{"id":"https://openalex.org/W2342901323","doi":"https://doi.org/10.1371/journal.pcbi.1004884","title":"A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells","display_name":"A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells","publication_year":2016,"publication_date":"2016-04-28","ids":{"openalex":"https://openalex.org/W2342901323","doi":"https://doi.org/10.1371/journal.pcbi.1004884","mag":"2342901323","pmid":"https://pubmed.ncbi.nlm.nih.gov/27124473"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004884","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004884","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004884&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004884&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035500744","display_name":"V\u00edctor Trevi\u00f1o","orcid":"https://orcid.org/0000-0002-7472-9844"},"institutions":[{"id":"https://openalex.org/I98461037","display_name":"Tecnol\u00f3gico de Monterrey","ror":"https://ror.org/03ayjn504","country_code":"MX","type":"education","lineage":["https://openalex.org/I98461037"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Victor Trevino","raw_affiliation_strings":["Catedra de Bioinformatica, Escuela de Medicina, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catedra de Bioinformatica, Escuela de Medicina, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico","institution_ids":["https://openalex.org/I98461037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021757607","display_name":"Alberto Cassese","orcid":"https://orcid.org/0000-0001-5830-4136"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alberto Cassese","raw_affiliation_strings":["Department of Methodology and Statistics, Maastricht University, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Methodology and Statistics, Maastricht University, Maastricht, Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016026205","display_name":"Zsuzsanna Nagy","orcid":"https://orcid.org/0000-0002-6700-4829"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zsuzsanna Nagy","raw_affiliation_strings":["School of Experimental and Clinical Medicine, University of Birmingham, Edgbaston, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Experimental and Clinical Medicine, University of Birmingham, Edgbaston, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054796837","display_name":"Xiaodong Zhuang","orcid":"https://orcid.org/0000-0002-6870-9003"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiaodong Zhuang","raw_affiliation_strings":["School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040357793","display_name":"John Herbert","orcid":"https://orcid.org/0000-0003-1657-356X"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Herbert","raw_affiliation_strings":["Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083978685","display_name":"Philipp Antzack","orcid":null},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philipp Antzack","raw_affiliation_strings":["Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067892307","display_name":"Kim Clarke","orcid":"https://orcid.org/0000-0001-9176-6199"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kim Clarke","raw_affiliation_strings":["Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043746958","display_name":"Nicholas Davies","orcid":"https://orcid.org/0000-0003-0163-637X"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Davies","raw_affiliation_strings":["School of Cancer Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cancer Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084663088","display_name":"Ayesha Rahman","orcid":"https://orcid.org/0000-0002-6971-8825"},"institutions":[{"id":"https://openalex.org/I119664326","display_name":"University of Wolverhampton","ror":"https://ror.org/01k2y1055","country_code":"GB","type":"education","lineage":["https://openalex.org/I119664326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ayesha Rahman","raw_affiliation_strings":["School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, United Kingdom","institution_ids":["https://openalex.org/I119664326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060760341","display_name":"Moray J. Campbell","orcid":"https://orcid.org/0000-0002-3355-0928"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moray J. Campbell","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065405793","display_name":"Michele Guindani","orcid":"https://orcid.org/0000-0002-6363-9907"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Guindani","raw_affiliation_strings":["Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6363-9907","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034857234","display_name":"Roy Bicknell","orcid":"https://orcid.org/0000-0002-0941-8919"},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roy Bicknell","raw_affiliation_strings":["School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030348494","display_name":"Marina Vannucci","orcid":"https://orcid.org/0000-0002-7360-5321"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Vannucci","raw_affiliation_strings":["Department of Statistics, Rice University, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Rice University, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082775010","display_name":"Francesco Falciani","orcid":"https://orcid.org/0000-0003-1432-2871"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Francesco