{"id":"https://openalex.org/W2559001160","doi":"https://doi.org/10.1371/journal.pcbi.1005122","title":"Macromolecular Crowding Regulates the Gene Expression Profile by Limiting Diffusion","display_name":"Macromolecular Crowding Regulates the Gene Expression Profile by Limiting Diffusion","publication_year":2016,"publication_date":"2016-11-28","ids":{"openalex":"https://openalex.org/W2559001160","doi":"https://doi.org/10.1371/journal.pcbi.1005122","mag":"2559001160","pmid":"https://pubmed.ncbi.nlm.nih.gov/27893768"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005122","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1005122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071702389","display_name":"Mahdi Golkaram","orcid":"https://orcid.org/0000-0002-8981-0047"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mahdi Golkaram","raw_affiliation_strings":["Department of Mechanical Engineering, University of California, Santa Barbara, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of California, Santa Barbara, California, United States of America","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062472918","display_name":"Stefan Hellander","orcid":null},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Hellander","raw_affiliation_strings":["Department of Computer Science, University of California, Santa Barbara, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, California, United States of America","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048416905","display_name":"Brian Drawert","orcid":"https://orcid.org/0000-0002-0543-8189"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Drawert","raw_affiliation_strings":["Department of Computer Science, University of California, Santa Barbara, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, California, United States of America","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021640058","display_name":"Linda Petzold","orcid":"https://orcid.org/0000-0001-6251-6078"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda R. Petzold","raw_affiliation_strings":["Department of Computer Science, University of California, Santa Barbara, California, United States of America","Department of Mechanical Engineering, University of California, Santa Barbara, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Santa Barbara, California, United States of America","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of California, Santa Barbara, California, United States of America","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071702389"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.2447,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.88324478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"11","first_page":"e1005122","last_page":"e1005122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macromolecular-crowding","display_name":"Macromolecular crowding","score":0.9082628488540649},{"id":"https://openalex.org/keywords/crowding","display_name":"Crowding","score":0.7235111594200134},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6600608825683594},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.6467317342758179},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5519424080848694},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.525375247001648},{"id":"https://openalex.org/keywords/macromolecule","display_name":"Macromolecule","score":0.3924689292907715},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.34266090393066406},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.32692858576774597},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32235243916511536},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3064808249473572},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.08799701929092407}],"concepts":[{"id":"https://openalex.org/C181990884","wikidata":"https://www.wikidata.org/wiki/Q11396092","display_name":"Macromolecular crowding","level":3,"score":0.9082628488540649},{"id":"https://openalex.org/C149333683","wikidata":"https://www.wikidata.org/wiki/Q5189188","display_name":"Crowding","level":2,"score":0.7235111594200134},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6600608825683594},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6467317342758179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5519424080848694},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.525375247001648},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.3924689292907715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34266090393066406},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32692858576774597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32235243916511536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3064808249473572},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08799701929092407},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1005122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005122","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27893768","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27893768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1005122","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005122","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4b1f62b6c8fe400db06f6b401e94ac94","is_oa":true,"landing_page_url":"https://doaj.org/article/4b1f62b6c8fe400db06f6b401e94ac94","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 11, p e1005122 (2016)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt59x7m45h","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/59x7m45h","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 12, iss 11","raw_type":"article"},{"id":"pmh:oai:osti.gov:1345287","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1345287","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1423941","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1423941","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5125560","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:qt59x7m45h","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/59x7m45h","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Golkaram, M; Hellander, S; Drawert, B; & Petzold, LR. (2016). Macromolecular Crowding Regulates the Gene Expression Profile by Limiting Diffusion. PLOS COMPUTATIONAL BIOLOGY, 12(11), e1005122. doi: 10.1371/journal.pcbi.1005122. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/59x7m45h","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005122","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.5199999809265137}],"awards":[{"id":"https://openalex.org/G1052905512","display_name":null,"funder_award_id":"R01-EB014877","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1115769823","display_name":null,"funder_award_id":"W911NF-09-0001","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G1909066449","display_name":null,"funder_award_id":"R01GM113241","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3289994172","display_name":null,"funder_award_id":"R01 EB014877","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G385765661","display_name":null,"funder_award_id":"R01-GM113241","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4181972126","display_name":null,"funder_award_id":"GM113241","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4950536974","display_name":null,"funder_award_id":"-0001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5030867871","display_name":"Collaborative Research: Next-Generation Algorithms for Stochastic Spatial Simulation of Cell Polarization","funder_award_id":"1001012","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5284602366","display_name":"HIGH PERFORMANCE ALGORITHMS FOR DISCRETE STOCHASTIC SIMULATION","funder_award_id":"DESC0008975","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G663763901","display_name":null,"funder_award_id":"DMS-1001012","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1770591670","https://openalex.org/W1977771126","https://openalex.org/W1984543814","https://openalex.org/W1986419282","https://openalex.org/W1988377264","https://openalex.org/W1988498168","https://openalex.org/W1988791304","https://openalex.org/W1994706449","https://openalex.org/W1995012220","https://openalex.org/W1998477338","https://openalex.org/W2000342325","https://openalex.org/W2003470745","https://openalex.org/W2003771679","https://openalex.org/W2010295908","https://openalex.org/W2017676413","https://openalex.org/W2027615985","https://openalex.org/W2035753075","https://openalex.org/W2039569152","https://openalex.org/W2040889971","https://openalex.org/W2044692345","https://openalex.org/W2047614519","https://openalex.org/W2060872711","https://openalex.org/W2067432938","https://openalex.org/W2068978083","https://openalex.org/W2074142433","https://openalex.org/W2077046573","https://openalex.org/W2078201066","https://openalex.org/W2078723335","https://openalex.org/W2081298797","https://openalex.org/W2081588627","https://openalex.org/W2085223420","https://openalex.org/W2091198609","https://openalex.org/W2100879474","https://openalex.org/W2104680358","https://openalex.org/W2104763072","https://openalex.org/W2107342968","https://openalex.org/W2110804923","https://openalex.org/W2110823478","https://openalex.org/W2111510713","https://openalex.org/W2115368299","https://openalex.org/W2117915703","https://openalex.org/W2118020555","https://openalex.org/W2122087743","https://openalex.org/W2123971246","https://openalex.org/W2124924107","https://openalex.org/W2130419960","https://openalex.org/W2131187223","https://openalex.org/W2134859821","https://openalex.org/W2137088684","https://openalex.org/W2138825607","https://openalex.org/W2143826692","https://openalex.org/W2145006655","https://openalex.org/W2146447332","https://openalex.org/W2149242848","https://openalex.org/W2157457604","https://openalex.org/W2165591265","https://openalex.org/W2167287693","https://openalex.org/W2171280873","https://openalex.org/W2171327609","https://openalex.org/W2174499708","https://openalex.org/W2315200889","https://openalex.org/W2321801137","https://openalex.org/W2324607131","https://openalex.org/W2329601201","https://openalex.org/W2340241948","https://openalex.org/W2962740627","https://openalex.org/W2963911376","https://openalex.org/W3103927232","https://openalex.org/W3105895233","https://openalex.org/W4211018930"],"related_works":["https://openalex.org/W2160718357","https://openalex.org/W592281890","https://openalex.org/W2047443826","https://openalex.org/W2005674839","https://openalex.org/W2409577334","https://openalex.org/W1770591670","https://openalex.org/W2007779811","https://openalex.org/W2124068105","https://openalex.org/W2972716842","https://openalex.org/W2155342128"],"abstract_inverted_index":{"We":[0,76],"seek":[1],"to":[2,24,64,82],"elucidate":[3],"the":[4,46,99,102,111,118,144,153,158,161],"role":[5,48],"of":[6,45,49,101,113,157],"macromolecular":[7,50,60,92],"crowding":[8,61,93,124,133],"in":[9,19,30,66,70,105,147,160],"transcription":[10,114],"and":[11,28,122],"translation.":[12],"It":[13,52],"is":[14],"well":[15,151],"known":[16],"that":[17,59,91,123,143],"stochasticity":[18],"gene":[20,26,67],"expression":[21,27],"can":[22,53,62,163],"lead":[23,63],"differential":[25],"heterogeneity":[29],"a":[31,71,78,106,165],"cell":[32,74,107,167],"population.":[33,75,168],"Recent":[34],"experimental":[35],"observations":[36,58],"by":[37,98,109,125,134],"Tan":[38],"et":[39],"al.":[40],"have":[41],"improved":[42],"our":[43,138],"understanding":[44],"functional":[47],"crowding.":[51],"be":[54],"inferred":[55],"from":[56],"their":[57],"robustness":[65],"expression,":[68],"resulting":[69],"more":[72,130],"homogeneous":[73],"introduce":[77],"spatial":[79],"stochastic":[80],"model":[81],"provide":[83,141],"insight":[84],"into":[85],"this":[86],"process.":[87],"Our":[88],"results":[89,140],"show":[90],"reduces":[94,128],"noise":[95,129],"(as":[96],"measured":[97],"kurtosis":[100],"mRNA":[103],"distribution)":[104],"population":[108],"limiting":[110],"diffusion":[112],"factors":[115],"(i.e.":[116],"removing":[117],"unstable":[119],"intermediate":[120],"states),":[121],"large":[126],"molecules":[127],"efficiently":[131],"than":[132],"small":[135],"molecules.":[136],"Finally,":[137],"simulation":[139],"evidence":[142],"local":[145],"variation":[146],"chromatin":[148,159],"density":[149],"as":[150,152],"total":[154],"volume":[155],"exclusion":[156],"nucleus":[162],"induce":[164],"homogenous":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2016-12-08T00:00:00"}