{"id":"https://openalex.org/W2365745156","doi":"https://doi.org/10.1371/journal.pcbi.1004933","title":"Structural Determinants of Misfolding in Multidomain Proteins","display_name":"Structural Determinants of Misfolding in Multidomain Proteins","publication_year":2016,"publication_date":"2016-05-10","ids":{"openalex":"https://openalex.org/W2365745156","doi":"https://doi.org/10.1371/journal.pcbi.1004933","mag":"2365745156","pmid":"https://pubmed.ncbi.nlm.nih.gov/27163669"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004933","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004933","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004933&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004933&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068477254","display_name":"Pengfei Tian","orcid":"https://orcid.org/0000-0003-0255-8692"},"institutions":[{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengfei Tian","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I4210090567","https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059620610","display_name":"Robert B. Best","orcid":"https://orcid.org/0000-0002-7893-3543"},"institutions":[{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert B. Best","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I4210090567","https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059620610"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.7408,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.84668238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"5","first_page":"e1004933","last_page":"e1004933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.7482597827911377},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.6976979970932007},{"id":"https://openalex.org/keywords/f\u00f6rster-resonance-energy-transfer","display_name":"F\u00f6rster resonance energy transfer","score":0.6217212677001953},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.47265875339508057},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4396893084049225},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.4356600046157837},{"id":"https://openalex.org/keywords/energy-landscape","display_name":"Energy landscape","score":0.43295663595199585},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.42128580808639526},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3327915668487549},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3292352259159088},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2940050959587097},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2527986764907837},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11500701308250427}],"concepts":[{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.7482597827911377},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.6976979970932007},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.6217212677001953},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47265875339508057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4396893084049225},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4356600046157837},{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.43295663595199585},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42128580808639526},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3327915668487549},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3292352259159088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2940050959587097},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2527986764907837},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11500701308250427},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004933","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004933","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004933&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27163669","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27163669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1004933","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004933","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:41f0ef2af58444528f1d77a20c2f5a00","is_oa":true,"landing_page_url":"https://doaj.org/article/41f0ef2af58444528f1d77a20c2f5a00","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 5, p e1004933 (2016)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4862688","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4862688","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004933","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004933","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004933&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2365745156.pdf","grobid_xml":"https://content.openalex.org/works/W2365745156.