{"id":"https://openalex.org/W2550724046","doi":"https://doi.org/10.1371/journal.pcbi.1005205","title":"An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production","display_name":"An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production","publication_year":2016,"publication_date":"2016-11-17","ids":{"openalex":"https://openalex.org/W2550724046","doi":"https://doi.org/10.1371/journal.pcbi.1005205","mag":"2550724046","pmid":"https://pubmed.ncbi.nlm.nih.gov/27855161"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005205","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005205","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005205&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005205&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088031450","display_name":"Adaoha Ihekwaba","orcid":"https://orcid.org/0000-0003-2787-7286"},"institutions":[{"id":"https://openalex.org/I3018370718","display_name":"Quadram Institute","ror":"https://ror.org/04td3ys19","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799693246","https://openalex.org/I3018370718","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Adaoha E. C. Ihekwaba","raw_affiliation_strings":["Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom","institution_ids":["https://openalex.org/I2799300731","https://openalex.org/I3018370718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076828229","display_name":"Iv\u00e1n Mura","orcid":"https://orcid.org/0000-0001-5549-0324"},"institutions":[{"id":"https://openalex.org/I162096671","display_name":"Universidad de Los Andes","ror":"https://ror.org/02mhbdp94","country_code":"CO","type":"education","lineage":["https://openalex.org/I162096671"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Ivan Mura","raw_affiliation_strings":["Department of Industrial Engineering, Universidad de los Andes, Bogot\u00e1, Colombia"],"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, Universidad de los Andes, Bogot\u00e1, Colombia","institution_ids":["https://openalex.org/I162096671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084275170","display_name":"John Walshaw","orcid":"https://orcid.org/0000-0002-9357-469X"},"institutions":[{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]},{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]},{"id":"https://openalex.org/I3018370718","display_name":"Quadram Institute","ror":"https://ror.org/04td3ys19","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799693246","https://openalex.org/I3018370718","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Walshaw","raw_affiliation_strings":["Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom","School of Computing Sciences, University of East Anglia, Norwich, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom","institution_ids":["https://openalex.org/I2799300731","https://openalex.org/I3018370718"]},{"raw_affiliation_string":"School of Computing Sciences, University of East Anglia, Norwich, United Kingdom","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039017980","display_name":"Michael W. Peck","orcid":"https://orcid.org/0000-0002-7993-0125"},"institutions":[{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]},{"id":"https://openalex.org/I3018370718","display_name":"Quadram Institute","ror":"https://ror.org/04td3ys19","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799693246","https://openalex.org/I3018370718","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael W. Peck","raw_affiliation_strings":["Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom","institution_ids":["https://openalex.org/I2799300731","https://openalex.org/I3018370718"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085303986","display_name":"Gary C. Barker","orcid":"https://orcid.org/0000-0003-1844-6257"},"institutions":[{"id":"https://openalex.org/I3018370718","display_name":"Quadram Institute","ror":"https://ror.org/04td3ys19","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799693246","https://openalex.org/I3018370718","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gary C. Barker","raw_affiliation_strings":["Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom","institution_ids":["https://openalex.org/I2799300731","https://openalex.org/I3018370718"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076828229","https://openalex.org/A5088031450"],"corresponding_institution_ids":["https://openalex.org/I162096671","https://openalex.org/I2799300731","https://openalex.org/I3018370718"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3335,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.8152177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"11","first_page":"e1005205","last_page":"e1005205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulism","display_name":"Botulism","score":0.7685985565185547},{"id":"https://openalex.org/keywords/clostridium-botulinum","display_name":"Clostridium botulinum","score":0.750206708908081},{"id":"https://openalex.org/keywords/toxin","display_name":"Toxin","score":0.5709232091903687},{"id":"https://openalex.org/keywords/neurotoxin","display_name":"Neurotoxin","score":0.5124676823616028},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4672513008117676},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4496772289276123},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4334193170070648},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23490846157073975},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18760168552398682},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13288521766662598}],"concepts":[{"id":"https://openalex.org/C2779186577","wikidata":"https://www.wikidata.org/wiki/Q154865","display_name":"Botulism","level":2,"score":0.7685985565185547},{"id":"https://openalex.org/C2777010668","wikidata":"https://www.wikidata.org/wiki/Q131268","display_name":"Clostridium botulinum","level":3,"score":0.750206708908081},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5709232091903687},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.5124676823616028},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4672513008117676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4496772289276123},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4334193170070648},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23490846157073975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18760168552398682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13288521766662598},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047013","descriptor_name":"Clostridium botulinum type A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005205","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005205","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005205&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27855161","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27855161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:ueaeprints.uea.ac.uk:61596","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:b31355ecdeb440448104c80aa4b5e391","is_oa":true,"landing_page_url":"https://doaj.org/article/b31355ecdeb440448104c80aa4b5e391","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 