{"id":"https://openalex.org/W2583167946","doi":"https://doi.org/10.1371/journal.pcbi.1005259","title":"A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth","display_name":"A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth","publication_year":2017,"publication_date":"2017-01-26","ids":{"openalex":"https://openalex.org/W2583167946","doi":"https://doi.org/10.1371/journal.pcbi.1005259","mag":"2583167946","pmid":"https://pubmed.ncbi.nlm.nih.gov/28125582"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005259","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005259&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005259&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036036733","display_name":"Vasileios Vavourakis","orcid":"https://orcid.org/0000-0002-4102-2084"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Vasileios Vavourakis","raw_affiliation_strings":["University College London, Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4102-2084","affiliations":[{"raw_affiliation_string":"University College London, Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023797729","display_name":"P. A. Wijeratne","orcid":"https://orcid.org/0000-0002-4885-6241"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter A. Wijeratne","raw_affiliation_strings":["University College London, Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016183478","display_name":"Rebecca J. Shipley","orcid":"https://orcid.org/0000-0002-2818-6228"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Shipley","raw_affiliation_strings":["University College London, Department of Mechanical Engineering, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Department of Mechanical Engineering, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056289306","display_name":"Marilena Loizidou","orcid":"https://orcid.org/0000-0002-0900-9795"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marilena Loizidou","raw_affiliation_strings":["University College London, Department of Surgery, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Department of Surgery, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057504407","display_name":"Triantafyllos Stylianopoulos","orcid":"https://orcid.org/0000-0002-3093-1696"},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Triantafyllos Stylianopoulos","raw_affiliation_strings":["University of Cyprus, Department of Mechanical & Manufacturing Engineering, Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cyprus, Department of Mechanical & Manufacturing Engineering, Nicosia, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113676136","display_name":"David J. Hawkes","orcid":null},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Hawkes","raw_affiliation_strings":["University College London, Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Centre for Medical Image Computing, Department of Medical Physics & Biomedical Engineering, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036036733"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2153,"currency":"EUR","value_usd":2322},"fwci":3.5406,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.92963036,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"e1005259","last_page":"e1005259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8411868810653687},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.7591507434844971},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.6231135129928589},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47527164220809937},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47365033626556396},{"id":"https://openalex.org/keywords/sprouting-angiogenesis","display_name":"Sprouting angiogenesis","score":0.47349056601524353},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.42885300517082214},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3940770924091339},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3762470483779907},{"id":"https://openalex.org/keywords/neovascularization","display_name":"Neovascularization","score":0.36219072341918945},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2839372754096985},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.20671164989471436},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07915487885475159}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8411868810653687},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7591507434844971},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6231135129928589},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47527164220809937},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47365033626556396},{"id":"https://openalex.org/C2910429298","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Sprouting angiogenesis","level":4,"score":0.47349056601524353},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42885300517082214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3940770924091339},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3762470483779907},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.36219072341918945},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2839372754096985},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.20671164989471436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07915487885475159},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1005259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005259","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005259&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28125582","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28125582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c4fbc4fbe6f949f588416499f79b82ba","is_oa":true,"landing_page_url":"https://doaj.org/article/c4fbc4fbe6f949f588416499f79b82ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 1, p e1005259 (2017)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1538446","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1538446/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology , 13 (1) , Article e1005259. (2017)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:4171765","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5268362","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/4604677","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Validated_Multiscale_In-Silico_Model_for_Mechano-sensitive_Tumour_Angiogenesis_and_Growth/4604677","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005259","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005259","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005259&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1419921832","display_name":null,"funder_award_id":"EP/K020439/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2557024270","display_name":null,"funder_award_id":"FP7-PEOPLE-2013-IEF","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"},{"id":"https://openalex.org/G2810537366","display_name":null,"funder_award_id":"EP/M020533/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3157788177","display_name":"Medical image computing for next-generation healthcare