{"id":"https://openalex.org/W2581400213","doi":"https://doi.org/10.1371/journal.pcbi.1005336","title":"Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction","display_name":"Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction","publication_year":2017,"publication_date":"2017-01-30","ids":{"openalex":"https://openalex.org/W2581400213","doi":"https://doi.org/10.1371/journal.pcbi.1005336","mag":"2581400213","pmid":"https://pubmed.ncbi.nlm.nih.gov/28135270"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005336","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005336","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005336&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005336&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062453288","display_name":"Shenshen Wang","orcid":"https://orcid.org/0000-0001-9951-2118"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shenshen Wang","raw_affiliation_strings":["Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9951-2118","affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062453288"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.131,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.86944349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"e1005336","last_page":"e1005336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7266148924827576},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.6654629707336426},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.6074070930480957},{"id":"https://openalex.org/keywords/affinity-maturation","display_name":"Affinity maturation","score":0.5528839230537415},{"id":"https://openalex.org/keywords/immunization","display_name":"Immunization","score":0.5512896776199341},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.5236606001853943},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5102949142456055},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.44364961981773376},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40716832876205444},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36393868923187256},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.32748347520828247},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16451320052146912}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7266148924827576},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6654629707336426},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6074070930480957},{"id":"https://openalex.org/C2781377902","wikidata":"https://www.wikidata.org/wiki/Q21418769","display_name":"Affinity maturation","level":3,"score":0.5528839230537415},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5512896776199341},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5236606001853943},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5102949142456055},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.44364961981773376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40716832876205444},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36393868923187256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32748347520828247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16451320052146912}],"mesh":[{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000916","descriptor_name":"Antibody Diversity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000916","descriptor_name":"Antibody Diversity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000916","descriptor_name":"Antibody Diversity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000916","descriptor_name":"Antibody Diversity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000916","descriptor_name":"Antibody Diversity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000916","descriptor_name":"Antibody Diversity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007115","descriptor_name":"Immunization Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007115","descriptor_name":"Immunization Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007115","descriptor_name":"Immunization Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055261","descriptor_name":"Immunogenetic Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055261","descriptor_name":"Immunogenetic Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055261","descriptor_name":"Immunogenetic Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005336","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005336","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005336&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28135270","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28135270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:fb7b95b1ad5f45e89554d949262de265","is_oa":false,"landing_page_url":"https://doaj.org/article/fb7b95b1ad5f45e89554d949262de265","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 1, p e1005336 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4171779","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5279722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/4599586","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Optimal_Sequential_Immunization_Can_Focus_Antibody_Responses_against_Diversity_Loss_and_Distraction/4599586","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005336","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005336","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005336&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313818","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13"},{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337427","display_name":"Kavli Institute for Theoretical Physics, University of California, Santa Barbara","ror":"https://ror.org/02t274463"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2581400213.pdf","grobid_xml":"https://content.openalex.org/works/W2581400213.