Falciani","raw_affiliation_strings":["Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5082775010"],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8543,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75652835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"12","issue":"4","first_page":"e1004884","last_page":"e1004884"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6468818187713623},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5705026388168335},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5611326098442078},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.5475375652313232},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4985995292663574},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.47204315662384033},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4617604911327362},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.43215233087539673},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.42867806553840637},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3527269959449768},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.3247281312942505},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3100960850715637},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.30626237392425537},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.24496665596961975},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17772233486175537}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6468818187713623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5705026388168335},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5611326098442078},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5475375652313232},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4985995292663574},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.47204315662384033},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4617604911327362},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.43215233087539673},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.42867806553840637},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3527269959449768},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3247281312942505},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3100960850715637},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30626237392425537},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24496665596961975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17772233486175537},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":14,"locations":[{"id":"doi:10.1371/journal.pcbi.1004884","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004884","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004884&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27124473","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27124473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/c718eccc-7e2d-4f8f-8738-778aceabb108","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/c718eccc-7e2d-4f8f-8738-778aceabb108","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trevino, V, Cassese, A, Nagy, Z, Zhuang, X, Herbert, J, Antzack, P, Clarke, K, Davies, N, Rahman, A, Campbell, M J, Guindani, M, Bicknell, R, Vannucci, M & Falciani, F 2016, 'A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells', PLoS Computational Biology, vol. 12, no. 4, e1004884. https://doi.org/10.1371/journal.pcbi.1004884","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:3472a02772584d088edb598268c1b9e8","is_oa":true,"landing_page_url":"https://doaj.org/article/3472a02772584d088edb598268c1b9e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 4, p e1004884 (2016)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7pr1d2qj","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7pr1d2qj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 12, iss 4","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3213247","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Network_Biology_Approach_Identifies_Molecular_Cross-Talk_between_Normal_Prostate_Epithelial_and_Prostate_Carcinoma_Cells/3213247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:flore.unifi.it:2158/1280505","is_oa":true,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004884","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4849722","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4849722","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:Publications/60d74e2d-d2b1-40b3-be56-1f9f7689bf18","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/60d74e2d-d2b1-40b3-be56-1f9f7689bf18","is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/60d74e2d-d2b1-40b3-be56-1f9f7689bf18","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trevino, V, Cassese, A, Nagy, Z, Zhuang, X, Herbert, J, Antzack, P, Clarke, K, Davies, N, Rahman, A, Campbell, M J, Guindani, M, Bicknell, R, Vannucci, M & Falciani, F 2016, 'A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells', PLoS Computational Biology, vol. 12, no. 4, e1004884. https://doi.org/10.1371/journal.pcbi.1004884, https://doi.org/10.1371/journal.pcbi.1004884","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/60d74e2d-d2b1-40b3-be56-1f9f7689bf18","is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/portal/en/publications/a-network-biology-approach-identifies-molecular-crosstalk-between-normal-prostate-epithelial-and-prostate-carcinoma-cells(60d74e2d-d2b1-40b3-be56-1f9f7689bf18).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:repositorio.itesm.mx:11285/630657","is_oa":true,"landing_page_url":"http://hdl.handle.net/11285/630657","pdf_url":null,"source":{"id":"https://openalex.org/S4306401729","display_name":"Institutional Repository of Tecnol\u00f3gico de Monterrey (Tecnol\u00f3gico de Monterrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98461037","host_organization_name":"Tecnol\u00f3gico de Monterrey","host_organization_lineage":["https://openalex.org/I98461037"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"Art\u00edculo"},{"id":"pmh:oai:wlv.openrepository.com:2436/614442","is_oa":true,"landing_page_url":"http://hdl.handle.net/2436/614442","pdf_url":null,"source":{"id":"https://openalex.org/S4306401000","display_name":"Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I119664326","host_organization_name":"University of Wolverhampton","host_organization_lineage":["https://openalex.org/I119664326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"12","raw_type":"Journal article"},{"id":"pmh:qt7pr1d2qj","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/7pr1d2qj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trevino, V; Cassese, A; Nagy, Z; Zhuang, X; Herbert, J; Antzack, P; \u00c2\u00a0et al.(2016). A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells. PLoS Computational Biology, 12(4), e1004884. doi: 10.1371/journal.pcbi.1004884. