{"id":"https://openalex.org/W2588798735","doi":"https://doi.org/10.1371/journal.pcbi.1005275","title":"A mathematical model of calcium dynamics in HSY cells","display_name":"A mathematical model of calcium dynamics in HSY cells","publication_year":2017,"publication_date":"2017-02-15","ids":{"openalex":"https://openalex.org/W2588798735","doi":"https://doi.org/10.1371/journal.pcbi.1005275","mag":"2588798735","pmid":"https://pubmed.ncbi.nlm.nih.gov/28199326"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005275","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005275","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005275&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005275&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103196719","display_name":"Jung Min Han","orcid":"https://orcid.org/0000-0002-2253-4156"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Jung Min Han","raw_affiliation_strings":["Department of Mathematics, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070677437","display_name":"Akihiko Tanimura","orcid":"https://orcid.org/0000-0002-1480-6721"},"institutions":[{"id":"https://openalex.org/I163793406","display_name":"Health Sciences University of Hokkaido","ror":"https://ror.org/04tqcn816","country_code":"JP","type":"education","lineage":["https://openalex.org/I163793406"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Tanimura","raw_affiliation_strings":["Department of Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan","institution_ids":["https://openalex.org/I163793406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024860090","display_name":"Vivien Kirk","orcid":"https://orcid.org/0000-0001-7519-1145"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Vivien Kirk","raw_affiliation_strings":["Department of Mathematics, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079587534","display_name":"James Sneyd","orcid":"https://orcid.org/0000-0001-7305-2862"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"James Sneyd","raw_affiliation_strings":["Department of Mathematics, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103196719"],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":1.5177,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.82007496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"2","first_page":"e1005275","last_page":"e1005275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.638996958732605},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6108074188232422},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.6045055985450745},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"Inositol trisphosphate","score":0.5704402327537537},{"id":"https://openalex.org/keywords/inositol-trisphosphate-receptor","display_name":"Inositol trisphosphate receptor","score":0.5528410077095032},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.5374361276626587},{"id":"https://openalex.org/keywords/inositol","display_name":"Inositol","score":0.5333813428878784},{"id":"https://openalex.org/keywords/calcium-in-biology","display_name":"Calcium in biology","score":0.4924484193325043},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4865766763687134},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2847263216972351},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28441256284713745},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.1877976953983307}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.638996958732605},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6108074188232422},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6045055985450745},{"id":"https://openalex.org/C2781387506","wikidata":"https://www.wikidata.org/wiki/Q138145","display_name":"Inositol trisphosphate","level":4,"score":0.5704402327537537},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.5528410077095032},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5374361276626587},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.5333813428878784},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.4924484193325043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4865766763687134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2847263216972351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28441256284713745},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1877976953983307},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018987","descriptor_name":"Salivary Ducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018987","descriptor_name":"Salivary Ducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018987","descriptor_name":"Salivary Ducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005275","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005275","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005275&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28199326","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28199326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5310762","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5310762","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1005275","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005275","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2a032bc58cbc441fbd130420785f054e","is_oa":true,"landing_page_url":"https://doaj.org/article/2a032bc58cbc441fbd130420785f054e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 2, p e1005275 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005275","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005275","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005275&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1486021451","display_name":null,"funder_award_id":"R01-DE019245","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6378343760","display_name":"Development of low invasive long-term imaging technique for studying salivary gland Ca2+ response and functional regeneration","funder_award_id":"16K11484","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8051430855","display_name":null,"funder_award_id":"16H01433","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320774","display_name":"Royal Society Te Ap\u0101rangi","ror":"https://ror.org/04tajb587"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335369","display_name":"Marsden Fund","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2588798735.pdf","grobid_xml":"https://content.openalex.org/works/W2588798735.