{"id":"https://openalex.org/W2291974241","doi":"https://doi.org/10.1371/journal.pcbi.1004787","title":"Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System","display_name":"Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System","publication_year":2016,"publication_date":"2016-02-29","ids":{"openalex":"https://openalex.org/W2291974241","doi":"https://doi.org/10.1371/journal.pcbi.1004787","mag":"2291974241","pmid":"https://pubmed.ncbi.nlm.nih.gov/26928575"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004787","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004787&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004787&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085228117","display_name":"Beata Hat","orcid":"https://orcid.org/0000-0002-7049-5729"},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"funder","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Beata Hat","raw_affiliation_strings":["Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041747421","display_name":"Marek Kocha\u0144czyk","orcid":"https://orcid.org/0000-0003-1215-3920"},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"funder","lineage":["https://openalex.org/I99542240"]},{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Marek Kocha\u0144czyk","raw_affiliation_strings":["Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068402419","display_name":"Marta N. Bogda\u0142","orcid":null},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"funder","lineage":["https://openalex.org/I99542240"]},{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Marta N. Bogda\u0142","raw_affiliation_strings":["Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024103451","display_name":"Tomasz Lipniacki","orcid":"https://orcid.org/0000-0002-3488-2561"},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"funder","lineage":["https://openalex.org/I99542240"]}],"countries":["PL","US"],"is_corresponding":true,"raw_author_name":"Tomasz Lipniacki","raw_affiliation_strings":["Department of Statistics, Rice University, Houston, Texas, United States of America","Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Rice University, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024103451","https://openalex.org/A5041747421","https://openalex.org/A5068402419","https://openalex.org/A5085228117"],"corresponding_institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I74775410","https://openalex.org/I99542240"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.0423,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.9346224,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"2","first_page":"e1004787","last_page":"e1004787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.8308669328689575},{"id":"https://openalex.org/keywords/limit-cycle","display_name":"Limit cycle","score":0.642043948173523},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.6096228957176208},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.5544146299362183},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.494476318359375},{"id":"https://openalex.org/keywords/positive-feedback","display_name":"Positive feedback","score":0.4759661555290222},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.46792009472846985},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.4673965871334076},{"id":"https://openalex.org/keywords/bifurcation","display_name":"Bifurcation","score":0.4616817831993103},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44993284344673157},{"id":"https://openalex.org/keywords/cell-cycle-checkpoint","display_name":"Cell cycle checkpoint","score":0.4239785075187683},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.4190846085548401},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3811257779598236},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.37617722153663635},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.3522821068763733},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3496093153953552},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.27391889691352844},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2517387866973877},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2206435203552246},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.1693800985813141},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12142303586006165},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11850228905677795},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.10290473699569702}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.8308669328689575},{"id":"https://openalex.org/C93357160","wikidata":"https://www.wikidata.org/wiki/Q1545916","display_name":"Limit