{"id":"https://openalex.org/W2346996506","doi":"https://doi.org/10.1371/journal.pcbi.1004799","title":"Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals","display_name":"Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals","publication_year":2016,"publication_date":"2016-05-06","ids":{"openalex":"https://openalex.org/W2346996506","doi":"https://doi.org/10.1371/journal.pcbi.1004799","mag":"2346996506","pmid":"https://pubmed.ncbi.nlm.nih.gov/27152856"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004799","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004799","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004799&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004799&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032612485","display_name":"Luke I. Rast","orcid":null},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke I. Rast","raw_affiliation_strings":["Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033605267","display_name":"Igor M. Rouzine","orcid":"https://orcid.org/0000-0002-0744-6705"},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor M. Rouzine","raw_affiliation_strings":["Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076137504","display_name":"Ganna Rozhnova","orcid":"https://orcid.org/0000-0002-6725-7359"},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ganna Rozhnova","raw_affiliation_strings":["Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112387886","display_name":"L.A. Bishop","orcid":null},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Bishop","raw_affiliation_strings":["Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079499965","display_name":"Ariel D. Weinberger","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ariel D. Weinberger","raw_affiliation_strings":["Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043702774","display_name":"Leor S. Weinberger","orcid":"https://orcid.org/0000-0002-9987-6357"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leor S. Weinberger","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America","Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America","QB3: California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"QB3: California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5043702774","https://openalex.org/A5079499965"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I1321430492","https://openalex.org/I180670191"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6022,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83173077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"5","first_page":"e1004799","last_page":"e1004799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6850954294204712},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"Viral evolution","score":0.5918969511985779},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5768460035324097},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5327931046485901},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5219213962554932},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.4851003885269165},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.4597480595111847},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.4449293315410614},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.44404086470603943},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3122827708721161},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.19067102670669556},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17601558566093445},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.16774523258209229},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15812444686889648},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07387471199035645}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6850954294204712},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.5918969511985779},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5768460035324097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5327931046485901},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5219213962554932},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4851003885269165},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4597480595111847},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4449293315410614},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.44404086470603943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3122827708721161},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.19067102670669556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17601558566093445},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16774523258209229},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15812444686889648},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07387471199035645},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004799","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004799","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004799&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27152856","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27152856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/27320202","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320202","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ffd917ab5d91403e947bcf09262512a3","is_oa":false,"landing_page_url":"https://doaj.org/article/ffd917ab5d91403e947bcf09262512a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 5, p e1004799 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3367726","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Conflicting_Selection_Pressures_Will_Constrain_Viral_Escape_from_Interfering_Particles_Principles_for_Designing_Resistance-Proof_Antivirals/3367726","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4859541","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4859541","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004799","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004799","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004799&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G6406572750","display_name":null,"funder_award_id":"OD017181","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320333979","display_name":"Hansj\u00f6rg