{"id":"https://openalex.org/W2231782838","doi":"https://doi.org/10.1371/journal.pcbi.1005179","title":"Fundamental Activity Constraints Lead to Specific Interpretations of the Connectome","display_name":"Fundamental Activity Constraints Lead to Specific Interpretations of the Connectome","publication_year":2017,"publication_date":"2017-02-01","ids":{"openalex":"https://openalex.org/W2231782838","doi":"https://doi.org/10.1371/journal.pcbi.1005179","mag":"2231782838","pmid":"https://pubmed.ncbi.nlm.nih.gov/28146554"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005179&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079443284","display_name":"Jannis Schuecker","orcid":"https://orcid.org/0000-0001-6203-1126"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210133912","display_name":"J\u00fclich Aachen Research Alliance","ror":"https://ror.org/02r0e4r58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I4210133912"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jannis Schuecker","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758","https://openalex.org/I4210133912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023077945","display_name":"Maximilian Schmidt","orcid":"https://orcid.org/0000-0003-1040-2567"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210133912","display_name":"J\u00fclich Aachen Research Alliance","ror":"https://ror.org/02r0e4r58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I4210133912"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Schmidt","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758","https://openalex.org/I4210133912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063638455","display_name":"Sacha J. van Albada","orcid":"https://orcid.org/0000-0003-0682-4855"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210133912","display_name":"J\u00fclich Aachen Research Alliance","ror":"https://ror.org/02r0e4r58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I4210133912"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sacha J. van Albada","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758","https://openalex.org/I4210133912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043692408","display_name":"Markus Diesmann","orcid":"https://orcid.org/0000-0002-2308-5727"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210133912","display_name":"J\u00fclich Aachen Research Alliance","ror":"https://ror.org/02r0e4r58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I4210133912"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Diesmann","raw_affiliation_strings":["Department of Physics, Faculty 1, RWTH Aachen University, Aachen, Germany","Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany","Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Faculty 1, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758","https://openalex.org/I4210133912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032616213","display_name":"Moritz Helias","orcid":"https://orcid.org/0000-0002-0404-8656"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210133912","display_name":"J\u00fclich Aachen Research Alliance","ror":"https://ror.org/02r0e4r58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I4210133912"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Moritz Helias","raw_affiliation_strings":["Department of Physics, Faculty 1, RWTH Aachen University, Aachen, Germany","Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Faculty 1, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, J\u00fclich Research Centre, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758","https://openalex.org/I4210133912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079443284"],"corresponding_institution_ids":["https://openalex.org/I171892758","https://openalex.org/I4210133912"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2108,"currency":"EUR","value_usd":2273},"fwci":1.8206,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.84385347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"e1005179","last_page":"e1005179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7128896713256836},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.5388073921203613},{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.5384781956672668},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4764814078807831},{"id":"https://openalex.org/keywords/network-dynamics","display_name":"Network dynamics","score":0.4460603892803192},{"id":"https://openalex.org/keywords/network-model","display_name":"Network