{"id":"https://openalex.org/W2533118661","doi":"https://doi.org/10.1371/journal.pcbi.1005075","title":"Viral RNA Degradation and Diffusion Act as a Bottleneck for the Influenza A Virus Infection Efficiency","display_name":"Viral RNA Degradation and Diffusion Act as a Bottleneck for the Influenza A Virus Infection Efficiency","publication_year":2016,"publication_date":"2016-10-25","ids":{"openalex":"https://openalex.org/W2533118661","doi":"https://doi.org/10.1371/journal.pcbi.1005075","mag":"2533118661","pmid":"https://pubmed.ncbi.nlm.nih.gov/27780209"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005075","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005075&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005075&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032878032","display_name":"Max Schelker","orcid":"https://orcid.org/0000-0002-3723-5722"},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Max Schelker","raw_affiliation_strings":["Theoretical Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3723-5722","affiliations":[{"raw_affiliation_string":"Theoretical Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028047561","display_name":"Caroline Mair","orcid":null},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caroline Maria Mair","raw_affiliation_strings":["Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076476994","display_name":"Fabian Jolmes","orcid":"https://orcid.org/0000-0002-2005-8002"},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Jolmes","raw_affiliation_strings":["Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007869116","display_name":"Robert-William Welke","orcid":null},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert-William Welke","raw_affiliation_strings":["Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003799374","display_name":"Edda Klipp","orcid":"https://orcid.org/0000-0002-0567-7075"},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edda Klipp","raw_affiliation_strings":["Theoretical Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theoretical Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033530736","display_name":"Andreas Herrmann","orcid":"https://orcid.org/0000-0002-6716-2026"},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Herrmann","raw_affiliation_strings":["IRI Life Sciences, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRI Life Sciences, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025830249","display_name":"Max Fl\u00f6ttmann","orcid":null},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Max Fl\u00f6ttmann","raw_affiliation_strings":["Theoretical Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theoretical Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042011432","display_name":"Christian Sieben","orcid":"https://orcid.org/0000-0002-2836-2623"},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christian Sieben","raw_affiliation_strings":["Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2836-2623","affiliations":[{"raw_affiliation_string":"Molecular Biophysics, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025830249","https://openalex.org/A5042011432"],"corresponding_institution_ids":["https://openalex.org/I39343248"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3851,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88830801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"10","first_page":"e1005075","last_page":"e1005075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endosome","display_name":"Endosome","score":0.9158749580383301},{"id":"https://openalex.org/keywords/viral-entry","display_name":"Viral entry","score":0.6261578798294067},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6239098310470581},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6223111748695374},{"id":"https://openalex.org/keywords/lipid-bilayer-fusion","display_name":"Lipid bilayer fusion","score":0.6197551488876343},{"id":"https://openalex.org/keywords/viral-membrane","display_name":"Viral membrane","score":0.5585002899169922},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.5428547859191895},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"Nuclear transport","score":0.5006992816925049},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.47785302996635437},{"id":"https://openalex.org/keywords/escrt","display_name":"ESCRT","score":0.45514020323753357},{"id":"https://openalex.org/keywords/endocytic-cycle","display_name":"Endocytic cycle","score":0.4408394694328308},{"id":"https://openalex.org/keywords/viral-shedding","display_name":"Viral shedding","score":0.4354630708694458},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.4319442808628082},{"id":"https://openalex.org/keywords/viral-quasispecies","display_name":"Viral quasispecies","score":0.4194942116737366},{"id":"https://openalex.org/keywords/viral-envelope","display_name":"Viral envelope","score":0.34923553466796875},{"id":"https://openalex.org/keywords/endocytosis","display_name":"Endocytosis","score":0.3073287904262543},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.2726519703865051},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.2666093409061432},{"id":"https://openalex.org/keywords/nucleus","display_name":"Nucleus","score":0.21854248642921448},{"id":"https://openalex.org/keywords/cell-nucleus","display_name":"Cell nucleus","score":0.19558551907539368},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.16583165526390076},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12966176867485046}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.9158749580383301},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.6261578798294067},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6239098310470581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6223111748695374},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.6197551488876343},{"id":"https://openalex.org/C2909404852","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral membrane","level":4,"score":0.5585002899169922},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5428547859191895},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.5006992816925049},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47785302996635437},{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.45514020323753357},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.4408394694328308},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.4354630708694458},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.4319442808628082},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.4194942116737366},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.34923553466796875},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.3073287904262543},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2726519703865051},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2666093409061432},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.21854248642921448},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.19558551907539368},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16583165526390076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12966176867485046},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1005075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005075","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005075&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27780209","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27780209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:602d7560243d42a5afa2d5686a9516bf","is_oa":true,"landing_page_url":"https://doaj.org/article/602d7560243d42a5afa2d5686a9516bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 10, p e1005075 (2016)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4042259","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5079570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:infoscience.epfl.ch:225180","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/225180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005075","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005075&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1924933220","display_name":null,"funder_award_id":"DFG He-3763/15","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2347713323","display_name":null,"funder_award_id":"0316180A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G353333391","display_name":null,"funder_award_id":"He-3763/15","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2533118661.pdf","grobid_xml":"https://content.openalex.org/works/W2533118661.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1541159444","https://openalex.org/W1771500607","https://openalex.org/W1972376751","https://openalex.org/W1978019502","https://openalex.org/W1978028702","https://openalex.org/W1980451055","https://openalex.org/W1985675681","https://openalex.org/W1994451477","https://openalex.org/W1996903617","https://openalex.org/W2003591270","https://openalex.org/W2014092278","https://openalex.org/W2017886758","https://openalex.org/W2020316997","https://openalex.org/W2031249009","https://openalex.org/W2032828164","https://openalex.org/W2038163209","https://openalex.org/W2041315270","https://openalex.org/W2042492606","https://openalex.org/W2046486910","https://openalex.org/W2056298444","https://openalex.org/W2066383202","https://openalex.org/W2067135241","https://openalex.org/W2069813642","https://openalex.org/W2069971894","https://openalex.org/W2072726742","https://openalex.org/W2073153349","https://openalex.org/W2075780020","https://openalex.org/W2077346271","https://openalex.org/W2084324583","https://openalex.org/W2086223518","https://openalex.org/W2092735200","https://openalex.org/W2097375195","https://openalex.org/W2102434872","https://openalex.org/W2113092416","https://openalex.org/W2116823068","https://openalex.org/W2120040420","https://openalex.org/W2120658521","https://openalex.org/W2135682000","https://openalex.org/W2151613351","https://openalex.org/W2152307768","https://openalex.org/W2155418451","https://openalex.org/W2157510603","https://openalex.org/W2161617337","https://openalex.org/W2163126094","https://openalex.org/W2166751342","https://openalex.org/W2168648059","https://openalex.org/W2179083909","https://openalex.org/W2244397882","https://openalex.org/W2312836697","https://openalex.org/W2586256972","https://openalex.org/W3000665837","https://openalex.org/W4299895356"],"related_works":["https://openalex.org/W2370565492","https://openalex.org/W2016766059","https://openalex.org/W2029741357","https://openalex.org/W2062047503","https://openalex.org/W1993296488","https://openalex.org/W2321038792","https://openalex.org/W2954378755","https://openalex.org/W2144907742","https://openalex.org/W3005622563","https://openalex.org/W1748700469"],"abstract_inverted_index":{"After":[0],"endocytic":[1],"uptake,":[2],"influenza":[3,110],"viruses":[4,126],"transit":[5],"early":[6],"endosomal":[7,23,55],"compartments":[8],"and":[9,24,75,120,141,165],"eventually":[10],"reach":[11,41],"late":[12],"endosomes.":[13],"There,":[14],"the":[15,35,42,54,65,72,81,88,106,135,143,147,152,169,179,187],"viral":[16,25,36,149,170],"glycoprotein":[17],"hemagglutinin":[18],"(HA)":[19],"triggers":[20],"fusion":[21,77,140],"between":[22],"membrane,":[26],"a":[27,48,100,155,182],"critical":[28,70,156],"step":[29],"that":[30,168],"leads":[31],"to":[32,40,151,174],"release":[33],"of":[34,53,79,83,90,109,131,138,146,181],"segmented":[37],"genome":[38,150,184],"destined":[39],"cell":[43],"nucleus.":[44,188],"Endosomal":[45],"maturation":[46],"is":[47,68,172],"complex":[49],"process":[50],"involving":[51],"acidification":[52],"lumen":[56],"as":[57,59,154],"well":[58],"endosome":[60],"motility":[61],"along":[62],"microtubules.":[63],"While":[64],"pH":[66,129],"drop":[67],"clearly":[69],"for":[71,105,158],"conformational":[73],"change":[74],"membrane":[76],"activity":[78],"HA,":[80],"effect":[82],"intracellular":[84],"transport":[85],"dynamics":[86],"on":[87],"progress":[89],"infection":[91],"remains":[92],"largely":[93],"unclear.":[94],"In":[95],"this":[96],"study,":[97],"we":[98,163],"developed":[99],"comprehensive":[101],"mathematical":[102],"model":[103,116],"accounting":[104],"first":[107],"steps":[108],"virus":[111,160],"infection.":[112,161],"We":[113,133],"calibrated":[114],"our":[115],"with":[117,127],"experimental":[118],"data":[119],"challenged":[121],"its":[122],"predictions":[123],"using":[124],"recombinant":[125],"altered":[128],"sensitivity":[130],"HA.":[132],"identified":[134],"time":[136],"point":[137],"virus-endosome":[139],"thereby":[142],"diffusion":[144],"distance":[145],"released":[148],"nucleus":[153],"bottleneck":[157],"efficient":[159],"Further,":[162],"concluded":[164],"supported":[166],"experimentally":[167],"RNA":[171],"subjected":[173],"cytosolic":[175],"degradation":[176],"strongly":[177],"limiting":[178],"probability":[180],"successful":[183],"import":[185],"into":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}