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W202553697","https://openalex.org/W1533138158","https://openalex.org/W1592765831","https://openalex.org/W1604656968","https://openalex.org/W1780544763","https://openalex.org/W1964538907","https://openalex.org/W1966078827","https://openalex.org/W1967449074","https://openalex.org/W1969228305","https://openalex.org/W1971281089","https://openalex.org/W1973546204","https://openalex.org/W1973897761","https://openalex.org/W1974686816","https://openalex.org/W1974959278","https://openalex.org/W1980947093","https://openalex.org/W1980956149","https://openalex.org/W1981840107","https://openalex.org/W1983362126","https://openalex.org/W1992850460","https://openalex.org/W1995281770","https://openalex.org/W2001364436","https://openalex.org/W2002304568","https://openalex.org/W2006492496","https://openalex.org/W2007296976","https://openalex.org/W2009285492","https://openalex.org/W2010220189","https://openalex.org/W2010722241","https://openalex.org/W2019000267","https://openalex.org/W2020716464","https://openalex.org/W2031858991","https://openalex.org/W2033212730","https://openalex.org/W2034786275","https://openalex.org/W2034886735","https://openalex.org/W2045513654","https://openalex.org/W2046521790","https://openalex.org/W2046535373","https://openalex.org/W2050627654","https://openalex.org/W2053449516","https://openalex.org/W2053489904","https://openalex.org/W2053960740","https://openalex.org/W2055883333","https://openalex.org/W2056300292","https://openalex.org/W2065864578","https://openalex.org/W2067576503","https://openalex.org/W2067917889","https://openalex.org/W2073306024","https://openalex.org/W2074655761","https://openalex.org/W2075505388","https://openalex.org/W2078317530","https://openalex.org/W2086128277","https://openalex.org/W2087321793","https://openalex.org/W2089597488","https://openalex.org/W2090807504","https://openalex.org/W2095407452","https://openalex.org/W2110852566","https://openalex.org/W2112792893","https://openalex.org/W2115005877","https://openalex.org/W2115273980","https://openalex.org/W2115291348","https://openalex.org/W2117442710","https://openalex.org/W2120297746","https://openalex.org/W2127325055","https://openalex.org/W2130581715","https://openalex.org/W2137946890","https://openalex.org/W2139433006","https://openalex.org/W2141336992","https://openalex.org/W2150991944","https://openalex.org/W2153590204","https://openalex.org/W2153876071","https://openalex.org/W2156012420","https://openalex.org/W2156999424","https://openalex.org/W2165222310","https://openalex.org/W2169529439","https://openalex.org/W2209466135","https://openalex.org/W2286317713","https://openalex.org/W2323489328","https://openalex.org/W2329630164","https://openalex.org/W2338132158","https://openalex.org/W2949670980","https://openalex.org/W4253604693","https://openalex.org/W6696349270"],"related_works":["https://openalex.org/W1560296431","https://openalex.org/W2186061937","https://openalex.org/W2476476683","https://openalex.org/W2789914061","https://openalex.org/W2331699234","https://openalex.org/W2907629594","https://openalex.org/W2113188411","https://openalex.org/W1974862140","https://openalex.org/W2467603891","https://openalex.org/W2081866413"],"abstract_inverted_index":{"Recent":[0],"single":[1],"molecule":[2],"experiments,":[3],"using":[4],"either":[5],"atomic":[6],"force":[7],"microscopy":[8],"(AFM)":[9],"or":[10,142,157,209],"F\u00f6rster":[11],"resonance":[12],"energy":[13],"transfer":[14],"(FRET)":[15],"have":[16,32,70],"shown":[17],"that":[18,56,129,163,185],"multidomain":[19,58,103,271],"proteins":[20,104],"containing":[21],"tandem":[22],"repeats":[23],"may":[24],"form":[25,106],"stable":[26],"misfolded":[27,158,181,195],"structures.":[28,159],"Topology-based":[29],"simulation":[30,94],"models":[31,38,231],"been":[33],"used":[34],"successfully":[35],"to":[36,87,105,114,155,170,206,234,263],"generate":[37],"for":[39,64,145,267],"these":[40,186],"structures":[41],"with":[42,47,204,228,237],"domain-swapped":[43,89,107,268],"features,":[44],"fully":[45,226],"consistent":[46,227],"the":[48,76,81,99,122,130,138,147,151,164,171,175,192,200,210,222,229,242,249,265],"available":[49],"data.":[50],"However,":[51],"it":[52,161],"is":[53,111,134,166],"also":[54],"known":[55,100],"some":[57],"protein":[59],"folds":[60],"exhibit":[61],"no":[62],"evidence":[63],"misfolding,":[65,236,256],"even":[66],"when":[67],"adjacent":[68],"domains":[69,148,176,196],"identical":[71],"sequences.":[72],"Here":[73],"we":[74,96,127,247],"pose":[75],"question:":[77],"what":[78,115],"factors":[79],"influence":[80],"propensity":[82,165,266],"of":[83,102,132,174,199,219,241,270],"a":[84,92,215,238,259],"given":[85],"fold":[86],"undergo":[88],"misfolding?":[90],"Using":[91],"coarse-grained":[93],"model,":[95],"can":[97,188],"reproduce":[98],"propensities":[101],"misfolds,":[108],"where":[109],"data":[110],"available.":[112],"Contrary":[113],"might":[116],"be":[117,189],"naively":[118],"expected":[119],"based":[120],"on":[121],"previously":[123,232],"described":[124],"misfolding":[125,133,269],"mechanism,":[126],"find":[128],"extent":[131],"not":[135],"determined":[136],"by":[137],"relative":[139,172],"folding":[140,202],"rates":[141],"barrier":[143],"heights":[144],"forming":[146],"present":[149,177],"in":[150,178],"initial":[152],"intermediates":[153],"leading":[154],"folded":[156,179,193],"Instead,":[160],"appears":[162],"more":[167],"closely":[168],"related":[169],"stability":[173],"and":[180,194,255,257],"intermediates.":[182],"We":[183],"show":[184],"findings":[187],"rationalized":[190],"if":[191],"are":[197,224],"part":[198],"same":[201],"funnel,":[203],"commitment":[205],"one":[207],"structure":[208],"other":[211],"occurring":[212],"only":[213],"at":[214],"relatively":[216],"late":[217],"stage":[218],"folding.":[220],"Nonetheless,":[221],"results":[223],"still":[225],"kinetic":[230],"proposed":[233],"explain":[235],"specific":[239],"interpretation":[240],"observed":[243],"rate":[244],"coefficients.":[245],"Finally,":[246],"investigate":[248],"relation":[250],"between":[251],"interdomain":[252],"linker":[253],"length":[254],"propose":[258],"simple":[260],"alchemical":[261],"model":[262],"predict":[264],"proteins.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