model","score":0.4417825937271118},{"id":"https://openalex.org/keywords/macaque","display_name":"Macaque","score":0.42212679982185364},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.41144871711730957},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40713128447532654},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.30802154541015625},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.281941294670105},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.22830989956855774},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10815379023551941},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10776534676551819}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7128896713256836},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.5388073921203613},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.5384781956672668},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4764814078807831},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.4460603892803192},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.4417825937271118},{"id":"https://openalex.org/C2778950215","wikidata":"https://www.wikidata.org/wiki/Q177601","display_name":"Macaque","level":2,"score":0.42212679982185364},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.41144871711730957},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40713128447532654},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30802154541015625},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.281941294670105},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.22830989956855774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10815379023551941},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10776534676551819},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005074","descriptor_name":"Evoked Potentials, Visual","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005074","descriptor_name":"Evoked Potentials, Visual","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005074","descriptor_name":"Evoked Potentials, Visual","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014796","descriptor_name":"Visual Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014796","descriptor_name":"Visual Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014796","descriptor_name":"Visual Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1005179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:28146554","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28146554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1509.03162","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1509.03162","pdf_url":"https://arxiv.org/pdf/1509.03162","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1005179","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005179","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4a0bb2ac7f704e51a9db384c77e411e0","is_oa":true,"landing_page_url":"https://doaj.org/article/4a0bb2ac7f704e51a9db384c77e411e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 13, Iss 2, p e1005179 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4172018","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5287462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:juser.fz-juelich.de:827437","is_oa":true,"landing_page_url":"http://juser.fz-juelich.de/record/827437","pdf_url":null,"source":{"id":"https://openalex.org/S4306401090","display_name":"JuSER (Forschungszentrum J\u00fclich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I171892758","host_organization_name":"Forschungszentrum J\u00fclich","host_organization_lineage":["https://openalex.org/I171892758"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology 13(2), e1005179 - (2017). doi:10.1371/journal.pcbi.1005179","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publications.rwth-aachen.de:687874","is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/record/687874","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology 13(2), e1005179 (2017). doi:10.1371/journal.pcbi.1005179","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1095062678","display_name":"The Human Brain Project","funder_award_id":"604102","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2609499171","display_name":null,"funder_award_id":"VH-NG- 1028","funder_id":"https://openalex.org/F4320320876","funder_display_name":"Helmholtz-Gemeinschaft"},{"id":"https://openalex.org/G3218930219","display_name":"Brain-inspired multiscale computation in neuromorphic hybrid systems","funder_award_id":"269921","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G398560324","display_name":"Human Brain Project Specific Grant Agreement 1","funder_award_id":"720270","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320876","display_name":"Helmholtz-Gemeinschaft","ror":"https://ror.org/0281dp749"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2231782838.pdf","grobid_xml":"https://content.openalex.org/works/W2231782838.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1190410299","https://openalex.org/W1246381107","https://openalex.org/W1514853588","https://openalex.org/W1536357320","https://openalex.org/W1582051163","https://openalex.org/W1825637327","https://openalex.org/W1963789865","https://openalex.org/W1967437213","https://openalex.org/W1973272857","https://openalex.org/W1978171511","https://openalex.org/W1978927740","https://openalex.org/W1981268055","https://openalex.org/W1986014504","https://openalex.org/W1988334437","https://openalex.org/W1993665893","https://openalex.org/W2002627566","https://openalex.org/W2006546731","https://openalex.org/W2008284899","https://openalex.org/W2012529953","https://openalex.org/W2013155738","https://openalex.org/W2027063265","https://openalex.org/W2031703351","https://openalex.org/W2033710332","https://openalex.org/W2035457380","https://openalex.