{"id":"https://openalex.org/W2557615995","doi":"https://doi.org/10.1371/journal.pcbi.1005222","title":"Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway","display_name":"Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway","publication_year":2016,"publication_date":"2016-11-30","ids":{"openalex":"https://openalex.org/W2557615995","doi":"https://doi.org/10.1371/journal.pcbi.1005222","mag":"2557615995","pmid":"https://pubmed.ncbi.nlm.nih.gov/27902699"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005222","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005222","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005222&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005222&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030927963","display_name":"Kazunari Iwamoto","orcid":"https://orcid.org/0000-0001-9794-9420"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazunari Iwamoto","raw_affiliation_strings":["Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Suita, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070183376","display_name":"Yuki Shindo","orcid":"https://orcid.org/0000-0001-5313-5492"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuki Shindo","raw_affiliation_strings":["Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Suita, Osaka, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102870944","display_name":"Koichi Takahashi","orcid":"https://orcid.org/0000-0002-4235-9914"},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koichi Takahashi","raw_affiliation_strings":["Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan","Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Suita, Osaka, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102870944"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.7086,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85058868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"12","issue":"11","first_page":"e1005222","last_page":"e1005222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.758036732673645},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.679297149181366},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5565417408943176},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.547601580619812},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"Epidermal growth factor","score":0.5072107315063477},{"id":"https://openalex.org/keywords/nuclear-localization-sequence","display_name":"Nuclear localization sequence","score":0.45170652866363525},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.4503539502620697},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.44653406739234924},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.4444889426231384},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.42392072081565857},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4210500717163086},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.288893461227417},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1940370798110962},{"id":"https://openalex.org/keywords/nucleus","display_name":"Nucleus","score":0.126235693693161},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.0729016363620758}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.758036732673645},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.679297149181366},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5565417408943176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.547601580619812},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5072107315063477},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.45170652866363525},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4503539502620697},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.44653406739234924},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4444889426231384},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42392072081565857},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4210500717163086},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.288893461227417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1940370798110962},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.126235693693161},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0729016363620758},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022022","descriptor_name":"Nuclear Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1005222","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005222","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005222&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27902699","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27902699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1005222","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005222","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d6ad40cd93cf42e5825f0cf9072035ea","is_oa":true,"landing_page_url":"https://doaj.org/article/d6ad40cd93cf42e5825f0cf9072035ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 11, p e1005222 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4273445","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Modeling_Cellular_Noise_Underlying_Heterogeneous_Cell_Responses_in_the_Epidermal_Growth_Factor_Signaling_Pathway/4273445","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5130170","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5130170","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005222","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005222","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005222&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2196126575","display_name":null,"funder_award_id":"JP16K21624","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4785402039","display_name":"\u751f\u7d30\u80de\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308b\uff25\uff32\uff2b\u3000\uff2d\uff21\uff30\uff2b\u7d4c\u8def\u306b\u304a\u3051\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u52d5\u614b\u306e\u5b9a\u91cf\u89e3\u6790","funder_award_id":"14J03140","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8407103406","display_name":"Predicting heterogeneity in EGF signaling by machine learning","funder_award_id":"16K21624","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2557615995.