{"id":"https://openalex.org/W2293244428","doi":"https://doi.org/10.1371/journal.pcbi.1004802","title":"Dynamical Allocation of Cellular Resources as an Optimal Control Problem: Novel Insights into Microbial Growth Strategies","display_name":"Dynamical Allocation of Cellular Resources as an Optimal Control Problem: Novel Insights into Microbial Growth Strategies","publication_year":2016,"publication_date":"2016-03-09","ids":{"openalex":"https://openalex.org/W2293244428","doi":"https://doi.org/10.1371/journal.pcbi.1004802","mag":"2293244428","pmid":"https://pubmed.ncbi.nlm.nih.gov/26958858"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004802","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004802","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004802&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004802&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025699145","display_name":"Nils Giordano","orcid":"https://orcid.org/0000-0003-2549-6631"},"institutions":[{"id":"https://openalex.org/I4210113150","display_name":"Laboratoire Interdisciplinaire de Physique","ror":"https://ror.org/023n9q531","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210113150","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4210101348","display_name":"Centre Inria de l'Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/00n8d6z93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I4210101348"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nils Giordano","raw_affiliation_strings":["Inria, Grenoble - Rh\u00f4ne-Alpes research centre, Montbonnot, Saint Ismier Cedex, France","Universit\u00e9 Grenoble Alpes, Laboratoire Interdisciplinaire de Physique (CNRS UMR 5588), Saint Martin d'H\u00e8res, France","Laboratoire Interdisciplinaire de Physique [Saint Martin d\u2019H\u00e8res]","Modeling, simulation, measurement, and control of bacterial regulatory networks"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria, Grenoble - Rh\u00f4ne-Alpes research centre, Montbonnot, Saint Ismier Cedex, France","institution_ids":["https://openalex.org/I4210101348","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Laboratoire Interdisciplinaire de Physique (CNRS UMR 5588), Saint Martin d'H\u00e8res, France","institution_ids":[]},{"raw_affiliation_string":"Laboratoire Interdisciplinaire de Physique [Saint Martin d\u2019H\u00e8res]","institution_ids":["https://openalex.org/I4210113150"]},{"raw_affiliation_string":"Modeling, simulation, measurement, and control of bacterial regulatory networks","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084554345","display_name":"Francis Mairet","orcid":"https://orcid.org/0000-0002-3236-9772"},"institutions":[{"id":"https://openalex.org/I4210106545","display_name":"Research Centre Inria Sophia Antipolis - M\u00e9diterran\u00e9e","ror":"https://ror.org/01nzkaw91","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283","https://openalex.org/I201841394","https://openalex.org/I4210106545"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francis Mairet","raw_affiliation_strings":["Inria, Sophia-Antipolis M\u00e9diterran\u00e9e research centre, Sophia-Antipolis Cedex, France","Biological control of artificial ecosystems"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria, Sophia-Antipolis M\u00e9diterran\u00e9e research centre, Sophia-Antipolis Cedex, France","institution_ids":["https://openalex.org/I4210106545"]},{"raw_affiliation_string":"Biological control of artificial ecosystems","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066109797","display_name":"Jean\u2010Luc Gouz\u00e9","orcid":"https://orcid.org/0000-0001-7156-7934"},"institutions":[{"id":"https://openalex.org/I4210106545","display_name":"Research Centre Inria Sophia Antipolis - M\u00e9diterran\u00e9e","ror":"https://ror.org/01nzkaw91","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283","https://openalex.org/I201841394","https://openalex.org/I4210106545"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Luc Gouz\u00e9","raw_affiliation_strings":["Inria, Sophia-Antipolis M\u00e9diterran\u00e9e research centre, Sophia-Antipolis Cedex, France","Biological control of artificial ecosystems"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria, Sophia-Antipolis M\u00e9diterran\u00e9e research centre, Sophia-Antipolis Cedex, France","institution_ids":["https://openalex.org/I4210106545"]},{"raw_affiliation_string":"Biological control of artificial ecosystems","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068981088","display_name":"Johannes Geiselmann","orcid":"https://orcid.org/0000-0002-1329-7558"},"institutions":[{"id":"https://openalex.org/I4210101348","display_name":"Centre Inria de l'Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/00n8d6z93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I4210101348"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4210113150","display_name":"Laboratoire