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W40267425","https://openalex.org/W1549990382","https://openalex.org/W1911432365","https://openalex.org/W1915453701","https://openalex.org/W1919561613","https://openalex.org/W1937669064","https://openalex.org/W1954069242","https://openalex.org/W1969156908","https://openalex.org/W1972341594","https://openalex.org/W1975431323","https://openalex.org/W1978398372","https://openalex.org/W1980811933","https://openalex.org/W1981197474","https://openalex.org/W1982289564","https://openalex.org/W1984179187","https://openalex.org/W1987263883","https://openalex.org/W1989134497","https://openalex.org/W1989174077","https://openalex.org/W1992566288","https://openalex.org/W1995355944","https://openalex.org/W1997677784","https://openalex.org/W1999483871","https://openalex.org/W2000885937","https://openalex.org/W2010843874","https://openalex.org/W2016932039","https://openalex.org/W2030816309","https://openalex.org/W2031231782","https://openalex.org/W2037320559","https://openalex.org/W2043487490","https://openalex.org/W2052937459","https://openalex.org/W2054069391","https://openalex.org/W2058473280","https://openalex.org/W2059583074","https://openalex.org/W2063195211","https://openalex.org/W2068747743","https://openalex.org/W2070505228","https://openalex.org/W2071380288","https://openalex.org/W2074179519","https://openalex.org/W2074309287","https://openalex.org/W2077808580","https://openalex.org/W2081291921","https://openalex.org/W2087179955","https://openalex.org/W2095903025","https://openalex.org/W2097591929","https://openalex.org/W2113236498","https://openalex.org/W2122210861","https://openalex.org/W2134803208","https://openalex.org/W2135847964","https://openalex.org/W2140498738","https://openalex.org/W2143528254","https://openalex.org/W2153453530","https://openalex.org/W2153683760","https://openalex.org/W2168912344","https://openalex.org/W2170960409","https://openalex.org/W2171478268","https://openalex.org/W2181008927","https://openalex.org/W2277351499","https://openalex.org/W2289942604","https://openalex.org/W2302583067","https://openalex.org/W2332239663","https://openalex.org/W2515956381","https://openalex.org/W2951737759","https://openalex.org/W2963367348","https://openalex.org/W3105020603","https://openalex.org/W3123992600","https://openalex.org/W4246504300"],"related_works":["https://openalex.org/W1979044599","https://openalex.org/W2021824670","https://openalex.org/W2009867644","https://openalex.org/W2363997565","https://openalex.org/W1981120125","https://openalex.org/W3036615648","https://openalex.org/W2027075647","https://openalex.org/W2042380996","https://openalex.org/W3160376113","https://openalex.org/W3113502364"],"abstract_inverted_index":{"Affinity":[0],"maturation":[1,63,84],"is":[2,225],"a":[3,138,153,182,253],"Darwinian":[4],"process":[5],"in":[6,79,96,137,177,181,269],"which":[7,125],"B":[8,97,156,208],"lymphocytes":[9],"evolve":[10],"potent":[11],"antibodies":[12,42],"to":[13,31,53,85,92,190,227,267],"encountered":[14],"antigens":[15],"and":[16,35,59,107,130,164,211,243,259],"generate":[17],"immune":[18],"memory.":[19],"Highly":[20],"mutable":[21],"complex":[22,67],"pathogens":[23],"present":[24,77],"an":[25,78],"immense":[26],"antigenic":[27,202],"diversity":[28,46,99],"that":[29,113,140,231],"continues":[30],"challenge":[32],"natural":[33],"immunity":[34],"vaccine":[36,93,272],"design.":[37],"Induction":[38],"of":[39,82,110,118,147,166,187,196,207,216,236,249,271],"broadly":[40],"neutralizing":[41],"(bnAbs)":[43],"against":[44,104,274],"this":[45],"by":[47,240],"vaccination":[48],"likely":[49],"requires":[50],"multiple":[51],"exposures":[52],"distinct":[54],"but":[55,169],"related":[56],"antigen":[57,250],"variants,":[58,106],"yet":[60],"how":[61,201],"affinity":[62,83],"advances":[64],"under":[65],"such":[66],"stimulation":[68],"remains":[69],"poorly":[70],"understood.":[71],"To":[72],"fill":[73],"the":[74,108,116,144,162,185,194,213,237],"gap,":[75],"we":[76],"silico":[80],"model":[81],"examine":[86],"two":[87],"realistic":[88],"new":[89,123],"aspects":[90],"pertinent":[91],"development:":[94],"loss":[95],"cell":[98,157,209],"across":[100],"successive":[101],"immunization":[102,148,220],"periods":[103],"different":[105],"presence":[109],"distracting":[111],"epitopes":[112],"entropically":[114],"disfavor":[115],"evolution":[117],"bnAbs.":[119],"We":[120,198],"find":[121],"these":[122],"factors,":[124],"introduce":[126],"additional":[127],"selection":[128,150,173],"pressures":[129],"constraints,":[131],"significantly":[132],"influence":[133],"antibody":[134,217],"breadth":[135],"development,":[136],"way":[139],"depends":[141],"crucially":[142],"on":[143,233],"temporal":[145],"pattern":[146],"(or":[149],"forces).":[151],"Curiously,":[152],"less":[154],"diverse":[155],"seed":[158],"may":[159],"even":[160],"favor":[161],"expansion":[163],"dominance":[165],"cross-reactive":[167],"clones,":[168],"only":[170],"when":[171],"conflicting":[172],"forces":[174],"are":[175],"presented":[176],"series":[178],"rather":[179],"than":[180],"mixture.":[183],"Moreover,":[184],"level":[186],"frustration":[188],"due":[189],"evolutionary":[191,205],"conflict":[192],"dictates":[193],"degree":[195],"distraction.":[197],"further":[199],"describe":[200],"histories":[203],"select":[204],"paths":[206],"lineages":[210],"determine":[212],"predominant":[214],"mode":[215],"responses.":[218],"Sequential":[219],"with":[221],"mutationally":[222],"distant":[223],"variants":[224],"shown":[226],"robustly":[228],"induce":[229],"bnAbs":[230],"focus":[232],"conserved":[234],"elements":[235],"target":[238],"epitope,":[239],"thwarting":[241],"strain-specific":[242],"distracted":[244],"lineages.":[245],"An":[246],"optimal":[247],"range":[248],"dose":[251],"underlies":[252],"fine":[254],"balance":[255],"between":[256],"efficient":[257],"adaptation":[258],"persistent":[260],"reaction.":[261],"These":[262],"findings":[263],"provide":[264],"mechanistic":[265],"guides":[266],"aid":[268],"design":[270],"strategies":[273],"fast":[275],"mutating":[276],"pathogens.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}