{"id":"https://openalex.org/W2529752180","doi":"https://doi.org/10.1371/journal.pcbi.1005126","title":"Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study","display_name":"Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study","publication_year":2016,"publication_date":"2016-10-07","ids":{"openalex":"https://openalex.org/W2529752180","doi":"https://doi.org/10.1371/journal.pcbi.1005126","mag":"2529752180","pmid":"https://pubmed.ncbi.nlm.nih.gov/27716775"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005126","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005126","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005126&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005126&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023993925","display_name":"Lauren J. Dupuis","orcid":"https://orcid.org/0000-0003-2606-3045"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Lauren J. Dupuis","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-2606-3045","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034213745","display_name":"Joost Lumens","orcid":"https://orcid.org/0000-0001-8129-7384"},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210086115","display_name":"Electrophysiology and Heart Modeling Institute","ror":"https://ror.org/00jsv7j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210086115"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Joost Lumens","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","Universit\u00e9 de Bordeaux, LIRYC L'Institut de Rythmologie et Mod\u00e9lisation Cardiaque, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Universit\u00e9 de Bordeaux, LIRYC L'Institut de Rythmologie et Mod\u00e9lisation Cardiaque, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210086115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019378102","display_name":"Theo Arts","orcid":"https://orcid.org/0000-0003-0223-8496"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theo Arts","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080175953","display_name":"Tammo Delhaas","orcid":"https://orcid.org/0000-0001-6897-9700"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tammo Delhaas","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023993925"],"corresponding_institution_ids":["https://openalex.org/I34352273"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.661,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.85918688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"12","issue":"10","first_page":"e1005126","last_page":"e1005126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcomere","display_name":"Sarcomere","score":0.9511171579360962},{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.7837250828742981},{"id":"https://openalex.org/keywords/tropomyosin","display_name":"Tropomyosin","score":0.6998236775398254},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.6941360235214233},{"id":"https://openalex.org/keywords/cardiac-muscle","display_name":"Cardiac muscle","score":0.594517707824707},{"id":"https://openalex.org/keywords/troponin","display_name":"Troponin","score":0.5800955891609192},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.579174280166626},{"id":"https://openalex.org/keywords/contraction","display_name":"Contraction (grammar)","score":0.5539268851280212},{"id":"https://openalex.org/keywords/protein-filament","display_name":"Protein filament","score":0.5176001787185669},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"Muscle contraction","score":0.4949416518211365},{"id":"https://openalex.org/keywords/troponin-c","display_name":"Troponin C","score":0.47832727432250977},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4636813998222351},{"id":"https://openalex.org/keywords/tension","display_name":"Tension (geology)","score":0.45496541261672974},{"id":"https://openalex.org/keywords/myofilament","display_name":"Myofilament","score":0.4124303162097931},{"id":"https://openalex.org/keywords/myocyte","display_name":"Myocyte","score":0.3834517002105713},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.2788565158843994},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.27364641427993774},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.26158952713012695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15610766410827637},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14969423413276672},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12506189942359924},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.07990258932113647},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07436344027519226},{"id":"https://openalex.org/keywords/compression","display_name":"Compression (physics)","score":0.0668688714504242},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.06478345394134521}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.9511171579360962},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.7837250828742981},{"id":"https://openalex.org/C205875245","wikidata":"https://www.wikidata.org/wiki/Q418454","display_name":"Tropomyosin","level":3,"score":0.6998236775398254},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6941360235214233},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.594517707824707},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.5800955891609192},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.579174280166626},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5539268851280212},{"id":"https://openalex.org/C14228908","wikidata":"https://www.wikidata.org/wiki/Q2920483","display_name":"Protein filament","level":2,"score":0.5176001787185669},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.4949416518211365},{"id":"https://openalex.org/C133927893","wikidata":"https://www.wikidata.org/wiki/Q4383200","display_name":"Troponin C","level":4,"score":0.47832727432250977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4636813998222351},{"id":"https://openalex.org/C186068551","wikidata":"https://www.wikidata.org/wiki/Q13255585","display_name":"Tension (geology)","level":3,"score":0.45496541261672974},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.4124303162097931},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.3834517002105713},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2788565158843994},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.27364641427993774},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26158952713012695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15610766410827637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14969423413276672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12506189942359924},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07990258932113647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07436344027519226},{"id":"https://openalex.org/C180016635","wikidata":"https://www.wikidata.org/wiki/Q2712821","display_name":"Compression (physics)","level":2,"score":0.0668688714504242},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06478345394134521},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020409","descriptor_name":"Molecular Motor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020409","descriptor_name":"Molecular Motor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020409","descriptor_name":"Molecular Motor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020409","descriptor_name":"Molecular Motor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020409","descriptor_name":"Molecular Motor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020409","descriptor_name":"Molecular Motor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1005126","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005126","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005126&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27716775","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27716775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/ac428f7d-9b06-44bd-b772-dbab57f168d6","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/ac428f7d-9b06-44bd-b772-dbab57f168d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dupuis, L J, Lumens, J, Arts, T & Delhaas, T 2016, 'Mechano-chemical Interactions in Cardiac Sarcomere Contraction : A Computational Modeling Study', PLoS Computational Biology, vol. 12, no. 10. https://doi.org/10.1371/journal.pcbi.1005126","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:5055322","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5055322","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1005126","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005126","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:750b21538fd542748e8d2a048fceb632","is_oa":true,"landing_page_url":"https://doaj.org/article/750b21538fd542748e8d2a048fceb632","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 10, p e1005126 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4002906","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Mechano-chemical_Interactions_in_Cardiac_Sarcomere_Contraction_A_Computational_Modeling_Study/4002906","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005126","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005126","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005126&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8500000238418579,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G1864516712","display_name":null,"funder_award_id":"2012T010","funder_id":"https://openalex.org/F4320321642","funder_display_name":"Hartstichting"}],"funders":[{"id":"https://openalex.org/F4320321642","display_name":"Hartstichting","ror":"https://ror.org/05nxhgm70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2529752180.pdf","grobid_xml":"https://content.openalex.org/works/W2529752180.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W588526523","https://openalex.org/W1200736547","https://openalex.org/W1550330933","https://openalex.org/W1615913735","https://openalex.org/W1901823973","https://openalex.org/W1968778374","https://openalex.org/W1973738031","https://openalex.org/W1981414344","https://openalex.org/W1989461632","https://openalex.org/W1992331713","https://openalex.org/W1992924616","https://openalex.org/W1993451622","https://openalex.org/W1996288114","https://openalex.org/W2003031432","https://openalex.org/W2006998430","https://openalex.org/W2009599957","https://openalex.org/W2014383313","https://openalex.org/W2019201408","https://openalex.org/W2019718894","https://openalex.org/W2021655720","https://openalex.org/W2025469050","https://openalex.org/W2038112396","https://openalex.org/W2065278823","https://openalex.org/W2070967303","https://openalex.org/W2078148011","https://openalex.org/W2079905044","https://openalex.org/W2090182122","https://openalex.org/W2091776886","https://openalex.org/W2093572356","https://openalex.org/W2097949661","https://openalex.org/W2104043477","https://openalex.org/W2107954466","https://openalex.org/W2139565971","https://openalex.org/W2145077702","https://openalex.org/W2158284790","https://openalex.org/W2159453909","https://openalex.org/W2163508440","https://openalex.org/W2165535734","https://openalex.org/W2169400659","https://openalex.org/W2170842924","https://openalex.org/W2242726375","https://openalex.org/W2276337236","https://openalex.org/W4235081531"],"related_works":["https://openalex.org/W1979286094","https://openalex.org/W2079130687","https://openalex.org/W2782843407","https://openalex.org/W2102036742","https://openalex.org/W2012305640","https://openalex.org/W2914415696","https://openalex.org/W2026461827","https://openalex.org/W4312988498","https://openalex.org/W2017443949","https://openalex.org/W2055982439"],"abstract_inverted_index":{"We":[0,71],"developed":[1,117],"a":[2,35,44,78,95,118,123],"model":[3,120,181],"of":[4,65,81,98,108,125,130,195,204],"cardiac":[5,14,18],"sarcomere":[6,134],"contraction":[7,19],"to":[8,43,84,171,191],"study":[9],"the":[10,56,63,67,73,85,102,106,154,160,168,175,180,184,192,196,201],"calcium-tension":[11],"relationship":[12],"in":[13,38,47,101,121,137,144,159],"muscle.":[15],"Calcium":[16],"mediates":[17],"through":[20],"its":[21],"interactions":[22],"with":[23,147,186],"troponin":[24],"(Tn)":[25],"and":[26,128,133],"subsequently":[27],"tropomyosin":[28],"molecules.":[29],"Experimental":[30],"studies":[31],"have":[32],"shown":[33],"that":[34,55,75,88,156,183],"slight":[36],"increase":[37,46,58],"intracellular":[39],"calcium":[40,109,131,173],"concentration":[41,132,203],"leads":[42],"rapid":[45,57],"sarcomeric":[48],"tension.":[49,139,150],"Though":[50],"it":[51],"is":[52,59,69,89],"widely":[53],"accepted":[54],"not":[60],"possible":[61],"without":[62],"concept":[64],"cooperativity,":[66],"mechanism":[68],"debated.":[70],"use":[72],"hypothesis":[74,155],"there":[76],"exists":[77],"base":[79],"level":[80,97],"cooperativity":[82],"intrinsic":[83],"thin":[86,103,161],"filament":[87,104,162],"boosted":[90],"by":[91,166],"mechanical":[92,99],"tension,":[93,188],"i.e.":[94,189],"high":[96,157],"tension":[100,158],"impedes":[105,163],"unbinding":[107],"from":[110,174],"Tn.":[111,176],"To":[112],"test":[113],"these":[114],"hypotheses,":[115],"we":[116],"computational":[119],"which":[122],"set":[124],"three":[126],"parameters":[127],"inputs":[129],"length":[135],"result":[136],"output":[138],"Tension":[140],"as":[141],"simulated":[142],"appeared":[143],"good":[145],"agreement":[146],"experimentally":[148],"measured":[149],"Our":[151],"results":[152],"support":[153],"Tn":[164],"deactivation":[165],"increasing":[167],"energy":[169],"required":[170],"detach":[172],"Given":[177],"this":[178],"hypothesis,":[179],"predicted":[182],"areas":[185],"highest":[187],"closest":[190],"Z-disk":[193],"end":[194],"single":[197],"overlap":[198],"region,":[199],"show":[200],"largest":[202],"active":[205],"Tn's.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
