{"id":"https://openalex.org/W2555867792","doi":"https://doi.org/10.1371/journal.pcbi.1005197","title":"The Environment Shapes the Inner Vestibule of LeuT","display_name":"The Environment Shapes the Inner Vestibule of LeuT","publication_year":2016,"publication_date":"2016-11-11","ids":{"openalex":"https://openalex.org/W2555867792","doi":"https://doi.org/10.1371/journal.pcbi.1005197","mag":"2555867792","pmid":"https://pubmed.ncbi.nlm.nih.gov/27835643"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005197","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005197","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005197&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005197&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062076530","display_name":"Azmat Sohail","orcid":null},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Azmat Sohail","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051240927","display_name":"Kumaresan Jayaraman","orcid":"https://orcid.org/0000-0002-4891-5571"},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Kumaresan Jayaraman","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111985161","display_name":"Santhoshkannan Venkatesan","orcid":null},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Santhoshkannan Venkatesan","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041215173","display_name":"Kamil Gotfryd","orcid":"https://orcid.org/0000-0002-0299-0779"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kamil Gotfryd","raw_affiliation_strings":["University of Copenhagen, Faculty of Health Sciences Denmark, Department of Biomedical Sciences, Copenhagen, Denmark","University of Copenhagen, Faculty of Health and Medical Sciences Denmark, Department of Neuroscience and Pharmacology, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen, Faculty of Health Sciences Denmark, Department of Biomedical Sciences, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Copenhagen, Faculty of Health and Medical Sciences Denmark, Department of Neuroscience and Pharmacology, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016231055","display_name":"Markus Daerr","orcid":null},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Daerr","raw_affiliation_strings":["Ludwig Maximilians University Munich, Department of Pharmacy, Center of Drug Research, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Maximilians University Munich, Department of Pharmacy, Center of Drug Research, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070435563","display_name":"Ulrik Gether","orcid":"https://orcid.org/0000-0002-0020-3807"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ulrik Gether","raw_affiliation_strings":["University of Copenhagen, Faculty of Health and Medical Sciences Denmark, Department of Neuroscience and Pharmacology, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen, Faculty of Health and Medical Sciences Denmark, Department of Neuroscience and Pharmacology, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088331047","display_name":"Claus J. L\u00f8land","orcid":"https://orcid.org/0000-0002-1773-1446"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claus J. Loland","raw_affiliation_strings":["University of Copenhagen, Faculty of Health and Medical Sciences Denmark, Department of Neuroscience and Pharmacology, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen, Faculty of Health and Medical Sciences Denmark, Department of Neuroscience and Pharmacology, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039007961","display_name":"Klaus T. Wanner","orcid":"https://orcid.org/0000-0003-4399-1425"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus T. Wanner","raw_affiliation_strings":["Ludwig Maximilians University Munich, Department of Pharmacy, Center of Drug Research, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Maximilians University Munich, Department of Pharmacy, Center of Drug Research, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060360807","display_name":"Michael Freissmuth","orcid":"https://orcid.org/0000-0001-9398-1765"},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michael Freissmuth","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0001-9398-1765","affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079264101","display_name":"Harald H. Sitte","orcid":"https://orcid.org/0000-0002-1339-7444"},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Harald H. Sitte","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-1339-7444","affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086541043","display_name":"Walter Sandtner","orcid":"https://orcid.org/0000-0003-3637-260X"},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Walter Sandtner","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038910133","display_name":"Thomas Stockner","orcid":"https://orcid.org/0000-0002-7071-8283"},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Stockner","raw_affiliation_strings":["Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5079264101"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2113,"currency":"EUR","value_usd":2278},"fwci":1.5667,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84073025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"11","first_page":"e1005197","last_page":"e1005197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aquifex-aeolicus","display_name":"Aquifex