{"id":"https://openalex.org/W2467468633","doi":"https://doi.org/10.1371/journal.pcbi.1005009","title":"Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks","display_name":"Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks","publication_year":2016,"publication_date":"2016-06-30","ids":{"openalex":"https://openalex.org/W2467468633","doi":"https://doi.org/10.1371/journal.pcbi.1005009","mag":"2467468633","pmid":"https://pubmed.ncbi.nlm.nih.gov/27359334"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1005009","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005009","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005009&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005009&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037871488","display_name":"Anthony Szedlak","orcid":"https://orcid.org/0000-0003-4827-3027"},"institutions":[{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Szedlak","raw_affiliation_strings":["Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan, United States of America","institution_ids":["https://openalex.org/I4210111179","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086834400","display_name":"Nicholas H. Smith","orcid":"https://orcid.org/0009-0008-0026-0757"},"institutions":[{"id":"https://openalex.org/I4210157378","display_name":"Salgomed (United States)","ror":"https://ror.org/045s0p143","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157378"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Smith","raw_affiliation_strings":["Salgomed Inc., Del Mar, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salgomed Inc., Del Mar, California, United States of America","institution_ids":["https://openalex.org/I4210157378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418934","display_name":"Li Liu","orcid":"https://orcid.org/0000-0003-4588-4906"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["College of Health Solutions, Arizona State University, Tempe, Arizona, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health Solutions, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004265401","display_name":"Giovanni Paternostro","orcid":"https://orcid.org/0000-0003-4029-5467"},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Giovanni Paternostro","raw_affiliation_strings":["Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I2799424032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053987245","display_name":"Carlo Piermarocchi","orcid":"https://orcid.org/0000-0003-2762-8562"},"institutions":[{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carlo Piermarocchi","raw_affiliation_strings":["Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan, United States of America","institution_ids":["https://openalex.org/I4210111179","https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5004265401","https://openalex.org/A5053987245"],"corresponding_institution_ids":["https://openalex.org/I188891513","https://openalex.org/I2799424032","https://openalex.org/I4210111179","https://openalex.org/I87216513"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6407,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72093264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"12","issue":"6","first_page":"e1005009","last_page":"e1005009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.8028858304023743},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6181284785270691},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.6098834276199341},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5693799257278442},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5542977452278137},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5068235993385315},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.43410515785217285},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.33521270751953125},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.27110904455184937}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.8028858304023743},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6181284785270691},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.6098834276199341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5693799257278442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5542977452278137},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5068235993385315},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.43410515785217285},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.33521270751953125},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27110904455184937},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1005009","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005009","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005009&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27359334","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27359334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1512.08798","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1512.08798","pdf_url":"https://arxiv.org/pdf/1512.08798","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:europepmc.org:3913890","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928929","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:item:43689","is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.43689","pdf_url":null,"source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1005009","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005009","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:aa996077b360496282d7f500d001ac4a","is_oa":true,"landing_page_url":"https://doaj.org/article/aa996077b360496282d7f500d001ac4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 