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1960299898","https://openalex.org/W1964321121","https://openalex.org/W1965684839","https://openalex.org/W1967717472","https://openalex.org/W1968916032","https://openalex.org/W1969111055","https://openalex.org/W1969294711","https://openalex.org/W1971475788","https://openalex.org/W1975108731","https://openalex.org/W1975816997","https://openalex.org/W1979572498","https://openalex.org/W1983651343","https://openalex.org/W1992864103","https://openalex.org/W1995624041","https://openalex.org/W1996405087","https://openalex.org/W2010552175","https://openalex.org/W2012792590","https://openalex.org/W2013947447","https://openalex.org/W2021058886","https://openalex.org/W2021521697","https://openalex.org/W2027657888","https://openalex.org/W2034188706","https://openalex.org/W2034906775","https://openalex.org/W2039480619","https://openalex.org/W2042023927","https://openalex.org/W2042321087","https://openalex.org/W2044702943","https://openalex.org/W2046855815","https://openalex.org/W2050568471","https://openalex.org/W2050826226","https://openalex.org/W2053460598","https://openalex.org/W2056388892","https://openalex.org/W2057364858","https://openalex.org/W2057453987","https://openalex.org/W2066489051","https://openalex.org/W2075161553","https://openalex.org/W2096283457","https://openalex.org/W2096575630","https://openalex.org/W2096595244","https://openalex.org/W2099203391","https://openalex.org/W2108352582","https://openalex.org/W2111510713","https://openalex.org/W2115260641","https://openalex.org/W2120170134","https://openalex.org/W2136822754","https://openalex.org/W2141167338","https://openalex.org/W2149199536","https://openalex.org/W2149242848","https://openalex.org/W2155418451","https://openalex.org/W2165685835","https://openalex.org/W2170486182","https://openalex.org/W2171280873","https://openalex.org/W2172213445","https://openalex.org/W2211016425","https://openalex.org/W2273488592","https://openalex.org/W2292276251","https://openalex.org/W2336184425","https://openalex.org/W2560367415","https://openalex.org/W4239672577"],"related_works":["https://openalex.org/W2040933678","https://openalex.org/W1984446732","https://openalex.org/W4320913516","https://openalex.org/W3147844193","https://openalex.org/W2377326938","https://openalex.org/W2884371102","https://openalex.org/W3175810710","https://openalex.org/W2008897992","https://openalex.org/W1998271033","https://openalex.org/W146556653"],"abstract_inverted_index":{"Cellular":[0],"heterogeneity,":[1,252],"which":[2,105,290],"plays":[3],"an":[4],"essential":[5],"role":[6],"in":[7,31,80,167,200,234,264],"biological":[8,134],"phenomena,":[9],"such":[10,276],"as":[11,287],"drug":[12],"resistance":[13],"and":[14,25,100,247,274],"migration,":[15],"is":[16,67,106,122,136,268],"considered":[17],"to":[18,43,125,155,266,293],"arise":[19],"from":[20,279],"intrinsic":[21,152],"(i.e.,":[22,27],"reaction":[23],"kinetics)":[24],"extrinsic":[26,74,148,272],"protein":[28,197,221,226,283],"variability)":[29],"noise":[30,42,75,135],"the":[32,35,45,58,81,89,112,117,128,131,170,196,215,219,235,294],"cell.":[33],"However,":[34],"mechanistic":[36],"effects":[37,230],"of":[38,41,47,60,76,88,111,119,133,158,169,179,194,211,242,281,296],"these":[39],"types":[40],"determine":[44],"heterogeneity":[46,157,210,263,277],"signal":[48,171],"responses":[49],"have":[50],"not":[51,151],"been":[52],"elucidated.":[53],"Here,":[54],"we":[55,163],"report":[56],"that":[57,147,224,261,275,285],"output":[59],"epidermal":[61],"growth":[62],"factor":[63],"(EGF)":[64],"signaling":[65,78,91],"activity":[66],"modulated":[68],"by":[69,73,176,271],"cellular":[70,251,262],"noise,":[71,149,153,273],"particularly":[72],"particular":[77,282],"components":[79],"pathway.":[82],"We":[83],"developed":[84],"a":[85,201],"mathematical":[86],"model":[87],"EGF":[90,243,267],"pathway":[92],"incorporating":[93],"regulation":[94],"between":[95,173],"extracellular":[96],"signal-regulated":[97],"kinase":[98],"(ERK)":[99],"nuclear":[101,113,159,212,236],"pore":[102],"complex":[103],"(NPC),":[104],"necessary":[107],"for":[108,139],"switch-like":[109,120],"activation":[110],"ERK":[114,237],"response.":[115,238],"As":[116],"threshold":[118],"behavior":[121],"more":[123],"sensitive":[124,288],"perturbations":[126],"than":[127],"graded":[129],"response,":[130],"effect":[132],"potentially":[137],"critical":[138],"cell":[140],"fate":[141],"decision.":[142],"Our":[143],"simulation":[144,183],"analysis":[145],"indicated":[146,260],"but":[150],"contributes":[154],"cell-to-cell":[156,209,232],"ERK.":[160],"In":[161,239],"addition,":[162],"accurately":[164],"estimated":[165,220],"variations":[166],"abundance":[168],"proteins":[172,207],"individual":[174],"cells":[175],"direct":[177],"comparison":[178],"experimental":[180],"data":[181],"with":[182],"results":[184,259,278],"using":[185,218],"Apparent":[186],"Measurement":[187],"Error":[188],"(AME).":[189],"AME":[190],"was":[191],"constant":[192],"regardless":[193],"whether":[195],"levels":[198],"varied":[199],"correlated":[202],"manner,":[203],"while":[204,253],"covariation":[205],"among":[206],"influenced":[208,250],"ERK,":[213],"suppressing":[214],"variation.":[216],"Simulations":[217],"abundances":[222],"showed":[223],"each":[225],"species":[227,284],"has":[228],"different":[229],"on":[231],"variation":[233],"particular,":[240],"variability":[241,280],"receptor,":[244],"Ras,":[245],"Raf,":[246],"MEK":[248],"strongly":[249,269],"others":[254],"did":[255],"not.":[256],"Overall,":[257],"our":[258],"response":[265],"driven":[270],"function":[286],"nodes,":[289],"may":[291],"contribute":[292],"pathogenesis":[295],"human":[297],"diseases.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-01-15T23:16:33.117629","created_date":"2025-10-10T00:00:00"}
