{"id":"https://openalex.org/W2532282002","doi":"https://doi.org/10.1371/journal.pcbi.1005087","title":"A Parsimonious Model of the Rabbit Action Potential Elucidates the Minimal Physiological Requirements for Alternans and Spiral Wave Breakup","display_name":"A Parsimonious Model of the Rabbit Action Potential Elucidates the Minimal Physiological Requirements for Alternans and Spiral Wave Breakup","publication_year":2016,"publication_date":"2016-10-17","ids":{"openalex":"https://openalex.org/W2532282002","doi":"https://doi.org/10.1371/journal.pcbi.1005087","mag":"2532282002","pmid":"https://pubmed.ncbi.nlm.nih.gov/27749895"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005087","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005087","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005087&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005087&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013310955","display_name":"Richard A. Gray","orcid":"https://orcid.org/0000-0003-2798-6378"},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I39565521","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08","country_code":"US","type":"government","lineage":["https://openalex.org/I1330989302","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard A. Gray","raw_affiliation_strings":["Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2798-6378","affiliations":[{"raw_affiliation_string":"Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States of America","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072917093","display_name":"Pras Pathmanathan","orcid":"https://orcid.org/0000-0003-2111-6689"},"institutions":[{"id":"https://openalex.org/I1335686170","display_name":"Center for Devices and Radiological Health","ror":"https://ror.org/007x9se63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1335686170"]},{"id":"https://openalex.org/I39565521","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08","country_code":"US","type":"government","lineage":["https://openalex.org/I1330989302","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pras Pathmanathan","raw_affiliation_strings":["Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2111-6689","affiliations":[{"raw_affiliation_string":"Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States of America","institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013310955"],"corresponding_institution_ids":["https://openalex.org/I1335686170","https://openalex.org/I39565521"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.9787,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92117696,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"10","first_page":"e1005087","last_page":"e1005087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9753999710083008,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breakup","display_name":"Breakup","score":0.693331241607666},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5890971422195435},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.5803120732307434},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.554487407207489},{"id":"https://openalex.org/keywords/voltage-clamp","display_name":"Voltage clamp","score":0.4872080683708191},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"Cardiac electrophysiology","score":0.4708772599697113},{"id":"https://openalex.org/keywords/refractory-period","display_name":"Refractory period","score":0.46046823263168335},{"id":"https://openalex.org/keywords/spiral-wave","display_name":"Spiral wave","score":0.44242122769355774},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.4327564537525177},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.3967648148536682},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3755306601524353},{"id":"https://openalex.org/keywords/spiral","display_name":"Spiral (railway)","score":0.36675718426704407},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3648809790611267},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.3573892116546631},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3375367522239685},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30837512016296387},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20649045705795288},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10693302750587463}],"concepts":[{"id":"https://openalex.org/C2777871205","wikidata":"https://www.wikidata.org/wiki/Q100926628","display_name":"Breakup","level":2,"score":0.693331241607666},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5890971422195435},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.5803120732307434},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.554487407207489},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.4872080683708191},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.4708772599697113},{"id":"https://openalex.org/C70616116","wikidata":"https://www.wikidata.org/wiki/Q1736732","display_name":"Refractory period","level":2,"score":0.46046823263168335},{"id":"https://openalex.org/C2777485032","wikidata":"https://www.wikidata.org/wiki/Q22908993","display_name":"Spiral wave","level":3,"score":0.44242122769355774},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4327564537525177},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3967648148536682},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3755306601524353},{"id":"https://openalex.org/C174128100","wikidata":"https://www.wikidata.org/wiki/Q846907","display_name":"Spiral (railway)","level":2,"score":0.36675718426704407},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3648809790611267},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.3573892116546631},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3375367522239685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30837512016296387},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20649045705795288},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10693302750587463},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1005087","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005087","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005087&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27749895","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27749895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1005087","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005087","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:fc7a1d59f8ec415b845c44105bb40bcc","is_oa":true,"landing_page_url":"https://doaj.org/article/fc7a1d59f8ec415b845c44105bb40bcc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 10, p e1005087 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4039641","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Parsimonious_Model_of_the_Rabbit_Action_Potential_Elucidates_the_Minimal_Physiological_Requirements_for_Alternans_and_Spiral_Wave_Breakup/4039641","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:5066986","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5066986","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005087","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005087","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005087&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.47999998927116394}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2532282002.pdf","grobid_xml":"https://content.openalex.org/works/W2532282002.