6, p e1005009 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3917196","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Evolutionary_and_Topological_Properties_of_Genes_and_Community_Structures_in_Human_Gene_Regulatory_Networks/3917196","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1005009","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1005009","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005009&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"awards":[{"id":"https://openalex.org/G1233018838","display_name":"STTR Phase I:  Systems approaches to combinatorial therapies targeting cancer metabolism","funder_award_id":"1346482","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4289087300","display_name":null,"funder_award_id":"R41CA174059","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5848470430","display_name":null,"funder_award_id":"1R41CA174059-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337396","display_name":"Division of Industrial Innovation and Partnerships","ror":"https://ror.org/03xyg3m20"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2467468633.pdf","grobid_xml":"https://content.openalex.org/works/W2467468633.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1255676896","https://openalex.org/W1854214752","https://openalex.org/W1875112053","https://openalex.org/W1945661233","https://openalex.org/W1971937094","https://openalex.org/W1974097587","https://openalex.org/W1977067307","https://openalex.org/W1996379253","https://openalex.org/W2011340259","https://openalex.org/W2011537739","https://openalex.org/W2016907728","https://openalex.org/W2029158589","https://openalex.org/W2038012561","https://openalex.org/W2047405437","https://openalex.org/W2060464767","https://openalex.org/W2061674320","https://openalex.org/W2074443723","https://openalex.org/W2080125599","https://openalex.org/W2080247229","https://openalex.org/W2107175979","https://openalex.org/W2112609377","https://openalex.org/W2118398017","https://openalex.org/W2122340450","https://openalex.org/W2122683221","https://openalex.org/W2123558100","https://openalex.org/W2125118217","https://openalex.org/W2125126554","https://openalex.org/W2127640118","https://openalex.org/W2131681506","https://openalex.org/W2133147430","https://openalex.org/W2133347001","https://openalex.org/W2136495792","https://openalex.org/W2137549067","https://openalex.org/W2143837955","https://openalex.org/W2162522101","https://openalex.org/W2163480486","https://openalex.org/W2171688574","https://openalex.org/W2204695746","https://openalex.org/W2599277042","https://openalex.org/W2950903538","https://openalex.org/W3099768174","https://openalex.org/W3101756747","https://openalex.org/W4210370111","https://openalex.org/W4238452917"],"related_works":["https://openalex.org/W4229078645","https://openalex.org/W1977345676","https://openalex.org/W4282032776","https://openalex.org/W2047552823","https://openalex.org/W4321606905","https://openalex.org/W3130445735","https://openalex.org/W2105110616","https://openalex.org/W2747930654","https://openalex.org/W2739658809","https://openalex.org/W2419362237"],"abstract_inverted_index":{"The":[0],"diverse,":[1],"specialized":[2],"genes":[3,19,64,81,125,142,161,173],"present":[4],"in":[5,36,43],"today's":[6],"lifeforms":[7],"evolved":[8],"from":[9],"a":[10,29,109,209],"common":[11],"core":[12],"of":[13,32,59,63,72,79,86,102,167,190],"ancient,":[14],"elementary":[15],"genes.":[16,138],"However,":[17],"these":[18,52,202],"did":[20],"not":[21],"evolve":[22],"individually:":[23],"gene":[24,38,53,156],"expression":[25],"is":[26,90],"controlled":[27],"by":[28],"complex":[30,50],"network":[31],"interactions,":[33],"and":[34,82,108,162,170,174,186,195,213],"alterations":[35],"one":[37],"may":[39],"drive":[40],"reciprocal":[41],"changes":[42],"its":[44,117,214],"proteins'":[45],"binding":[46],"partners.":[47],"Like":[48],"many":[49],"networks,":[51,169],"regulatory":[54],"networks":[55],"(GRNs)":[56],"are":[57,113],"composed":[58],"communities,":[60],"or":[61],"clusters":[62],"with":[65,116,129,148,182],"relatively":[66,149],"high":[67],"connectivity.":[68],"A":[69],"deep":[70],"understanding":[71,222],"the":[73,76,83,87,99,165,168,177,192,196,206],"relationship":[74],"between":[75,208],"evolutionary":[77,93,119,151,216,223],"history":[78],"single":[80],"topological":[84,100],"properties":[85,101,217],"underlying":[88],"GRN":[89,107,112],"integral":[91],"to":[92,127,143],"genetics.":[94,224],"Here,":[95],"we":[96],"show":[97],"that":[98,155,201],"an":[103],"acute":[104],"myeloid":[105],"leukemia":[106],"general":[110],"human":[111],"strongly":[114],"coupled":[115],"genes'":[118,215],"properties.":[120],"Slowly":[121],"evolving":[122,135],"(\"cold\"),":[123],"old":[124],"tend":[126],"interact":[128],"each":[130],"other,":[131],"as":[132],"do":[133],"rapidly":[134],"(\"hot\"),":[136],"young":[137],"This":[139],"naturally":[140],"causes":[141],"segregate":[144],"into":[145],"community":[146,211],"structures":[147,212],"homogeneous":[150],"histories.":[152],"We":[153,179,199],"argue":[154],"duplication":[157],"placed":[158],"old,":[159],"cold":[160],"communities":[163,175],"at":[164,176],"center":[166],"young,":[171],"hot":[172],"periphery.":[178],"demonstrate":[180],"this":[181],"single-node":[183],"centrality":[184],"measures":[185,189],"two":[187],"new":[188,219],"efficiency,":[191],"set":[193],"efficiency":[194],"interset":[197],"efficiency.":[198],"conclude":[200],"methods":[203],"for":[204,221],"studying":[205],"relationships":[207],"GRN's":[210],"provide":[218],"perspectives":[220]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}