{"id":"https://openalex.org/W2552144059","doi":"https://doi.org/10.1371/journal.pcbi.1005188","title":"Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay","display_name":"Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay","publication_year":2016,"publication_date":"2016-11-16","ids":{"openalex":"https://openalex.org/W2552144059","doi":"https://doi.org/10.1371/journal.pcbi.1005188","mag":"2552144059","pmid":"https://pubmed.ncbi.nlm.nih.gov/27851764"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005188","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005188","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005188&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005188&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029015158","display_name":"Adam Prasanphanich","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam F. Prasanphanich","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103922163","display_name":"Douglas E. White","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas E. White","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020961934","display_name":"Margaret A. Gran","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Gran","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048778639","display_name":"Melissa L. Kemp","orcid":"https://orcid.org/0000-0003-3781-8802"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melissa L. Kemp","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3781-8802","affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5048778639"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I2802612298"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7885,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76683014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"11","first_page":"e1005188","last_page":"e1005188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9776999950408936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9664999842643738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transporter","display_name":"Transporter","score":0.7230572700500488},{"id":"https://openalex.org/keywords/side-population","display_name":"Side population","score":0.7176509499549866},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.6572632789611816},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6404586434364319},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6072574853897095},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5152626037597656},{"id":"https://openalex.org/keywords/differential-staining","display_name":"Differential staining","score":0.4680335819721222},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.41682377457618713},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3462068736553192},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.25801169872283936},{"id":"https://openalex.org/keywords/cancer-stem-cell","display_name":"Cancer stem cell","score":0.25711023807525635},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.21632713079452515},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17102789878845215},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0828315019607544},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07059362530708313}],"concepts":[{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.7230572700500488},{"id":"https://openalex.org/C2780546549","wikidata":"https://www.wikidata.org/wiki/Q7508338","display_name":"Side population","level":4,"score":0.7176509499549866},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6572632789611816},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6404586434364319},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6072574853897095},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5152626037597656},{"id":"https://openalex.org/C173372395","wikidata":"https://www.wikidata.org/wiki/Q5275365","display_name":"Differential staining","level":3,"score":0.4680335819721222},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41682377457618713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3462068736553192},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25801169872283936},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.25711023807525635},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21632713079452515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17102789878845215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0828315019607544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07059362530708313},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005188","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005188","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005188&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27851764","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27851764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1005188","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005188","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8d5cf0b512e841ab9345ef0788830a76","is_oa":true,"landing_page_url":"https://doaj.org/article/8d5cf0b512e841ab9345ef0788830a76","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 11, p e1005188 (2016)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5113006","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5113006","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005188","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005188","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005188&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.550000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G6229840961","display_name":null,"funder_award_id":"1DP2OD006483","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2552144059.pdf","grobid_xml":"https://content.openalex.org/works/W2552144059.