aeolicus","score":0.9460480213165283},{"id":"https://openalex.org/keywords/neurotransmitter-transporter","display_name":"Neurotransmitter transporter","score":0.8214802742004395},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.7099379301071167},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6388216018676758},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.550270140171051},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5466530323028564},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.5448347330093384},{"id":"https://openalex.org/keywords/helix","display_name":"Helix (gastropod)","score":0.523421049118042},{"id":"https://openalex.org/keywords/synaptic-cleft","display_name":"Synaptic cleft","score":0.48652857542037964},{"id":"https://openalex.org/keywords/bilayer","display_name":"Bilayer","score":0.47113269567489624},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.43494173884391785},{"id":"https://openalex.org/keywords/neurotransmitter","display_name":"Neurotransmitter","score":0.4019644856452942},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.3926629424095154},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3789752125740051},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24597737193107605},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13474366068840027},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.12585213780403137},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.06548315286636353}],"concepts":[{"id":"https://openalex.org/C2777400929","wikidata":"https://www.wikidata.org/wiki/Q4034249","display_name":"Aquifex aeolicus","level":4,"score":0.9460480213165283},{"id":"https://openalex.org/C16696662","wikidata":"https://www.wikidata.org/wiki/Q17079236","display_name":"Neurotransmitter transporter","level":4,"score":0.8214802742004395},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.7099379301071167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6388216018676758},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.550270140171051},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5466530323028564},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5448347330093384},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.523421049118042},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.48652857542037964},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.47113269567489624},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.43494173884391785},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.4019644856452942},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3926629424095154},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3789752125740051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24597737193107605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13474366068840027},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.12585213780403137},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06548315286636353},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050479","descriptor_name":"Neurotransmitter Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005197","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005197","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005197&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27835643","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27835643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:df1deda31b4c4be3b4346ef9e659d1d0","is_oa":true,"landing_page_url":"https://doaj.org/article/df1deda31b4c4be3b4346ef9e659d1d0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 11, p e1005197 (2016)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:37465","is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-37465-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology","raw_type":"doc-type:article"},{"id":"pmh:oai:figshare.com:article/4231220","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Environment_Shapes_the_Inner_Vestibule_of_LeuT/4231220","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5105988","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5105988","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/81555015-f13a-439e-840d-5606d5cd330c","is_oa":true,"landing_page_url":"https://curis.ku.dk/portal/da/publications/the-environment-shapes-the-inner-vestibule-of-leut(81555015-f13a-439e-840d-5606d5cd330c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005197","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005197","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005197&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8700000047683716,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G202517312","display_name":null,"funder_award_id":"CM1306","funder_id":"https://openalex.org/F4320320366","funder_display_name":"European Cooperation in Science and Technology"},{"id":"https://openalex.org/G3723022085","display_name":null,"funder_award_id":"F3524","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3769513776","display_name":null,"funder_award_id":"F3506","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G4395245066","display_name":null,"funder_award_id":"0602-02100B","funder_id":"https://openalex.org/F4320322928","funder_display_name":"Danmarks