{"id":"https://openalex.org/W2345542299","doi":"https://doi.org/10.1371/journal.pcbi.1004909","title":"A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion","display_name":"A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion","publication_year":2016,"publication_date":"2016-05-03","ids":{"openalex":"https://openalex.org/W2345542299","doi":"https://doi.org/10.1371/journal.pcbi.1004909","mag":"2345542299","pmid":"https://pubmed.ncbi.nlm.nih.gov/27138333"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004909","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004909","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004909&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004909&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071660253","display_name":"Joseph H. R. Hetmanski","orcid":"https://orcid.org/0000-0002-1493-351X"},"institutions":[{"id":"https://openalex.org/I2800776015","display_name":"Wellcome Centre for Cell-Matrix Research","ror":"https://ror.org/0094tm228","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800776015","https://openalex.org/I28407311","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph H. R. Hetmanski","raw_affiliation_strings":["Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2800776015","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084642834","display_name":"Egor Zindy","orcid":"https://orcid.org/0000-0003-0033-0002"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I2800776015","display_name":"Wellcome Centre for Cell-Matrix Research","ror":"https://ror.org/0094tm228","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800776015","https://openalex.org/I28407311","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Egor Zindy","raw_affiliation_strings":["Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2800776015","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046134592","display_name":"Jean\u2010Marc Schwartz","orcid":"https://orcid.org/0000-0002-6472-0184"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I2800776015","display_name":"Wellcome Centre for Cell-Matrix Research","ror":"https://ror.org/0094tm228","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800776015","https://openalex.org/I28407311","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jean-Marc Schwartz","raw_affiliation_strings":["Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2800776015","https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040368685","display_name":"Patrick T. Caswell","orcid":"https://orcid.org/0000-0002-2633-2324"},"institutions":[{"id":"https://openalex.org/I2800776015","display_name":"Wellcome Centre for Cell-Matrix Research","ror":"https://ror.org/0094tm228","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800776015","https://openalex.org/I28407311","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Patrick T. Caswell","raw_affiliation_strings":["Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2800776015","https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040368685"],"corresponding_institution_ids":["https://openalex.org/I2800776015","https://openalex.org/I28407311"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1994,"currency":"EUR","value_usd":2150},"fwci":4.7282,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.94842329,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"12","issue":"5","first_page":"e1004909","last_page":"e1004909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhoa","display_name":"RHOA","score":0.8154537677764893},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.76664137840271},{"id":"https://openalex.org/keywords/cell-migration","display_name":"Cell migration","score":0.621286928653717},{"id":"https://openalex.org/keywords/lamellipodium","display_name":"Lamellipodium","score":0.6079941391944885},{"id":"https://openalex.org/keywords/rac1","display_name":"RAC1","score":0.5673966407775879},{"id":"https://openalex.org/keywords/cdc42","display_name":"CDC42","score":0.5611847639083862},{"id":"https://openalex.org/keywords/rac-gtp-binding-proteins","display_name":"Rac GTP-Binding Proteins","score":0.5303481221199036},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.4666718542575836},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.44328880310058594},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42999354004859924},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3720470070838928},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.353610634803772},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3363587558269501},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.3197784125804901},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.1397741734981537},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10547530651092529}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.8154537677764893},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.76664137840271},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.621286928653717},{"id":"https://openalex.org/C109185818","wikidata":"https://www.wikidata.org/wiki/Q3092607","display_name":"Lamellipodium","level":4,"score":0.6079941391944885},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.5673966407775879},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.5611847639083862},{"id":"https://openalex.org/C2909331102","wikidata":"https://www.wikidata.org/wiki/Q7278834","display_name":"Rac