Center for Mathematical Research, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Center for Quantitative Biology, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100780849","display_name":"Feng Liu","orcid":"https://orcid.org/0000-0001-9724-6127"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391767693","display_name":"State Key Laboratory of Nuclear Physics and Technology","ror":"https://ror.org/00tp8bz22","country_code":null,"type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Liu","raw_affiliation_strings":["Center for Quantitative Biology, Peking University, Beijing, People's Republic of China","State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-9724-6127","affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391767693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100433917","https://openalex.org/A5100780849"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391767693"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0226,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85353363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"e1005354","last_page":"e1005354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-polarity","display_name":"Cell polarity","score":0.5752944350242615},{"id":"https://openalex.org/keywords/cell-membrane","display_name":"Cell membrane","score":0.5658142566680908},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.564316987991333},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5581905841827393},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5473359823226929},{"id":"https://openalex.org/keywords/polarization","display_name":"Polarization (electrochemistry)","score":0.5387275218963623},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.4783496558666229},{"id":"https://openalex.org/keywords/pseudopodia","display_name":"Pseudopodia","score":0.4481314420700073},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.4292525053024292},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4146122634410858},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3414102792739868},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22794011235237122},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17290911078453064},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.07906979322433472}],"concepts":[{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.5752944350242615},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.5658142566680908},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.564316987991333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5581905841827393},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5473359823226929},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.5387275218963623},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4783496558666229},{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.4481314420700073},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4292525053024292},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4146122634410858},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3414102792739868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22794011235237122},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17290911078453064},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07906979322433472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005354","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005354","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005354&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28135277","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28135277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:ce892d4118ea48558ed0e9d134a67608","is_oa":true,"landing_page_url":"https://doaj.org/article/ce892d4118ea48558ed0e9d134a67608","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 1, p e1005354 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4599937","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Exploring_the_inhibitory_effect_of_membrane_tension_on_cell_polarization/4599937","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5305267","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5305267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005354","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005354","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005354&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4756590386","display_name":null,"funder_award_id":"11434001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5776305788","display_name":null,"funder_award_id":"11421110001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6009599162","display_name":null,"funder_award_id":"31670852","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8156349892","display_name":null,"funder_award_id":"91430217","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2582554495.pdf","grobid_xml":"https://content.openalex.org/works/W2582554495.