technology","funder_award_id":"EP/M020533/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3191604378","display_name":null,"funder_award_id":"K020439","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3606929955","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0509-10143","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3959461325","display_name":"Intelligent Imaging: Motion, Form and Function Across Scale","funder_award_id":"EP/H046410/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4573962518","display_name":"Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy Through Integrated Tissue Micro-Structure Modeling","funder_award_id":"601040","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5274052941","display_name":"Medical imaging markers of cancer initiation, progression and therapeutic response in the breast based on tissue microstructure","funder_award_id":"EP/K020439/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6758621970","display_name":null,"funder_award_id":"627025","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"},{"id":"https://openalex.org/G725762644","display_name":"Towards the simulation of breast surgical lumpectomy and surgery planning through an isogeometric numerical analysis approach","funder_award_id":"627025","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7486377412","display_name":null,"funder_award_id":"EP/H046410/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7868512380","display_name":null,"funder_award_id":"FP7-PEOPLE-2013","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320320","display_name":"Rosetrees Trust","ror":"https://ror.org/04e3zg361"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320338368","display_name":"FP7 People: Marie-Curie Actions","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338370","display_name":"FP7 Information and Communication Technologies","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2583167946.pdf","grobid_xml":"https://content.openalex.org/works/W2583167946.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W218692517","https://openalex.org/W608535524","https://openalex.org/W1573363574","https://openalex.org/W1589288858","https://openalex.org/W1603491949","https://openalex.org/W1964128680","https://openalex.org/W1972135632","https://openalex.org/W1977887541","https://openalex.org/W1983530966","https://openalex.org/W1990983926","https://openalex.org/W1992420233","https://openalex.org/W1992560794","https://openalex.org/W1992829400","https://openalex.org/W1998266575","https://openalex.org/W2000315161","https://openalex.org/W2008076604","https://openalex.org/W2013496530","https://openalex.org/W2025538125","https://openalex.org/W2034600723","https://openalex.org/W2035663157","https://openalex.org/W2036212055","https://openalex.org/W2039097069","https://openalex.org/W2040387077","https://openalex.org/W2041065162","https://openalex.org/W2043416386","https://openalex.org/W2045484383","https://openalex.org/W2048195900","https://openalex.org/W2050790000","https://openalex.org/W2051553844","https://openalex.org/W2052275446","https://openalex.org/W2052672777","https://openalex.org/W2052917365","https://openalex.org/W2055009621","https://openalex.org/W2055384999","https://openalex.org/W2058651524","https://openalex.org/W2066724170","https://openalex.org/W2067055586","https://openalex.org/W2068072750","https://openalex.org/W2072537043","https://openalex.org/W2074011353","https://openalex.org/W2090004981","https://openalex.org/W2090144600","https://openalex.org/W2090683259","https://openalex.org/W2093036411","https://openalex.org/W2100409677","https://openalex.org/W2104300873","https://openalex.org/W2105564229","https://openalex.org/W2106571889","https://openalex.org/W2108626063","https://openalex.org/W2118271592","https://openalex.org/W2119308535","https://openalex.org/W2122077673","https://openalex.org/W2122913894","https://openalex.org/W2125284193","https://openalex.org/W2126410943","https://openalex.org/W2137757086","https://openalex.org/W2137780330","https://openalex.org/W2137816700","https://openalex.org/W2141766828","https://openalex.org/W2142533154","https://openalex.org/W2150881999","https://openalex.org/W2152689442","https://openalex.org/W2160524286","https://openalex.org/W2161590805","https://openalex.org/W2163308073","https://openalex.org/W2163737596","https://openalex.org/W2163778004","https://openalex.org/W2164878073","https://openalex.org/W2165673724","https://openalex.org/W2168957713","https://openalex.org/W2169139442","https://openalex.org/W2171157655","https://openalex.org/W2179074094","https://openalex.org/W2489790729","https://openalex.org/W2546947170","https://openalex.org/W2625210926","https://openalex.org/W4245967584","https://openalex.org/W6680463659"],"related_works":["https://openalex.org/W2104752154","https://openalex.org/W2414879916","https://openalex.org/W2460667757","https://openalex.org/W2051449188","https://openalex.org/W73242545","https://openalex.org/W2114498041","https://openalex.org/W1946062636","https://openalex.org/W13443198","https://openalex.org/W2146672236","https://openalex.org/W2378478338"],"abstract_inverted_index":{"Vascularisation":[0],"is":[1,23,109,127,153],"a":[2,121],"key":[3],"feature":[4],"of":[5,49,69,85,103,145,166],"cancer":[6],"growth,":[7],"invasion":[8],"and":[9,18,56,87,92,113,158],"metastasis.":[10],"To":[11],"better":[12],"understand":[13],"the":[14,47,65,83,143],"governing":[15],"biophysical":[16],"processes":[17],"their":[19],"relative":[20],"importance,":[21],"it":[22,152],"instructive":[24],"to":[25,33,35,45,111,119,155,160],"develop":[26],"physiologically":[27,122],"representative":[28],"mathematical":[29],"models":[30,60],"with":[31,137],"which":[32],"compare":[34],"experimental":[36],"data.":[37],"Previous":[38],"studies":[39],"have":[40],"successfully":[41],"applied":[42],"this":[43],"approach":[44],"test":[46],"effect":[48],"various":[50],"biochemical":[51],"factors":[52],"on":[53,73,89,141],"tumour":[54,107],"growth":[55,108],"angiogenesis.":[57],"However,":[58],"these":[59],"do":[61],"not":[62],"account":[63],"for":[64],"experimentally":[66],"observed":[67,162],"dependency":[68],"angiogenic":[70,106,167],"network":[71],"evolution":[72],"growth-induced":[74],"solid":[75],"stresses.":[76],"This":[77],"work":[78],"introduces":[79],"two":[80],"novel":[81],"features:":[82],"effects":[84],"hapto-":[86,157],"mechanotaxis":[88,159],"vessel":[90],"sprouting,":[91],"mechano-sensitive":[93],"dynamic":[94],"vascular":[95],"remodelling.":[96],"The":[97,125],"proposed":[98],"three-dimensional,":[99],"multiscale,":[100],"in-silico":[101],"model":[102,126],"dynamically":[104],"coupled":[105],"specified":[110],"in-vivo":[112,131],"in-vitro":[114],"data,":[115],"chosen,":[116],"where":[117],"possible,":[118],"provide":[120],"consistent":[123],"description.":[124],"then":[128],"validated":[129],"against":[130],"data":[132],"from":[133],"murine":[134],"mammary":[135],"carcinomas,":[136],"particular":[138],"focus":[139],"placed":[140],"identifying":[142],"influence":[144],"mechanical":[146],"factors.":[147],"Crucially,":[148],"we":[149],"find":[150],"that":[151],"necessary":[154],"include":[156],"recapitulate":[161],"time-varying":[163],"spatial":[164],"distributions":[165],"vasculature.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4}],"updated_date":"2026-07-19T07:52:34.831488","created_date":"2025-10-10T00:00:00"}