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7pr1d2qj","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004884","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004884","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004884&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.550000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1207441742","display_name":null,"funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1575601887","display_name":null,"funder_award_id":"P30 CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3894535583","display_name":null,"funder_award_id":"C8504/A9488","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2342901323.pdf","grobid_xml":"https://content.openalex.org/works/W2342901323.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1506981339","https://openalex.org/W1931245889","https://openalex.org/W1968302410","https://openalex.org/W1969096316","https://openalex.org/W1977058523","https://openalex.org/W1978314682","https://openalex.org/W1980582637","https://openalex.org/W1980981697","https://openalex.org/W1990899950","https://openalex.org/W1992452843","https://openalex.org/W2002189255","https://openalex.org/W2004939067","https://openalex.org/W2005659463","https://openalex.org/W2012730900","https://openalex.org/W2017645062","https://openalex.org/W2019083327","https://openalex.org/W2026734022","https://openalex.org/W2028226531","https://openalex.org/W2039224704","https://openalex.org/W2046701443","https://openalex.org/W2049391622","https://openalex.org/W2052769787","https://openalex.org/W2057360439","https://openalex.org/W2058596530","https://openalex.org/W2058856931","https://openalex.org/W2061750459","https://openalex.org/W2063978763","https://openalex.org/W2069695705","https://openalex.org/W2070602352","https://openalex.org/W2074121391","https://openalex.org/W2074158520","https://openalex.org/W2076241295","https://openalex.org/W2078249603","https://openalex.org/W2095090145","https://openalex.org/W2098283434","https://openalex.org/W2102601764","https://openalex.org/W2105912300","https://openalex.org/W2107633226","https://openalex.org/W2108819945","https://openalex.org/W2112151002","https://openalex.org/W2113717933","https://openalex.org/W2114660910","https://openalex.org/W2124770588","https://openalex.org/W2124954099","https://openalex.org/W2138559546","https://openalex.org/W2138885372","https://openalex.org/W2139290043","https://openalex.org/W2144656637","https://openalex.org/W2149015358","https://openalex.org/W2159400887","https://openalex.org/W2159675211","https://openalex.org/W2163076992","https://openalex.org/W2163296115","https://openalex.org/W2165891030","https://openalex.org/W2177931982","https://openalex.org/W3099289621","https://openalex.org/W3099602059","https://openalex.org/W6644964510"],"related_works":["https://openalex.org/W2884256268","https://openalex.org/W2156431842","https://openalex.org/W3175249469","https://openalex.org/W2761860359","https://openalex.org/W3108451992","https://openalex.org/W2100045972","https://openalex.org/W2969238713","https://openalex.org/W1547016179","https://openalex.org/W2336795226","https://openalex.org/W2055418365"],"abstract_inverted_index":{"The":[0,25,186],"advent":[1],"of":[2,10,14,22,34,40,49,70,91,98,108,122,128,143,146,154,167,188,240,263,276,285],"functional":[3],"genomics":[4],"has":[5,36,81,86],"enabled":[6],"the":[7,11,38,46,68,89,120,126,144,165,200,238,274],"genome-wide":[8,195],"characterization":[9,97],"molecular":[12],"state":[13],"cells":[15,207],"and":[16,29,101,149,202,225,229,249,259],"tissues,":[17,151],"virtually":[18],"at":[19],"every":[20],"level":[21],"biological":[23,63,286],"organization.":[24],"difficulty":[26],"in":[27,62,105,132,281],"organizing":[28],"mining":[30],"this":[31,79,158,189,231,267],"unprecedented":[32],"amount":[33],"information":[35],"stimulated":[37],"development":[39,69],"computational":[41],"methods":[42],"designed":[43,173],"to":[44,88,94,102,174,192,246,273],"infer":[45,175],"underlying":[47],"structure":[48],"regulatory":[50],"networks":[51,124,280],"from":[52],"observational":[53],"data.":[54],"These":[55],"important":[56],"developments":[57],"had":[58],"a":[59,71,95,103,133,168,183,219,270,282],"profound":[60],"impact":[61],"sciences":[64],"since":[65],"they":[66],"triggered":[67],"novel":[72,92],"data-driven":[73],"investigative":[74],"approach.":[75],"In":[76],"cancer":[77,109,194],"research,":[78],"strategy":[80,172,191],"been":[82],"particularly":[83],"successful.":[84],"It":[85],"contributed":[87],"identification":[90],"biomarkers,":[93],"better":[96],"disease":[99],"heterogeneity":[100],"more":[104],"depth":[106],"understanding":[107],"pathophysiology.":[110],"However,":[111],"so":[112],"far":[113],"these":[114,137],"approaches":[115],"have":[116],"not":[117],"explicitly":[118],"addressed":[119],"challenge":[121,159,275],"identifying":[123],"representing":[125],"interaction":[127],"different":[129],"cell":[130,180,242,278],"types":[131,181],"complex":[134,184],"tissue.":[135,185],"Since":[136],"interactions":[138],"represent":[139],"an":[140,209],"essential":[141],"part":[142],"biology":[145],"both":[147],"diseased":[148],"healthy":[150],"it":[152,260],"is":[153,160,251,261],"paramount":[155],"importance":[156],"that":[157,204,237],"addressed.":[161],"Here":[162],"we":[163,235],"report":[164],"definition":[166],"network":[169],"reverse":[170],"engineering":[171],"directional":[176],"signals":[177],"linking":[178],"adjacent":[179],"within":[182],"application":[187],"inference":[190],"prostate":[193,213],"expression":[196,227,239],"profiling":[197],"data":[198,228],"validated":[199],"approach":[201,272],"revealed":[203],"normal":[205],"epithelial":[206],"exert":[208],"anti-tumour":[210],"activity":[211],"on":[212],"carcinoma":[214],"cells.":[215],"Moreover,":[216],"by":[217,253],"using":[218],"Bayesian":[220],"hierarchical":[221],"model":[222],"integrating":[223],"genetics":[224],"gene":[226,255],"combining":[230],"with":[232],"survival":[233],"analysis,":[234],"show":[236],"putative":[241],"communication":[243,279],"genes":[244],"related":[245],"focal":[247],"adhesion":[248],"secretion":[250],"affected":[252],"epistatic":[254],"copy":[256],"number":[257],"variation":[258],"predictive":[262],"patient":[264],"survival.":[265],"Ultimately,":[266],"study":[268],"represents":[269],"generalizable":[271],"deciphering":[277],"wide":[283],"spectrum":[284],"systems.":[287]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}