Interdisciplinaire de Physique","ror":"https://ror.org/023n9q531","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210113150","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Johannes Geiselmann","raw_affiliation_strings":["Inria, Grenoble - Rh\u00f4ne-Alpes research centre, Montbonnot, Saint Ismier Cedex, France","Universit\u00e9 Grenoble Alpes, Laboratoire Interdisciplinaire de Physique (CNRS UMR 5588), Saint Martin d'H\u00e8res, France","Modeling, simulation, measurement, and control of bacterial regulatory networks","Laboratoire Interdisciplinaire de Physique [Saint Martin d\u2019H\u00e8res]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria, Grenoble - Rh\u00f4ne-Alpes research centre, Montbonnot, Saint Ismier Cedex, France","institution_ids":["https://openalex.org/I4210101348","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, Laboratoire Interdisciplinaire de Physique (CNRS UMR 5588), Saint Martin d'H\u00e8res, France","institution_ids":[]},{"raw_affiliation_string":"Modeling, simulation, measurement, and control of bacterial regulatory networks","institution_ids":[]},{"raw_affiliation_string":"Laboratoire Interdisciplinaire de Physique [Saint Martin d\u2019H\u00e8res]","institution_ids":["https://openalex.org/I4210113150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054406248","display_name":"Hidde de Jong","orcid":"https://orcid.org/0000-0002-2226-650X"},"institutions":[{"id":"https://openalex.org/I4210101348","display_name":"Centre Inria de l'Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/00n8d6z93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I4210101348"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Hidde de Jong","raw_affiliation_strings":["Inria, Grenoble - Rh\u00f4ne-Alpes research centre, Montbonnot, Saint Ismier Cedex, France","Modeling, simulation, measurement, and control of bacterial regulatory networks"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria, Grenoble - Rh\u00f4ne-Alpes research centre, Montbonnot, Saint Ismier Cedex, France","institution_ids":["https://openalex.org/I4210101348","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Modeling, simulation, measurement, and control of bacterial regulatory networks","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054406248","https://openalex.org/A5068981088"],"corresponding_institution_ids":["https://openalex.org/I4210101348","https://openalex.org/I4210113150","https://openalex.org/I899635006"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":6.4419,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.96998156,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"12","issue":"3","first_page":"e1004802","last_page":"e1004802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maximization","display_name":"Maximization","score":0.6514940857887268},{"id":"https://openalex.org/keywords/bacterial-growth","display_name":"Bacterial growth","score":0.5450253486633301},{"id":"https://openalex.org/keywords/exponential-growth","display_name":"Exponential growth","score":0.45538970828056335},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.4354422092437744},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.4326436221599579},{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.42466315627098083},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.41101551055908203},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3955550193786621},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.333164781332016},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3087822496891022},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2351360023021698},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.18238726258277893},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.1296178698539734}],"concepts":[{"id":"https://openalex.org/C2776330181","wikidata":"https://www.wikidata.org/wiki/Q18358244","display_name":"Maximization","level":2,"score":0.6514940857887268},{"id":"https://openalex.org/C17741926","wikidata":"https://www.wikidata.org/wiki/Q762045","display_name":"Bacterial growth","level":3,"score":0.5450253486633301},{"id":"https://openalex.org/C75235859","wikidata":"https://www.wikidata.org/wiki/Q582659","display_name":"Exponential