GTP-Binding Proteins","level":4,"score":0.5303481221199036},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4666718542575836},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44328880310058594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42999354004859924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3720470070838928},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.353610634803772},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3363587558269501},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3197784125804901},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1397741734981537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10547530651092529},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020830","descriptor_name":"rac1 GTP-Binding Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020830","descriptor_name":"rac1 GTP-Binding Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020830","descriptor_name":"rac1 GTP-Binding Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020830","descriptor_name":"rac1 GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020830","descriptor_name":"rac1 GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020830","descriptor_name":"rac1 GTP-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1004909","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004909","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004909&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27138333","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27138333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/221d8235-1eb2-46ee-9937-1214e91be1c7","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/221d8235-1eb2-46ee-9937-1214e91be1c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hetmanski, J, Zindy, E, Schwartz, J-M & Caswell, P 2016, 'A MAPK-driven feedback loop suppresses Rac activity to promote RhoA-driven cancer cell invasion', PL o S Computational Biology, vol. 12, no. 5, e1004909. https://doi.org/10.1371/journal.pcbi.1004909","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:bura.brunel.ac.uk:2438/28529","is_oa":true,"landing_page_url":"https://bura.brunel.ac.uk/handle/2438/28529","pdf_url":"http://bura.brunel.ac.uk/bitstream/2438/28529/1/FullText.pdf","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/324143","is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/324143","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, 12 (5","raw_type":"info:ulb-repo/semantics/openurl/article"},{"id":"pmh:oai:doaj.org/article:42d6f3bda6bb4d6ca1341ea67f43efa7","is_oa":false,"landing_page_url":"https://doaj.org/article/42d6f3bda6bb4d6ca1341ea67f43efa7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 5, p e1004909 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3246439","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_MAPK-Driven_Feedback_Loop_Suppresses_Rac_Activity_to_Promote_RhoA-Driven_Cancer_Cell_Invasion/3246439","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4854413","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4854413","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/221d8235-1eb2-46ee-9937-1214e91be1c7","is_oa":true,"landing_page_url":"https://www.research.manchester.ac.uk/portal/en/publications/a-mapkdriven-feedback-loop-suppresses-rac-activity-to-promote-rhoadriven-cancer-cell-invasion(221d8235-1eb2-46ee-9937-1214e91be1c7).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hetmanski, J, Zindy, E, Schwartz, J-M & Caswell, P 2016, 'A MAPK-driven feedback loop suppresses Rac activity to promote RhoA-driven cancer cell invasion', PL o S Computational Biology, vol. 12, no. 5, e1004909. https://doi.org/10.1371/journal.pcbi.1004909","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004909","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004909","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004909&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1636717100","display_name":"BB/J014478/1","funder_award_id":"BB/J014478/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6390798491","display_name":null,"funder_award_id":"090453/Z/09/A","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G751887163","display_name":null,"funder_award_id":"090453/Z/09/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G783596487","display_name":null,"funder_award_id":"088785/Z/09/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"}],"funders":[{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2345542299.pdf","grobid_xml":"https://content.openalex.org/works/W2345542299.