cycle","level":3,"score":0.642043948173523},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6096228957176208},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5544146299362183},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.494476318359375},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.4759661555290222},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46792009472846985},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4673965871334076},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.4616817831993103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44993284344673157},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4239785075187683},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4190846085548401},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3811257779598236},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.37617722153663635},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3522821068763733},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3496093153953552},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27391889691352844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2517387866973877},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2206435203552246},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1693800985813141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12142303586006165},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11850228905677795},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.10290473699569702},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004787","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004787&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26928575","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26928575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:d152e6391b6b4463a84252266ef8fe81","is_oa":true,"landing_page_url":"https://doaj.org/article/d152e6391b6b4463a84252266ef8fe81","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 2, p e1004787 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3082492","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Feedbacks_Bifurcations_and_Cell_Fate_Decision_Making_in_the_p53_System/3082492","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4771203","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4771203","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004787","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004787&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions","score":0.800000011920929}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313934","display_name":"Institut national de recherche en informatique et en automatique (INRIA)","ror":"https://ror.org/02kvxyf05"},{"id":"https://openalex.org/F4320321042","display_name":"Fundacja na rzecz Nauki Polskiej","ror":"https://ror.org/048zd9m77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291974241.pdf","grobid_xml":"https://content.openalex.org/works/W2291974241.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W571141297","https://openalex.org/W1545893705","https://openalex.org/W1546636359","https://openalex.org/W1575619134","https://openalex.org/W1591281137","https://openalex.org/W1605218581","https://openalex.org/W1637251086","https://openalex.org/W1650797637","https://openalex.org/W1758114794","https://openalex.org/W1847864430","https://openalex.org/W1870720170","https://openalex.org/W1908445283","https://openalex.org/W1909097318","https://openalex.org/W1970329931","https://openalex.org/W1971306595","https://openalex.org/W1972856271","https://openalex.org/W1976295398","https://openalex.org/W1976372568","https://openalex.org/W1976873804","https://openalex.org/W1977701732","https://openalex.org/W1978518304","https://openalex.org/W1979012323","https://openalex.org/W1979634817","https://openalex.org/W1981306189","https://openalex.org/W1991494214","https://openalex.org/W1995117660","https://openalex.org/W1998713719","https://openalex.org/W1999266701","https://openalex.org/W2001533493","https://openalex.org/W2005082854","https://openalex.org/W2005236007","https://openalex.org/W2005732822","https://openalex.org/W2007275707","https://openalex.org/W2008757142","https://openalex.org/W2008887283","https://openalex.org/W2010114834","https://openalex.org/W2010134143","https://openalex.org/W2015519364","https://openalex.org/W2016503230","https://openalex.org/W2017739035","https://openalex.org/W2019838988","https://openalex.org/W2021862810","https://openalex.org/W2022811243","https://openalex.org/W2026779704","https://openalex.org/W2027217537","https://openalex.org/W2027572713","https://openalex.org/W2027573197","https://openalex.org/W2028109941","https://openalex.org/W2033144194","https://openalex.org/W2033194496","https://openalex.org/W2034269086","https://openalex.org/W2037643541","https://openalex.org/W2039030772","https://openalex.org/W2040169548","https://openalex.org/W2045086385","https://openalex.org/W2047365291","https://openalex.org/W2047979773","https://openalex.org/W2050981751","https://openalex.org/W2054208935","https://openalex.org/W2054311839","https://openalex.org/W2056349777","https://openalex.org/W2058631780","https://openalex.org/W2058830224","https://openalex.org/W2066511043","https://openalex.org/W2067751798","https://openalex.org/W2068345721","https://openalex.org/W2068371312","https://openalex.org/W2070732456","https://openalex.org/W2071420454","https://openalex.org/W2074320863","https://openalex.org/W2074545297","https://openalex.org/W2077783560","https://openalex.org/W2079706088","https://openalex.org/W2082979850","https://openalex.org/W2085418817","https://openalex.org/W2088308108","https://openalex.org/W2089574530","https://openalex.org/W2091545748","https://openalex.org/W2093380519","https://openalex.org/W2096008575","https://openalex.org/W2097651998","https://openalex.org/W2099627146","https://openalex.org/W2101019828","https://openalex.org/W2102684430","https://openalex.org/W2113126782","https://openalex.org/W2113628074","https://openalex.org/W2117591057","https://openalex.org/W2124037827","https://openalex.org/W2125505694","https://openalex.org/W2129172946","https://openalex.org/W2133959309","https://openalex.org/W2138919043","https://openalex.org/W2139374901","https://openalex.org/W2141973741","https://openalex.org/W2141997480","https://openalex.org/W2148535591","https://openalex.org/W2149013144","https://openalex.org/W2152750766","https://openalex.org/W2154692501","https://openalex.org/W2154893943","https://openalex.org/W2155418451","https://openalex.org/W2158005145","https://openalex.org/W2158367427","https://openalex.org/W2158691993","https://openalex.org/W2159099751","https://openalex.org/W2161810908","https://openalex.org/W2164489545","https://openalex.org/W2165526493","https://openalex.org/W2171407623","https://openalex.org/W2175715045","https://openalex.org/W2180487778","https://openalex.org/W2313997600","https://openalex.org/W2334359642","https://openalex.org/W2398163779","https://openalex.org/W2944782266","https://openalex.org/W4212962560","https://openalex.org/W4239403073","https://openalex.org/W6639182995","https://openalex.org/W6668165172","https://openalex.org/W6683963520","https://openalex.org/W6817966389"],"related_works":["https://openalex.org/W1718070434","https://openalex.org/W2060350357","https://openalex.org/W1996912812","https://openalex.org/W3208766294","https://openalex.org/W2101647844","https://openalex.org/W2032674711","https://openalex.org/W1513979854","https://openalex.org/W2767213640","https://openalex.org/W2123880844","https://openalex.org/W2951711641"],"abstract_inverted_index":{"The":[0,41,63],"p53":[1,31,198,201,220],"transcription":[2],"factor":[3],"is":[4,66,135],"a":[5,141,181,190,194],"regulator":[6],"of":[7,29,47,98,101,120,140,176,184,197],"key":[8],"cellular":[9],"processes":[10],"including":[11],"DNA":[12,187],"repair,":[13],"cell":[14,38,58,167,233],"cycle":[15,59,149],"arrest,":[16],"and":[17,51,61,76,81,91,113,178,214],"apoptosis.":[18,62],"In":[19],"this":[20],"theoretical":[21],"study,":[22],"we":[23,105],"investigate":[24],"how":[25],"the":[26,30,48,102,107,121,127,131,138,147],"complex":[27],"circuitry":[28],"network":[32],"allows":[33],"for":[34,57,79,94],"stochastic":[35,122],"yet":[36],"unambiguous":[37],"fate":[39],"decision-making.":[40],"proposed":[42],"Markov":[43],"chain":[44],"model":[45],"consists":[46],"regulatory":[49,64],"core":[50,65],"two":[52,69,82],"subordinated":[53],"bistable":[54],"modules":[55],"responsible":[56,78,93],"arrest":[60],"controlled":[67],"by":[68,74,88,137,153,211],"negative":[70],"feedback":[71,85],"loops":[72,86],"(regulated":[73,87],"Mdm2":[75],"Wip1)":[77],"oscillations,":[80],"antagonistic":[83],"positive":[84],"phosphatases":[89],"Wip1":[90,177,216],"PTEN)":[92],"bistability.":[95],"By":[96],"means":[97],"bifurcation":[99,144],"analysis":[100,161],"deterministic":[103],"approximation":[104],"capture":[106],"recurrent":[108],"solutions":[109],"(i.e.,":[110],"steady":[111,133],"states":[112],"limit":[114,148],"cycles)":[115],"that":[116],"delineate":[117],"temporal":[118],"responses":[119,185],"system.":[123],"Direct":[124],"switching":[125],"from":[126,189],"limit-cycle":[128],"oscillations":[129,222],"to":[130,170,186,193,206,218],"\"apoptotic\"":[132],"state":[134],"enabled":[136],"existence":[139],"subcritical":[142],"Neimark-Sacker":[143],"in":[145,208,223],"which":[146,203],"loses":[150],"its":[151],"stability":[152],"merging":[154],"with":[155],"an":[156,163],"unstable":[157],"invariant":[158],"torus.":[159],"Our":[160],"provides":[162],"explanation":[164],"why":[165],"cancer":[166],"lines":[168],"known":[169],"have":[171],"vastly":[172],"diverse":[173],"expression":[174],"levels":[175,217],"PTEN":[179,213,226],"exhibit":[180],"broad":[182],"spectrum":[183],"damage:":[188],"fast":[191],"transition":[192],"high":[195,212],"level":[196,221],"killer":[199],"(a":[200],"phosphoform":[202],"promotes":[204],"commitment":[205],"apoptosis)":[207],"cells":[209,224],"characterized":[210],"low":[215],"long-lasting":[219],"having":[225],"promoter":[227],"methylated":[228],"(as":[229],"in,":[230],"e.g.,":[231],"MCF-7":[232],"line).":[234]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