org/W2044613381","https://openalex.org/W2046699283","https://openalex.org/W2046878543","https://openalex.org/W2050492453","https://openalex.org/W2052061512","https://openalex.org/W2054296371","https://openalex.org/W2054549571","https://openalex.org/W2063840511","https://openalex.org/W2067990176","https://openalex.org/W2070246276","https://openalex.org/W2076642833","https://openalex.org/W2083798523","https://openalex.org/W2085989895","https://openalex.org/W2090067353","https://openalex.org/W2094225088","https://openalex.org/W2096629297","https://openalex.org/W2098580305","https://openalex.org/W2106365733","https://openalex.org/W2106529987","https://openalex.org/W2109234859","https://openalex.org/W2110344324","https://openalex.org/W2111177605","https://openalex.org/W2112151839","https://openalex.org/W2113345172","https://openalex.org/W2113669112","https://openalex.org/W2115292289","https://openalex.org/W2116680601","https://openalex.org/W2119899403","https://openalex.org/W2120259469","https://openalex.org/W2131416538","https://openalex.org/W2135207361","https://openalex.org/W2135908272","https://openalex.org/W2137228404","https://openalex.org/W2142329149","https://openalex.org/W2145687948","https://openalex.org/W2151542182","https://openalex.org/W2153113253","https://openalex.org/W2160239507","https://openalex.org/W2162270152","https://openalex.org/W2162515722","https://openalex.org/W2163218780","https://openalex.org/W2168202614","https://openalex.org/W2168336873","https://openalex.org/W2189007715","https://openalex.org/W2222721727","https://openalex.org/W2287067416","https://openalex.org/W2289997072","https://openalex.org/W2293265110","https://openalex.org/W2337311206","https://openalex.org/W2384550918","https://openalex.org/W2404400936","https://openalex.org/W2585198072","https://openalex.org/W2605543710","https://openalex.org/W2770344141","https://openalex.org/W2797638056","https://openalex.org/W2801179766","https://openalex.org/W2963720877","https://openalex.org/W4245564453","https://openalex.org/W4300223101","https://openalex.org/W4302078450","https://openalex.org/W6647604917","https://openalex.org/W6667392280","https://openalex.org/W7000791799","https://openalex.org/W7053011049"],"related_works":["https://openalex.org/W2357501381","https://openalex.org/W4393584224","https://openalex.org/W4398184957","https://openalex.org/W3135209450","https://openalex.org/W3023551525","https://openalex.org/W4389115607","https://openalex.org/W2021210734","https://openalex.org/W2047439469","https://openalex.org/W2767044922","https://openalex.org/W2516414717"],"abstract_inverted_index":{"The":[0,180,201],"continuous":[1],"integration":[2],"of":[3,9,16,42,60,78,104,117,125,130,134,166,184],"experimental":[4,35,50],"data":[5,51,197],"into":[6,114],"coherent":[7],"models":[8,20,41],"the":[10,30,58,72,76,79,87,105,115,122,131,145,167,173,185],"brain":[11,53],"is":[12],"an":[13,178],"increasing":[14],"challenge":[15],"modern":[17],"neuroscience.":[18],"Such":[19],"provide":[21],"a":[22,101,126,213],"bridge":[23],"between":[24],"structure":[25,168],"and":[26,28,91,150,160,192,198],"activity,":[27,146],"identify":[29],"mechanisms":[31,88],"giving":[32],"rise":[33],"to":[34,57,110,156,177,188,206],"observations.":[36],"Nevertheless,":[37],"structurally":[38],"realistic":[39,93,158],"network":[40,128,174,186],"spiking":[43],"neurons":[44],"are":[45,55,169],"necessarily":[46],"underconstrained":[47],"even":[48],"if":[49],"on":[52,82,144],"connectivity":[54],"incorporated":[56],"best":[59],"our":[61],"knowledge.":[62],"Guided":[63],"by":[64,137],"physiological":[65],"observations,":[66],"any":[67,209],"model":[68,118,129,211],"must":[69],"therefore":[70],"explore":[71],"parameter":[73],"ranges":[74],"within":[75],"uncertainty":[77],"data.":[80],"Based":[81],"simulation":[83],"results":[84],"alone,":[85],"however,":[86],"underlying":[89],"stable":[90],"physiologically":[92],"activity":[94,112],"often":[95],"remain":[96],"obscure.":[97],"We":[98,120],"here":[99],"employ":[100],"mean-field":[102],"reduction":[103],"dynamics,":[106],"which":[107],"allows":[108],"us":[109],"include":[111],"constraints":[113,143],"process":[116],"construction.":[119],"shape":[121],"phase":[123],"space":[124],"multi-scale":[127],"vision-related":[132],"areas":[133],"macaque":[135],"cortex":[136],"systematically":[138],"refining":[139],"its":[140,189],"connectivity.":[141],"Fundamental":[142],"i.e.,":[147],"prohibiting":[148],"quiescence":[149],"requiring":[151],"global":[152],"stability,":[153],"prove":[154],"sufficient":[155],"obtain":[157],"layer-":[159],"area-specific":[161],"activity.":[162],"Only":[163],"small":[164],"adaptations":[165],"required,":[170],"showing":[171],"that":[172],"operates":[175],"close":[176],"instability.":[179],"procedure":[181],"identifies":[182],"components":[183],"critical":[187],"collective":[190],"dynamics":[191],"creates":[193],"hypotheses":[194],"for":[195],"structural":[196],"future":[199],"experiments.":[200],"method":[202],"can":[203],"be":[204],"applied":[205],"networks":[207],"involving":[208],"neuron":[210],"with":[212],"known":[214],"gain":[215],"function.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}