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W43634832","https://openalex.org/W1512355975","https://openalex.org/W1905742426","https://openalex.org/W1967057211","https://openalex.org/W1967861082","https://openalex.org/W1968640383","https://openalex.org/W1970523400","https://openalex.org/W1972148801","https://openalex.org/W1977582100","https://openalex.org/W1983443986","https://openalex.org/W1991937659","https://openalex.org/W2007660746","https://openalex.org/W2012376126","https://openalex.org/W2013329576","https://openalex.org/W2019621874","https://openalex.org/W2019731805","https://openalex.org/W2021012077","https://openalex.org/W2024781278","https://openalex.org/W2026446225","https://openalex.org/W2039193709","https://openalex.org/W2039210293","https://openalex.org/W2039584708","https://openalex.org/W2039983290","https://openalex.org/W2040196938","https://openalex.org/W2045300715","https://openalex.org/W2056785598","https://openalex.org/W2056850877","https://openalex.org/W2057514304","https://openalex.org/W2058083313","https://openalex.org/W2063220206","https://openalex.org/W2065959414","https://openalex.org/W2066139399","https://openalex.org/W2066469176","https://openalex.org/W2068652881","https://openalex.org/W2069738597","https://openalex.org/W2074238963","https://openalex.org/W2075104267","https://openalex.org/W2084011640","https://openalex.org/W2088678425","https://openalex.org/W2093226717","https://openalex.org/W2095554214","https://openalex.org/W2096791952","https://openalex.org/W2099987999","https://openalex.org/W2102855030","https://openalex.org/W2105841205","https://openalex.org/W2108040056","https://openalex.org/W2116504572","https://openalex.org/W2117403796","https://openalex.org/W2124670362","https://openalex.org/W2126653712","https://openalex.org/W2127020923","https://openalex.org/W2134789155","https://openalex.org/W2137604636","https://openalex.org/W2138231208","https://openalex.org/W2138388305","https://openalex.org/W2141916872","https://openalex.org/W2143468862","https://openalex.org/W2144066782","https://openalex.org/W2144963939","https://openalex.org/W2145899141","https://openalex.org/W2150401872","https://openalex.org/W2153071013","https://openalex.org/W2157246902","https://openalex.org/W2161378694","https://openalex.org/W2161682775","https://openalex.org/W2162147795","https://openalex.org/W2167437179","https://openalex.org/W2168243900","https://openalex.org/W2171599819","https://openalex.org/W2175627344","https://openalex.org/W4238567307","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W4298369285","https://openalex.org/W2002287427","https://openalex.org/W2410772600","https://openalex.org/W2070765312","https://openalex.org/W1489644142","https://openalex.org/W1532764674","https://openalex.org/W2055200787","https://openalex.org/W2295841818","https://openalex.org/W2124417063","https://openalex.org/W2128797396"],"abstract_inverted_index":{"Cell":[0],"migration":[1,244],"in":[2,52,131,164,241],"3D":[3,165],"microenvironments":[4],"is":[5],"fundamental":[6],"to":[7,55,129,138,149,207],"development,":[8],"homeostasis":[9],"and":[10,25,58,67,142,147,153,192,211,216,229,245],"the":[11,43,78,122,158,181,203,222],"pathobiology":[12],"of":[13,23,45,118,151,155,161,177,225,238],"diseases":[14],"such":[15],"as":[16],"cancer.":[17],"Rab-coupling":[18],"protein":[19],"(RCP)":[20],"dependent":[21],"co-trafficking":[22],"\u03b15\u03b21":[24],"EGFR1":[26,40],"promotes":[27,49],"cancer":[28],"cell":[29],"invasion":[30],"into":[31],"fibronectin":[32],"(FN)":[33],"containing":[34],"extracellular":[35],"matrix":[36],"(ECM),":[37],"by":[38,103,120],"potentiating":[39],"signalling":[41,54,79,115,201],"at":[42,157],"front":[44],"invasive":[46,84,132,172,196,217,243],"cells.":[47],"This":[48],"a":[50,60,88,232],"switch":[51],"RhoGTPase":[53,190],"inhibit":[56],"Rac1":[57,119],"activate":[59],"RhoA-ROCK-Formin":[61],"homology":[62],"domain-containing":[63],"3":[64],"(FHOD3)":[65],"pathway":[66],"generate":[68],"filopodial":[69,144,213],"actin-spike":[70,145,214],"protrusions":[71],"which":[72],"drive":[73],"invasion.":[74],"To":[75],"further":[76],"understand":[77],"network":[80,95],"that":[81,199,231],"drives":[82],"RCP-driven":[83],"migration,":[85,197],"we":[86],"generated":[87],"Boolean":[89],"logical":[90],"model":[91,107],"based":[92],"on":[93,189],"existing":[94],"pathways/models,":[96],"where":[97],"each":[98],"node":[99],"can":[100],"be":[101,237],"interrogated":[102],"computational":[104],"simulation.":[105],"The":[106],"predicted":[108],"an":[109],"unanticipated":[110],"feedback":[111],"loop,":[112],"whereby":[113],"Raf/MEK/ERK":[114],"maintains":[116],"suppression":[117],"inhibiting":[121],"Rac-activating":[123,204],"Sos1-Eps8-Abi1":[124],"complex,":[125],"allowing":[126],"RhoA":[127,156,209],"activity":[128,191,210],"predominate":[130],"protrusions.":[133],"MEK":[134,168,184],"inhibition":[135,169,185],"was":[136],"sufficient":[137],"promote":[139,212],"lamellipodia":[140],"formation":[141,215],"oppose":[143,195],"formation,":[146],"led":[148],"activation":[150],"Rac":[152],"inactivation":[154],"leading":[159],"edge":[160],"cells":[162],"moving":[163],"matrix.":[166],"Furthermore,":[167],"abrogated":[170],"RCP/\u03b15\u03b21/EGFR1-driven":[171],"migration.":[173,218],"However,":[174],"upon":[175],"knockdown":[176],"Eps8":[178],"(to":[179],"suppress":[180],"Sos1-Abi1-Eps8":[182,205],"complex),":[183],"had":[186],"no":[187],"effect":[188],"did":[193],"not":[194],"suggesting":[198],"MEK-ERK":[200],"suppresses":[202],"complex":[206],"maintain":[208],"Our":[219],"study":[220],"highlights":[221],"predictive":[223],"potential":[224],"mathematical":[226],"modelling":[227],"approaches,":[228],"demonstrates":[230],"simple":[233],"intervention":[234],"(MEK-inhibition)":[235],"could":[236],"therapeutic":[239],"benefit":[240],"preventing":[242],"metastasis.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}