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W1434327692","https://openalex.org/W1483167997","https://openalex.org/W1534586188","https://openalex.org/W1546135534","https://openalex.org/W1560682235","https://openalex.org/W1568323318","https://openalex.org/W1602048773","https://openalex.org/W1647333222","https://openalex.org/W1750652828","https://openalex.org/W1767073733","https://openalex.org/W1922793792","https://openalex.org/W1964881422","https://openalex.org/W1965747780","https://openalex.org/W1966166667","https://openalex.org/W1967069846","https://openalex.org/W1967330678","https://openalex.org/W1969589143","https://openalex.org/W1973070600","https://openalex.org/W1976501995","https://openalex.org/W1976915106","https://openalex.org/W1980829537","https://openalex.org/W1988214015","https://openalex.org/W1989124411","https://openalex.org/W1992668691","https://openalex.org/W1994105833","https://openalex.org/W1994526050","https://openalex.org/W1996991816","https://openalex.org/W1998655034","https://openalex.org/W2004128999","https://openalex.org/W2004294595","https://openalex.org/W2004588854","https://openalex.org/W2008453541","https://openalex.org/W2010728401","https://openalex.org/W2012101115","https://openalex.org/W2012885846","https://openalex.org/W2014562331","https://openalex.org/W2014731896","https://openalex.org/W2015780328","https://openalex.org/W2022606789","https://openalex.org/W2023590177","https://openalex.org/W2025914422","https://openalex.org/W2026402231","https://openalex.org/W2026579395","https://openalex.org/W2037768790","https://openalex.org/W2039768312","https://openalex.org/W2039844852","https://openalex.org/W2041029553","https://openalex.org/W2042158497","https://openalex.org/W2045443814","https://openalex.org/W2046792018","https://openalex.org/W2049378696","https://openalex.org/W2051870121","https://openalex.org/W2056751212","https://openalex.org/W2059256473","https://openalex.org/W2059312700","https://openalex.org/W2060651470","https://openalex.org/W2062703811","https://openalex.org/W2066382432","https://openalex.org/W2070145385","https://openalex.org/W2071982425","https://openalex.org/W2074420260","https://openalex.org/W2076174476","https://openalex.org/W2077046573","https://openalex.org/W2077223423","https://openalex.org/W2078321432","https://openalex.org/W2090513410","https://openalex.org/W2091773228","https://openalex.org/W2094296176","https://openalex.org/W2100488521","https://openalex.org/W2105546352","https://openalex.org/W2108349673","https://openalex.org/W2112599840","https://openalex.org/W2117149968","https://openalex.org/W2117543305","https://openalex.org/W2121504505","https://openalex.org/W2127013070","https://openalex.org/W2137956382","https://openalex.org/W2142024216","https://openalex.org/W2142459000","https://openalex.org/W2144134201","https://openalex.org/W2148386985","https://openalex.org/W2154548288","https://openalex.org/W2167960944","https://openalex.org/W2168392730","https://openalex.org/W2168471377","https://openalex.org/W2170632492","https://openalex.org/W2174049160","https://openalex.org/W2613805784","https://openalex.org/W4235958526","https://openalex.org/W4236871280","https://openalex.org/W4237124975"],"related_works":["https://openalex.org/W2413690952","https://openalex.org/W161898803","https://openalex.org/W1980162086","https://openalex.org/W4242441811","https://openalex.org/W2036473521","https://openalex.org/W2008849624","https://openalex.org/W2060561756","https://openalex.org/W2036174425","https://openalex.org/W983725980","https://openalex.org/W1982083328"],"abstract_inverted_index":{"The":[0,42],"side":[1],"population":[2,61],"(SP)":[3],"assay,":[4],"a":[5,60,145,154,162,202,234],"technique":[6],"used":[7],"in":[8,23,78,107,112,195,201,212],"cancer":[9],"and":[10,26,33,90,114,132,179,207,227],"stem":[11],"cell":[12,35,98,159,164,182],"research,":[13],"assesses":[14],"the":[15,24,45,50,65,82,96,142,170,174,205,213,216],"activity":[16,70,178,199,236,243],"of":[17,28,44,68,125,144,149,173,176,204,215,233,241,251],"ABC":[18],"transporters":[19],"on":[20,71,181],"Hoechst":[21],"staining":[22,40,72,99,160,210],"presence":[25],"absence":[27],"transporter":[29,69,177,198,235,242],"inhibition,":[30],"identifying":[31],"SP":[32,121,131,136,186,190,226],"non-SP":[34],"(NSP)":[36],"subpopulations":[37],"by":[38],"differential":[39,97,209],"intensity.":[41,73],"interpretation":[43,148],"assay":[46,187],"is":[47,138],"complicated":[48],"because":[49],"transporter-mediated":[51,88],"mechanisms":[52],"fail":[53],"to":[54],"account":[55],"for":[56,95,169,192,221],"cell-to-cell":[57],"variability":[58],"within":[59,161],"or":[62],"adequately":[63],"control":[64],"direct":[66,171],"role":[67,175],"We":[74,104],"hypothesized":[75],"that":[76,100,118,135,157,239],"differences":[77],"dye":[79],"kinetics":[80],"at":[81,230],"single-cell":[83,222],"level,":[84],"such":[85],"as":[86,244,246],"ABCG2":[87],"efflux":[89],"DNA":[91,247],"binding,":[92],"are":[93,249],"responsible":[94],"demarcates":[101],"SP/NSP":[102,150,252],"identity.":[103,253],"report":[105],"changes":[106],"A549":[108],"phenotype":[109],"during":[110],"time":[111],"culture":[113],"with":[115,120],"TGF\u03b2":[116],"treatment":[117],"correlate":[119],"size.":[122],"Clonal":[123],"expansion":[124],"individually":[126],"sorted":[127],"cells":[128,206,229],"re-established":[129],"both":[130,231],"NSPs,":[133],"indicating":[134],"membership":[137],"dynamic.":[139],"To":[140],"assess":[141],"validity":[143],"purely":[146],"kinetics-based":[147],"identity,":[151],"we":[152,224],"developed":[153],"computational":[155],"approach":[156,220],"simulated":[158,185],"heterogeneous":[163],"population;":[165],"this":[166],"exercise":[167],"allowed":[168],"inference":[172],"inhibition":[180],"staining.":[183],"Our":[184],"yielded":[188],"appropriate":[189],"responses":[191],"kinetic":[193],"scenarios":[194],"which":[196],"high":[197],"existed":[200],"portion":[203],"little":[208],"occurred":[211],"majority":[214],"population.":[217],"With":[218],"our":[219],"analysis,":[223],"observed":[225],"NSP":[228],"ends":[232],"continuum,":[237],"demonstrating":[238],"features":[240],"well":[245],"content":[248],"determinants":[250]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}