Wyss Institute for Biologically Inspired Engineering, Harvard University","ror":"https://ror.org/008cfmj78"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2346996506.pdf"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W26122824","https://openalex.org/W95904255","https://openalex.org/W1493165726","https://openalex.org/W1522687244","https://openalex.org/W1583066216","https://openalex.org/W1605127401","https://openalex.org/W1606697907","https://openalex.org/W1663829637","https://openalex.org/W1967266366","https://openalex.org/W1981259148","https://openalex.org/W1985693980","https://openalex.org/W1988240917","https://openalex.org/W1991930264","https://openalex.org/W1994307941","https://openalex.org/W2002574877","https://openalex.org/W2005364009","https://openalex.org/W2011630381","https://openalex.org/W2013957789","https://openalex.org/W2014903591","https://openalex.org/W2022098233","https://openalex.org/W2022101730","https://openalex.org/W2023763412","https://openalex.org/W2026020811","https://openalex.org/W2030069816","https://openalex.org/W2032735736","https://openalex.org/W2033084767","https://openalex.org/W2036938218","https://openalex.org/W2042891181","https://openalex.org/W2045614978","https://openalex.org/W2050337032","https://openalex.org/W2057850137","https://openalex.org/W2059977620","https://openalex.org/W2069251911","https://openalex.org/W2070649137","https://openalex.org/W2071886854","https://openalex.org/W2072615942","https://openalex.org/W2077294064","https://openalex.org/W2086666408","https://openalex.org/W2090080821","https://openalex.org/W2093519165","https://openalex.org/W2097471623","https://openalex.org/W2098625990","https://openalex.org/W2098729341","https://openalex.org/W2099535983","https://openalex.org/W2099782613","https://openalex.org/W2102653709","https://openalex.org/W2105264560","https://openalex.org/W2114705914","https://openalex.org/W2116738092","https://openalex.org/W2117031304","https://openalex.org/W2120612096","https://openalex.org/W2124139689","https://openalex.org/W2125957866","https://openalex.org/W2128726449","https://openalex.org/W2129395994","https://openalex.org/W2130719514","https://openalex.org/W2146950428","https://openalex.org/W2152177323","https://openalex.org/W2156075763","https://openalex.org/W2156293023","https://openalex.org/W2159481668","https://openalex.org/W2160226661","https://openalex.org/W2161778049","https://openalex.org/W2164084984","https://openalex.org/W2171689424","https://openalex.org/W2178473640","https://openalex.org/W2190326339","https://openalex.org/W4235416980","https://openalex.org/W4239648059","https://openalex.org/W4295837538"],"related_works":["https://openalex.org/W2155835698","https://openalex.org/W4288713694","https://openalex.org/W2076096978","https://openalex.org/W2094337488","https://openalex.org/W2350587855","https://openalex.org/W2044028228","https://openalex.org/W2047730886","https://openalex.org/W2009307527","https://openalex.org/W2074878346","https://openalex.org/W1995324211"],"abstract_inverted_index":{"The":[0],"rapid":[1],"evolution":[2],"of":[3,110,126,139,149,201,252],"RNA-encoded":[4],"viruses":[5],"such":[6],"as":[7,115],"HIV":[8,81,111,116,151,209,214,233],"presents":[9],"a":[10,99,154,199],"major":[11],"barrier":[12],"to":[13,33,49,52,102,132,170,184,226,249],"infectious":[14],"disease":[15],"control":[16,35,109],"using":[17],"conventional":[18],"pharmaceuticals":[19],"and":[20,195,219],"vaccines.":[21],"Previously,":[22],"it":[23],"was":[24],"proposed":[25],"that":[26,144,207,245],"defective":[27],"interfering":[28,68],"particles":[29],"could":[30],"be":[31,50,57,247],"developed":[32],"indefinitely":[34],"the":[36,77,93,113,124,137,147,204,236,250],"HIV/AIDS":[37],"pandemic;":[38],"in":[39,92,153,162,175,192],"individual":[40],"patients,":[41],"these":[42,66,179,202],"engineered":[43,67,225],"molecular":[44],"parasites":[45],"were":[46],"further":[47],"predicted":[48],"refractory":[51,248],"HIV's":[53],"mutational":[54],"escape":[55],"(i.e.,":[56,189],"'resistance-proof').":[58],"However,":[59],"an":[60],"outstanding":[61],"question":[62],"has":[63],"been":[64],"whether":[65,104],"particles-termed":[69],"Therapeutic":[70],"Interfering":[71],"Particles":[72],"(TIPs)-would":[73],"remain":[74],"resistance-proof":[75],"at":[76,112,216],"population-scale,":[78,114],"where":[79],"TIP-resistant":[80,150,166,180,213],"mutants":[82,152,167,181,215],"may":[83,246],"transmit":[84],"more":[85,229],"efficiently":[86],"by":[87,122],"reaching":[88],"higher":[89],"viral":[90,127],"loads":[91],"TIP-treated":[94,163,194],"subpopulation.":[95],"Here,":[96],"we":[97],"develop":[98],"multi-scale":[100],"model":[101,205],"test":[103],"TIPs":[105,131,223],"will":[106],"maintain":[107],"indefinite":[108],"('unilaterally')":[117],"evolves":[118],"toward":[119],"TIP":[120],"resistance":[121],"limiting":[123],"production":[125],"proteins":[128],"available":[129],"for":[130,241],"parasitize.":[133],"Model":[134],"results":[135,237],"capture":[136],"existence":[138],"two":[140],"intrinsic":[141],"evolutionary":[142],"tradeoffs":[143],"collectively":[145],"prevent":[146],"spread":[148],"population.":[155],"First,":[156],"despite":[157],"their":[158],"increased":[159],"transmission":[160,173],"rates":[161,174,188],"sub-populations,":[164],"unilateral":[165],"are":[168,182,224],"shown":[169,183],"have":[171,185],"reduced":[172,186],"TIP-untreated":[176,196],"sub-populations.":[177],"Second,":[178],"growth":[187],"replicative":[190],"fitness)":[191],"both":[193,217],"individuals.":[197],"As":[198],"result":[200],"tradeoffs,":[203],"finds":[206],"TIP-susceptible":[208],"strains":[210],"continually":[211],"outcompete":[212],"patient":[218],"population":[220],"scales":[221],"when":[222],"express":[227],">3-fold":[228],"genomic":[230],"RNA":[231],"than":[232],"expresses.":[234],"Thus,":[235],"provide":[238],"design":[239],"constraints":[240],"engineering":[242],"population-scale":[243],"therapies":[244],"acquisition":[251],"antiviral":[253],"resistance.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}