11, p e1005205 (2016)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5113860","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5113860","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005205","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005205","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005205&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G5320101875","display_name":null,"funder_award_id":"J004529","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6516974564","display_name":null,"funder_award_id":"BBS/E/F/00044401","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6700059501","display_name":null,"funder_award_id":"BBS/E/F/00044407","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8714263259","display_name":null,"funder_award_id":"BB/J004529/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2550724046.pdf","grobid_xml":"https://content.openalex.org/works/W2550724046.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W31718483","https://openalex.org/W159636843","https://openalex.org/W1483437518","https://openalex.org/W1536878917","https://openalex.org/W1539337342","https://openalex.org/W1563585372","https://openalex.org/W1649931880","https://openalex.org/W1879538049","https://openalex.org/W1918147071","https://openalex.org/W1963588379","https://openalex.org/W1969532190","https://openalex.org/W1969789782","https://openalex.org/W1970561932","https://openalex.org/W1971621552","https://openalex.org/W1975299202","https://openalex.org/W1979356143","https://openalex.org/W1981764249","https://openalex.org/W1987516070","https://openalex.org/W1997608510","https://openalex.org/W1999744038","https://openalex.org/W2006762969","https://openalex.org/W2006904100","https://openalex.org/W2011465236","https://openalex.org/W2017685580","https://openalex.org/W2018363788","https://openalex.org/W2018992929","https://openalex.org/W2028619968","https://openalex.org/W2029255761","https://openalex.org/W2034437013","https://openalex.org/W2035545621","https://openalex.org/W2038477730","https://openalex.org/W2045061466","https://openalex.org/W2046316608","https://openalex.org/W2047066109","https://openalex.org/W2048148658","https://openalex.org/W2050109821","https://openalex.org/W2059718574","https://openalex.org/W2060643562","https://openalex.org/W2066375562","https://openalex.org/W2072999122","https://openalex.org/W2074929645","https://openalex.org/W2075449190","https://openalex.org/W2075844222","https://openalex.org/W2082349641","https://openalex.org/W2088213270","https://openalex.org/W2091631416","https://openalex.org/W2092332746","https://openalex.org/W2094506363","https://openalex.org/W2100370202","https://openalex.org/W2102653059","https://openalex.org/W2102705532","https://openalex.org/W2102970572","https://openalex.org/W2107093868","https://openalex.org/W2109144121","https://openalex.org/W2115554472","https://openalex.org/W2120172405","https://openalex.org/W2121439235","https://openalex.org/W2128591134","https://openalex.org/W2133247037","https://openalex.org/W2133479189","https://openalex.org/W2138163322","https://openalex.org/W2151445754","https://openalex.org/W2163917981","https://openalex.org/W2165833997","https://openalex.org/W2205430043","https://openalex.org/W2229218125","https://openalex.org/W2291075227","https://openalex.org/W2415112924","https://openalex.org/W2495129654","https://openalex.org/W4234291014","https://openalex.org/W4253393884","https://openalex.org/W7034517369"],"related_works":["https://openalex.org/W2160081225","https://openalex.org/W2605850300","https://openalex.org/W2998458153","https://openalex.org/W4235298720","https://openalex.org/W2153029252","https://openalex.org/W2019937395","https://openalex.org/W2098806042","https://openalex.org/W2108780469","https://openalex.org/W2606522623","https://openalex.org/W1763461541"],"abstract_inverted_index":{"Clostridium":[0],"botulinum":[1,3,17,63,137,184],"produces":[2],"neurotoxins":[4],"(BoNTs),":[5],"highly":[6],"potent":[7],"substances":[8],"responsible":[9],"for":[10,57,135,175,227,235],"botulism.":[11],"Currently,":[12],"mathematical":[13,198],"models":[14],"of":[15,72,87,98,154,165,171,182,191,197,207,230],"C.":[16,62,136,183],"growth":[18],"and":[19,27,47,93,100,115,125,179,221],"toxigenesis":[20],"are":[21,109,116],"largely":[22],"aimed":[23],"at":[24,104,157,200],"risk":[25],"assessment":[26],"do":[28],"not":[29],"include":[30],"explicit":[31],"genetic":[32],"information":[33,74],"beyond":[34],"group":[35],"level":[36],"but":[37],"integrate":[38,126],"many":[39],"component":[40],"processes,":[41],"such":[42],"as":[43,111,204],"signalling,":[44],"membrane":[45],"permeability":[46],"metabolic":[48],"activity.":[49],"In":[50],"this":[51,192],"paper":[52],"we":[53,122],"present":[54],"a":[55,143,163,205],"scheme":[56],"modelling":[58,199],"neurotoxin":[59],"production":[60,86,156,229],"in":[61,80,132,210],"Group":[64,138,185],"I":[65,139,186],"type":[66,140,178,187],"A1,":[67],"based":[68],"on":[69,90],"the":[70,81,91,96,105,133,149,158,195,201,228],"integration":[71],"diverse":[73],"coming":[75],"from":[76],"experimental":[77,173],"results":[78],"available":[79],"literature.":[82],"Experiments":[83],"show":[84],"that":[85,214,232],"BoNTs":[88],"depends":[89],"growth-phase":[92],"is":[94,233],"under":[95],"control":[97],"positive":[99],"negative":[101],"regulatory":[102,128],"elements":[103,129],"intracellular":[106],"level.":[107,160],"Toxins":[108],"released":[110],"large":[112],"protein":[113],"complexes":[114],"associated":[117],"with":[118],"non-toxic":[119],"components.":[120],"Here,":[121],"systematically":[123],"review":[124],"those":[127],"previously":[130],"described":[131],"literature":[134],"A1":[141],"into":[142],"population":[144],"dynamics":[145],"model,":[146],"to":[147,218,224],"build":[148],"very":[150],"first":[151],"computational":[152],"model":[153,167],"toxin":[155,231],"molecular":[159],"We":[161],"conduct":[162],"validation":[164],"our":[166],"against":[168],"several":[169],"items":[170],"published":[172],"data":[174],"different":[176],"wild":[177],"mutant":[180],"strains":[181],"A1.":[188],"The":[189],"result":[190],"process":[193],"underscores":[194],"potential":[196],"cellular":[202],"level,":[203],"means":[206],"creating":[208],"opportunities":[209],"developing":[211],"new":[212],"strategies":[213],"could":[215],"be":[216],"used":[217,234],"prevent":[219],"botulism;":[220],"potentially":[222],"contribute":[223],"improved":[225],"methods":[226],"therapeutics.":[236]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-11T14:59:36.786465","created_date":"2025-10-10T00:00:00"}