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W20301122","https://openalex.org/W1576847343","https://openalex.org/W1964145620","https://openalex.org/W1965650717","https://openalex.org/W1966073555","https://openalex.org/W1968421448","https://openalex.org/W1969410032","https://openalex.org/W1974047237","https://openalex.org/W1974524647","https://openalex.org/W1975553175","https://openalex.org/W1989324364","https://openalex.org/W1990742363","https://openalex.org/W1994186189","https://openalex.org/W2005521304","https://openalex.org/W2005800972","https://openalex.org/W2009718333","https://openalex.org/W2016664053","https://openalex.org/W2024826879","https://openalex.org/W2025944355","https://openalex.org/W2026279251","https://openalex.org/W2027052704","https://openalex.org/W2031811488","https://openalex.org/W2032619326","https://openalex.org/W2039438672","https://openalex.org/W2039825295","https://openalex.org/W2040640429","https://openalex.org/W2041040218","https://openalex.org/W2043420241","https://openalex.org/W2043664423","https://openalex.org/W2050300062","https://openalex.org/W2053064509","https://openalex.org/W2055001913","https://openalex.org/W2061869750","https://openalex.org/W2062837933","https://openalex.org/W2063220206","https://openalex.org/W2076493085","https://openalex.org/W2079175432","https://openalex.org/W2080145523","https://openalex.org/W2080232352","https://openalex.org/W2080484884","https://openalex.org/W2083293201","https://openalex.org/W2084200985","https://openalex.org/W2087538969","https://openalex.org/W2094236575","https://openalex.org/W2106217679","https://openalex.org/W2107625694","https://openalex.org/W2109693065","https://openalex.org/W2109803081","https://openalex.org/W2112876185","https://openalex.org/W2113175033","https://openalex.org/W2116548783","https://openalex.org/W2121179265","https://openalex.org/W2125527918","https://openalex.org/W2126022125","https://openalex.org/W2127515106","https://openalex.org/W2133493253","https://openalex.org/W2138402450","https://openalex.org/W2139151018","https://openalex.org/W2143425711","https://openalex.org/W2145273315","https://openalex.org/W2145699930","https://openalex.org/W2146749791","https://openalex.org/W2149058887","https://openalex.org/W2153124851","https://openalex.org/W2154641485","https://openalex.org/W2162689493","https://openalex.org/W2163802608","https://openalex.org/W2164318727","https://openalex.org/W2167158605","https://openalex.org/W2167452849","https://openalex.org/W2188659719","https://openalex.org/W2328469267","https://openalex.org/W2473079420","https://openalex.org/W4244301759","https://openalex.org/W6634461048"],"related_works":["https://openalex.org/W3110817878","https://openalex.org/W2607743808","https://openalex.org/W2535010168","https://openalex.org/W2003822104","https://openalex.org/W2143232130","https://openalex.org/W2044699623","https://openalex.org/W2051747697","https://openalex.org/W2046047219","https://openalex.org/W2470956167","https://openalex.org/W2128312394"],"abstract_inverted_index":{"Cell":[0],"polarization":[1,53,84,113,134,137],"toward":[2],"an":[3],"attractant":[4],"is":[5,114,202],"influenced":[6],"by":[7,76,154],"both":[8,105],"physical":[9],"and":[10,22,64,90,108,123,130,164,174,182],"chemical":[11,27],"factors.":[12],"Most":[13],"existing":[14],"mathematical":[15],"models":[16],"are":[17,145],"based":[18],"on":[19,25,104],"reaction-diffusion":[20],"systems":[21],"only":[23],"focus":[24],"the":[26,56,71,82,96,109,128,146,150,177,184,192,199],"process":[28],"occurring":[29],"during":[30],"cell":[31,46,52,65,79,100,112,133,193,197],"polarization.":[32,47],"However,":[33],"membrane":[34,66,101,121,125],"tension":[35,126,187],"has":[36],"been":[37],"shown":[38],"to":[39,117,148],"act":[40],"as":[41,95],"a":[42,51,171,196],"long-range":[43],"inhibitor":[44],"of":[45,73,81,85,132,162,167,176,179,186,191],"Here,":[48],"we":[49],"present":[50],"model":[54,75,107],"incorporating":[55],"interplay":[57],"between":[58],"Rac":[59],"GTPase,":[60],"filamentous":[61],"actin":[62],"(F-actin),":[63],"tension.":[67,102],"We":[68],"further":[69],"test":[70],"predictions":[72],"this":[74],"performing":[77],"single":[78],"measurements":[80],"spontaneous":[83],"cancer":[86,92],"stem":[87],"cells":[88,93],"(CSCs)":[89],"non-stem":[91],"(NSCCs),":[94],"former":[97],"have":[98],"lower":[99],"Based":[103],"our":[106,143],"experimental":[110,151],"results,":[111],"more":[115],"sensitive":[116],"stimuli":[118],"under":[119,139],"low":[120],"tension,":[122],"high":[124],"improves":[127],"robustness":[129],"stability":[131],"such":[135],"that":[136,159,183],"persists":[138],"random":[140],"perturbations.":[141],"Furthermore,":[142],"simulations":[144],"first":[147],"recapitulate":[149],"results":[152],"described":[153],"Houk":[155],"et":[156],"al.,":[157],"revealing":[158],"aspiration":[160],"(elevation":[161],"tension)":[163,168],"release":[165],"(reduction":[166],"result":[169],"in":[170,173],"decrease":[172],"recovery":[175],"activity":[178],"Rac-GTP,":[180],"respectively,":[181],"relaxation":[185],"induces":[188],"new":[189],"polarity":[190],"body":[194],"when":[195],"with":[198],"pseudopod-neck-body":[200],"morphology":[201],"severed.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3}],"updated_date":"2026-05-18T08:16:58.900851","created_date":"2025-10-10T00:00:00"}