growth","level":2,"score":0.45538970828056335},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4354422092437744},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4326436221599579},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.42466315627098083},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.41101551055908203},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3955550193786621},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.333164781332016},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3087822496891022},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2351360023021698},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.18238726258277893},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1296178698539734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011755","descriptor_name":"Pyrophosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011755","descriptor_name":"Pyrophosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011755","descriptor_name":"Pyrophosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1004802","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004802","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004802&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26958858","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26958858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-01332394v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-01332394","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2016, 12 (3), pp.e1004802. ⟨10.1371/journal.pcbi.1004802⟩","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1004802","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004802","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:archimer.ifremer.fr:49020","is_oa":true,"landing_page_url":"https://archimer.ifremer.fr/doc/00379/49020/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196267","display_name":"Institutional Archive of Ifremer (French Research Institute for Exploitation of the Sea)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I154202486","host_organization_name":"Ifremer","host_organization_lineage":["https://openalex.org/I154202486"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Computational Biology (1553-734X), 2016-03 , Vol. 12 , N. 3 , P. e1004802 (1-28)","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7d26a17dafaa4919ba0f18281c332cc6","is_oa":true,"landing_page_url":"https://doaj.org/article/7d26a17dafaa4919ba0f18281c332cc6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 3, p e1004802 (2016)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3769774","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4784908","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/3105673","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Dynamical_Allocation_of_Cellular_Resources_as_an_Optimal_Control_Problem_Novel_Insights_into_Microbial_Growth_Strategies/3105673","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004802","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004802","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004802&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.4399999976158142,"display_name":"Responsible consumption and production"}],"awards":[{"id":"https://openalex.org/G3635314633","display_name":null,"funder_award_id":"11-LABX-0028-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3710251737","display_name":null,"funder_award_id":"-11-LABX-0028-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5103729303","display_name":null,"funder_award_id":"ANR-11-BINF-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G799220982","display_name":null,"funder_award_id":"ANR-11-LABX-0028-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8533281491","display_name":null,"funder_award_id":"ANR-11-LABX-0028","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2293244428.pdf","grobid_xml":"https://content.openalex.org/works/W2293244428.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W108474905","https://openalex.org/W208046272","https://openalex.org/W235677381","https://openalex.org/W338168858","https://openalex.org/W1179069838","https://openalex.org/W1506462986","https://openalex.org/W1512810258","https://openalex.org/W1586251222","https://openalex.org/W1590996315","https://openalex.org/W1592648094","https://openalex.org/W1595159159","https://openalex.org/W1597762351","https://openalex.org/W1871441147","https://openalex.org/W1883779479","https://openalex.org/W1967039865","https://openalex.org/W1967104799","https://openalex.org/W1970707057","https://openalex.org/W1971167763","https://openalex.org/W1973670099","https://openalex.org/W1983260383","https://openalex.org/W1984251647","https://openalex.org/W1985161570","https://openalex.org/W1986842298","https://openalex.org/W1990503265","https://openalex.org/W1993004545","https://openalex.org/W1994782818","https://openalex.org/W1996238107","https://openalex.org/W2004252769","https://openalex.org/W2012757382","https://openalex.org/W2020083385","https://openalex.org/W2025663053","https://openalex.org/W2027257502","https://openalex.org/W2029213666","https://openalex.org/W2034876354","https://openalex.org/W2036449301","https://openalex.org/W2037135781","https://openalex.org/W2038701138","https://openalex.org/W2042493870","https://openalex.org/W2042632725","https://openalex.org/W2044889656","https://openalex