{"id":"https://openalex.org/W2409695549","doi":"https://doi.org/10.1371/journal.pcbi.1004960","title":"Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches","display_name":"Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches","publication_year":2016,"publication_date":"2016-06-02","ids":{"openalex":"https://openalex.org/W2409695549","doi":"https://doi.org/10.1371/journal.pcbi.1004960","mag":"2409695549","pmid":"https://pubmed.ncbi.nlm.nih.gov/27253392"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004960","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004960","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1004960","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066366031","display_name":"Tobias Sikosek","orcid":"https://orcid.org/0000-0001-9929-3525"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tobias Sikosek","raw_affiliation_strings":["Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9929-3525","affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061571670","display_name":"Heinrich Krobath","orcid":"https://orcid.org/0000-0001-6473-8109"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Heinrich Krobath","raw_affiliation_strings":["Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481856","display_name":"Hue Sun Chan","orcid":"https://orcid.org/0000-0002-1381-923X"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Hue Sun Chan","raw_affiliation_strings":["Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053481856"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0503,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86790215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"6","first_page":"e1004960","last_page":"e1004960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsynonymous-substitution","display_name":"Nonsynonymous substitution","score":0.7773716449737549},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.5285648107528687},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5241782069206238},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.5031678080558777},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.45005062222480774},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.44231700897216797},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43160009384155273},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"Directed evolution","score":0.4165901243686676},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4128715693950653},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37079858779907227},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.340736448764801},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.33480924367904663},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12012141942977905},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08946743607521057}],"concepts":[{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.7773716449737549},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.5285648107528687},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5241782069206238},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5031678080558777},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.45005062222480774},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.44231700897216797},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43160009384155273},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.4165901243686676},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4128715693950653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37079858779907227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.340736448764801},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33480924367904663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12012141942977905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08946743607521057},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004960","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004960","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27253392","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27253392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1004960","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004960","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:516fa2438732494c8291dc77f36e2836","is_oa":true,"landing_page_url":"https://doaj.org/article/516fa2438732494c8291dc77f36e2836","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 6, p e1004960 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3410782","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Theoretical_Insights_into_the_Biophysics_of_Protein_Bi-stability_and_Evolutionary_Switches/3410782","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4890782","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4890782","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004960","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004960","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3331476647","display_name":null,"funder_award_id":"MOP-84281","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W406995970","https://openalex.org/W938283201","https://openalex.org/W1505900198","https://openalex.org/W1561923743","https://openalex.org/W1569560802","https://openalex.org/W1606622913","https://openalex.org/W1947569378","https://openalex.org/W1963768262","https://openalex.org/W1964166907","https://openalex.org/W1966103056","https://openalex.org/W1968790827","https://openalex.org/W1970747152","https://openalex.org/W1970900907","https://openalex.org/W1971870267","https://openalex.org/W1973459793","https://openalex.org/W1973546204","https://openalex.org/W1975969507","https://openalex.org/W1976650381","https://openalex.org/W1981369098","https://openalex.org/W1983301339","https://openalex.org/W1985297174","https://openalex.org/W1986117336","https://openalex.org/W1988778988","https://openalex.org/W1992359647","https://openalex.org/W1993646374","https://openalex.org/W1994756593","https://openalex.org/W2001438084","https://openalex.org/W2002449583","https://openalex.org/W2013425283","https://openalex.org/W2014425795","https://openalex.org/W2014798121","https://openalex.org/W2018838993","https://openalex.org/W2018970839","https://openalex.org/W2020353121","https://openalex.org/W2024170281","https://openalex.org/W2025587541","https://openalex.org/W2026699081","https://openalex.org/W2027025821","https://openalex.org/W2030384127","https://openalex.org/W2033572216","https://openalex.org/W2035041418","https://openalex.org/W2036872878","https://openalex.org/W2040809566","https://openalex.org/W2042041233","https://openalex.org/W2042742761","https://openalex.org/W2044882887","https://openalex.org/W2047510784","https://openalex.org/W2048370177","https://openalex.org/W2048631643","https://openalex.org/W2049342852","https://openalex.org/W2049888624","https://openalex.org/W2054525948","https://openalex.org/W2056245019","https://openalex.org/W2056760934","https://openalex.org/W2057022167","https://openalex.org/W2065864578","https://openalex.org/W2065991225","https://openalex.org/W2067204014","https://openalex.org/W2067236515","https://openalex.org/W2069504710","https://openalex.org/W2069677863","https://openalex.org/W2071036069","https://openalex.org/W2077496131","https://openalex.org/W2081926098","https://openalex.org/W2082759836","https://openalex.org/W2084123612","https://openalex.org/W2085142174","https://openalex.org/W2085161458","https://openalex.org/W2085544483","https://openalex.org/W2091312128","https://openalex.org/W2092432276","https://openalex.org/W2094597106","https://openalex.org/W2096344315","https://openalex.org/W2104145621","https://openalex.org/W2107656097","https://openalex.org/W2112154906","https://openalex.org/W2113449266","https://openalex.org/W2114675905","https://openalex.org/W2115005877","https://openalex.org/W2115925919","https://openalex.org/W2117569373","https://openalex.org/W2118552089","https://openalex.org/W2122576346","https://openalex.org/W2126091147","https://openalex.org/W2126196981","https://openalex.org/W2127218421","https://openalex.org/W2135232979","https://openalex.org/W2136141445","https://openalex.org/W2139236870","https://openalex.org/W2140565568","https://openalex.org/W2141846102","https://openalex.org/W2143264455","https://openalex.org/W2147988069","https://openalex.org/W2148525773","https://openalex.org/W2149744037","https://openalex.org/W2156042112","https://openalex.org/W2157362913","https://openalex.org/W2157693914","https://openalex.org/W2158733418","https://openalex.org/W2161859154","https://openalex.org/W2163614321","https://openalex.org/W2163987934","https://openalex.org/W2168749685","https://openalex.org/W2332252149","https://openalex.org/W2334071623","https://openalex.org/W3098405609","https://openalex.org/W3102492053"],"related_works":["https://openalex.org/W2738420712","https://openalex.org/W2560969884","https://openalex.org/W2949879109","https://openalex.org/W2888815005","https://openalex.org/W2084119008","https://openalex.org/W2092845657","https://openalex.org/W2773467731","https://openalex.org/W1983164158","https://openalex.org/W2591717931","https://openalex.org/W2091714383"],"abstract_inverted_index":{"Deciphering":[0],"the":[1,23,30,66,92,99,102,160,185,191,207,224],"effects":[2],"of":[3,14,19,25,29,32,52,69,227],"nonsynonymous":[4],"mutations":[5,38,54,71],"on":[6,37],"protein":[7,33],"structure":[8,44],"is":[9,18,72,109],"central":[10],"to":[11,22,48,57,62,75,123,156,177],"many":[12],"areas":[13],"biomedical":[15],"research":[16],"and":[17,105,152,165,238],"fundamental":[20],"importance":[21],"study":[24],"molecular":[26],"evolution.":[27],"Much":[28],"investigation":[31],"evolution":[34],"has":[35],"focused":[36],"that":[39,55,136,216],"leave":[40],"a":[41,73,87,146,180,199,217],"protein's":[42],"folded":[43],"essentially":[45],"unchanged.":[46],"However,":[47],"evolve":[49],"novel":[50],"folds":[51,108],"proteins,":[53],"lead":[56],"large":[58],"conformational":[59,89,173,241],"modifications":[60],"have":[61,119],"be":[63],"involved.":[64],"Unraveling":[65],"basic":[67],"biophysics":[68],"such":[70,94],"challenge":[74],"theory,":[76],"especially":[77],"when":[78],"only":[79],"one":[80,100],"or":[81],"two":[82],"amino":[83],"acid":[84],"substitutions":[85],"cause":[86],"large-scale":[88],"switch.":[90,211],"Among":[91],"few":[93],"mutational":[95],"switches":[96],"identified":[97],"experimentally,":[98],"between":[101,163],"GA":[103,164,176],"all-\u03b1":[104],"GB":[106,178],"\u03b1+\u03b2":[107],"extensively":[110],"characterized;":[111],"but":[112],"all-atom":[113],"simulations":[114],"using":[115],"fully":[116],"transferrable":[117],"potentials":[118],"not":[120],"been":[121],"able":[122],"account":[124],"for":[125,141],"this":[126,154,210],"striking":[127],"switching":[128,174],"behavior.":[129],"Here":[130],"we":[131,171],"introduce":[132],"an":[133],"explicit-chain":[134],"model":[135,197],"combines":[137],"structure-based":[138],"native":[139],"biases":[140],"multiple":[142],"alternative":[143],"structures":[144],"with":[145,169,190],"general":[147],"physical":[148,233],"atomic":[149],"force":[150],"field,":[151],"apply":[153],"construct":[155],"twelve":[157],"mutants":[158,208],"spanning":[159],"sequence":[161],"variation":[162],"GB.":[166],"In":[167,188],"agreement":[168],"experiment,":[170],"observe":[172],"from":[175,223],"upon":[179],"single":[181],"L45Y":[182],"substitution":[183],"in":[184,203,206],"GA98":[186],"mutant.":[187],"line":[189],"latent":[192],"evolutionary":[193,240],"potential":[194],"concept,":[195],"our":[196],"shows":[198],"gradual":[200],"sequence-dependent":[201],"change":[202],"fold":[204],"preference":[205],"before":[209],"Our":[212],"analysis":[213],"also":[214],"indicates":[215],"sharp":[218],"GA/GB":[219],"switch":[220],"may":[221],"arise":[222],"orientation":[225],"dependence":[226],"aromatic":[228],"\u03c0-interactions.":[229],"These":[230],"findings":[231],"provide":[232],"insights":[234],"toward":[235],"rationalizing,":[236],"predicting":[237],"designing":[239],"switches.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