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W198155925","https://openalex.org/W403978743","https://openalex.org/W1485297825","https://openalex.org/W1488122477","https://openalex.org/W1519576356","https://openalex.org/W1528703967","https://openalex.org/W1536184700","https://openalex.org/W1598957092","https://openalex.org/W1599277155","https://openalex.org/W1863023627","https://openalex.org/W1965515779","https://openalex.org/W1966886300","https://openalex.org/W1968540123","https://openalex.org/W1969893357","https://openalex.org/W1971639385","https://openalex.org/W1973040508","https://openalex.org/W1977712999","https://openalex.org/W1977927141","https://openalex.org/W1985758189","https://openalex.org/W1992462569","https://openalex.org/W1992489278","https://openalex.org/W1997721549","https://openalex.org/W1998052338","https://openalex.org/W2002571557","https://openalex.org/W2011257591","https://openalex.org/W2013072110","https://openalex.org/W2015426350","https://openalex.org/W2016809903","https://openalex.org/W2026965359","https://openalex.org/W2034021984","https://openalex.org/W2035934264","https://openalex.org/W2036044394","https://openalex.org/W2036145275","https://openalex.org/W2037758567","https://openalex.org/W2042679775","https://openalex.org/W2051497876","https://openalex.org/W2052794702","https://openalex.org/W2059036957","https://openalex.org/W2061357474","https://openalex.org/W2065099255","https://openalex.org/W2066877291","https://openalex.org/W2070869619","https://openalex.org/W2073263421","https://openalex.org/W2077847058","https://openalex.org/W2078900999","https://openalex.org/W2081596592","https://openalex.org/W2084805245","https://openalex.org/W2085027708","https://openalex.org/W2087651066","https://openalex.org/W2087760897","https://openalex.org/W2088093088","https://openalex.org/W2092868876","https://openalex.org/W2096272013","https://openalex.org/W2096513562","https://openalex.org/W2098050840","https://openalex.org/W2104397667","https://openalex.org/W2105549977","https://openalex.org/W2106279167","https://openalex.org/W2111298748","https://openalex.org/W2113193681","https://openalex.org/W2114663015","https://openalex.org/W2128513164","https://openalex.org/W2132204920","https://openalex.org/W2135822679","https://openalex.org/W2138312572","https://openalex.org/W2141955111","https://openalex.org/W2145038407","https://openalex.org/W2196813901","https://openalex.org/W2337373837","https://openalex.org/W2612743911","https://openalex.org/W4211132321","https://openalex.org/W4255760236","https://openalex.org/W6737361061"],"related_works":["https://openalex.org/W2064525306","https://openalex.org/W2063903820","https://openalex.org/W2401644871","https://openalex.org/W2074993713","https://openalex.org/W2337457843","https://openalex.org/W1572146622","https://openalex.org/W975796270","https://openalex.org/W2123890105","https://openalex.org/W1974981036","https://openalex.org/W2199396374"],"abstract_inverted_index":{"Saliva":[0],"is":[1,128,169,224],"an":[2,173],"essential":[3],"part":[4],"of":[5,44,95,108,140,144,149,159,167,198,211,213],"activities":[6],"such":[7],"as":[8],"speaking,":[9],"masticating":[10],"and":[11,19,24,40,46,98,104,179,200,220],"swallowing.":[12],"Enzymes":[13],"in":[14,37,51,101,156,175,182,205],"salivary":[15,56],"fluid":[16],"protect":[17],"teeth":[18],"gums":[20],"from":[21,124],"infectious":[22],"diseases,":[23],"also":[25],"initiate":[26],"the":[27,63,125,157,160,176,183,209,214,222,227],"digestion":[28],"process.":[29],"Intracellular":[30],"calcium":[31],"(Ca2+)":[32],"plays":[33],"a":[34,54,92,142,153,180],"critical":[35],"role":[36],"saliva":[38],"secretion":[39],"regulation.":[41],"Experimental":[42],"measurements":[43],"Ca2+":[45,79,97,115,122,161,199,203],"inositol":[47],"trisphosphate":[48],"(IP3)":[49],"concentrations":[50,197],"HSY":[52,102,206],"cells,":[53],"human":[55],"duct":[57],"cell":[58],"line,":[59],"show":[60],"that":[61,120,147,221],"when":[62,121,164],"cells":[64,103,207],"are":[65,188,208],"stimulated":[66],"with":[67,78],"adenosine":[68],"triphosphate":[69],"(ATP)":[70],"or":[71],"carbachol":[72],"(CCh),":[73],"they":[74,135],"exhibit":[75],"coupled":[76,96],"oscillations":[77,100,130,204],"spike":[80,84],"peaks":[81],"preceding":[82],"IP3":[83,99,145,151,201,215,229],"peaks.":[85],"Based":[86],"on":[87],"these":[88],"data,":[89],"we":[90,171],"construct":[91],"mathematical":[93],"model":[94,106,118,138,186],"perform":[105],"simulations":[107],"three":[109],"different":[110],"experimental":[111,191],"settings":[112],"to":[113],"forecast":[114],"responses.":[116],"The":[117,137],"predicts":[119,146],"influx":[123],"extracellular":[126],"space":[127],"removed,":[129],"gradually":[131],"slow":[132],"down":[133],"until":[134],"stop.":[136],"simulation":[139],"applying":[141],"pulse":[143],"photolysis":[148],"caged":[150],"causes":[152],"transient":[154],"increase":[155,174],"frequency":[158,178],"oscillations.":[162,230],"Lastly,":[163],"Ca2+-dependent":[165],"activation":[166],"PLC":[168],"inhibited,":[170],"see":[172],"oscillation":[177],"decrease":[181],"amplitude.":[184],"These":[185],"predictions":[187],"confirmed":[189],"by":[190,217,226],"data.":[192],"We":[193],"conclude":[194],"that,":[195],"although":[196],"oscillate,":[202],"result":[210],"modulation":[212],"receptor":[216],"intracellular":[218],"Ca2+,":[219],"period":[223],"modulated":[225],"accompanying":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-25T07:29:55.448023","created_date":"2025-10-10T00:00:00"}