.org/W2050758027","https://openalex.org/W2055631855","https://openalex.org/W2056747378","https://openalex.org/W2056756011","https://openalex.org/W2059690875","https://openalex.org/W2065744029","https://openalex.org/W2067252347","https://openalex.org/W2068165068","https://openalex.org/W2072447727","https://openalex.org/W2075210082","https://openalex.org/W2076477598","https://openalex.org/W2085482368","https://openalex.org/W2086128646","https://openalex.org/W2090433162","https://openalex.org/W2092122738","https://openalex.org/W2103087390","https://openalex.org/W2105028012","https://openalex.org/W2107275175","https://openalex.org/W2111354165","https://openalex.org/W2111421616","https://openalex.org/W2113468128","https://openalex.org/W2121530742","https://openalex.org/W2130863397","https://openalex.org/W2134001789","https://openalex.org/W2138611595","https://openalex.org/W2138990352","https://openalex.org/W2139500219","https://openalex.org/W2151153178","https://openalex.org/W2152199309","https://openalex.org/W2154282828","https://openalex.org/W2160541874","https://openalex.org/W2161782059","https://openalex.org/W2166374078","https://openalex.org/W2166751342","https://openalex.org/W2170806980","https://openalex.org/W2171582254","https://openalex.org/W2175978653","https://openalex.org/W2289479632","https://openalex.org/W2414074724","https://openalex.org/W2479760086","https://openalex.org/W2981557816","https://openalex.org/W4245882143","https://openalex.org/W4250523863","https://openalex.org/W4293078920","https://openalex.org/W6611659717","https://openalex.org/W6635158341"],"related_works":["https://openalex.org/W2003979390","https://openalex.org/W3036406961","https://openalex.org/W3021810344","https://openalex.org/W2005764988","https://openalex.org/W2004565981","https://openalex.org/W4240380089","https://openalex.org/W2011980925","https://openalex.org/W2076877976","https://openalex.org/W2799197989","https://openalex.org/W2043738678"],"abstract_inverted_index":{"Microbial":[0],"physiology":[1],"exhibits":[2],"growth":[3,15,69,81,107,130,146,230],"laws":[4],"that":[5,21,88,114],"relate":[6],"the":[7,11,14,65,175,184,201,214],"macromolecular":[8],"composition":[9],"of":[10,31,59,67,106,177,203,216],"cell":[12],"to":[13,63,71,132,140,157,219],"rate.":[16,147],"Recent":[17],"work":[18],"has":[19,171],"shown":[20,156],"these":[22,35],"empirical":[23],"regularities":[24],"can":[25,89],"be":[26,90],"derived":[27],"from":[28,128],"coarse-grained":[29],"models":[30],"resource":[32],"allocation.":[33],"While":[34],"studies":[36],"focus":[37],"on":[38,160],"steady-state":[39],"growth,":[40],"such":[41],"conditions":[42,154],"are":[43,51,124],"rarely":[44],"found":[45],"in":[46,109,152,183,206,231],"natural":[47],"habitats,":[48],"where":[49],"microorganisms":[50],"continually":[52],"challenged":[53],"by":[54,181],"environmental":[55],"fluctuations.":[56],"The":[57],"aim":[58],"this":[60,98,169],"paper":[61],"is":[62,155,226],"extend":[64],"study":[66],"microbial":[68],"strategies":[70,117],"dynamical":[72,80,153],"environments,":[73],"using":[74,92],"a":[75,141,144,164,191,207,232],"self-replicator":[76],"model.":[77],"We":[78,96,112],"formulate":[79],"maximization":[82,120],"as":[83,198,200],"an":[84],"optimal":[85],"control":[86,108,116,150],"problem":[87],"solved":[91],"Pontryagin's":[93],"Maximum":[94],"Principle.":[95],"compare":[97],"theoretical":[99],"gold":[100],"standard":[101],"with":[102,174],"different":[103],"possible":[104],"implementations":[105],"bacterial":[110,138],"cells.":[111],"find":[113],"simple":[115],"enabling":[118],"growth-rate":[119],"at":[121],"steady":[122],"state":[123],"suboptimal":[125],"for":[126,134,228],"transitions":[127],"one":[129],"regime":[131],"another,":[133],"example":[135],"when":[136],"shifting":[137],"cells":[139],"medium":[142],"supporting":[143],"higher":[145],"A":[148],"near-optimal":[149],"strategy":[151,170],"require":[158],"information":[159,221],"several,":[161],"rather":[162],"than":[163],"single":[165],"physiological":[166,224],"variable.":[167],"Interestingly,":[168],"structural":[172],"analogies":[173],"regulation":[176],"ribosomal":[178],"protein":[179],"synthesis":[180,205],"ppGpp":[182],"enterobacterium":[185],"Escherichia":[186],"coli.":[187],"It":[188],"involves":[189],"sensing":[190],"mismatch":[192],"between":[193],"precursor":[194],"and":[195],"ribosome":[196,204],"concentrations,":[197],"well":[199],"adjustment":[202],"switch-like":[208],"manner.":[209],"Our":[210],"results":[211],"show":[212],"how":[213],"capability":[215],"regulatory":[217],"systems":[218],"integrate":[220],"about":[222],"several":[223],"variables":[225],"critical":[227],"optimizing":[229],"changing":[233],"environment.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":2}],"updated_date":"2026-06-05T09:01:59.212387","created_date":"2025-10-10T00:00:00"}