{"id":"https://openalex.org/W2340724314","doi":"https://doi.org/10.1371/journal.pcbi.1005129","title":"Optimized Treatment Schedules for Chronic Myeloid Leukemia","display_name":"Optimized Treatment Schedules for Chronic Myeloid Leukemia","publication_year":2016,"publication_date":"2016-10-20","ids":{"openalex":"https://openalex.org/W2340724314","doi":"https://doi.org/10.1371/journal.pcbi.1005129","mag":"2340724314","pmid":"https://pubmed.ncbi.nlm.nih.gov/27764087"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005129","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005129","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005129&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005129&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102788103","display_name":"Qie He","orcid":"https://orcid.org/0000-0001-7405-0295"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qie He","raw_affiliation_strings":["Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024226315","display_name":"Junfeng Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junfeng Zhu","raw_affiliation_strings":["Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-6561-3647","affiliations":[{"raw_affiliation_string":"Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007747233","display_name":"David Dingli","orcid":"https://orcid.org/0000-0001-7477-3004"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Dingli","raw_affiliation_strings":["Department of Hematology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035234146","display_name":"Jasmine Foo","orcid":"https://orcid.org/0000-0001-8238-325X"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jasmine Foo","raw_affiliation_strings":["Department of Mathematics, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075829177","display_name":"Kevin Leder","orcid":"https://orcid.org/0000-0001-9192-7829"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin Zox Leder","raw_affiliation_strings":["Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5035234146","https://openalex.org/A5075829177","https://openalex.org/A5102788103"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3666,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82356633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"12","issue":"10","first_page":"e1005129","last_page":"e1005129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dasatinib","display_name":"Dasatinib","score":0.7539533376693726},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7440112829208374},{"id":"https://openalex.org/keywords/nilotinib","display_name":"Nilotinib","score":0.6566002368927002},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.5391296744346619},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"Combination therapy","score":0.5222419500350952},{"id":"https://openalex.org/keywords/imatinib","display_name":"Imatinib","score":0.5131807923316956},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4471057057380676},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.38977470993995667},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2705722749233246},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07735511660575867}],"concepts":[{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.7539533376693726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7440112829208374},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.6566002368927002},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5391296744346619},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5222419500350952},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.5131807923316956},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4471057057380676},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38977470993995667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2705722749233246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07735511660575867},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005129","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005129","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005129&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27764087","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27764087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1604.04913","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1604.04913","pdf_url":"https://arxiv.org/pdf/1604.04913","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3134e0b145c5469b9dad92a1b05f267c","is_oa":true,"landing_page_url":"https://doaj.org/article/3134e0b145c5469b9dad92a1b05f267c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 10, p e1005129 (2016)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5072565","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5072565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005129","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005129","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005129&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"awards":[{"id":"https://openalex.org/G106860712","display_name":null,"funder_award_id":"DMS-1224362","funder_id":"https://openalex.org/F4320337380","funder_display_name":"Division of Mathematical Sciences"},{"id":"https://openalex.org/G1290757170","display_name":"New Mathematical Models for Optimal Anti-Cancer Therapy","funder_award_id":"1362236","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1718818588","display_name":null,"funder_award_id":"DMS-1349724","funder_id":"https://openalex.org/F4320337380","funder_display_name":"Division