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1569110296","https://openalex.org/W1575021701","https://openalex.org/W1583128097","https://openalex.org/W1835542263","https://openalex.org/W1933285794","https://openalex.org/W1953269516","https://openalex.org/W1971060829","https://openalex.org/W1972081273","https://openalex.org/W1974668957","https://openalex.org/W1976104097","https://openalex.org/W1982054477","https://openalex.org/W1982140992","https://openalex.org/W1984336411","https://openalex.org/W1985940938","https://openalex.org/W1986023817","https://openalex.org/W1986200470","https://openalex.org/W1992983955","https://openalex.org/W2002172163","https://openalex.org/W2009549127","https://openalex.org/W2010739041","https://openalex.org/W2017853278","https://openalex.org/W2023177578","https://openalex.org/W2024157977","https://openalex.org/W2028146834","https://openalex.org/W2028685719","https://openalex.org/W2042316811","https://openalex.org/W2053151923","https://openalex.org/W2073736747","https://openalex.org/W2077331262","https://openalex.org/W2078344772","https://openalex.org/W2080148075","https://openalex.org/W2080959388","https://openalex.org/W2081547734","https://openalex.org/W2091866393","https://openalex.org/W2093497167","https://openalex.org/W2098044063","https://openalex.org/W2101556468","https://openalex.org/W2111716749","https://openalex.org/W2117765582","https://openalex.org/W2119899260","https://openalex.org/W2123292612","https://openalex.org/W2123858305","https://openalex.org/W2129514645","https://openalex.org/W2130321115","https://openalex.org/W2133041530","https://openalex.org/W2133719258","https://openalex.org/W2139852988","https://openalex.org/W2142929645","https://openalex.org/W2144360453","https://openalex.org/W2145982578","https://openalex.org/W2156871072","https://openalex.org/W2161023180","https://openalex.org/W2161260161","https://openalex.org/W2164321130","https://openalex.org/W2167903785","https://openalex.org/W2301270528","https://openalex.org/W2400043273","https://openalex.org/W3106463402","https://openalex.org/W6673813488"],"related_works":["https://openalex.org/W2109108066","https://openalex.org/W2330789609","https://openalex.org/W3143054629","https://openalex.org/W2342813147","https://openalex.org/W1987290888","https://openalex.org/W2082651030","https://openalex.org/W1975294801","https://openalex.org/W2053905738","https://openalex.org/W1969312278","https://openalex.org/W2093465664"],"abstract_inverted_index":{"Elucidating":[0],"the":[1,44,89,138,152,159,171,180,216,219,232,243,249,256,259],"underlying":[2],"mechanisms":[3],"of":[4,12,20,70,75,88,128,134,176,218,245,252,255],"fatal":[5],"cardiac":[6],"arrhythmias":[7],"requires":[8],"a":[9,68,73,86,108,124,131,278],"tight":[10],"integration":[11],"electrophysiological":[13],"experiments,":[14],"models,":[15],"and":[16,31,184,222,237,248,258,275],"theory.":[17],"Existing":[18],"models":[19,39,60,84,286],"transmembrane":[21],"action":[22],"potential":[23],"(AP)":[24],"are":[25,40],"complex":[26,289],"(resulting":[27],"in":[28,207],"over":[29,120],"parameterization)":[30],"varied":[32],"(leading":[33],"to":[34,42,48,137,281,287],"dissimilar":[35],"predictions).":[36],"Thus,":[37],"simpler":[38],"needed":[41],"elucidate":[43],"\"minimal":[45],"physiological":[46,164,265],"requirements\"":[47],"reproduce":[49],"significant":[50],"observable":[51],"phenomena":[52,196],"using":[53,151],"as":[54,57,205,213],"few":[55],"parameters":[56,263],"possible.":[58],"Moreover,":[59],"have":[61,264],"been":[62],"derived":[63],"from":[64,67,100,158],"experimental":[65,154],"studies":[66],"variety":[69],"species":[71,161],"under":[72,163],"range":[74],"environmental":[76],"conditions":[77],"(for":[78],"example,":[79],"all":[80],"existing":[81],"rabbit":[82,111,208,220,290],"AP":[83,112,172,177],"incorporate":[85],"formulation":[87,127],"rapid":[90,174],"sodium":[91],"current,":[92],"INa,":[93],"based":[94],"on":[95,215],"30":[96],"year":[97],"old":[98],"data":[99,155],"chick":[101],"embryo":[102],"cell":[103],"aggregates).":[104],"Here":[105],"we":[106],"develop":[107],"simple":[109],"\"parsimonious\"":[110],"model":[113,133,148],"that":[114,261],"is":[115],"mathematically":[116],"identifiable":[117],"(i.e.,":[118],"not":[119],"parameterized)":[121],"by":[122],"combining":[123],"novel":[125],"Hodgkin-Huxley":[126],"INa":[129,186,246],"with":[130],"phenomenological":[132],"repolarization":[135],"similar":[136],"voltage":[139,189],"dependent,":[140],"time-independent":[141],"rectifying":[142],"outward":[143],"potassium":[144],"current":[145],"(IK).":[146],"The":[147],"was":[149],"calibrated":[150],"following":[153],"sets":[156],"measured":[157],"same":[160],"(rabbit)":[162],"conditions:":[165],"dynamic":[166],"current-voltage":[167],"(I-V)":[168],"relationships":[169],"during":[170,179],"upstroke;":[173],"recovery":[175],"excitability":[178],"relative":[181],"refractory":[182],"period;":[183],"steady-state":[185],"inactivation":[187,247],"via":[188],"clamp.":[190],"Simulations":[191],"reproduced":[192],"several":[193],"important":[194],"\"emergent\"":[195],"including":[197],"cellular":[198],"alternans":[199,236],"at":[200],"rates":[201],">":[202],"250":[203],"bpm":[204],"observed":[206,214],"myocytes,":[209],"reentrant":[210],"spiral":[211,223,238],"waves":[212],"surface":[217],"heart,":[221],"wave":[224,239],"breakup.":[225],"Model":[226],"variants":[227],"were":[228],"studied":[229],"which":[230],"elucidated":[231],"minimal":[233],"requirements":[234],"for":[235,270],"break":[240],"up,":[241],"namely":[242],"kinetics":[244],"non-linear":[250],"rectification":[251],"IK.The":[253],"simplicity":[254],"model,":[257],"fact":[260],"its":[262],"meaning,":[266],"make":[267],"it":[268],"ideal":[269],"engendering":[271],"generalizable":[272],"mechanistic":[273],"insight":[274],"should":[276],"provide":[277],"solid":[279],"\"building-block\"":[280],"generate":[282],"more":[283],"detailed":[284],"ionic":[285],"represent":[288],"electrophysiology.":[291]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}