Frie Forskningsfond"},{"id":"https://openalex.org/G5053374963","display_name":"Molecular Drug Targets","funder_award_id":"W1232","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G5488786026","display_name":null,"funder_award_id":"R108-A10755","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G8400391810","display_name":null,"funder_award_id":"F3510","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320320366","display_name":"European Cooperation in Science and Technology","ror":"https://ror.org/01bstzn19"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320322928","display_name":"Danmarks Frie Forskningsfond","ror":"https://ror.org/02sptwz63"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2555867792.pdf","grobid_xml":"https://content.openalex.org/works/W2555867792.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1579841613","https://openalex.org/W1867249393","https://openalex.org/W1964628514","https://openalex.org/W1970124769","https://openalex.org/W1972107705","https://openalex.org/W1980384899","https://openalex.org/W1980843573","https://openalex.org/W1982240205","https://openalex.org/W1982970909","https://openalex.org/W1985176332","https://openalex.org/W1985903963","https://openalex.org/W1997279293","https://openalex.org/W1997432723","https://openalex.org/W1999613945","https://openalex.org/W2000739851","https://openalex.org/W2002580946","https://openalex.org/W2009818941","https://openalex.org/W2016892586","https://openalex.org/W2017058666","https://openalex.org/W2020717114","https://openalex.org/W2021317870","https://openalex.org/W2028294447","https://openalex.org/W2029980462","https://openalex.org/W2032245417","https://openalex.org/W2035266068","https://openalex.org/W2036856449","https://openalex.org/W2039597629","https://openalex.org/W2044092676","https://openalex.org/W2046520759","https://openalex.org/W2054881399","https://openalex.org/W2056488018","https://openalex.org/W2056632893","https://openalex.org/W2057477511","https://openalex.org/W2058981075","https://openalex.org/W2063933464","https://openalex.org/W2067174909","https://openalex.org/W2067662902","https://openalex.org/W2073139135","https://openalex.org/W2073623394","https://openalex.org/W2080769511","https://openalex.org/W2081260116","https://openalex.org/W2084290194","https://openalex.org/W2086564171","https://openalex.org/W2091153506","https://openalex.org/W2091260123","https://openalex.org/W2093110330","https://openalex.org/W2095083074","https://openalex.org/W2103945336","https://openalex.org/W2104622728","https://openalex.org/W2112154906","https://openalex.org/W2114520383","https://openalex.org/W2123148213","https://openalex.org/W2124518597","https://openalex.org/W2128572087","https://openalex.org/W2129495111","https://openalex.org/W2131790216","https://openalex.org/W2160544821","https://openalex.org/W2164892580","https://openalex.org/W2171043072","https://openalex.org/W2179576161","https://openalex.org/W2227181960","https://openalex.org/W2245403965","https://openalex.org/W2315787811","https://openalex.org/W6685511074","https://openalex.org/W7073691207"],"related_works":["https://openalex.org/W2091220997","https://openalex.org/W2555867792","https://openalex.org/W2057516615","https://openalex.org/W1986078734","https://openalex.org/W1969304491","https://openalex.org/W2104622728","https://openalex.org/W2164192718","https://openalex.org/W2740620087","https://openalex.org/W2097985571","https://openalex.org/W2058981075"],"abstract_inverted_index":{"Human":[0],"neurotransmitter":[1,16],"transporters":[2],"are":[3],"found":[4,26],"in":[5,27,32,46,77,140],"the":[6,19,38,85,90,98,132,147],"nervous":[7],"system":[8],"terminating":[9],"synaptic":[10,20],"signals":[11],"by":[12,110,115,125],"rapid":[13],"removal":[14],"of":[15,41,61,89,97,108,120],"molecules":[17],"from":[18,143,146],"cleft.":[21],"The":[22,81],"homologous":[23],"transporter":[24],"LeuT,":[25],"Aquifex":[28],"aeolicus,":[29],"was":[30,75,113],"crystallized":[31],"different":[33,137],"conformations.":[34],"Here,":[35],"we":[36],"investigated":[37],"inward-open":[39,138],"state":[40],"LeuT.":[42],"We":[43],"compared":[44],"LeuT":[45,63],"membranes":[47],"and":[48,54,67,84],"micelles":[49],"using":[50],"molecular":[51],"dynamics":[52],"simulations":[53],"lanthanide-based":[55],"resonance":[56],"energy":[57,103,118],"transfer":[58],"(LRET).":[59],"Simulations":[60],"micelle-solubilized":[62],"revealed":[64],"a":[65,78,116,135],"stable":[66],"widely":[68],"open":[69],"inward-facing":[70],"conformation.":[71],"However,":[72],"this":[73],"conformation":[74,139],"unstable":[76],"membrane":[79,100],"environment.":[80],"helix":[82,93],"dipole":[83],"charged":[86],"amino":[87],"acid":[88],"first":[91],"transmembrane":[92],"(TM1A)":[94],"partitioned":[95],"out":[96],"hydrophobic":[99],"core.":[101],"Free":[102],"calculations":[104],"showed":[105,127],"that":[106,144],"movement":[107],"TM1A":[109,128],"0.30":[111],"nm":[112],"driven":[114],"free":[117],"difference":[119],"~15":[121],"kJ/mol.":[122],"Distance":[123],"measurements":[124],"LRET":[126],"movements,":[129],"consistent":[130],"with":[131],"simulations,":[133],"confirming":[134],"substantially":[136],"lipid":[141],"bilayer":[142],"inferred":[145],"crystal":[148],"structure.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