of Mathematical Sciences"},{"id":"https://openalex.org/G2516804138","display_name":"Understanding stochasticity in cancer recurrence timing","funder_award_id":"1224362","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3386730155","display_name":null,"funder_award_id":"1362236","funder_id":"https://openalex.org/F4320337391","funder_display_name":"Division of Civil, Mechanical and Manufacturing Innovation"},{"id":"https://openalex.org/G3675057276","display_name":null,"funder_award_id":"CMMI-1362236","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G554772991","display_name":null,"funder_award_id":"CMMI-1362236","funder_id":"https://openalex.org/F4320337391","funder_display_name":"Division of Civil, Mechanical and Manufacturing Innovation"},{"id":"https://openalex.org/G6179319079","display_name":null,"funder_award_id":"1552764","funder_id":"https://openalex.org/F4320337391","funder_display_name":"Division of Civil, Mechanical and Manufacturing Innovation"},{"id":"https://openalex.org/G750410376","display_name":null,"funder_award_id":"DMS-1224362","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8217975892","display_name":null,"funder_award_id":"CMMI-1552764","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8467438166","display_name":"CAREER: Rare Events in Cancer Evolution","funder_award_id":"1552764","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2340724314.pdf","grobid_xml":"https://content.openalex.org/works/W2340724314.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1552094772","https://openalex.org/W1567204338","https://openalex.org/W1968143987","https://openalex.org/W1970135399","https://openalex.org/W1977785806","https://openalex.org/W1980473329","https://openalex.org/W1985090267","https://openalex.org/W2004492241","https://openalex.org/W2008933596","https://openalex.org/W2012962381","https://openalex.org/W2017848065","https://openalex.org/W2031658816","https://openalex.org/W2050948710","https://openalex.org/W2051728915","https://openalex.org/W2055502046","https://openalex.org/W2060085351","https://openalex.org/W2066848036","https://openalex.org/W2067443700","https://openalex.org/W2079547747","https://openalex.org/W2080000401","https://openalex.org/W2083937970","https://openalex.org/W2107268345","https://openalex.org/W2118913158","https://openalex.org/W2133670229","https://openalex.org/W2146658081","https://openalex.org/W2154856176","https://openalex.org/W2163329109","https://openalex.org/W2223423195","https://openalex.org/W2408132225","https://openalex.org/W2798566347","https://openalex.org/W4249832303","https://openalex.org/W4302615404","https://openalex.org/W6632961146","https://openalex.org/W6724904386","https://openalex.org/W7073965107"],"related_works":["https://openalex.org/W1992121712","https://openalex.org/W2763572665","https://openalex.org/W2890336441","https://openalex.org/W2314058894","https://openalex.org/W2150962457","https://openalex.org/W2163329109","https://openalex.org/W2025422981","https://openalex.org/W2056917031","https://openalex.org/W1963599260","https://openalex.org/W2360725119"],"abstract_inverted_index":{"Over":[0],"the":[1,81,100,110,132,140,159,178,209],"past":[2],"decade,":[3],"several":[4],"targeted":[5,78],"therapies":[6,86,137],"(e.g.":[7],"imatinib,":[8],"dasatinib,":[9],"nilotinib)":[10],"have":[11,37],"been":[12],"developed":[13],"to":[14,24,67,72,105,130,145,158,186],"treat":[15],"Chronic":[16],"Myeloid":[17],"Leukemia":[18],"(CML).":[19],"Despite":[20],"an":[21,91,127],"initial":[22],"response":[23,104,185],"therapy,":[25],"drug":[26,173],"resistance":[27,40],"remains":[28,90],"a":[29,49,74],"problem":[30,129,154],"for":[31],"some":[32],"CML":[33,103,143],"patients.":[34],"Recent":[35],"studies":[36],"shown":[38],"that":[39,42,55,193],"mutations":[41],"preexist":[43],"treatment":[44,62,69,114,117,197],"can":[45],"be":[46,58],"detected":[47],"in":[48,119,184,208],"substantial":[50],"number":[51],"of":[52,76,83,102,112,135,142,161,180],"patients,":[53,201],"and":[54,108,166],"this":[56,95],"may":[57],"associated":[59],"with":[60,121],"eventual":[61],"failure.":[63],"One":[64],"proposed":[65],"method":[66],"extend":[68],"efficacy":[70,118],"is":[71,155],"use":[73],"combination":[75,85,106,113,191],"multiple":[77,136],"therapies.":[79],"However,":[80],"design":[82],"such":[84],"(timing,":[87],"sequence,":[88],"etc.)":[89],"open":[92],"challenge.":[93],"In":[94],"work":[96],"we":[97],"mathematically":[98],"model":[99,170],"dynamics":[101,179],"therapy":[107],"analyze":[109],"impact":[111],"schedules":[115],"on":[116,139,199],"patients":[120],"preexisting":[122],"resistance.":[123],"We":[124,188],"then":[125],"propose":[126],"optimization":[128,153],"find":[131],"best":[133],"schedule":[134],"based":[138],"evolution":[141],"according":[144],"our":[146],"ordinary":[147,162],"differential":[148],"equation":[149,164],"model.":[150],"This":[151],"resulting":[152],"nontrivial":[156],"due":[157],"presence":[160],"different":[163],"constraints":[165,175],"integer":[167],"variables.":[168],"Our":[169],"also":[171],"incorporates":[172],"toxicity":[174],"by":[176],"tracking":[177],"patient":[181],"neutrophil":[182],"counts":[183],"therapy.":[187],"determine":[189],"optimal":[190],"strategies":[192],"maximize":[194],"time":[195],"until":[196],"failure":[198],"hypothetical":[200],"using":[202],"parameters":[203],"estimated":[204],"from":[205],"clinical":[206],"data":[207],"literature.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}